Aliases for AHSA1 Gene

Aliases for AHSA1 Gene

  • Activator Of HSP90 ATPase Activity 1 2 3 5
  • P38 2 3 4
  • Activator Of 90 KDa Heat Shock Protein ATPase Homolog 1 3 4
  • C14orf3 3 4
  • HAha1 2 3
  • AHA1 3 4
  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) 2
  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 3
  • Chromosome 14 Open Reading Frame 3 2
  • AHSA1 5
  • Aha1 2

External Ids for AHSA1 Gene

Previous HGNC Symbols for AHSA1 Gene

  • C14orf3

Previous GeneCards Identifiers for AHSA1 Gene

  • GC14P075914
  • GC14P076994
  • GC14P077924
  • GC14P058090

Summaries for AHSA1 Gene

GeneCards Summary for AHSA1 Gene

AHSA1 (Activator Of HSP90 ATPase Activity 1) is a Protein Coding gene. Diseases associated with AHSA1 include Stomatitis and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include chaperone binding and ATPase activator activity.

UniProtKB/Swiss-Prot Summary for AHSA1 Gene

  • Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).

Gene Wiki entry for AHSA1 Gene

Additional gene information for AHSA1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AHSA1 Gene

Genomics for AHSA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AHSA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AHSA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AHSA1

Top Transcription factor binding sites by QIAGEN in the AHSA1 gene promoter:
  • c-Myb
  • FOXF2
  • IRF-2
  • ISGF-3
  • MIF-1
  • MZF-1
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58

Genomic Locations for AHSA1 Gene

Genomic Locations for AHSA1 Gene
chr14:77,457,867-77,469,472
(GRCh38/hg38)
Size:
11,606 bases
Orientation:
Plus strand
chr14:77,924,213-77,935,817
(GRCh37/hg19)
Size:
11,605 bases
Orientation:
Plus strand

Genomic View for AHSA1 Gene

Genes around AHSA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHSA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHSA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSA1 Gene

Proteins for AHSA1 Gene

  • Protein details for AHSA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95433-AHSA1_HUMAN
    Recommended name:
    Activator of 90 kDa heat shock protein ATPase homolog 1
    Protein Accession:
    O95433
    Secondary Accessions:
    • B2R9L2
    • B4DUR9
    • Q96IL6
    • Q9P060

    Protein attributes for AHSA1 Gene

    Size:
    338 amino acids
    Molecular mass:
    38274 Da
    Quaternary structure:
    • Interacts with HSPCA/HSP90 (PubMed:12504007, PubMed:12604615). Interacts (phosphorylated on Tyr-223) with HSP90AA1; the interaction activates HSP90AA1 ATPase activity (PubMed:27353360, PubMed:29127155). Interacts with HSP90AB1 (By similarity). Interacts with GCH1 (PubMed:16696853). Interacts with SRPK1 (PubMed:19240134). Interacts with FLCN (PubMed:27353360).
    • (Microbial infection) Interacts with vesicular stomatitis virus glycoprotein (VSV G) (via cytoplasmic tail).

    Three dimensional structures from OCA and Proteopedia for AHSA1 Gene

    Alternative splice isoforms for AHSA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AHSA1 Gene

Post-translational modifications for AHSA1 Gene

  • Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1.
  • Ubiquitination at Lys3, Lys94, Lys212, Lys249, and Lys328
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AHSA1 Gene

Domains & Families for AHSA1 Gene

Gene Families for AHSA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for AHSA1 Gene

InterPro:
Blocks:
  • Activator of Hsp90 ATPase homologue 1-like
ProtoNet:

Suggested Antigen Peptide Sequences for AHSA1 Gene

GenScript: Design optimal peptide antigens:
  • p38 (AHSA1_HUMAN)
  • cDNA FLJ56675, highly similar to Activator of 90 kDa heat shock protein ATPase homolog 1 (B4DUR9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95433

UniProtKB/Swiss-Prot:

AHSA1_HUMAN :
  • Belongs to the AHA1 family.
Family:
  • Belongs to the AHA1 family.
genes like me logo Genes that share domains with AHSA1: view

Function for AHSA1 Gene

Molecular function for AHSA1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).
UniProtKB/Swiss-Prot Induction:
By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).

Phenotypes From GWAS Catalog for AHSA1 Gene

Gene Ontology (GO) - Molecular Function for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IEA,IDA 12504007
GO:0005515 protein binding IPI 12604615
GO:0045296 cadherin binding HDA 25468996
GO:0051087 chaperone binding IEA,IDA 12504007
GO:0051879 Hsp90 protein binding IEA,IPI 29127155
genes like me logo Genes that share ontologies with AHSA1: view
genes like me logo Genes that share phenotypes with AHSA1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHSA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AHSA1 Gene

Localization for AHSA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHSA1 Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AHSA1 gene
Compartment Confidence
cytosol 5
extracellular 4
endoplasmic reticulum 4
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA,IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with AHSA1: view

Pathways & Interactions for AHSA1 Gene

PathCards logo

SuperPathways for AHSA1 Gene

SuperPathway Contained pathways
1 Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
.37
.37
2 T cell receptor signaling pathway
genes like me logo Genes that share pathways with AHSA1: view

Pathways by source for AHSA1 Gene

2 GeneGo (Thomson Reuters) pathways for AHSA1 Gene
  • CFTR folding and maturation (norm and CF)
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

SIGNOR curated interactions for AHSA1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA 21873635
GO:0016032 viral process IEA --
GO:0032781 positive regulation of ATPase activity IEA,IDA 29127155
genes like me logo Genes that share ontologies with AHSA1: view

Drugs & Compounds for AHSA1 Gene

No Compound Related Data Available

Transcripts for AHSA1 Gene

mRNA/cDNA for AHSA1 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHSA1

Alternative Splicing Database (ASD) splice patterns (SP) for AHSA1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: -
SP8:

Relevant External Links for AHSA1 Gene

GeneLoc Exon Structure for
AHSA1

Expression for AHSA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AHSA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AHSA1 Gene



Protein tissue co-expression partners for AHSA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AHSA1

SOURCE GeneReport for Unigene cluster for AHSA1 Gene:

Hs.204041

mRNA Expression by UniProt/SwissProt for AHSA1 Gene:

O95433-AHSA1_HUMAN
Tissue specificity: Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.

Evidence on tissue expression from TISSUES for AHSA1 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Liver(4.5)
  • Adrenal gland(4.4)
  • Blood(4.4)
  • Skin(3.7)
  • Pancreas(3.1)
  • Intestine(2.7)
  • Heart(2.7)
  • Kidney(2.7)
  • Muscle(2.7)
  • Spleen(2.4)
  • Stomach(2.2)
  • Lymph node(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with AHSA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AHSA1 Gene

Orthologs for AHSA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AHSA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AHSA1 30 31
  • 99.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AHSA1 30 31
  • 94.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AHSA1 30 31
  • 92.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ahsa1 30 17 31
  • 91.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ahsa1 30
  • 90.14 (n)
Oppossum
(Monodelphis domestica)
Mammalia AHSA1 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia AHSA1 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves AHSA1 30 31
  • 74.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AHSA1 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ahsa1 30
  • 67.16 (n)
Zebrafish
(Danio rerio)
Actinopterygii ahsa1l 30 31
  • 65.78 (n)
OneToMany
ahsa1 31
  • 60 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG1416 30 31
  • 52.38 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010514 30
  • 51.88 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_C01G10.8 30
  • 49.6 (n)
C01G10.8 31
  • 37 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04147g 30
  • 43.57 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHA1 30 31 33
  • 43.27 (n)
ManyToMany
HCH1 31
  • 28 (a)
ManyToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGL090W 30
  • 41.91 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G12050 30
  • 44.71 (n)
Rice
(Oryza sativa)
Liliopsida Os08g0464000 30
  • 47.82 (n)
Os.8027 30
Wheat
(Triticum aestivum)
Liliopsida Ta.1318 30
Bread mold
(Neurospora crassa)
Ascomycetes NCU04087 30
  • 45.49 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.08 30
  • 41.61 (n)
Species where no ortholog for AHSA1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AHSA1 Gene

ENSEMBL:
Gene Tree for AHSA1 (if available)
TreeFam:
Gene Tree for AHSA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AHSA1: view image

Paralogs for AHSA1 Gene

(22) SIMAP similar genes for AHSA1 Gene using alignment to 8 proteins:

  • AHSA1_HUMAN
  • B4DUR9_HUMAN
  • G3V3W9_HUMAN
  • G3V438_HUMAN
  • H0YJ63_HUMAN
  • H0YJG6_HUMAN
  • H0YJG7_HUMAN
  • H0YJU2_HUMAN

Pseudogenes.org Pseudogenes for AHSA1 Gene

genes like me logo Genes that share paralogs with AHSA1: view

No data available for Paralogs for AHSA1 Gene

Variants for AHSA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AHSA1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
773558 Benign: not provided 77,464,691(+) A/G INTRON_VARIANT
790280 Likely Benign: not provided 77,462,685(+) T/C MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for AHSA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AHSA1 Gene

Variant ID Type Subtype PubMed ID
nsv1041985 CNV loss 25217958
nsv832835 CNV gain 17160897

Variation tolerance for AHSA1 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AHSA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AHSA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHSA1 Gene

Disorders for AHSA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AHSA1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
stomatitis
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search AHSA1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with AHSA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AHSA1 Gene

Publications for AHSA1 Gene

  1. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PMID: 12604615) Lotz GP … Obermann WM (The Journal of biological chemistry 2003) 3 4 23
  2. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. (PMID: 29127155) Woodford MR … Mollapour M (The EMBO journal 2017) 3 4
  3. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4
  4. AHSA1 regulates proliferation, apoptosis, migration, and invasion of osteosarcoma. (PMID: 26796264) Shao J … Li Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 2 3
  5. Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. (PMID: 18556464) Sun F … Frizzell RA (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008) 3 23

Products for AHSA1 Gene

  • Signalway Proteins for AHSA1

Sources for AHSA1 Gene