Aliases for AHR Gene
Aliases for AHR Gene
External Ids for AHR Gene
- HGNC: 348
- Entrez Gene: 196
- Ensembl: ENSG00000106546
- OMIM: 600253
- UniProtKB: P35869
Previous GeneCards Identifiers for AHR Gene
- GC07P016982
- GC07P017082
- GC07P017111
- GC07P017304
Summaries for AHR Gene
-
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
GeneCards Summary for AHR Gene
AHR (Aryl Hydrocarbon Receptor) is a Protein Coding gene. Diseases associated with AHR include Eosinophilic Fasciitis and Aryl Hydrocarbon Hydroxylase Inducibility. Among its related pathways are Aryl Hydrocarbon Receptor and Th17 cell differentiation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ENSG00000283321.
UniProtKB/Swiss-Prot for AHR Gene
-
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
-
Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.
Additional gene information for AHR Gene
- Monarch Initiative
- Search for AHR at DataMed
- Search for AHR at HumanCyc
No data available for CIViC summary , fRNAdb sequence ontologies and piRNA Summary for AHR Gene
Genomics for AHR Gene
GeneHancer (GH) Regulatory Elements for AHR Gene
Promoters and enhancers for AHR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around AHR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AHR gene promoter:
Regulatory Element Products
Genomic Locations for AHR Gene
Genomic Locations for AHR Gene
- chr7:17,298,622-17,346,152
- (GRCh38/hg38)
- Size:
- 47,531 bases
- Orientation:
- Plus strand
- chr7:17,338,246-17,385,776
- (GRCh37/hg19)
Genomic View for AHR Gene
Genes around AHR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p21.1 by Ensembl
- 7p21.1 by Entrez Gene
- 7p21.1 by HGNC
AHR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AHR Gene
Proteins for AHR Gene
-
Protein details for AHR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35869-AHR_HUMAN
- Recommended name:
- Aryl hydrocarbon receptor
- Protein Accession:
- P35869
- A4D130
- Q13728
- Q13803
- Q13804
Protein attributes for AHR Gene
- Size:
- 848 amino acids
- Molecular mass:
- 96147 Da
- Quaternary structure:
-
- Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1. Interacts with HSP90AB1 (By similarity).
Protein Expression for AHR Gene
Post-translational modifications for AHR Gene
Other Protein References for AHR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for AHR (AHR)
- Novus Biologicals Antibodies for AHR
-
Abcam antibodies for AHR
-
Cloud-Clone Corp. Antibodies for AHR
- Invitrogen Antibodies for AHR
- antibodies-online: Search results for 257 available Aryl Hydrocarbon Receptor Antibodies ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Antibodies
-
Recommended
- 1 IHC (p) Antibody (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
- 95 WB Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 72 WB Antibodies (anti-rat)
- 1 DB Antibody (anti-human)
- 2 FACS Antibodies (anti-human)
- 12 IHC Antibodies (anti-human)
- 37 IHC (p) Antibodies (anti-human)
- 148 WB Antibodies (anti-human)
- GeneTex AHR antibody for AHR
-
Santa Cruz Biotechnology (SCBT) Antibodies for AHR
- Sino Biological Antibodies for AHR
Protein Products
-
OriGene Purified Proteins for AHR
- Search Origene for MassSpec and Protein Over-expression Lysates for AHR
- Origene Custom Protein Services for AHR
-
Cloud-Clone Corp. Proteins for AHR
- Search GeneTex for Proteins for AHR
-
Abcam proteins for AHR
No data available for DME Specific Peptides for AHR Gene
Domains & Families for AHR Gene
Gene Families for AHR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for AHR Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AHR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for AHR Gene
Function for AHR Gene
Molecular function for AHR Gene
- GENATLAS Biochemistry:
- aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest
- UniProtKB/Swiss-Prot Function:
- Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
- UniProtKB/Swiss-Prot Induction:
- Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).
Phenotypes From GWAS Catalog for AHR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001094 | TFIID-class transcription factor binding | IPI | 15641800 |
| GO:0001223 | transcription coactivator binding | IPI | 15641800 |
| GO:0003677 | DNA binding | TAS,IDA | 19538249 |
| GO:0003700 | DNA binding transcription factor activity | IDA | 11782478 |
| GO:0004874 | aryl hydrocarbon receptor activity | IEA | -- |
Phenotypes for AHR Gene
- MGI mutant phenotypes for AHR:
-
inferred from 14 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for AHR:
Animal Model Products
-
Taconic Biosciences Mouse Models for AHR
- Cyagen custom Knockout/knockin (KOKI) mouse models for AHR
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AHR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AHR gene
- Search ViGene Biosciences for AHR
CRISPR Products
-
OriGene CRISPR knockouts for AHR
- Applied Biological Materials CRISPR for AHR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHR
- GenScript: Design CRISPR guide RNA sequences for AHR
miRNA for AHR Gene
- miRTarBase miRNAs that target AHR
-
- hsa-mir-124-3p (MIRT002653)
- hsa-mir-130b-3p (MIRT020178)
- hsa-mir-98-5p (MIRT027562)
- hsa-mir-625-5p (MIRT039593)
- hsa-mir-26a-5p (MIRT050123)
- hsa-mir-3927-3p (MIRT103158)
- hsa-mir-6831-5p (MIRT103162)
- hsa-mir-181a-5p (MIRT438216)
- hsa-mir-1273e (MIRT482169)
- hsa-mir-6516-5p (MIRT482170)
- hsa-mir-550b-2-5p (MIRT482171)
- hsa-mir-455-3p (MIRT482172)
- hsa-mir-6807-5p (MIRT482173)
- hsa-mir-1227-3p (MIRT482174)
- hsa-mir-4451 (MIRT482175)
- hsa-mir-6086 (MIRT482176)
- hsa-mir-6499-3p (MIRT482177)
- hsa-mir-377-5p (MIRT482178)
- hsa-mir-4500 (MIRT482179)
- hsa-mir-4458 (MIRT482180)
- hsa-let-7i-5p (MIRT482181)
- hsa-let-7g-5p (MIRT482182)
- hsa-let-7f-5p (MIRT482183)
- hsa-let-7e-5p (MIRT482184)
- hsa-let-7d-5p (MIRT482185)
- hsa-let-7c-5p (MIRT482186)
- hsa-let-7b-5p (MIRT482187)
- hsa-let-7a-5p (MIRT482188)
- hsa-mir-6840-3p (MIRT482189)
- hsa-mir-665 (MIRT482190)
- hsa-mir-4459 (MIRT482191)
- hsa-mir-3152-5p (MIRT482192)
- hsa-mir-4774-3p (MIRT482193)
- hsa-mir-3117-3p (MIRT482194)
- hsa-mir-4775 (MIRT482195)
- hsa-mir-1258 (MIRT482196)
- hsa-mir-4645-3p (MIRT482197)
- hsa-mir-4699-5p (MIRT482198)
- hsa-mir-16-1-3p (MIRT482199)
- hsa-mir-545-5p (MIRT482200)
- hsa-mir-1197 (MIRT482201)
- hsa-mir-383-5p (MIRT482202)
- hsa-mir-6513-5p (MIRT675724)
- hsa-mir-887-5p (MIRT675725)
- hsa-mir-3913-5p (MIRT675726)
- hsa-mir-3122 (MIRT675727)
- hsa-mir-450a-1-3p (MIRT675728)
- hsa-mir-6780a-5p (MIRT675729)
- hsa-mir-6779-5p (MIRT675730)
- hsa-mir-3689c (MIRT675731)
- hsa-mir-3689b-3p (MIRT675732)
- hsa-mir-3689a-3p (MIRT675733)
- hsa-mir-30b-3p (MIRT675734)
- hsa-mir-1273h-5p (MIRT675735)
- hsa-mir-6788-5p (MIRT675736)
- hsa-mir-30c-2-3p (MIRT675737)
- hsa-mir-30c-1-3p (MIRT675738)
- hsa-mir-7977 (MIRT675739)
- hsa-mir-6778-5p (MIRT675740)
- hsa-mir-1233-5p (MIRT675741)
- hsa-mir-6799-5p (MIRT675742)
- hsa-mir-6883-5p (MIRT675743)
- hsa-mir-6785-5p (MIRT675744)
- hsa-mir-4728-5p (MIRT675745)
- hsa-mir-149-3p (MIRT675746)
- hsa-mir-7106-5p (MIRT675747)
- hsa-mir-4284 (MIRT675748)
- hsa-mir-2467-5p (MIRT675749)
- hsa-mir-383-3p (MIRT675750)
- hsa-mir-4761-5p (MIRT675751)
- hsa-mir-29a-3p (MIRT733336)
Transcription Factor Targets for AHR Gene
miRNA Products
- Search ViGene Biosciences for AHR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
-
ViGene Biosciences ready-to-package AAV shRNAs for AHR gene
Clone Products
- Sino Biological Human cDNA Clone for AHR
- VectorBuilder custom plasmid, inducible vectors for AHR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AHR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AHR
- genomics-online: cdna clones - Search results for 105 available Aryl Hydrocarbon Receptor gene related products
- Overview of 105 available Aryl Hydrocarbon Receptor gene related products
- orf clones - Search results for 105 available Aryl Hydrocarbon Receptor gene related products
- Overview of 105 available Aryl Hydrocarbon Receptor gene related products
- Applied Biological Materials Clones for AHR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for AHR
-
ViGene Biosciences adenoviral particle packaged cDNA for AHR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AHR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AHR gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for AHR Gene
Localization for AHR Gene
Subcellular locations from UniProtKB/Swiss-Prot for AHR Gene
- Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 10395741 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | TAS | 19538249 |
| GO:0005737 | cytoplasm | IDA | 15681594 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for AHR Gene
Pathways by source for AHR Gene
6 BioSystems pathways for AHR Gene
11 Reactome pathways for AHR Gene
1 KEGG pathway for AHR Gene
1 GeneGo (Thomson Reuters) pathway for AHR Gene
1 R&D Systems pathway for AHR Gene
1 Qiagen pathway for AHR Gene
Interacting Proteins for AHR Gene
Selected Interacting proteins:
ENSP00000242057
P35869-AHR_HUMAN
for AHR Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001568 | blood vessel development | NAS | 19538249 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 10395741 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 15681594 |
| GO:0006366 | transcription by RNA polymerase II | IDA | 10395741 |
Drugs & Compounds for AHR Gene
(75) Drugs for AHR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Leflunomide | Approved, Investigational | Pharma | Target, agonist | AHR agonist,immunosuppressive agent | 69 | |
| Flutamide | Approved, Investigational | Pharma | Target, agonist | 65 | ||
| Mexiletine | Approved, Investigational | Pharma | Target, agonist | 20 | ||
| Nimodipine | Approved, Investigational | Pharma | Potentiation, Activator, Target, agonist | 27 | ||
| Diosmin | Approved, Investigational | Pharma | Target, agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for AHR Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6,2',4'-Trimethoxyflavone | Aryl hydrocarbon receptor antagonist | 720675-74-1 |
| CH 223191 | Potent aryl hydrocarbon receptor (AhR) antagonist | 301326-22-7 |
| FICZ | High affinity aryl hydrocarbon receptor (AhR) agonist | 172922-91-7 |
| ITE | Endogenous agonist for the transcription factor aryl hydrocarbon receptor | 448906-42-1 |
| L-Kynurenine | Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand | 2922-83-0 |
(14) ApexBio Compounds for AHR Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6,2',4'-Trimethoxyflavone | 720675-74-1 | |
| CH 223191 | AhR antagonist | 301326-22-7 |
| DiMNF | AHR modulator | 14756-24-2 |
| FICZ | 172922-91-7 | |
| ITE | AHR agonist | 448906-42-1 |
| Kaempferol | Apoptosis inducer;antioxidant;flavonoid | 520-18-3 |
| Leflunomide | AHR agonist,immunosuppressive agent | 75706-12-6 |
| L-Kynurenine | 2922-83-0 | |
| MeBIO | CDK/Cyclin/ GSK-3/p25/AhR agonist | 667463-95-8 |
| Oltipraz | An antischistosomal agent | 64224-21-1 |
| Phortress | Prodrug of antitumor agent 5F 203 | 328087-38-3 |
| StemRegenin 1 (SR1) | AhR antagonist | 1227633-49-9 |
| SU5416 | VEGF receptor inhibitor and AHR agonist | 204005-46-9 |
| UM 729 | Enhancer of AhR antagonists | 1448723-60-1 |
Transcripts for AHR Gene
mRNA/cDNA for AHR Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (208) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AHR Gene
CRISPR Products
-
OriGene CRISPR knockouts for AHR
- Applied Biological Materials CRISPR for AHR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHR
- GenScript: Design CRISPR guide RNA sequences for AHR
miRNA Products
- Search ViGene Biosciences for AHR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
-
ViGene Biosciences ready-to-package AAV shRNAs for AHR gene
Clone Products
- Sino Biological Human cDNA Clone for AHR
- VectorBuilder custom plasmid, inducible vectors for AHR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AHR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AHR
- genomics-online: cdna clones - Search results for 105 available Aryl Hydrocarbon Receptor gene related products
- Overview of 105 available Aryl Hydrocarbon Receptor gene related products
- orf clones - Search results for 105 available Aryl Hydrocarbon Receptor gene related products
- Overview of 105 available Aryl Hydrocarbon Receptor gene related products
- Applied Biological Materials Clones for AHR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for AHR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
mRNA differential expression in normal tissues according to GTEx for AHR Gene
This gene is overexpressed in Nerve - Tibial (x4.5).
This gene is overexpressed in Placenta (63.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AHR Gene
NURSA nuclear receptor signaling pathways regulating expression of AHR Gene:
AHRSOURCE GeneReport for Unigene cluster for AHR Gene:
Hs.171189mRNA Expression by UniProt/SwissProt for AHR Gene:
P35869-AHR_HUMAN
Tissue specificity:
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
Evidence on tissue expression from TISSUES for AHR Gene
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs for AHR
-
OriGene qPCR primer pairs and template standards for AHR
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AHR Gene
Orthologs for AHR Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AHR 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | AHR 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | AHR 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ahr 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ahr 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | AHR 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | AHR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AHR 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ahr 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | AHR 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ahr1b 33 |
|
||
| ahr1a 34 |
|
OneToOne | |||
| ahr1 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11494 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ss 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ahr-1 35 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12569 33 |
|
- Species where no ortholog for AHR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for AHR Gene
Paralogs for AHR Gene
Pseudogenes.org Pseudogenes for AHR Gene
Variants for AHR Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009536 | -- | 17,320,724(+) | C/T | intron_variant | |
| rs1000049380 | -- | 17,341,666(+) | T/A | intron_variant | |
| rs1000055820 | -- | 17,305,921(+) | C/T | intron_variant | |
| rs1000137040 | -- | 17,314,471(+) | T/G | intron_variant | |
| rs1000235061 | -- | 17,305,620(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11225n54 | CNV | gain | 21841781 |
| dgv6289n100 | CNV | gain | 25217958 |
| dgv6290n100 | CNV | gain | 25217958 |
| esv2422294 | CNV | duplication | 17116639 |
| esv2759515 | CNV | gain+loss | 17122850 |
| esv2764001 | CNV | gain+loss | 21179565 |
| esv34717 | CNV | gain | 17911159 |
| esv3612420 | CNV | loss | 21293372 |
| esv3612421 | CNV | gain | 21293372 |
| esv3891076 | CNV | gain | 25118596 |
| esv3891077 | CNV | gain | 25118596 |
| nsv1029065 | CNV | loss | 25217958 |
| nsv1114920 | CNV | deletion | 24896259 |
| nsv464398 | CNV | gain | 19166990 |
| nsv464399 | CNV | gain | 19166990 |
| nsv606343 | CNV | gain | 21841781 |
| nsv8064 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.78;
73.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AHR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHR Gene
Disorders for AHR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| eosinophilic fasciitis |
|
|
| aryl hydrocarbon hydroxylase inducibility |
|
|
| seborrheic dermatitis |
|
|
| toxic oil syndrome |
|
|
| peanut allergy |
|
|
Search AHR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AHR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for AHR Gene
Publications for AHR Gene
- Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 22 44 58
- Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. (PMID: 18818557) Chen D … Lu D (Pharmacogenetics and genomics 2009) 3 22 44 58
- Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. (PMID: 17429315) Long JR … Zheng W (Pharmacogenetics and genomics 2007) 3 22 44 58
- Modifying effect of the AR gene trinucleotide repeats and SNPs in the AHR and AHRR genes on the association between persistent organohalogen pollutant exposure and human sperm Y:X ratio. (PMID: 17244640) Tiido T … Giwercman YL (Molecular human reproduction 2007) 3 22 44 58
- Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. (PMID: 16103451) Le Marchand L … Wilkens LR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005) 3 22 44 58
Products for AHR Gene
- R&D Systems Antibodies for AHR (AHR)
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for AHR
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AHR
- antibodies-online: Search results for 257 available Aryl Hydrocarbon Receptor Antibodies ranked by validation data
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- 148 WB Antibodies (anti-human)
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- GeneTex AHR antibody for AHR
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- ViGene Biosciences adenoviral particle packaged cDNA for AHR gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for AHR
- Search Santa Cruz Biotechnology (SCBT) for AHR siRNA/shRNA
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- Horizon Cell Lines for AHR
- genomics-online: cdna clones - Search results for 105 available Aryl Hydrocarbon Receptor gene related products
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- Overview of 105 available Aryl Hydrocarbon Receptor gene related products
Sources for AHR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
