Aliases for AHRR Gene
External Ids for AHRR Gene
Previous HGNC Symbols for AHRR Gene
Previous GeneCards Identifiers for AHRR Gene
The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
GeneCards Summary for AHRR Gene
AHRR (Aryl-Hydrocarbon Receptor Repressor) is a Protein Coding gene. Diseases associated with AHRR include Aryl Hydrocarbon Hydroxylase Inducibility and Male Infertility. Among its related pathways are Cytochrome P450 - arranged by substrate type and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and obsolete transcriptional repressor activity, RNA polymerase II transcription factor binding. An important paralog of this gene is AHR.
UniProtKB/Swiss-Prot Summary for AHRR Gene
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.