Aliases for AGXT Gene
External Ids for AGXT Gene
Previous HGNC Symbols for AGXT Gene
Previous GeneCards Identifiers for AGXT Gene
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGXT Gene
AGXT (Alanine--Glyoxylate And Serine--Pyruvate Aminotransferase) is a Protein Coding gene. Diseases associated with AGXT include Hyperoxaluria, Primary, Type I and Primary Hyperoxaluria. Among its related pathways are Glyoxylate and dicarboxylate metabolism and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and pyridoxal phosphate binding. An important paralog of this gene is PSAT1.