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The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this pro... See more...
Aliases for AHR Gene
Aliases for AHR Gene
External Ids for AHR Gene
- HGNC: 348
- Entrez Gene: 196
- Ensembl: ENSG00000106546
- OMIM: 600253
- UniProtKB: P35869
Previous GeneCards Identifiers for AHR Gene
- GC07P016982
- GC07P017082
- GC07P017111
- GC07P017304
- GC07P017224
Summaries for AHR Gene
-
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
GeneCards Summary for AHR Gene
AHR (Aryl Hydrocarbon Receptor) is a Protein Coding gene. Diseases associated with AHR include Retinitis Pigmentosa 85 and Retinitis Pigmentosa. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ENSG00000283321.
UniProtKB/Swiss-Prot Summary for AHR Gene
-
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
-
Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.
Additional gene information for AHR Gene
- Monarch Initiative
- Search for AHR at DataMed
- Search for AHR at HumanCyc
No data available for CIViC Summary , Rfam classification and piRNA Summary for AHR Gene
Genomics for AHR Gene
GeneHancer (GH) Regulatory Elements for AHR Gene
Promoters and enhancers for AHR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AHR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AHR gene promoter:
-
- c-Myc
- GR
- GR-alpha
- HNF-3beta
- Max1
- PPAR-gamma1
- PPAR-gamma2
- Sp1
Genomic Locations for AHR Gene
Genomic Locations for AHR Gene
- chr7:16,916,359-17,346,152
- (GRCh38/hg38)
- Size:
- 429,794 bases
- Orientation:
- Plus strand
- chr7:17,338,246-17,385,776
- (GRCh37/hg19)
- Size:
- 47,531 bases
- Orientation:
- Plus strand
Genomic View for AHR Gene
Genes around AHR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p21.1 by HGNC
- 7p21.1 by Entrez Gene
- 7p21.1 by Ensembl
AHR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AHR Gene
Proteins for AHR Gene
-
Protein details for AHR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35869-AHR_HUMAN
- Recommended name:
- Aryl hydrocarbon receptor
- Protein Accession:
- P35869
- A4D130
- Q13728
- Q13803
- Q13804
Protein attributes for AHR Gene
- Size:
- 848 amino acids
- Molecular mass:
- 96147 Da
- Quaternary structure:
-
- Homodimer (By similarity). Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1. Interacts with HSP90AB1 (By similarity). Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). Interacts with TIPARP; leading to mono-ADP-ribosylation of AHR and subsequent inhibition of AHR (PubMed:23275542, PubMed:30373764).
Protein Expression for AHR Gene
Post-translational modifications for AHR Gene
- Mono-ADP-ribosylated, leading to inhibit transcription activator activity of AHR.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for AHR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents Aryl Hydrocarbon Receptor Antibody (AHR)
- Atlas Antibodies Anti-AHR Antibody (HPA029722) and Anti-AHR Antibody (HPA029723)
-
Creative Biolabs
- Recombinant Anti-Human AHR Antibody
- Recombinant Anti-Human AHR Antibody Fab Fragment
- Mouse Anti-AHR Recombinant Antibody (3B12)
- Rat Anti-AHR Recombinant Antibody (W16012A)
- Mouse Anti-AHR Recombinant Antibody (RPT1)
- Mouse Anti-AHR Recombinant Antibody (CBYC-A446)
- Mouse Anti-AHR Recombinant Antibody (3B9)
- Rat Anti-AHR Recombinant Antibody (4MEJJ)
- Mouse Anti-AHR Recombinant Antibody (CBYC-A444)
- Mouse Anti-AHR Recombinant Antibody (FF3399)
- Mouse Anti-AHR Recombinant Antibody (8J216)
- Mouse Anti-AHR Recombinant Antibody (CBYC-A447)
- GeneTex Anti-AHR antibody [RPT1] and Anti-AHR antibody
- Novus Biologicals Antibodies for AHR
-
Abcam antibodies for AHR
- Invitrogen Antibodies for AHR (AFLGC-AHR)
- antibodies-online: Show 205 available Aryl Hydrocarbon Receptor Antibodies ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Antibodies
-
Recommended
- 159 WB Antibodies (anti-human)
- 35 IHC (p) Antibodies (anti-human)
- 17 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 82 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 106 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for AHR
- Sino Biological Antibodies for AHR
Protein Products
- Atlas Antibodies PrEST Antigen AHR (APrEST78064) and PrEST Antigen AHR (APrEST78063)
-
OriGene Purified Proteins for AHR
- Search Origene for MassSpec and Protein Over-expression Lysates for AHR
- Origene Custom Protein Services for AHR
-
Abcam proteins for AHR
Assay Products
- Aviva Systems Biology AHR Chemi-Luminescent ELISA Kit (Human) (OKCD03289)
- Novus Biologicals ELISA Kits for AHR
- antibodies-online: Show 64 available Aryl Hydrocarbon Receptor Elisa Kits ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Elisa Kits
-
Quality Products:
- ABIN1113590
- ABIN414628
- ABIN364993
- ABIN1028163
- ABIN5519710
- ABIN5668303
- ABIN1169612
- ABIN626297
- ABIN454470
- ABIN1380335
- ABIN1568247
- ABIN1113589
- ABIN5519711
- ABIN5669683
- ABIN627554
- ABIN5591534
- ABIN1380908
- ABIN2945428
- ABIN4967327
- ABIN1113591
- ABIN810515
- ABIN432072
- ABIN1568248
- ABIN5519712
- ABIN5670349
- ABIN626724
- ABIN5652025
- ABIN1559435
- ABIN778153
- ABIN6201139
No data available for DME Specific Peptides for AHR Gene
Domains & Families for AHR Gene
Gene Families for AHR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for AHR Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AHR Gene
- GenScript: Design optimal peptide antigens:
-
- Class E basic helix-loop-helix protein 76 (AHR_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P35869UniProtKB/Swiss-Prot:
AHR_HUMAN :- The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.
- Domain:
-
- The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.
Function for AHR Gene
Molecular function for AHR Gene
- UniProtKB/Swiss-Prot Function:
- Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
- UniProtKB/Swiss-Prot Induction:
- Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).
- GENATLAS Biochemistry:
- aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest
Phenotypes From GWAS Catalog for AHR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0001094 | TFIID-class transcription factor complex binding | IPI | 15641800 |
| GO:0001223 | transcription coactivator binding | IPI | 15641800 |
| GO:0003677 | DNA binding | TAS,IDA | 19538249 |
| GO:0003700 | DNA-binding transcription factor activity | IDA,NAS | 11782478 |
Phenotypes for AHR Gene
- MGI mutant phenotypes for AHR:
-
inferred from 14 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for AHR:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased cell death HMECs cells
- Reduced mammosphere formation
- Decreased viability
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for AHR Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for AHR
CRISPR Products
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
- Applied Biological Materials (abm): CRISPR Clones for AHR - Select products 50% OFF >
- * AHR CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * AHR CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHR
miRNA for AHR Gene
- miRTarBase miRNAs that target AHR
-
- hsa-mir-124-3p (MIRT002653)
- hsa-mir-130b-3p (MIRT020178)
- hsa-mir-98-5p (MIRT027562)
- hsa-mir-625-5p (MIRT039593)
- hsa-mir-26a-5p (MIRT050123)
- hsa-mir-3927-3p (MIRT103158)
- hsa-mir-6831-5p (MIRT103162)
- hsa-mir-181a-5p (MIRT438216)
- hsa-mir-1273e (MIRT482169)
- hsa-mir-6516-5p (MIRT482170)
- hsa-mir-550b-2-5p (MIRT482171)
- hsa-mir-455-3p (MIRT482172)
- hsa-mir-6807-5p (MIRT482173)
- hsa-mir-1227-3p (MIRT482174)
- hsa-mir-4451 (MIRT482175)
- hsa-mir-6086 (MIRT482176)
- hsa-mir-6499-3p (MIRT482177)
- hsa-mir-377-5p (MIRT482178)
- hsa-mir-4500 (MIRT482179)
- hsa-mir-4458 (MIRT482180)
- hsa-let-7i-5p (MIRT482181)
- hsa-let-7g-5p (MIRT482182)
- hsa-let-7f-5p (MIRT482183)
- hsa-let-7e-5p (MIRT482184)
- hsa-let-7d-5p (MIRT482185)
- hsa-let-7c-5p (MIRT482186)
- hsa-let-7b-5p (MIRT482187)
- hsa-let-7a-5p (MIRT482188)
- hsa-mir-6840-3p (MIRT482189)
- hsa-mir-665 (MIRT482190)
- hsa-mir-4459 (MIRT482191)
- hsa-mir-3152-5p (MIRT482192)
- hsa-mir-4774-3p (MIRT482193)
- hsa-mir-3117-3p (MIRT482194)
- hsa-mir-4775 (MIRT482195)
- hsa-mir-1258 (MIRT482196)
- hsa-mir-4645-3p (MIRT482197)
- hsa-mir-4699-5p (MIRT482198)
- hsa-mir-16-1-3p (MIRT482199)
- hsa-mir-545-5p (MIRT482200)
- hsa-mir-1197 (MIRT482201)
- hsa-mir-383-5p (MIRT482202)
- hsa-mir-6513-5p (MIRT675724)
- hsa-mir-887-5p (MIRT675725)
- hsa-mir-3913-5p (MIRT675726)
- hsa-mir-3122 (MIRT675727)
- hsa-mir-450a-1-3p (MIRT675728)
- hsa-mir-6780a-5p (MIRT675729)
- hsa-mir-6779-5p (MIRT675730)
- hsa-mir-3689c (MIRT675731)
- hsa-mir-3689b-3p (MIRT675732)
- hsa-mir-3689a-3p (MIRT675733)
- hsa-mir-30b-3p (MIRT675734)
- hsa-mir-1273h-5p (MIRT675735)
- hsa-mir-6788-5p (MIRT675736)
- hsa-mir-30c-2-3p (MIRT675737)
- hsa-mir-30c-1-3p (MIRT675738)
- hsa-mir-7977 (MIRT675739)
- hsa-mir-6778-5p (MIRT675740)
- hsa-mir-1233-5p (MIRT675741)
- hsa-mir-6799-5p (MIRT675742)
- hsa-mir-6883-5p (MIRT675743)
- hsa-mir-6785-5p (MIRT675744)
- hsa-mir-4728-5p (MIRT675745)
- hsa-mir-149-3p (MIRT675746)
- hsa-mir-7106-5p (MIRT675747)
- hsa-mir-4284 (MIRT675748)
- hsa-mir-2467-5p (MIRT675749)
- hsa-mir-383-3p (MIRT675750)
- hsa-mir-4761-5p (MIRT675751)
- hsa-mir-29a-3p (MIRT733336)
Transcription Factor Targets for AHR Gene
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Clone Products
- Sino Biological Human cDNA Clone for AHR
- Addgene plasmids for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
- genomics-online: cdna clones - Search for available Aryl Hydrocarbon Receptor CDNA products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- orf clones - Search for available Aryl Hydrocarbon Receptor ORF products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- Applied Biological Materials (abm): Clones for AHR - Select products 50% OFF >
- * AHR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * AHR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for AHR
No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for AHR Gene
Localization for AHR Gene
Subcellular locations from UniProtKB/Swiss-Prot for AHR Gene
- Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. {ECO:0000250 UniProtKB:P30561}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| peroxisome | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,TAS | 10395741 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | TAS | 19538249 |
| GO:0005737 | cytoplasm | IDA | 15681594 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for AHR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
|
| 2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 3 | Metabolism |
.40
|
|
| 4 | Aldosterone synthesis and secretion |
.41
|
|
| 5 | Th17 cell differentiation | ||
Pathways by source for AHR Gene
6 BioSystems pathways for AHR Gene
11 Reactome pathways for AHR Gene
2 KEGG pathways for AHR Gene
1 GeneGo (Thomson Reuters) pathway for AHR Gene
1 R&D Systems pathway for AHR Gene
1 Qiagen pathway for AHR Gene
- AHR Pathway
Interacting Proteins for AHR Gene
Selected Interacting proteins:
P35869-AHR_HUMAN
ENSP00000242057
for AHR Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for AHR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001568 | blood vessel development | NAS | 19538249 |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 10395741 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 15681594 |
| GO:0006366 | transcription by RNA polymerase II | IDA | 10395741 |
| GO:0006805 | xenobiotic metabolic process | TAS | 19538249 |
Drugs & Compounds for AHR Gene
(78) Drugs for AHR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Leflunomide | Approved, Investigational | Pharma | Target, agonist | AHR agonist,immunosuppressive agent | 84 | |
| Flutamide | Approved, Investigational | Pharma | Target, agonist | 68 | ||
| Mexiletine | Approved, Investigational | Pharma | Target, agonist | 21 | ||
| Nimodipine | Approved, Investigational | Pharma | Potentiation, Activator, Target, agonist | Ca2+ channel blocker (L-type) | 33 | |
| Diosmin | Approved, Investigational | Pharma | Target, agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for AHR Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6,2',4'-Trimethoxyflavone | Aryl hydrocarbon receptor antagonist | 720675-74-1 |
| CH 223191 | Potent aryl hydrocarbon receptor (AhR) antagonist | 301326-22-7 |
| FICZ | High affinity aryl hydrocarbon receptor (AhR) agonist | 172922-91-7 |
| ITE | Endogenous agonist for the transcription factor aryl hydrocarbon receptor | 448906-42-1 |
| L-Kynurenine | Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand | 2922-83-0 |
(14) ApexBio Compounds for AHR Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6,2',4'-Trimethoxyflavone | 720675-74-1 | |
| CH 223191 | AhR antagonist | 301326-22-7 |
| DiMNF | AHR modulator | 14756-24-2 |
| FICZ | 172922-91-7 | |
| ITE | AHR agonist | 448906-42-1 |
| Kaempferol | Apoptosis inducer;antioxidant;flavonoid | 520-18-3 |
| Leflunomide | AHR agonist,immunosuppressive agent | 75706-12-6 |
| L-Kynurenine | 2922-83-0 | |
| MeBIO | CDK/Cyclin/ GSK-3/p25/AhR agonist | 667463-95-8 |
| Oltipraz | An antischistosomal agent | 64224-21-1 |
| Phortress | Prodrug of antitumor agent 5F 203 | 328087-38-3 |
| StemRegenin 1 (SR1) | AhR antagonist | 1227633-49-9 |
| SU5416 | VEGF receptor inhibitor and AHR agonist | 204005-46-9 |
| UM 729 | Enhancer of AhR antagonists | 1448723-60-1 |
Drug Products
- Atlas Antibodies PrEST Antigen AHR (APrEST78064) and PrEST Antigen AHR (APrEST78063)
- ApexBio compounds for AHR
Transcripts for AHR Gene
mRNA/cDNA for AHR Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (208) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000645559 93 bps (ENST00000645559.1)
- ENST00000642825 6958 bps (ENST00000642825.1)
- ENST00000242057 6243 bps (ENST00000242057.8)
- ENST00000463496 4820 bps (ENST00000463496.1)
- ENST00000475440 388 bps (ENST00000475440.1)
CRISPR Products
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
- Applied Biological Materials (abm): CRISPR Clones for AHR - Select products 50% OFF >
- * AHR CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * AHR CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHR
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for AHR
- Browse OriGene Inhibitory RNA Products For AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Clone Products
- Sino Biological Human cDNA Clone for AHR
- Addgene plasmids for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
- genomics-online: cdna clones - Search for available Aryl Hydrocarbon Receptor CDNA products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- orf clones - Search for available Aryl Hydrocarbon Receptor ORF products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- Applied Biological Materials (abm): Clones for AHR - Select products 50% OFF >
- * AHR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * AHR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for AHR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
mRNA differential expression in normal tissues according to GTEx for AHR Gene
This gene is overexpressed in Nerve - Tibial (x4.5).
This gene is overexpressed in Placenta (63.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AHR Gene
NURSA nuclear receptor signaling pathways regulating expression of AHR Gene:
AHRSOURCE GeneReport for Unigene cluster for AHR Gene:
Hs.171189mRNA Expression by UniProt/SwissProt for AHR Gene:
P35869-AHR_HUMAN
Tissue specificity:
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
Evidence on tissue expression from TISSUES for AHR Gene
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs for AHR
-
OriGene qPCR primer pairs and template standards for AHR
- genomics-online: primer clones - Search for available Aryl Hydrocarbon Receptor Primer products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AHR Gene
Orthologs for AHR Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AHR 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | AHR 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | AHR 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ahr 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ahr 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | AHR 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | AHR 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AHR 33 32 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ahr 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | AHR 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ahr1b 32 |
|
||
| ahr1a 33 |
|
OneToOne | |||
| ahr1 32 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11494 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ss 33 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ahr-1 33 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany | |
| Cin.12569 32 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12569 32 |
|
- Species where no ortholog for AHR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for AHR Gene
- ENSEMBL:
- Gene Tree for AHR (if available)
- TreeFam:
- Gene Tree for AHR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AHR: view image
Paralogs for AHR Gene
Paralogs for AHR Gene
Pseudogenes.org Pseudogenes for AHR Gene
Variants for AHR Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1562481438 | pathogenic, Retinitis pigmentosa 85 | 17,335,787(+) | G/A | splice_donor_variant | |
| rs1562482694 | likely-pathogenic, Infantile nystagmus with foveal hypoplasia | 17,339,686(+) | C/T | coding_sequence_variant, stop_gained | |
| rs1000009536 | -- | 17,320,724(+) | C/T | intron_variant | |
| rs1000049380 | -- | 17,341,666(+) | T/A | intron_variant | |
| rs1000055820 | -- | 17,305,921(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11225n54 | CNV | gain | 21841781 |
| dgv6289n100 | CNV | gain | 25217958 |
| dgv6290n100 | CNV | gain | 25217958 |
| esv2422294 | CNV | duplication | 17116639 |
| esv2759515 | CNV | gain+loss | 17122850 |
| esv2764001 | CNV | gain+loss | 21179565 |
| esv34717 | CNV | gain | 17911159 |
| esv3612420 | CNV | loss | 21293372 |
| esv3612421 | CNV | gain | 21293372 |
| esv3891076 | CNV | gain | 25118596 |
| esv3891077 | CNV | gain | 25118596 |
| nsv1029065 | CNV | loss | 25217958 |
| nsv1114920 | CNV | deletion | 24896259 |
| nsv464398 | CNV | gain | 19166990 |
| nsv464399 | CNV | gain | 19166990 |
| nsv606343 | CNV | gain | 21841781 |
| nsv8064 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.78;
73.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AHR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHR Gene
Disorders for AHR Gene
(15) MalaCards diseases for AHR Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 85 |
|
|
| retinitis pigmentosa |
|
|
| eosinophilic fasciitis |
|
|
| toxic oil syndrome |
|
|
| aryl hydrocarbon hydroxylase inducibility |
|
Search AHR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AHR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for AHR Gene
Publications for AHR Gene
- Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 23 43 56
- Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. (PMID: 18818557) Chen D … Lu D (Pharmacogenetics and genomics 2009) 3 23 43 56
- Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. (PMID: 17429315) Long JR … Zheng W (Pharmacogenetics and genomics 2007) 3 23 43 56
- Modifying effect of the AR gene trinucleotide repeats and SNPs in the AHR and AHRR genes on the association between persistent organohalogen pollutant exposure and human sperm Y:X ratio. (PMID: 17244640) Tiido T … Giwercman YL (Molecular human reproduction 2007) 3 23 43 56
- Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. (PMID: 16103451) Le Marchand L … Wilkens LR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005) 3 23 43 56
ExternalLinks
Products for AHR Gene
- Custom Antibody ServicesOriGene Antibodies for AHR
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for AHR
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- Browse Antibodies
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- Abcam antibodies for AHR
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- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- Taconic Biosciences Mouse Models for AHR
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for AHR (AFLGC-AHR)
- ApexBio compounds for AHR
- Addgene plasmids for AHR
- antibodies-online: Show 205 available Aryl Hydrocarbon Receptor Antibodies ranked by validation data
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- 82 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (fro) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 106 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
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- antibodies-online: Show 9 available Aryl Hydrocarbon Receptor Proteins ranked by validation data
- Compare Top Aryl Hydrocarbon Receptor Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for AHR
- Search Santa Cruz Biotechnology (SCBT) for AHR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AHR
- Horizon Cell Lines for AHR
- genomics-online: cdna clones - Search for available Aryl Hydrocarbon Receptor CDNA products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- orf clones - Search for available Aryl Hydrocarbon Receptor ORF products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- genomics-online: gRNA clones - Search for available Aryl Hydrocarbon Receptor gRNA products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- genomics-online: primer clones - Search for available Aryl Hydrocarbon Receptor Primer products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- genomics-online: shRNA clones - Search for available Aryl Hydrocarbon Receptor shRNA products
- Overview of 118 available Aryl Hydrocarbon Receptor gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHR
- Search GeneCopoeia for miRNA 3'UTR Target clone products for AHR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHR
Sources for AHR Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource