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The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this pro... See more...
Aliases for AHR Gene
Aliases for AHR Gene
External Ids for AHR Gene
- HGNC: 348
- Entrez Gene: 196
- Ensembl: ENSG00000106546
- OMIM: 600253
- UniProtKB: P35869
Previous GeneCards Identifiers for AHR Gene
- GC07P016982
- GC07P017082
- GC07P017111
- GC07P017304
- GC07P017224
Summaries for AHR Gene
-
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
GeneCards Summary for AHR Gene
AHR (Aryl Hydrocarbon Receptor) is a Protein Coding gene. Diseases associated with AHR include Retinitis Pigmentosa 85 and Retinitis Pigmentosa. Among its related pathways are Cytochrome P450 - arranged by substrate type and Aryl Hydrocarbon Receptor Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ENSG00000283321.
UniProtKB/Swiss-Prot Summary for AHR Gene
-
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
-
Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.
Additional gene information for AHR Gene
- HGNC(348)
- Entrez Gene(196)
- Ensembl(ENSG00000106546)
- OMIM(600253)
- UniProtKB(P35869)
- Open Targets Platform(ENSG00000106546)
- Monarch Initiative
- Search for AHR at DataMed
- Search for AHR at HumanCyc
No data available for CIViC Summary , Rfam classification and piRNA Summary for AHR Gene
Genomics for AHR Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for AHR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AHR on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AHR
- Top Transcription factor binding sites by QIAGEN in the AHR gene promoter:
-
- c-Myc
- GR
- GR-alpha
- HNF-3beta
- Max1
- PPAR-gamma1
- PPAR-gamma2
- Sp1
Genomic Locations for AHR Gene
Genomic Locations for AHR Gene
- chr7:16,916,359-17,346,152
- (GRCh38/hg38)
- Size:
- 429,794 bases
- Orientation:
- Plus strand
- chr7:17,338,246-17,385,776
- (GRCh37/hg19)
- Size:
- 47,531 bases
- Orientation:
- Plus strand
Genomic View for AHR Gene
Genes around AHR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p21.1 by HGNC
- 7p21.1 by Entrez Gene
- 7p21.1 by Ensembl
AHR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AHR Gene
Proteins for AHR Gene
-
Protein details for AHR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35869-AHR_HUMAN
- Recommended name:
- Aryl hydrocarbon receptor
- Protein Accession:
- P35869
- A4D130
- Q13728
- Q13803
- Q13804
Protein attributes for AHR Gene
- Size:
- 848 amino acids
- Molecular mass:
- 96147 Da
- Quaternary structure:
-
- Homodimer (By similarity). Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1. Interacts with HSP90AB1 (By similarity). Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). Interacts with TIPARP; leading to mono-ADP-ribosylation of AHR and subsequent inhibition of AHR (PubMed:23275542, PubMed:30373764).
Protein Expression for AHR Gene
Post-translational modifications for AHR Gene
- Mono-ADP-ribosylated, leading to inhibit transcription activator activity of AHR.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for AHR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences AHR Antibody (LS-A3018) and AHR Antibody (LS-A3391)
- NSJ Bioreagents Aryl Hydrocarbon Receptor Antibody (AHR)
- GeneTex Anti-AHR antibody [RPT1] and Anti-AHR antibody
- Novus Biologicals Antibodies for AHR
-
Abcam antibodies for AHR
- Invitrogen Antibodies for AHR (AFLGC-AHR)
- antibodies-online: Show 205 available Aryl Hydrocarbon Receptor Antibodies ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Antibodies
-
Recommended
- 159 WB Antibodies (anti-human)
- 35 IHC (p) Antibodies (anti-human)
- 17 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 82 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 106 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for AHR
- Sino Biological Antibodies for AHR
Protein Products
-
OriGene Purified Proteins for AHR
- Search Origene for MassSpec and Protein Over-expression Lysates for AHR
- Origene Custom Protein Services for AHR
-
Signalway Proteins for AHR
-
Abcam proteins for AHR
Assay Products
- Novus Biologicals ELISA Kits for AHR
- antibodies-online: Show 64 available Aryl Hydrocarbon Receptor Elisa Kits ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Elisa Kits
-
Quality Products:
- ABIN1113590
- ABIN414628
- ABIN364993
- ABIN1028163
- ABIN5519710
- ABIN5668303
- ABIN1169612
- ABIN626297
- ABIN454470
- ABIN1380335
- ABIN1568247
- ABIN1113589
- ABIN5519711
- ABIN5669683
- ABIN627554
- ABIN5591534
- ABIN1380908
- ABIN2945428
- ABIN4967327
- ABIN1113591
- ABIN810515
- ABIN432072
- ABIN1568248
- ABIN5519712
- ABIN5670349
- ABIN626724
- ABIN5652025
- ABIN1559435
- ABIN778153
- ABIN6201139
No data available for DME Specific Peptides for AHR Gene
Domains & Families for AHR Gene
Gene Families for AHR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for AHR Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- PAC motif
- PAS fold-3
- ProtoNet:
Suggested Antigen Peptide Sequences for AHR Gene
- GenScript: Design optimal peptide antigens:
-
- Class E basic helix-loop-helix protein 76 (AHR_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P35869UniProtKB/Swiss-Prot:
AHR_HUMAN :- The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.
- Domain:
-
- The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.
Function for AHR Gene
Molecular function for AHR Gene
- UniProtKB/Swiss-Prot Function:
- Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
- UniProtKB/Swiss-Prot Induction:
- Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).
- GENATLAS Biochemistry:
- aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest
Phenotypes From GWAS Catalog for AHR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 15681594 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0000987 | proximal promoter sequence-specific DNA binding | IDA | 23275542 |
| GO:0001094 | TFIID-class transcription factor complex binding | IPI | 15641800 |
| GO:0001223 | transcription coactivator binding | IPI | 15641800 |
Phenotypes for AHR Gene
- MGI mutant phenotypes for AHR:
-
inferred from 14 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for AHR:
-
- no effect
- Increased cell death HMECs cells
- Resistant to vaccinia virus (VACV-A4L) infection
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Reduced mammosphere formation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for AHR Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for AHR
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for AHR - Select products 50% OFF >
- * AHR CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHR
miRNA for AHR Gene
- miRTarBase miRNAs that target AHR
-
- mmu-miR-375-3p (MIRT001672)
- mmu-miR-124-3p (MIRT001720)
- hsa-miR-124-3p (MIRT002653)
- hsa-miR-130b-3p (MIRT020178)
- hsa-miR-98-5p (MIRT027562)
- hsa-miR-625-5p (MIRT039593)
- hsa-miR-26a-5p (MIRT050123)
- hsa-miR-3927-3p (MIRT103158)
- hsa-miR-6831-5p (MIRT103162)
- hsa-miR-181a-5p (MIRT438216)
- hsa-miR-1273e (MIRT482169)
- hsa-miR-6516-5p (MIRT482170)
- hsa-miR-550b-2-5p (MIRT482171)
- hsa-miR-455-3p (MIRT482172)
- hsa-miR-6807-5p (MIRT482173)
- hsa-miR-1227-3p (MIRT482174)
- hsa-miR-4451 (MIRT482175)
- hsa-miR-6086 (MIRT482176)
- hsa-miR-6499-3p (MIRT482177)
- hsa-miR-377-5p (MIRT482178)
- hsa-miR-4500 (MIRT482179)
- hsa-miR-4458 (MIRT482180)
- hsa-let-7i-5p (MIRT482181)
- hsa-let-7g-5p (MIRT482182)
- hsa-let-7f-5p (MIRT482183)
- hsa-let-7e-5p (MIRT482184)
- hsa-let-7d-5p (MIRT482185)
- hsa-let-7c-5p (MIRT482186)
- hsa-let-7b-5p (MIRT482187)
- hsa-let-7a-5p (MIRT482188)
- hsa-miR-6840-3p (MIRT482189)
- hsa-miR-665 (MIRT482190)
- hsa-miR-4459 (MIRT482191)
- hsa-miR-3152-5p (MIRT482192)
- hsa-miR-4774-3p (MIRT482193)
- hsa-miR-3117-3p (MIRT482194)
- hsa-miR-4775 (MIRT482195)
- hsa-miR-1258 (MIRT482196)
- hsa-miR-4645-3p (MIRT482197)
- hsa-miR-4699-5p (MIRT482198)
- hsa-miR-16-1-3p (MIRT482199)
- hsa-miR-545-5p (MIRT482200)
- hsa-miR-1197 (MIRT482201)
- hsa-miR-383-5p (MIRT482202)
- hsa-miR-6513-5p (MIRT675724)
- hsa-miR-887-5p (MIRT675725)
- hsa-miR-3913-5p (MIRT675726)
- hsa-miR-3122 (MIRT675727)
- hsa-miR-450a-1-3p (MIRT675728)
- hsa-miR-6780a-5p (MIRT675729)
- hsa-miR-6779-5p (MIRT675730)
- hsa-miR-3689c (MIRT675731)
- hsa-miR-3689b-3p (MIRT675732)
- hsa-miR-3689a-3p (MIRT675733)
- hsa-miR-30b-3p (MIRT675734)
- hsa-miR-1273h-5p (MIRT675735)
- hsa-miR-6788-5p (MIRT675736)
- hsa-miR-30c-2-3p (MIRT675737)
- hsa-miR-30c-1-3p (MIRT675738)
- hsa-miR-7977 (MIRT675739)
- hsa-miR-6778-5p (MIRT675740)
- hsa-miR-1233-5p (MIRT675741)
- hsa-miR-6799-5p (MIRT675742)
- hsa-miR-6883-5p (MIRT675743)
- hsa-miR-6785-5p (MIRT675744)
- hsa-miR-4728-5p (MIRT675745)
- hsa-miR-149-3p (MIRT675746)
- hsa-miR-7106-5p (MIRT675747)
- hsa-miR-4284 (MIRT675748)
- hsa-miR-2467-5p (MIRT675749)
- hsa-miR-383-3p (MIRT675750)
- hsa-miR-4761-5p (MIRT675751)
- hsa-miR-29a-3p (MIRT733336)
Transcription Factor Targets for AHR Gene
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Clone Products
- Applied Biological Materials (abm): Clones for AHR - Select products 50% OFF >
- * AHR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for AHR
- Addgene plasmids for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
Cell Line Products
-
Horizon Cell Lines for AHR
No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for AHR Gene
Localization for AHR Gene
Subcellular locations from UniProtKB/Swiss-Prot for AHR Gene
- Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. {ECO:0000250 UniProtKB:P30561}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | TAS,IDA | 10395741 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | TAS | 19538249 |
| GO:0005737 | cytoplasm | IDA | 15681594 |
Pathways & Interactions for AHR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
|
| 2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 3 | Metabolism |
.40
|
|
| 4 | Aldosterone synthesis and secretion |
.41
|
|
| 5 | Th17 cell differentiation | ||
Pathways by source for AHR Gene
6 BioSystems pathways for AHR Gene
11 Reactome pathways for AHR Gene
2 KEGG pathways for AHR Gene
1 GeneGo (Thomson Reuters) pathway for AHR Gene
- Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
1 R&D Systems pathway for AHR Gene
1 Qiagen pathway for AHR Gene
- AHR Pathway
Interacting Proteins for AHR Gene
Selected Interacting proteins:
P35869-AHR_HUMAN
ENSP00000242057
for AHR Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for AHR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0001568 | blood vessel development | NAS | 19538249 |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 10395741 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 15681594 |
| GO:0006366 | transcription by RNA polymerase II | IDA | 10395741 |
Drugs & Compounds for AHR Gene
(77) Drugs for AHR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Leflunomide | Approved, Investigational | Pharma | Target, agonist | AHR agonist,immunosuppressive agent | 91 | |
| Flutamide | Approved, Investigational | Pharma | Target, agonist | 68 | ||
| Mexiletine | Approved, Investigational | Pharma | Target, agonist | 21 | ||
| Nimodipine | Approved, Investigational | Pharma | Activator, Potentiation, Target, agonist | Ca2+ channel blocker (L-type) | 42 | |
| Diosmin | Approved, Investigational | Pharma | Target, agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| FICZ |
|
172922-91-7 |
|
|
(5) Tocris Compounds for AHR Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6,2',4'-Trimethoxyflavone | Aryl hydrocarbon receptor antagonist | 720675-74-1 |
| CH 223191 | Potent aryl hydrocarbon receptor (AhR) antagonist | 301326-22-7 |
| FICZ | High affinity aryl hydrocarbon receptor (AhR) agonist | 172922-91-7 |
| ITE | Endogenous agonist for the transcription factor aryl hydrocarbon receptor | 448906-42-1 |
| L-Kynurenine | Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand | 2922-83-0 |
(11) ApexBio Compounds for AHR Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6,2',4'-Trimethoxyflavone | 720675-74-1 | |
| CH 223191 | AhR antagonist | 301326-22-7 |
| DiMNF | AHR modulator | 14756-24-2 |
| ITE | AHR agonist | 448906-42-1 |
| Leflunomide | AHR agonist,immunosuppressive agent | 75706-12-6 |
| L-Kynurenine | 2922-83-0 | |
| MeBIO | CDK/Cyclin/ GSK-3/p25/AhR agonist | 667463-95-8 |
| Oltipraz | An antischistosomal agent | 64224-21-1 |
| Phortress | Prodrug of antitumor agent 5F 203 | 328087-38-3 |
| StemRegenin 1 (SR1) | AhR antagonist | 1227633-49-9 |
| SU5416 | VEGF receptor inhibitor and AHR agonist | 204005-46-9 |
Transcripts for AHR Gene
mRNA/cDNA for AHR Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000645559 93 nts (view in UCSC)
- ENST00000642825 6958 nts (view in UCSC)
- ENST00000242057 6243 nts (view in UCSC)
- ENST00000463496 4820 nts (view in UCSC)
- ENST00000475440 388 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for AHR - Select products 50% OFF >
- * AHR CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHR
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Clone Products
- Applied Biological Materials (abm): Clones for AHR - Select products 50% OFF >
- * AHR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for AHR
- Addgene plasmids for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
Relevant External Links for AHR Gene
- GeneLoc Exon Structure for
- AHR
Expression for AHR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
mRNA differential expression in normal tissues according to GTEx for AHR Gene
This gene is overexpressed in Nerve - Tibial (x4.5).
This gene is overexpressed in Placenta (63.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AHR Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AHR
SOURCE GeneReport for Unigene cluster for AHR Gene:
Hs.171189mRNA Expression by UniProt/SwissProt for AHR Gene:
P35869-AHR_HUMAN
Tissue specificity:
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Expressed in retinal photoreceptors (PubMed:29726989).
Evidence on tissue expression from TISSUES for AHR Gene
- Liver(4.7)
- Intestine(3.4)
- Spleen(3.2)
- Lung(3.2)
- Nervous system(3.2)
- Lymph node(3.1)
- Skin(3.1)
- Bone marrow(3.1)
- Blood(3)
- Heart(2.9)
- Kidney(2.9)
- Stomach(2.8)
- Thyroid gland(2.8)
- Muscle(2.7)
- Gall bladder(2.5)
- Adrenal gland(2.5)
- Pancreas(2.3)
- Eye(2.1)
- Urine(2)
Primer Products
-
OriGene qPCR primer pairs for AHR
-
OriGene qPCR primer pairs and template standards for AHR
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AHR Gene
Orthologs for AHR Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | AHR 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | AHR 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | AHR 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ahr 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ahr 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | AHR 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | AHR 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | AHR 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ahr 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | AHR 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ahr1b 30 |
|
||
| ahr1a 31 |
|
OneToOne | |||
| ahr1 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11494 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | ss 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ahr-1 31 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12569 30 |
|
- Species where no ortholog for AHR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for AHR Gene
- ENSEMBL:
- Gene Tree for AHR (if available)
- TreeFam:
- Gene Tree for AHR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AHR: view image
Paralogs for AHR Gene
Paralogs for AHR Gene
Pseudogenes.org Pseudogenes for AHR Gene
Variants for AHR Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AHR Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709061 | Benign: not provided | 17,339,013(+) | A/G | SYNONYMOUS_VARIANT | |
| 724009 | Likely Benign: not provided | 17,327,755(+) | G/A | INTRON_VARIANT | |
| 724383 | Likely Benign: not provided | 17,339,223(+) | T/A | SYNONYMOUS_VARIANT | |
| 724384 | Likely Benign: not provided | 17,339,226(+) | T/A | SYNONYMOUS_VARIANT | |
| 726412 | Benign: not provided | 17,339,284(+) | A/G | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11225n54 | CNV | gain | 21841781 |
| dgv6289n100 | CNV | gain | 25217958 |
| dgv6290n100 | CNV | gain | 25217958 |
| esv2422294 | CNV | duplication | 17116639 |
| esv2759515 | CNV | gain+loss | 17122850 |
| esv2764001 | CNV | gain+loss | 21179565 |
| esv34717 | CNV | gain | 17911159 |
| esv3612420 | CNV | loss | 21293372 |
| esv3612421 | CNV | gain | 21293372 |
| esv3891076 | CNV | gain | 25118596 |
| esv3891077 | CNV | gain | 25118596 |
| nsv1029065 | CNV | loss | 25217958 |
| nsv1114920 | CNV | deletion | 24896259 |
| nsv464398 | CNV | gain | 19166990 |
| nsv464399 | CNV | gain | 19166990 |
| nsv606343 | CNV | gain | 21841781 |
| nsv8064 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.78;
73.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AHR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHR Gene
Disorders for AHR Gene
(24) MalaCards diseases for AHR Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 85 |
|
|
| retinitis pigmentosa |
|
|
| eosinophilia-myalgia syndrome |
|
|
| seborrheic dermatitis |
|
|
| eosinophilic fasciitis |
|
|
Search AHR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
AHR_HUMAN- Retinitis pigmentosa 85 (RP85) [MIM:618345]: A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP85 is an autosomal recessive form manifesting as early-onset progressive difficulty to adapt in dim light and gradually decreasing visual acuity in both eyes. {ECO:0000269 PubMed:29726989}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for AHR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for AHR Gene
Publications for AHR Gene
- Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PMID: 11698344) Cauchi S … Massaad-Massade L (Carcinogenesis 2001) 3 4 23 41
- Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. (PMID: 18818557) Chen D … Lu D (Pharmacogenetics and genomics 2009) 3 23 41
- Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 23 41
- Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. (PMID: 19736056) Gold LS … Baris D (Cancer epidemiology 2009) 3 23 41
- The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. (PMID: 17559847) Merisalu A … Salumets A (Fertility and sterility 2007) 3 23 41
ExternalLinks
Products for AHR Gene
- Custom Antibody ServicesOriGene Antibodies for AHR
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for AHR
- Search Origene for MassSpec and Protein Over-expression Lysates for AHR
- Origene Custom Protein Services for AHR
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
- OriGene qPCR primer pairs for AHR
- OriGene qPCR primer pairs and template standards for AHR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AHR
- Sino Biological Human cDNA Clone for AHR
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for AHR
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for AHR
- Novus Biologicals proteins and lysates for AHR
- Novus Biologicals ELISA Kits for AHR
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for AHR
- Abcam proteins for AHR
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for AHR (AFLGC-AHR)
- ApexBio compounds for AHR
- VectorBuilder Custom and pre-made DNA vectors for AHR (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for AHR (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for AHR (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for AHR CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for AHR
- Addgene plasmids for AHR
- antibodies-online: Show 205 available Aryl Hydrocarbon Receptor Antibodies ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Antibodies
- Recommended
- 159 WB Antibodies (anti-human)
- 35 IHC (p) Antibodies (anti-human)
- 17 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 82 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 106 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- antibodies-online: Show 64 available Aryl Hydrocarbon Receptor Elisa Kits ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Elisa Kits
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- ABIN1113590
- ABIN414628
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- ABIN1028163
- ABIN5519710
- ABIN5668303
- ABIN1169612
- ABIN626297
- ABIN454470
- ABIN1380335
- ABIN1568247
- ABIN1113589
- ABIN5519711
- ABIN5669683
- ABIN627554
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- ABIN1380908
- ABIN2945428
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- ABIN810515
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- ABIN5519712
- ABIN5670349
- ABIN626724
- ABIN5652025
- ABIN1559435
- ABIN778153
- ABIN6201139
- antibodies-online: Show 9 available Aryl Hydrocarbon Receptor Proteins ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for AHR
- Search Santa Cruz Biotechnology (SCBT) for AHR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AHR
- Horizon Cell Lines for AHR
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
- Search GeneCopoeia for miRNA 3'UTR Target clone products for AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Sources for AHR Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB