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Aliases for AHR Gene

Aliases for AHR Gene

  • Aryl Hydrocarbon Receptor 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 76 3 4
  • Ah Receptor 3 4
  • BHLHe76 3 4
  • Aromatic Hydrocarbon Receptor 3
  • AH-Receptor 3
  • AhR 4

External Ids for AHR Gene

Previous GeneCards Identifiers for AHR Gene

  • GC07P016982
  • GC07P017082
  • GC07P017111
  • GC07P017304

Summaries for AHR Gene

Entrez Gene Summary for AHR Gene

  • The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

GeneCards Summary for AHR Gene

AHR (Aryl Hydrocarbon Receptor) is a Protein Coding gene. Diseases associated with AHR include Eosinophilic Fasciitis and Aryl Hydrocarbon Hydroxylase Inducibility. Among its related pathways are Aryl Hydrocarbon Receptor and Th17 cell differentiation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ENSG00000283321.

UniProtKB/Swiss-Prot for AHR Gene

  • Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Tocris Summary for AHR Gene

  • Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.

Gene Wiki entry for AHR Gene

PharmGKB "VIP" Summary for AHR Gene

Additional gene information for AHR Gene

No data available for CIViC summary , fRNAdb sequence ontologies and piRNA Summary for AHR Gene

Genomics for AHR Gene

GeneHancer (GH) Regulatory Elements for AHR Gene

Promoters and enhancers for AHR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I017297 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.8 1768 6.7 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 ATF7 ZHX2 REST ZNF518A LOC101927609 ENSG00000283321 AHR LOC101927630 LOC105375171
GH07I017233 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 29.1 -63.7 -63734 3.5 SMAD1 IRF4 TCF12 ATF7 FOS RUNX3 JUNB ZC3H11A ZNF518A MEF2D AHR LOC101927609 SNX13 ENSG00000199473 ENSG00000236318 ENSG00000278569
GH07I017142 Enhancer 1.4 FANTOM5 Ensembl ENCODE 30.6 -155.1 -155146 2.6 ELF3 FOXA2 ARID4B THRB RARA ETS1 RCOR1 ATF7 FOS CREM AHR LOC101927609 ENSG00000199473 ENSG00000236318 ENSG00000278569 GC07P017080
GH07I017185 Enhancer 1.2 FANTOM5 Ensembl ENCODE 27.8 -112.7 -112722 1 PKNOX1 BACH1 MAX BMI1 BATF IRF4 RAD21 ATF7 BCLAF1 IKZF2 AHR LOC101927609 ENSG00000278569 GC07P017080
GH07I017040 Enhancer 1.2 FANTOM5 Ensembl ENCODE 21.4 -256.5 -256547 3.9 JUN GATA3 ZNF766 ZNF366 NFE2 FOS NFE2L2 TCF7L2 RFX1 ZNF10 AHR LOC101927609 BRWD1P3 GC07P017052
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AHR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AHR gene promoter:

Genomic Locations for AHR Gene

Genomic Locations for AHR Gene
chr7:17,298,622-17,346,152
(GRCh38/hg38)
Size:
47,531 bases
Orientation:
Plus strand
chr7:17,338,246-17,385,776
(GRCh37/hg19)

Genomic View for AHR Gene

Genes around AHR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHR Gene

Proteins for AHR Gene

  • Protein details for AHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35869-AHR_HUMAN
    Recommended name:
    Aryl hydrocarbon receptor
    Protein Accession:
    P35869
    Secondary Accessions:
    • A4D130
    • Q13728
    • Q13803
    • Q13804

    Protein attributes for AHR Gene

    Size:
    848 amino acids
    Molecular mass:
    96147 Da
    Quaternary structure:
    • Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1. Interacts with HSP90AB1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for AHR Gene

neXtProt entry for AHR Gene

Post-translational modifications for AHR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AHR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AHR Gene

Domains & Families for AHR Gene

Gene Families for AHR Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for AHR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AHR: view

No data available for UniProtKB/Swiss-Prot for AHR Gene

Function for AHR Gene

Molecular function for AHR Gene

GENATLAS Biochemistry:
aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest
UniProtKB/Swiss-Prot Function:
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
UniProtKB/Swiss-Prot Induction:
Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).

Phenotypes From GWAS Catalog for AHR Gene

Gene Ontology (GO) - Molecular Function for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001094 TFIID-class transcription factor binding IPI 15641800
GO:0001223 transcription coactivator binding IPI 15641800
GO:0003677 DNA binding TAS,IDA 19538249
GO:0003700 DNA binding transcription factor activity IDA 11782478
GO:0004874 aryl hydrocarbon receptor activity IEA --
genes like me logo Genes that share ontologies with AHR: view
genes like me logo Genes that share phenotypes with AHR: view

Animal Models for AHR Gene

MGI Knock Outs for AHR:

Animal Model Products

miRNA for AHR Gene

miRTarBase miRNAs that target AHR

Transcription Factor Targets for AHR Gene

Selected GeneGlobe predicted Target genes for AHR

Clone Products

  • Addgene plasmids for AHR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for AHR Gene

Localization for AHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHR Gene

Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AHR gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 10395741
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex TAS 19538249
GO:0005737 cytoplasm IDA 15681594
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AHR: view

Pathways & Interactions for AHR Gene

genes like me logo Genes that share pathways with AHR: view

SIGNOR curated interactions for AHR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development NAS 19538249
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 10395741
GO:0006357 regulation of transcription by RNA polymerase II IDA 15681594
GO:0006366 transcription by RNA polymerase II IDA 10395741
genes like me logo Genes that share ontologies with AHR: view

Drugs & Compounds for AHR Gene

(75) Drugs for AHR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Leflunomide Approved, Investigational Pharma Target, agonist AHR agonist,immunosuppressive agent 69
Flutamide Approved, Investigational Pharma Target, agonist 65
Mexiletine Approved, Investigational Pharma Target, agonist 20
Nimodipine Approved, Investigational Pharma Potentiation, Activator, Target, agonist 27
Diosmin Approved, Investigational Pharma Target, agonist 0

(66) Additional Compounds for AHR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for AHR Gene

Compound Action Cas Number
6,2',4'-Trimethoxyflavone Aryl hydrocarbon receptor antagonist 720675-74-1
CH 223191 Potent aryl hydrocarbon receptor (AhR) antagonist 301326-22-7
FICZ High affinity aryl hydrocarbon receptor (AhR) agonist 172922-91-7
ITE Endogenous agonist for the transcription factor aryl hydrocarbon receptor 448906-42-1
L-Kynurenine Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand 2922-83-0

(14) ApexBio Compounds for AHR Gene

Compound Action Cas Number
6,2',4'-Trimethoxyflavone 720675-74-1
CH 223191 AhR antagonist 301326-22-7
DiMNF AHR modulator 14756-24-2
FICZ 172922-91-7
ITE AHR agonist 448906-42-1
Kaempferol Apoptosis inducer;antioxidant;flavonoid 520-18-3
Leflunomide AHR agonist,immunosuppressive agent 75706-12-6
L-Kynurenine 2922-83-0
MeBIO CDK/Cyclin/ GSK-3/p25/AhR agonist 667463-95-8
Oltipraz An antischistosomal agent 64224-21-1
Phortress Prodrug of antitumor agent 5F 203 328087-38-3
StemRegenin 1 (SR1) AhR antagonist 1227633-49-9
SU5416 VEGF receptor inhibitor and AHR agonist 204005-46-9
UM 729 Enhancer of AhR antagonists 1448723-60-1
genes like me logo Genes that share compounds with AHR: view

Drug Products

Transcripts for AHR Gene

Unigene Clusters for AHR Gene

Aryl hydrocarbon receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for AHR

Alternative Splicing Database (ASD) splice patterns (SP) for AHR Gene

No ASD Table

Relevant External Links for AHR Gene

GeneLoc Exon Structure for
AHR
ECgene alternative splicing isoforms for
AHR

Expression for AHR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AHR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AHR Gene

This gene is overexpressed in Nerve - Tibial (x4.5).

Protein differential expression in normal tissues from HIPED for AHR Gene

This gene is overexpressed in Placenta (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AHR Gene



Protein tissue co-expression partners for AHR Gene

NURSA nuclear receptor signaling pathways regulating expression of AHR Gene:

AHR

SOURCE GeneReport for Unigene cluster for AHR Gene:

Hs.171189

mRNA Expression by UniProt/SwissProt for AHR Gene:

P35869-AHR_HUMAN
Tissue specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.

Evidence on tissue expression from TISSUES for AHR Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with AHR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AHR Gene

Orthologs for AHR Gene

This gene was present in the common ancestor of animals.

Orthologs for AHR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AHR 33 34
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia AHR 33 34
  • 87.78 (n)
cow
(Bos Taurus)
Mammalia AHR 33 34
  • 84.39 (n)
mouse
(Mus musculus)
Mammalia Ahr 33 16 34
  • 79.17 (n)
rat
(Rattus norvegicus)
Mammalia Ahr 33
  • 77.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AHR 34
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AHR 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves AHR 33 34
  • 71.87 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ahr 33
  • 65.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia AHR 33
zebrafish
(Danio rerio)
Actinopterygii ahr1b 33
  • 60.47 (n)
ahr1a 34
  • 41 (a)
OneToOne
ahr1 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11494 33
fruit fly
(Drosophila melanogaster)
Insecta ss 35 34
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea ahr-1 35 34
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12569 33
Species where no ortholog for AHR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AHR Gene

ENSEMBL:
Gene Tree for AHR (if available)
TreeFam:
Gene Tree for AHR (if available)

Paralogs for AHR Gene

Paralogs for AHR Gene

Pseudogenes.org Pseudogenes for AHR Gene

genes like me logo Genes that share paralogs with AHR: view

Variants for AHR Gene

Sequence variations from dbSNP and Humsavar for AHR Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000009536 -- 17,320,724(+) C/T intron_variant
rs1000049380 -- 17,341,666(+) T/A intron_variant
rs1000055820 -- 17,305,921(+) C/T intron_variant
rs1000137040 -- 17,314,471(+) T/G intron_variant
rs1000235061 -- 17,305,620(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AHR Gene

Variant ID Type Subtype PubMed ID
dgv11225n54 CNV gain 21841781
dgv6289n100 CNV gain 25217958
dgv6290n100 CNV gain 25217958
esv2422294 CNV duplication 17116639
esv2759515 CNV gain+loss 17122850
esv2764001 CNV gain+loss 21179565
esv34717 CNV gain 17911159
esv3612420 CNV loss 21293372
esv3612421 CNV gain 21293372
esv3891076 CNV gain 25118596
esv3891077 CNV gain 25118596
nsv1029065 CNV loss 25217958
nsv1114920 CNV deletion 24896259
nsv464398 CNV gain 19166990
nsv464399 CNV gain 19166990
nsv606343 CNV gain 21841781
nsv8064 CNV gain 18304495

Variation tolerance for AHR Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.78; 73.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AHR Gene

Human Gene Mutation Database (HGMD)
AHR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AHR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHR Gene

Disorders for AHR Gene

MalaCards: The human disease database

(7) MalaCards diseases for AHR Gene - From: HGMD, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilic fasciitis
  • ef
aryl hydrocarbon hydroxylase inducibility
  • ahh inducibility; ahhi
seborrheic dermatitis
  • seborrhea
toxic oil syndrome
peanut allergy
  • allergy to peanuts
- elite association - COSMIC cancer census association via MalaCards
Search AHR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AHR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AHR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AHR Gene

Publications for AHR Gene

  1. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 22 44 58
  2. Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. (PMID: 18818557) Chen D … Lu D (Pharmacogenetics and genomics 2009) 3 22 44 58
  3. Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. (PMID: 17429315) Long JR … Zheng W (Pharmacogenetics and genomics 2007) 3 22 44 58
  4. Modifying effect of the AR gene trinucleotide repeats and SNPs in the AHR and AHRR genes on the association between persistent organohalogen pollutant exposure and human sperm Y:X ratio. (PMID: 17244640) Tiido T … Giwercman YL (Molecular human reproduction 2007) 3 22 44 58
  5. Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. (PMID: 16103451) Le Marchand L … Wilkens LR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005) 3 22 44 58

Products for AHR Gene

  • Addgene plasmids for AHR

Sources for AHR Gene

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