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The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this pro... See more...
Aliases for AHR Gene
Aliases for AHR Gene
External Ids for AHR Gene
- HGNC: 348
- NCBI Entrez Gene: 196
- Ensembl: ENSG00000106546
- OMIM®: 600253
- UniProtKB/Swiss-Prot: P35869
Previous GeneCards Identifiers for AHR Gene
- GC07P016982
- GC07P017082
- GC07P017111
- GC07P017304
- GC07P017224
Summaries for AHR Gene
-
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
GeneCards Summary for AHR Gene
AHR (Aryl Hydrocarbon Receptor) is a Protein Coding gene. Diseases associated with AHR include Retinitis Pigmentosa 85 and Retinitis Pigmentosa. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and AHR Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ENSG00000283321.
UniProtKB/Swiss-Prot Summary for AHR Gene
-
Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:30373764, PubMed:23275542, PubMed:7961644, PubMed:32818467). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:30373764, PubMed:23275542, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32866000, PubMed:32818467). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
-
Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.
Additional gene information for AHR Gene
No data available for CIViC Summary , Rfam classification and piRNA Summary for AHR Gene
Genomics for AHR Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for AHR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AHR on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AHR
- Top Transcription factor binding sites by QIAGEN in the AHR gene promoter:
-
- c-Myc
- GR
- GR-alpha
- HNF-3beta
- Max1
- PPAR-gamma1
- PPAR-gamma2
- Sp1
Genomic Locations for AHR Gene
Latest Assembly
- chr7:16,916,359-17,346,152
- (GRCh38/hg38)
- Size:
- 429,794 bases
- Orientation:
- Plus strand
Previous Assembly
- chr7:17,338,276-17,385,771
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 47,496 bases
- Orientation:
- Plus strand
Genomic View for AHR Gene
Genes around AHR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p21.1 by HGNC
- 7p21.1 by Entrez Gene
- 7p21.1 by Ensembl
AHR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AHR Gene
Proteins for AHR Gene
-
Protein details for AHR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35869-AHR_HUMAN
- Recommended name:
- Aryl hydrocarbon receptor
- Protein Accession:
- P35869
- A4D130
- Q13728
- Q13803
- Q13804
Protein attributes for AHR Gene
- Size:
- 848 amino acids
- Molecular mass:
- 96147 Da
- Quaternary structure:
-
- Homodimer (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:10395741, PubMed:28602820). Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). Binds MYBBP1A (By similarity). Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT (PubMed:10395741). Interacts with NEDD8 and IVNS1ABP (PubMed:12215427, PubMed:16582008). Interacts with ARNTL/BMAL1 (By similarity). Interacts with HSP90AB1 (By similarity). Interacts with TIPARP; leading to mono-ADP-ribosylation of AHR and subsequent inhibition of AHR (PubMed:23275542, PubMed:30373764).
Protein Expression for AHR Gene
Post-translational modifications for AHR Gene
- Mono-ADP-ribosylated, leading to inhibit transcription activator activity of AHR.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for AHR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences AHR Antibody (LS-A3018) and AHR Antibody (LS-A3391)
- NSJ Bioreagents Aryl Hydrocarbon Receptor Antibody (AHR)
- GeneTex Anti-AHR antibody [RPT1] and Anti-AHR antibody
- Novus Biologicals Antibodies for AHR
-
Abcam antibodies for AHR
- Invitrogen Antibodies for AHR (AFLGC-AHR)
- antibodies-online: Show 205 available Aryl Hydrocarbon Receptor Antibodies ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Antibodies
-
Recommended
- 159 WB Antibodies (anti-human)
- 35 IHC (p) Antibodies (anti-human)
- 17 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 82 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 106 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
-
Custom Antibody ServicesProSci Antibodies for AHR
- aryl hydrocarbon receptor [15-576]
- aryl hydrocarbon receptor [18-223]
- aryl hydrocarbon receptor [27-379]
- aryl hydrocarbon receptor [27-527]
- aryl hydrocarbon receptor [48-213]
- aryl hydrocarbon receptor [51-879]
- aryl hydrocarbon receptor [43-451]
- aryl hydrocarbon receptor [43-478]
- aryl hydrocarbon receptor [48-197]
- aryl hydrocarbon receptor [48-198]
- aryl hydrocarbon receptor [48-199]
- Aryl hydrocarbon receptor [61-965]
- aryl hydrocarbon receptor [70-830]
-
Santa Cruz Biotechnology (SCBT) Antibodies for AHR
- Sino Biological Antibodies for AHR
Protein products for research
-
OriGene Purified Proteins for AHR
- Search Origene for MassSpec and Protein Over-expression Lysates for AHR
- Origene Custom Protein Services for AHR
-
Abcam proteins for AHR
Assay products for research
- Novus Biologicals ELISA Kits for AHR
- antibodies-online: Show 64 available Aryl Hydrocarbon Receptor Elisa Kits ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Elisa Kits
-
Quality Products:
- ABIN1113590
- ABIN414628
- ABIN364993
- ABIN1028163
- ABIN5519710
- ABIN5668303
- ABIN1169612
- ABIN626297
- ABIN454470
- ABIN1380335
- ABIN1568247
- ABIN1113589
- ABIN5519711
- ABIN5669683
- ABIN627554
- ABIN5591534
- ABIN1380908
- ABIN2945428
- ABIN4967327
- ABIN1113591
- ABIN810515
- ABIN432072
- ABIN1568248
- ABIN5519712
- ABIN5670349
- ABIN626724
- ABIN5652025
- ABIN1559435
- ABIN778153
- ABIN6201139
No data available for DME Specific Peptides for AHR Gene
Domains & Families for AHR Gene
Gene Families for AHR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for AHR Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- PAC motif
- PAS fold-3
Suggested Antigen Peptide Sequences for AHR Gene
- GenScript: Design optimal peptide antigens:
-
- Class E basic helix-loop-helix protein 76 (AHR_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P35869UniProtKB/Swiss-Prot:
AHR_HUMAN :- The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.
- Domain:
-
- The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.
Function for AHR Gene
Molecular function for AHR Gene
- UniProtKB/Swiss-Prot Function:
- Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:30373764, PubMed:23275542, PubMed:7961644, PubMed:32818467). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:30373764, PubMed:23275542, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32866000, PubMed:32818467). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
- UniProtKB/Swiss-Prot Induction:
- Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).
- GENATLAS Biochemistry:
- aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest
Phenotypes From GWAS Catalog for AHR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 15681594 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0000987 | proximal promoter sequence-specific DNA binding | IDA | 23275542 |
| GO:0001094 | TFIID-class transcription factor complex binding | IPI | 15641800 |
| GO:0001223 | transcription coactivator binding | IPI | 15641800 |
Phenotypes for AHR Gene
- MGI mutant phenotypes for AHR:
-
inferred from 14 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for AHR:
-
- shRNA abundance <= 50%
- Reduced mammosphere formation
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased cell death HMECs cells
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for AHR Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for AHR
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for AHR - Starting at $85 >
- * AHR CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHR
miRNA for AHR Gene
- miRTarBase miRNAs that target AHR
-
- mmu-miR-375-3p (MIRT001672)
- mmu-miR-124-3p (MIRT001720)
- hsa-miR-124-3p (MIRT002653)
- hsa-miR-130b-3p (MIRT020178)
- hsa-miR-98-5p (MIRT027562)
- hsa-miR-625-5p (MIRT039593)
- hsa-miR-26a-5p (MIRT050123)
- hsa-miR-3927-3p (MIRT103158)
- hsa-miR-6831-5p (MIRT103162)
- hsa-miR-181a-5p (MIRT438216)
- hsa-miR-1273e (MIRT482169)
- hsa-miR-6516-5p (MIRT482170)
- hsa-miR-550b-2-5p (MIRT482171)
- hsa-miR-455-3p (MIRT482172)
- hsa-miR-6807-5p (MIRT482173)
- hsa-miR-1227-3p (MIRT482174)
- hsa-miR-4451 (MIRT482175)
- hsa-miR-6086 (MIRT482176)
- hsa-miR-6499-3p (MIRT482177)
- hsa-miR-377-5p (MIRT482178)
- hsa-miR-4500 (MIRT482179)
- hsa-miR-4458 (MIRT482180)
- hsa-let-7i-5p (MIRT482181)
- hsa-let-7g-5p (MIRT482182)
- hsa-let-7f-5p (MIRT482183)
- hsa-let-7e-5p (MIRT482184)
- hsa-let-7d-5p (MIRT482185)
- hsa-let-7c-5p (MIRT482186)
- hsa-let-7b-5p (MIRT482187)
- hsa-let-7a-5p (MIRT482188)
- hsa-miR-6840-3p (MIRT482189)
- hsa-miR-665 (MIRT482190)
- hsa-miR-4459 (MIRT482191)
- hsa-miR-3152-5p (MIRT482192)
- hsa-miR-4774-3p (MIRT482193)
- hsa-miR-3117-3p (MIRT482194)
- hsa-miR-4775 (MIRT482195)
- hsa-miR-1258 (MIRT482196)
- hsa-miR-4645-3p (MIRT482197)
- hsa-miR-4699-5p (MIRT482198)
- hsa-miR-16-1-3p (MIRT482199)
- hsa-miR-545-5p (MIRT482200)
- hsa-miR-1197 (MIRT482201)
- hsa-miR-383-5p (MIRT482202)
- hsa-miR-6513-5p (MIRT675724)
- hsa-miR-887-5p (MIRT675725)
- hsa-miR-3913-5p (MIRT675726)
- hsa-miR-3122 (MIRT675727)
- hsa-miR-450a-1-3p (MIRT675728)
- hsa-miR-6780a-5p (MIRT675729)
- hsa-miR-6779-5p (MIRT675730)
- hsa-miR-3689c (MIRT675731)
- hsa-miR-3689b-3p (MIRT675732)
- hsa-miR-3689a-3p (MIRT675733)
- hsa-miR-30b-3p (MIRT675734)
- hsa-miR-1273h-5p (MIRT675735)
- hsa-miR-6788-5p (MIRT675736)
- hsa-miR-30c-2-3p (MIRT675737)
- hsa-miR-30c-1-3p (MIRT675738)
- hsa-miR-7977 (MIRT675739)
- hsa-miR-6778-5p (MIRT675740)
- hsa-miR-1233-5p (MIRT675741)
- hsa-miR-6799-5p (MIRT675742)
- hsa-miR-6883-5p (MIRT675743)
- hsa-miR-6785-5p (MIRT675744)
- hsa-miR-4728-5p (MIRT675745)
- hsa-miR-149-3p (MIRT675746)
- hsa-miR-7106-5p (MIRT675747)
- hsa-miR-4284 (MIRT675748)
- hsa-miR-2467-5p (MIRT675749)
- hsa-miR-383-3p (MIRT675750)
- hsa-miR-4761-5p (MIRT675751)
- hsa-miR-29a-3p (MIRT733336)
Transcription Factor Targets for AHR Gene
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Clone products for research
- Applied Biological Materials (abm): Clones for AHR - Starting at $45 >
- * AHR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for AHR
- Addgene plasmids for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
Cell Lines for research
-
Horizon Cell Lines for AHR
No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for AHR Gene
Localization for AHR Gene
Subcellular locations from UniProtKB/Swiss-Prot for AHR Gene
- Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. {ECO:0000250 UniProtKB:P30561}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0005634 | nucleus | TAS,IDA | 10395741 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | TAS | 19538249 |
| GO:0005737 | cytoplasm | IDA | 15681594 |
Pathways & Interactions for AHR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
|
| 2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 3 | Metabolism |
.40
|
|
| 4 | Aldosterone synthesis and secretion |
.41
|
|
| 5 | Th17 cell differentiation | ||
Pathways by source for AHR Gene
6 BioSystems pathways for AHR Gene
11 Reactome pathways for AHR Gene
2 KEGG pathways for AHR Gene
1 GeneGo (Thomson Reuters) pathway for AHR Gene
- Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
1 R&D Systems pathway for AHR Gene
1 Qiagen pathway for AHR Gene
- AHR Pathway
Interacting Proteins for AHR Gene
Selected Interacting proteins:
P35869-AHR_HUMAN
ENSP00000242057
for AHR Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for AHR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001568 | blood vessel development | NAS | 19538249 |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 10395741 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 15681594 |
| GO:0006805 | xenobiotic metabolic process | TAS | 19538249 |
| GO:0006915 | apoptotic process | TAS | 12213388 |
Drugs & Compounds for AHR Gene
(77) Drugs for AHR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Leflunomide | Approved, Investigational | Pharma | Target, agonist | AHR agonist,immunosuppressive agent | 99 | |
| Flutamide | Approved, Investigational | Pharma | Target, agonist | 70 | ||
| Mexiletine | Approved, Investigational | Pharma | Target, agonist | 25 | ||
| Nimodipine | Approved, Investigational | Pharma | Target, agonist | Ca2+ channel blocker (L-type) | 44 | |
| Diosmin | Approved, Investigational | Pharma | Target, agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| FICZ |
|
172922-91-7 |
|
|
(5) Tocris Compounds for AHR Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6,2',4'-Trimethoxyflavone | Aryl hydrocarbon receptor antagonist | 720675-74-1 |
| CH 223191 | Potent aryl hydrocarbon receptor (AhR) antagonist | 301326-22-7 |
| FICZ | High affinity aryl hydrocarbon receptor (AhR) agonist | 172922-91-7 |
| ITE | Endogenous agonist for the transcription factor aryl hydrocarbon receptor | 448906-42-1 |
| L-Kynurenine | Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand | 2922-83-0 |
(11) ApexBio Compounds for AHR Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6,2',4'-Trimethoxyflavone | 720675-74-1 | |
| CH 223191 | AhR antagonist | 301326-22-7 |
| DiMNF | AHR modulator | 14756-24-2 |
| ITE | AHR agonist | 448906-42-1 |
| Leflunomide | AHR agonist,immunosuppressive agent | 75706-12-6 |
| L-Kynurenine | 2922-83-0 | |
| MeBIO | CDK/Cyclin/ GSK-3/p25/AhR agonist | 667463-95-8 |
| Oltipraz | An antischistosomal agent | 64224-21-1 |
| Phortress | Prodrug of antitumor agent 5F 203 | 328087-38-3 |
| StemRegenin 1 (SR1) | AhR antagonist | 1227633-49-9 |
| SU5416 | VEGF receptor inhibitor and AHR agonist | 204005-46-9 |
Transcripts for AHR Gene
mRNA/cDNA for AHR Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000242057 6243 nts (view in UCSC)
- ENST00000463496 4820 nts (view in UCSC)
- ENST00000475440 388 nts (view in UCSC)
- ENST00000481944 518 nts (view in UCSC)
- ENST00000492120 684 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for AHR - Starting at $85 >
- * AHR CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHR
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Clone products for research
- Applied Biological Materials (abm): Clones for AHR - Starting at $45 >
- * AHR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for AHR
- Addgene plasmids for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
Relevant External Links for AHR Gene
- GeneLoc Exon Structure for
- AHR
Expression for AHR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
mRNA differential expression in normal tissues according to GTEx for AHR Gene
This gene is overexpressed in Nerve - Tibial (x4.5).
This gene is overexpressed in Placenta (63.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AHR Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AHR
SOURCE GeneReport for Unigene cluster for AHR Gene:
Hs.171189mRNA Expression by UniProt/SwissProt for AHR Gene:
P35869-AHR_HUMAN
Tissue specificity:
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Expressed in retinal photoreceptors (PubMed:29726989).
Evidence on tissue expression from TISSUES for AHR Gene
- Liver(4.4)
Primer products for research
-
OriGene qPCR primer pairs for AHR
-
OriGene qPCR primer pairs and template standards for AHR
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AHR Gene
Orthologs for AHR Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | AHR 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | AHR 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | AHR 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ahr 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ahr 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | AHR 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | AHR 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | AHR 29 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ahr 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | AHR 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ahr1b 29 |
|
||
| ahr1a 30 |
|
OneToOne | |||
| ahr1 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11494 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | ss 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ahr-1 30 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12569 29 |
|
- Species where no ortholog for AHR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for AHR Gene
- ENSEMBL:
- Gene Tree for AHR (if available)
- TreeFam:
- Gene Tree for AHR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AHR: view image
- Alliance of Genome Resources:
- Additional Orthologs for AHR
Paralogs for AHR Gene
Paralogs for AHR Gene
Pseudogenes.org Pseudogenes for AHR Gene
Variants for AHR Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AHR Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1002056 | Uncertain Significance: not provided | 17,335,696(+) |
A/C NM_001621.5(AHR):c.1070A>C (p.Asn357Thr) |
MISSENSE | |
| 1004508 | Uncertain Significance: not provided | 17,340,197(+) |
T/G NM_001621.5(AHR):c.2372T>G (p.Val791Gly) |
MISSENSE | |
| 1004660 | Uncertain Significance: not provided | 17,342,945(+) |
A/G NM_001621.5(AHR):c.2428A>G (p.Thr810Ala) |
MISSENSE | |
| 1004766 | Uncertain Significance: not provided | 17,339,997(+) |
TGAA/T NM_001621.5(AHR):c.2173_2175del (p.Glu725del) |
INFRAME_DELETION | |
| 1004831 | Uncertain Significance: not provided | 17,334,035(+) |
A/G NM_001621.5(AHR):c.829A>G (p.Ile277Val) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11225n54 | CNV | gain | 21841781 |
| dgv6289n100 | CNV | gain | 25217958 |
| dgv6290n100 | CNV | gain | 25217958 |
| esv2422294 | CNV | duplication | 17116639 |
| esv2759515 | CNV | gain+loss | 17122850 |
| esv2764001 | CNV | gain+loss | 21179565 |
| esv34717 | CNV | gain | 17911159 |
| esv3612420 | CNV | loss | 21293372 |
| esv3612421 | CNV | gain | 21293372 |
| esv3891076 | CNV | gain | 25118596 |
| esv3891077 | CNV | gain | 25118596 |
| nsv1029065 | CNV | loss | 25217958 |
| nsv1114920 | CNV | deletion | 24896259 |
| nsv464398 | CNV | gain | 19166990 |
| nsv464399 | CNV | gain | 19166990 |
| nsv606343 | CNV | gain | 21841781 |
| nsv8064 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.78;
73.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AHR Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHR Gene
Disorders for AHR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 85 |
|
|
| retinitis pigmentosa |
|
|
| toxic oil syndrome |
|
|
| eosinophilic fasciitis |
|
|
| seborrheic dermatitis |
|
|
Search AHR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
AHR_HUMAN- Retinitis pigmentosa 85 (RP85) [MIM:618345]: A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP85 is an autosomal recessive form manifesting as early-onset progressive difficulty to adapt in dim light and gradually decreasing visual acuity in both eyes. {ECO:0000269 PubMed:29726989}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for AHR
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for AHR Gene
Publications for AHR Gene
- Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PMID: 11698344) Cauchi S … Massaad-Massade L (Carcinogenesis 2001) 3 4 22 40
- A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa. (PMID: 29726989) Zhou Y … Yang Z (Human molecular genetics 2018) 3 4 72
- Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. (PMID: 18818557) Chen D … Lu D (Pharmacogenetics and genomics 2009) 3 22 40
- Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 22 40
- Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. (PMID: 19736056) Gold LS … Baris D (Cancer epidemiology 2009) 3 22 40
ExternalLinks
Products for AHR Gene
- Custom Antibody ServicesOriGene Antibodies for AHR
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for AHR
- Search Origene for MassSpec and Protein Over-expression Lysates for AHR
- Origene Custom Protein Services for AHR
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
- OriGene qPCR primer pairs for AHR
- OriGene qPCR primer pairs and template standards for AHR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AHR
- Sino Biological Human cDNA Clone for AHR
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for AHR
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for AHR
- Novus Biologicals proteins and lysates for AHR
- Novus Biologicals ELISA Kits for AHR
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for AHR
- Abcam proteins for AHR
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
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- Browse Monoclonal Antibodies
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- Invitrogen Antibodies for AHR (AFLGC-AHR)
- ApexBio compounds for AHR
- VectorBuilder Custom and pre-made DNA vectors for AHR (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for AHR (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for AHR (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for AHR CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for AHR
- Addgene plasmids for AHR
- antibodies-online: Show 205 available Aryl Hydrocarbon Receptor Antibodies ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Antibodies
- Recommended
- 159 WB Antibodies (anti-human)
- 35 IHC (p) Antibodies (anti-human)
- 17 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 82 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 106 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- antibodies-online: Show 64 available Aryl Hydrocarbon Receptor Elisa Kits ranked by validation data
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- antibodies-online: Show 9 available Aryl Hydrocarbon Receptor Proteins ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for AHR
- Search Santa Cruz Biotechnology (SCBT) for AHR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AHR
- Custom Antibody ServicesProSci Antibodies for AHR
- aryl hydrocarbon receptor [15-576]
- aryl hydrocarbon receptor [18-223]
- aryl hydrocarbon receptor [27-379]
- aryl hydrocarbon receptor [27-527]
- aryl hydrocarbon receptor [48-213]
- aryl hydrocarbon receptor [51-879]
- aryl hydrocarbon receptor [43-451]
- aryl hydrocarbon receptor [43-478]
- aryl hydrocarbon receptor [48-197]
- aryl hydrocarbon receptor [48-198]
- aryl hydrocarbon receptor [48-199]
- Aryl hydrocarbon receptor [61-965]
- aryl hydrocarbon receptor [70-830]
- Search for AHR Proteins at ProSci
- Horizon Cell Lines for AHR
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
- Search GeneCopoeia for miRNA 3'UTR Target clone products for AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Sources for AHR Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources