This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] See more...

Aliases for AGTRAP Gene

Aliases for AGTRAP Gene

  • Angiotensin II Receptor Associated Protein 2 3 5
  • ATRAP 2 3 4
  • Type-1 Angiotensin II Receptor-Associated Protein 3 4
  • AT1 Receptor-Associated Protein 3 4
  • Angiotensin II, Type I Receptor-Associated Protein 3
  • ATI Receptor-Associated Protein 3
  • AGTRAP 5

External Ids for AGTRAP Gene

Previous GeneCards Identifiers for AGTRAP Gene

  • GC00U990804
  • GC01P011639
  • GC01P011405
  • GC01P011505
  • GC01P011730
  • GC01P011796
  • GC01P010950

Summaries for AGTRAP Gene

Entrez Gene Summary for AGTRAP Gene

  • This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGTRAP Gene

AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. Diseases associated with AGTRAP include Juvenile Astrocytoma and Hypertension, Essential. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include angiotensin type II receptor activity.

UniProtKB/Swiss-Prot Summary for AGTRAP Gene

  • Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Gene Wiki entry for AGTRAP Gene

Additional gene information for AGTRAP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGTRAP Gene

Genomics for AGTRAP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AGTRAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGTRAP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGTRAP

Top Transcription factor binding sites by QIAGEN in the AGTRAP gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • ITF-2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • SRY
  • Tal-1beta
  • USF-1
  • USF1

Genomic Locations for AGTRAP Gene

Genomic Locations for AGTRAP Gene
chr1:11,736,084-11,754,802
(GRCh38/hg38)
Size:
18,719 bases
Orientation:
Plus strand
chr1:11,796,141-11,814,859
(GRCh37/hg19)
Size:
18,719 bases
Orientation:
Plus strand

Genomic View for AGTRAP Gene

Genes around AGTRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTRAP Gene

Proteins for AGTRAP Gene

  • Protein details for AGTRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RW13-ATRAP_HUMAN
    Recommended name:
    Type-1 angiotensin II receptor-associated protein
    Protein Accession:
    Q6RW13
    Secondary Accessions:
    • A8MVQ5
    • Q5SNV4
    • Q5SNV5
    • Q96AC0
    • Q96PL4
    • Q9NRW9

    Protein attributes for AGTRAP Gene

    Size:
    159 amino acids
    Molecular mass:
    17419 Da
    Quaternary structure:
    • Interacts with RACK1, and with the C-terminal region of AGTR1.

    Alternative splice isoforms for AGTRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGTRAP Gene

Post-translational modifications for AGTRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGTRAP Gene

Domains & Families for AGTRAP Gene

Gene Families for AGTRAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for AGTRAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGTRAP Gene

GenScript: Design optimal peptide antigens:
  • AT1 receptor-associated protein (ATRAP_HUMAN)
genes like me logo Genes that share domains with AGTRAP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AGTRAP Gene

Function for AGTRAP Gene

Molecular function for AGTRAP Gene

UniProtKB/Swiss-Prot Function:
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Phenotypes From GWAS Catalog for AGTRAP Gene

Gene Ontology (GO) - Molecular Function for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004945 angiotensin type II receptor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with AGTRAP: view
genes like me logo Genes that share phenotypes with AGTRAP: view

Animal Model Products

CRISPR Products

miRNA for AGTRAP Gene

miRTarBase miRNAs that target AGTRAP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGTRAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGTRAP Gene

Localization for AGTRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTRAP Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Cytoplasmic vesicle membrane. Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGTRAP gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 4
endoplasmic reticulum 3
golgi apparatus 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

Pathways & Interactions for AGTRAP Gene

genes like me logo Genes that share pathways with AGTRAP: view

Pathways by source for AGTRAP Gene

Gene Ontology (GO) - Biological Process for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0008217 regulation of blood pressure IEA,IBA 21873635
GO:0038166 angiotensin-activated signaling pathway IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

No data available for SIGNOR curated interactions for AGTRAP Gene

Drugs & Compounds for AGTRAP Gene

(14) Drugs for AGTRAP Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azilsartan medoxomil Approved, Investigational Pharma Angiotensin II receptor type 1 antagonist 55
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 110
Angiotensin II Approved, Investigational Pharma Agonist, Full agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1347
Angiotensin 1-7 Investigational Pharma Vasoconstriction peptide hormone 0
Tranilast Investigational Pharma Angiogenesis inhibitor 11

(13) ApexBio Compounds for AGTRAP Gene

Compound Action Cas Number
Angiotensin (1-7) Vasoconstriction peptide hormone 51833-78-4
Angiotensin 1/2 (1-5) Vasoconstrictor 58442-64-1
Angiotensin 1/2 (1-6) Vasoconstrictor 47896-63-9
Angiotensin 1/2 + A (2 - 8) 51833-76-2
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
AVE 0991 Agonist of angiotensin-(1-7) receptor 304462-19-9
AVE 0991 sodium salt Ang-(1-7) receptor Mas agonist 306288-04-0
Azilsartan 147403-03-0
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist 863031-21-4
Eprosartan Mesylate 144143-96-4
Irbesartan Angiotensin II inhibitor 138402-11-6
PD123319 Angiotensin AT2 receptor antagonist 130663-39-7
Tranilast Angiogenesis inhibitor 53902-12-8
genes like me logo Genes that share compounds with AGTRAP: view

Drug Products

Transcripts for AGTRAP Gene

mRNA/cDNA for AGTRAP Gene

5 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGTRAP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGTRAP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - - - - -

Relevant External Links for AGTRAP Gene

GeneLoc Exon Structure for
AGTRAP

Expression for AGTRAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGTRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTRAP Gene

This gene is overexpressed in Whole Blood (x17.8).

Protein differential expression in normal tissues from HIPED for AGTRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Monocytes (11.9), NK cells (7.2), and Gallbladder (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AGTRAP Gene



Protein tissue co-expression partners for AGTRAP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGTRAP

SOURCE GeneReport for Unigene cluster for AGTRAP Gene:

Hs.464438

mRNA Expression by UniProt/SwissProt for AGTRAP Gene:

Q6RW13-ATRAP_HUMAN
Tissue specificity: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.

Evidence on tissue expression from TISSUES for AGTRAP Gene

  • Kidney(4.5)
  • Nervous system(4.5)
  • Intestine(4.4)
  • Eye(4.2)
  • Muscle(2.4)
  • Heart(2.4)
  • Lung(2.4)
  • Skin(2.3)
  • Blood(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with AGTRAP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AGTRAP Gene

Orthologs for AGTRAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTRAP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AGTRAP 30
  • 99.79 (n)
Dog
(Canis familiaris)
Mammalia AGTRAP 30 31
  • 83.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AGTRAP 30 31
  • 82.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Agtrap 30 17 31
  • 81.97 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Agtrap 30
  • 81.97 (n)
Oppossum
(Monodelphis domestica)
Mammalia AGTRAP 31
  • 61 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 47 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
Chicken
(Gallus gallus)
Aves AGTRAP 30 31
  • 66.67 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia agtrap 30
  • 60.42 (n)
Zebrafish
(Danio rerio)
Actinopterygii agtrap 30 31
  • 61.22 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10899 30
Species where no ortholog for AGTRAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AGTRAP Gene

ENSEMBL:
Gene Tree for AGTRAP (if available)
TreeFam:
Gene Tree for AGTRAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AGTRAP: view image

Paralogs for AGTRAP Gene

No data available for Paralogs for AGTRAP Gene

Variants for AGTRAP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGTRAP Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17875960 - p.Ala143Val

Additional dbSNP identifiers (rs#s) for AGTRAP Gene

Structural Variations from Database of Genomic Variants (DGV) for AGTRAP Gene

Variant ID Type Subtype PubMed ID
dgv108n54 CNV loss 21841781
nsv508880 CNV insertion 20534489
nsv545418 CNV loss 21841781
nsv545419 CNV gain 21841781
nsv545420 CNV loss 21841781
nsv545421 CNV loss 21841781
nsv832758 CNV loss 17160897

Variation tolerance for AGTRAP Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGTRAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGTRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTRAP Gene

Disorders for AGTRAP Gene

MalaCards: The human disease database

(2) MalaCards diseases for AGTRAP Gene - From: DISEASES

Disorder Aliases PubMed IDs
juvenile astrocytoma
  • pediatric astrocytoma
hypertension, essential
  • eht
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AGTRAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AGTRAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGTRAP Gene

Publications for AGTRAP Gene

  1. Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap). (PMID: 11733189) Wang W … Mao Y (The international journal of biochemistry & cell biology 2002) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C … Munroe PB (Nature genetics 2009) 3 41
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for AGTRAP Gene

Sources for AGTRAP Gene