AHCYL1 Gene (Protein Coding)

Adenosylhomocysteinase Like 1

GC01P109984
GIFtS:
43
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] See more...

Aliases for AHCYL1 Gene

Aliases for AHCYL1 Gene

  • Adenosylhomocysteinase Like 1 2 3 5
  • XPVKONA 2 3 4
  • IRBIT 2 3 4
  • Inositol 1,4,5-Trisphosphate Receptor-Binding Protein 2 3
  • S-Adenosylhomocysteine Hydrolase-Like Protein 1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 78 2 3
  • IP(3)Rs Binding Protein Released With IP(3) 3 4
  • S-Adenosyl-L-Homocysteine Hydrolase 2 3 4
  • Putative Adenosylhomocysteinase 2 3 4
  • DC-Expressed AHCY-Like Molecule 3 4
  • AdoHcyase 2 3 4
  • PPP1R78 2 3
  • DCAL 3 4
  • Dendritic Cell Expressed AHCY-Like Protein 3
  • Epididymis Secretory Sperm Binding Protein 3
  • S-Adenosyl Homocysteine Hydrolase Homolog 3
  • S-Adenosylhomocysteine Hydrolase-Like 1 2
  • Adenosylhomocysteinase-Like 1 2
  • Adenosylhomocysteinase 2 3
  • EC 3.3.1.1 51
  • PRO0233 3
  • AHCYL1 5

External Ids for AHCYL1 Gene

Previous GeneCards Identifiers for AHCYL1 Gene

  • GC01P110943
  • GC01P109393
  • GC01P109629
  • GC01P109826
  • GC01P110239
  • GC01P110328
  • GC01P110529
  • GC01P108396

Summaries for AHCYL1 Gene

Entrez Gene Summary for AHCYL1 Gene

  • The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for AHCYL1 Gene

AHCYL1 (Adenosylhomocysteinase Like 1) is a Protein Coding gene. Diseases associated with AHCYL1 include Intestinal Impaction and Spinocerebellar Ataxia 29. Among its related pathways are DAG and IP3 signaling and RET signaling. Gene Ontology (GO) annotations related to this gene include NAD binding and ketol-acid reductoisomerase activity. An important paralog of this gene is AHCYL2.

UniProtKB/Swiss-Prot Summary for AHCYL1 Gene

  • Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).

Gene Wiki entry for AHCYL1 Gene

Additional gene information for AHCYL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AHCYL1 Gene

Genomics for AHCYL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for AHCYL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AHCYL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AHCYL1

Top Transcription factor binding sites by QIAGEN in the AHCYL1 gene promoter:
  • AML1a
  • C/EBPalpha
  • CREB
  • HFH-1
  • IRF-7A
  • ISGF-3
  • MRF-2
  • POU3F2
  • Roaz

Genomic Locations for AHCYL1 Gene

Genomic Locations for AHCYL1 Gene
chr1:109,984,765-110,023,742
(GRCh38/hg38)
Size:
38,978 bases
Orientation:
Plus strand
chr1:110,527,308-110,566,364
(GRCh37/hg19)
Size:
39,057 bases
Orientation:
Plus strand

Genomic View for AHCYL1 Gene

Genes around AHCYL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHCYL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHCYL1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AHCYL1 Gene

Proteins for AHCYL1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AHCYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43865-SAHH2_HUMAN
    Recommended name:
    S-adenosylhomocysteine hydrolase-like protein 1
    Protein Accession:
    O43865
    Secondary Accessions:
    • B4E168
    • Q2TAJ6
    • Q502W8
    • Q5VSM0
    • Q6P171
    • Q96PK4
    • Q9UG84

    Protein attributes for AHCYL1 Gene

    Size:
    530 amino acids
    Molecular mass:
    58951 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540;
    Quaternary structure:
    • Forms multimers (PubMed:16793548). Forms heteromultimers with AHCYL2 (via the C-terminal region) (PubMed:19220705). Interacts (when phosphorylated) with ITPR1 (when not phosphorylated); the interaction suppresses inositol 1,4,5-trisphosphate binding to ITPR1 (PubMed:16793548). Interacts with CFTR and SLC26A6; the interactions take place once AHCYL1 is released from ITPR1 and increase CFTR and SLC26A6 activities (By similarity). Interacts with RRM1; in a phosphorylation- and (dATP)-dependent manner. Interacts (via PEST domain when phosphorylated) with SLC4A4 isoform 1 but not isoform 2; the interaction increases SLC4A4 isoform 1 activity (PubMed:16769890). Interacts (when phosphorylated) with SLC9A3; the interaction is required for SLC9A3 apical location and activity (PubMed:18829453, PubMed:20584908). Interacts (when phosphorylated) with FIP1L1; the interaction is direct and associates AHCYL1 with the CPSF complex and RNA (PubMed:19224921). Interacts with PAPOLA (PubMed:19224921). Interacts with ZCCHC4 (PubMed:31799605).
    SequenceCaution:
    • Sequence=AAC01960.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BI460083; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAB43223.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Ablation of expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.

    Three dimensional structures from OCA and Proteopedia for AHCYL1 Gene

    Alternative splice isoforms for AHCYL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AHCYL1 Gene

Protein Expression for AHCYL1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for AHCYL1 Gene

O43865:
  • LRKRAQGEKPLAGAKIVGCTHITAQTAVL
  • LDDGGDLT
  • TPELTWERVRSQVDH
  • QACMDGF
  • GRRSLSRSISQSSTDSYSSAASYTDSSDDE
  • ALGAQCRW
  • ITEIDPI
  • TQALALIEL
  • FGRREIEIAE
  • MFGGKQVVVCGYGEVGKGCCAALKA
  • QTAVLIETL
  • NMILDDGGD
  • GIVEESVTGVHRLY
  • NVNDSVTK
  • DPICALQA
  • EIDPICA
  • QAKYLGL
  • KNGPFKPN
  • DVYLLPKKMDEYVASLHL
  • ACNIYST
  • VKLNEVIRQVD
  • VFAWKGE

Post-translational modifications for AHCYL1 Gene

  • Phosphorylated at Ser/Thr residues between Ser-68 and Thr-72 in the PEST region: required for interaction with dATP-bound RRM1 and ITPR1. Phosphorylation at Ser-68 by PRKD1 and CAMK4 is required for further phosphorylations by CSNK1A1 (PubMed:16793548). Phosphorylation is induced by oxidative stress (PubMed:19224921). Probably phosphorylated by CAMK2A; phosphorylation at Ser-68 may be required for interaction with SLC9A3 (PubMed:20584908).
  • Ubiquitination at Lys377
  • Modification sites at PhosphoSitePlus

Other Protein References for AHCYL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for AHCYL1 Gene

Gene Families for AHCYL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AHCYL1 Gene

InterPro:
Blocks:
  • S-adenosyl-L-homocysteine hydrolase
ProtoNet:

Suggested Antigen Peptide Sequences for AHCYL1 Gene

GenScript: Design optimal peptide antigens:
  • Adenosylhomocysteinase (B4E168_HUMAN)
  • Adenosylhomocysteinase (Q2NKW8_HUMAN)
  • AHCYL1 protein (Q9BTL0_HUMAN)
  • cDNA, FLJ93926, Homo sapiens PRO0233 protein (PRO0233), mRNA (Q9UI76_HUMAN)
  • S-adenosylhomocysteine hydrolase-like protein 1 (SAHH2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43865

UniProtKB/Swiss-Prot:

SAHH2_HUMAN :
  • The PEST region is essential for the interaction with ITPR1, and, when phosphorylated, is also the RRM1-binding region. The PDZ-binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By similarity).
  • Belongs to the adenosylhomocysteinase family.
Domain:
  • The PEST region is essential for the interaction with ITPR1, and, when phosphorylated, is also the RRM1-binding region. The PDZ-binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By similarity).
Family:
  • Belongs to the adenosylhomocysteinase family.
genes like me logo Genes that share domains with AHCYL1: view

Function for AHCYL1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for AHCYL1 Gene

UniProtKB/Swiss-Prot Function:
Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).
GENATLAS Biochemistry:
S-adenosylhomocysteine hydrolase-like 1

Enzyme Numbers (IUBMB) for AHCYL1 Gene

Phenotypes From GWAS Catalog for AHCYL1 Gene

Gene Ontology (GO) - Molecular Function for AHCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004013 NOT adenosylhomocysteinase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 16769890
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with AHCYL1: view
genes like me logo Genes that share phenotypes with AHCYL1: view

Animal Models for AHCYL1 Gene

MGI Knock Outs for AHCYL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for AHCYL1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHCYL1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AHCYL1 Gene

Localization for AHCYL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHCYL1 Gene

Endoplasmic reticulum. Cytoplasm, cytosol. Microsome. Apical cell membrane. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1. {ECO:0000250 UniProtKB:Q80SW1}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AHCYL1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
extracellular 4
endoplasmic reticulum 4
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AHCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol IBA 21873635
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with AHCYL1: view

Pathways & Interactions for AHCYL1 Gene

genes like me logo Genes that share pathways with AHCYL1: view

Pathways by source for AHCYL1 Gene

1 BioSystems pathway for AHCYL1 Gene
2 KEGG pathways for AHCYL1 Gene
1 GeneGo (Thomson Reuters) pathway for AHCYL1 Gene
  • Methionine metabolism
1 Cell Signaling Technology pathway for AHCYL1 Gene

SIGNOR curated interactions for AHCYL1 Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for AHCYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IDA 19224921
GO:0006611 protein export from nucleus IEA --
GO:0006730 one-carbon metabolic process IEA --
GO:0010765 positive regulation of sodium ion transport IMP 16769890
GO:0031440 regulation of mRNA 3'-end processing IDA 19224921
genes like me logo Genes that share ontologies with AHCYL1: view

Drugs & Compounds for AHCYL1 Gene

Products:

  1. Drug

(5) Drugs for AHCYL1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist, Channel blocker 619
Water Approved Pharma 0
s-adenosylhomocysteine Experimental Pharma 0
Homocysteine Experimental Pharma 0
NAD Experimental Pharma Agonist, Full agonist, Activator 0

(4) Additional Compounds for AHCYL1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
 485-80-3
Se-Adenosylselenohomocysteine
Selenohomocysteine
  • 2-amino-4-Selanyl-butanoate
  • 2-amino-4-Selanyl-butanoic acid
  • Se-selenocysteine
 29412-93-9
genes like me logo Genes that share compounds with AHCYL1: view

Transcripts for AHCYL1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for AHCYL1 Gene

5 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHCYL1

Alternative Splicing Database (ASD) splice patterns (SP) for AHCYL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^
SP1: - - - - - - - - -
SP2: -
SP3: - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6:
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:

ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - -
SP12:
SP13:
SP14:

Relevant External Links for AHCYL1 Gene

GeneLoc Exon Structure for
AHCYL1

Expression for AHCYL1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AHCYL1 Gene

mRNA expression in normal human tissues for AHCYL1 Gene
mRNA expression by BioGPS for AHCYL1 GenemRNA expression by GTEx for AHCYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AHCYL1 Gene

This gene is overexpressed in Spinal cord (12.5) and Peripheral blood mononuclear cells (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AHCYL1 Gene



Protein tissue co-expression partners for AHCYL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AHCYL1

SOURCE GeneReport for Unigene cluster for AHCYL1 Gene:

Hs.743973

mRNA Expression by UniProt/SwissProt for AHCYL1 Gene:

O43865-SAHH2_HUMAN
Tissue specificity: Expressed in dendritic cells.

Evidence on tissue expression from TISSUES for AHCYL1 Gene

  • Nervous system(5)
  • Skin(4.6)
  • Kidney(4.6)
  • Intestine(4.5)
  • Eye(4.4)
  • Pancreas(3.1)
  • Liver(2.6)
  • Gall bladder(2.5)
  • Lung(2.4)
  • Thyroid gland(2.3)
  • Heart(2.2)
  • Stomach(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with AHCYL1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AHCYL1 Gene

Orthologs for AHCYL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AHCYL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia AHCYL1 30 31
  • 99.81 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia AHCYL1 31
  • 99 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia AHCYL1 31
  • 99 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia AHCYL1 30 31
  • 96.16 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia AHCYL1 30 31
  • 96.12 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ahcyl1 30
  • 94.57 (n)
Mouse
(Mus musculus)
 Mammalia Ahcyl1 30 17 31
  • 93.65 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves AHCYL1 30 31
  • 84.05 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia AHCYL1 31
  • 98 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii ahcyl1 30 31
  • 79.02 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG9977 30 31 32
  • 70.35 (n)
 ManyToMany
Ahcy89E 31 32
  • 67 (a)
 ManyToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000792 30
  • 68.44 (n)
Worm
(Caenorhabditis elegans)
 Secernentea ahcy-1 31
  • 51 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SAH1 31
  • 48 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.10842 31
  • 67 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.13830 30
Species where no ortholog for AHCYL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for AHCYL1 Gene

ENSEMBL:
Gene Tree for AHCYL1 (if available)
TreeFam:
Gene Tree for AHCYL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AHCYL1: view image

Paralogs for AHCYL1 Gene

Paralogs for AHCYL1 Gene

(2) SIMAP similar genes for AHCYL1 Gene using alignment to 4 proteins:

  • SAHH2_HUMAN
  • Q2NKW8_HUMAN
  • Q9BTL0_HUMAN
  • Q9UI76_HUMAN
genes like me logo Genes that share paralogs with AHCYL1: view

Variants for AHCYL1 Gene

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Additional dbSNP identifiers (rs#s) for AHCYL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AHCYL1 Gene

Variant ID Type Subtype PubMed ID
esv3305044 CNV mobile element insertion 20981092
esv3440155 CNV insertion 20981092

Variation tolerance for AHCYL1 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AHCYL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AHCYL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AHCYL1 Gene

Disorders for AHCYL1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for AHCYL1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AHCYL1

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
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No data available for UniProtKB/Swiss-Prot and Genatlas for AHCYL1 Gene

Publications for AHCYL1 Gene

  1. Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. (PMID: 16754674) Cooper BJ … Kato M (The Journal of biological chemistry 2006) 2 3 4 23
  2. Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation. (PMID: 11904675) Dekker JW … Kato M (Immunogenetics 2002) 2 3 4
  3. Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes. (PMID: 25237103) Arnaoutov A … Dasso M (Science (New York, N.Y.) 2014) 3 4
  4. Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II. (PMID: 20584908) He P … Yun CC (The Journal of biological chemistry 2010) 3 4
  5. An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. (PMID: 19220705) Ando H … Mikoshiba K (Journal of neurochemistry 2009) 3 4

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