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Aliases for AGTRAP Gene

Aliases for AGTRAP Gene

  • Angiotensin II Receptor Associated Protein 2 3 5
  • AT1 Receptor-Associated Protein 3 4
  • ATRAP 3 4
  • Angiotensin II, Type I Receptor-Associated Protein 3
  • Type-1 Angiotensin II Receptor-Associated Protein 3
  • ATI Receptor-Associated Protein 3

External Ids for AGTRAP Gene

Previous GeneCards Identifiers for AGTRAP Gene

  • GC00U990804
  • GC01P011639
  • GC01P011405
  • GC01P011505
  • GC01P011730
  • GC01P011796
  • GC01P010950

Summaries for AGTRAP Gene

Entrez Gene Summary for AGTRAP Gene

  • This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGTRAP Gene

AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include angiotensin type II receptor activity.

UniProtKB/Swiss-Prot for AGTRAP Gene

  • Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Gene Wiki entry for AGTRAP Gene

Additional gene information for AGTRAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTRAP Gene

Genomics for AGTRAP Gene

GeneHancer (GH) Regulatory Elements for AGTRAP Gene

Promoters and enhancers for AGTRAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I011735 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570.9 +1.4 1412 3.4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 AGTRAP TARDBP TNFRSF1B ENSG00000226849 MAD2L2 DRAXIN EXOSC10 C1orf127 MTHFR CLCN6
GH01I012166 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.8 +438.9 438941 15.6 HDGF FOXA2 PKNOX1 SMAD1 ARNT IRF4 YY1 ZNF766 ZNF207 ZNF143 TNFRSF1B MTHFR TNFRSF8 CLCN6 VPS13D AGTRAP MIIP MFN2 MIR7846 MIR4632
GH01I011784 Enhancer 1.6 VISTA Ensembl ENCODE dbSUPER 11 +53.2 53178 9.2 HDGF FOXA2 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A ZNF2 YY1 POLR2B GC01M011790 PIR55960 MTHFR NPPA-AS1 CLCN6 AGTRAP NPPB GC01M011785 LOC102724659 C1orf167
GH01I011739 Enhancer 1.1 ENCODE dbSUPER 15.9 +5.3 5311 1.7 ATF1 GATA2 ATF7 RUNX3 NCOA1 REST ZNF592 MEF2D GMEB1 SMARCA4 AGTRAP GC01P011758
GH01I011795 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 +61.9 61922 4.6 HDGF PKNOX1 SMAD1 ARNT POLR2B ZNF766 CBX5 E2F8 REST MEF2D GC01M011785 TARDBP CLCN6 NPPA-AS1 ENSG00000226849 MTHFR EXOSC10 AGTRAP NPPB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AGTRAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGTRAP gene promoter:

Genomic Locations for AGTRAP Gene

Genomic Locations for AGTRAP Gene
chr1:11,735,474-11,754,802
(GRCh38/hg38)
Size:
19,329 bases
Orientation:
Plus strand
chr1:11,796,141-11,814,859
(GRCh37/hg19)

Genomic View for AGTRAP Gene

Genes around AGTRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTRAP Gene

Proteins for AGTRAP Gene

  • Protein details for AGTRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RW13-ATRAP_HUMAN
    Recommended name:
    Type-1 angiotensin II receptor-associated protein
    Protein Accession:
    Q6RW13
    Secondary Accessions:
    • A8MVQ5
    • Q5SNV4
    • Q5SNV5
    • Q96AC0
    • Q96PL4
    • Q9NRW9

    Protein attributes for AGTRAP Gene

    Size:
    159 amino acids
    Molecular mass:
    17419 Da
    Quaternary structure:
    • Interacts with RACK1, and with the C-terminal region of AGTR1.
    SequenceCaution:
    • Sequence=CAI15876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGTRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGTRAP Gene

Post-translational modifications for AGTRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGTRAP Gene

Domains & Families for AGTRAP Gene

Gene Families for AGTRAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for AGTRAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGTRAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AGTRAP: view

No data available for UniProtKB/Swiss-Prot for AGTRAP Gene

Function for AGTRAP Gene

Molecular function for AGTRAP Gene

UniProtKB/Swiss-Prot Function:
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Phenotypes From GWAS Catalog for AGTRAP Gene

Gene Ontology (GO) - Molecular Function for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004945 angiotensin type II receptor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with AGTRAP: view
genes like me logo Genes that share phenotypes with AGTRAP: view

Animal Model Products

CRISPR Products

miRNA for AGTRAP Gene

miRTarBase miRNAs that target AGTRAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGTRAP Gene

Localization for AGTRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTRAP Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGTRAP gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endoplasmic reticulum 3
golgi apparatus 3
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

Pathways & Interactions for AGTRAP Gene

genes like me logo Genes that share pathways with AGTRAP: view

Pathways by source for AGTRAP Gene

Gene Ontology (GO) - Biological Process for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0008217 regulation of blood pressure IEA --
GO:0038166 angiotensin-activated signaling pathway IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

No data available for SIGNOR curated interactions for AGTRAP Gene

Drugs & Compounds for AGTRAP Gene

(14) Drugs for AGTRAP Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azilsartan medoxomil Approved, Investigational Pharma Angiotensin II receptor type 1 antagonist 0
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 102
Tranilast Approved, Investigational Pharma Angiogenesis inhibitor 7
Angiotensin II Approved, Investigational Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1217
Angiotensin (1-7) Pharma Vasoconstriction peptide hormone 0

(13) ApexBio Compounds for AGTRAP Gene

Compound Action Cas Number
Angiotensin (1-7) Vasoconstriction peptide hormone 51833-78-4
Angiotensin 1/2 (1-5) Vasoconstrictor 58442-64-1
Angiotensin 1/2 (1-6) Vasoconstrictor 47896-63-9
Angiotensin 1/2 + A (2 - 8) 51833-76-2
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
AVE 0991 Agonist of angiotensin-(1-7) receptor 304462-19-9
AVE 0991 sodium salt Ang-(1-7) receptor Mas agonist 306288-04-0
Azilsartan 147403-03-0
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist 863031-21-4
Eprosartan Mesylate 144143-96-4
Irbesartan Angiotensin II inhibitor 138402-11-6
PD123319 Angiotensin AT2 receptor antagonist 130663-39-7
Tranilast Angiogenesis inhibitor 53902-12-8
genes like me logo Genes that share compounds with AGTRAP: view

Drug Products

Transcripts for AGTRAP Gene

Unigene Clusters for AGTRAP Gene

Angiotensin II receptor-associated protein:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGTRAP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - - - - -

Relevant External Links for AGTRAP Gene

GeneLoc Exon Structure for
AGTRAP
ECgene alternative splicing isoforms for
AGTRAP

Expression for AGTRAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGTRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTRAP Gene

This gene is overexpressed in Whole Blood (x17.8).

Protein differential expression in normal tissues from HIPED for AGTRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Monocytes (11.9), NK cells (7.2), and Gallbladder (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGTRAP Gene



Protein tissue co-expression partners for AGTRAP Gene

NURSA nuclear receptor signaling pathways regulating expression of AGTRAP Gene:

AGTRAP

SOURCE GeneReport for Unigene cluster for AGTRAP Gene:

Hs.464438

mRNA Expression by UniProt/SwissProt for AGTRAP Gene:

Q6RW13-ATRAP_HUMAN
Tissue specificity: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.

Evidence on tissue expression from TISSUES for AGTRAP Gene

  • Kidney(4.5)
  • Intestine(4.3)
  • Nervous system(4.3)
  • Eye(4.1)
  • Lung(2.4)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with AGTRAP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AGTRAP Gene

Orthologs for AGTRAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGTRAP 33
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia AGTRAP 33 34
  • 83.22 (n)
cow
(Bos Taurus)
Mammalia AGTRAP 33 34
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Agtrap 33 16 34
  • 81.97 (n)
rat
(Rattus norvegicus)
Mammalia Agtrap 33
  • 81.97 (n)
oppossum
(Monodelphis domestica)
Mammalia AGTRAP 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
OneToMany
-- 34
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves AGTRAP 33 34
  • 66.67 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia agtrap 33
  • 60.42 (n)
zebrafish
(Danio rerio)
Actinopterygii agtrap 33 34
  • 61.22 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10899 33
Species where no ortholog for AGTRAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTRAP Gene

ENSEMBL:
Gene Tree for AGTRAP (if available)
TreeFam:
Gene Tree for AGTRAP (if available)

Paralogs for AGTRAP Gene

No data available for Paralogs for AGTRAP Gene

Variants for AGTRAP Gene

Sequence variations from dbSNP and Humsavar for AGTRAP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000148201 -- 11,739,766(+) G/A intron_variant
rs1000175147 -- 11,745,213(+) C/T intron_variant
rs1000218063 -- 11,751,211(+) C/T downstream_transcript_variant
rs1000272543 -- 11,737,842(+) C/G intron_variant
rs1000365655 -- 11,749,544(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AGTRAP Gene

Variant ID Type Subtype PubMed ID
dgv108n54 CNV loss 21841781
nsv508880 CNV insertion 20534489
nsv545418 CNV loss 21841781
nsv545419 CNV gain 21841781
nsv545420 CNV loss 21841781
nsv545421 CNV loss 21841781
nsv832758 CNV loss 17160897

Variation tolerance for AGTRAP Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGTRAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGTRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTRAP Gene

Disorders for AGTRAP Gene

Additional Disease Information for AGTRAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AGTRAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGTRAP Gene

Publications for AGTRAP Gene

  1. Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap). (PMID: 11733189) Wang W … Mao Y (The international journal of biochemistry & cell biology 2002) 2 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C … Munroe PB (Nature genetics 2009) 3 44 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for AGTRAP Gene

Sources for AGTRAP Gene

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