Aliases for AGTRAP Gene
External Ids for AGTRAP Gene
Previous GeneCards Identifiers for AGTRAP Gene
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGTRAP Gene
AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. Diseases associated with AGTRAP include Juvenile Astrocytoma and Hypertension, Essential. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include angiotensin type II receptor activity.
UniProtKB/Swiss-Prot Summary for AGTRAP Gene
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.