Aliases for AGTRAP Gene
External Ids for AGTRAP Gene
Previous GeneCards Identifiers for AGTRAP Gene
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGTRAP Gene
AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include angiotensin type II receptor activity.
UniProtKB/Swiss-Prot for AGTRAP Gene
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.