Aliases for AHSA1 Gene
External Ids for AHSA1 Gene
Previous HGNC Symbols for AHSA1 Gene
Previous GeneCards Identifiers for AHSA1 Gene
GeneCards Summary for AHSA1 Gene
AHSA1 (Activator Of HSP90 ATPase Activity 1) is a Protein Coding gene. Diseases associated with AHSA1 include Stomatitis and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include chaperone binding and ATPase activator activity.
UniProtKB/Swiss-Prot Summary for AHSA1 Gene
Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).