Aliases for AGTRAP Gene
Aliases for AGTRAP Gene
External Ids for AGTRAP Gene
- HGNC: 13539
- Entrez Gene: 57085
- Ensembl: ENSG00000177674
- OMIM: 608729
- UniProtKB: Q6RW13
Previous GeneCards Identifiers for AGTRAP Gene
- GC00U990804
- GC01P011639
- GC01P011405
- GC01P011505
- GC01P011730
- GC01P011796
- GC01P010950
Summaries for AGTRAP Gene
-
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGTRAP Gene
AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include angiotensin type II receptor activity.
UniProtKB/Swiss-Prot for AGTRAP Gene
-
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Additional gene information for AGTRAP Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTRAP Gene
Genomics for AGTRAP Gene
GeneHancer (GH) Regulatory Elements for AGTRAP Gene
Promoters and enhancers for AGTRAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around AGTRAP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AGTRAP gene promoter:
Regulatory Element Products
Genomic Locations for AGTRAP Gene
Genomic Locations for AGTRAP Gene
- chr1:11,735,474-11,754,802
- (GRCh38/hg38)
- Size:
- 19,329 bases
- Orientation:
- Plus strand
- chr1:11,796,141-11,814,859
- (GRCh37/hg19)
Genomic View for AGTRAP Gene
Genes around AGTRAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.22 by Ensembl
- 1p36.22 by Entrez Gene
- 1p36.22 by HGNC
AGTRAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AGTRAP Gene
Proteins for AGTRAP Gene
-
Protein details for AGTRAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6RW13-ATRAP_HUMAN
- Recommended name:
- Type-1 angiotensin II receptor-associated protein
- Protein Accession:
- Q6RW13
- A8MVQ5
- Q5SNV4
- Q5SNV5
- Q96AC0
- Q96PL4
- Q9NRW9
Protein attributes for AGTRAP Gene
- Size:
- 159 amino acids
- Molecular mass:
- 17419 Da
- Quaternary structure:
-
- Interacts with RACK1, and with the C-terminal region of AGTR1.
- SequenceCaution:
-
- Sequence=CAI15876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for AGTRAP Gene
Post-translational modifications for AGTRAP Gene
Other Protein References for AGTRAP Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for AGTRAP
- Novus Biologicals Antibodies for AGTRAP
-
Abcam antibodies for AGTRAP
- Invitrogen Antibodies for AGTRAP
- Search GeneTex for Antibodies for AGTRAP
-
Santa Cruz Biotechnology (SCBT) Antibodies for AGTRAP
Protein Products
-
OriGene Purified Proteins for AGTRAP
- Search Origene for MassSpec and Protein Over-expression Lysates for AGTRAP
- Origene Custom Protein Services for AGTRAP
- antibodies-online: Search results for 4 available AGTRAP Proteins ranked by validation data
- Compare Top AGTRAP Proteins
-
Quality Products:
- Search GeneTex for Proteins for AGTRAP
-
Abcam proteins for AGTRAP
Assay Products
- antibodies-online: Search results for 3 available AGTRAP Elisa Kits ranked by validation data
- Compare Top AGTRAP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for AGTRAP Gene
Domains & Families for AGTRAP Gene
Gene Families for AGTRAP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for AGTRAP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for AGTRAP Gene
Function for AGTRAP Gene
Molecular function for AGTRAP Gene
- UniProtKB/Swiss-Prot Function:
- Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Phenotypes From GWAS Catalog for AGTRAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004945 | angiotensin type II receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for AGTRAP Gene
- MGI mutant phenotypes for AGTRAP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for AGTRAP:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Increased HPV18 LCR reporter activity
- Increased Sindbis virus (SINV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for AGTRAP
-
- Search ViGene Biosciences for AGTRAP
CRISPR Products
-
OriGene CRISPR knockouts for AGTRAP
- genomics-online: gRNA clones - Search results for available AGTRAP gene related products
- Applied Biological Materials CRISPR for AGTRAP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AGTRAP
- GenScript: Design CRISPR guide RNA sequences for AGTRAP
miRNA for AGTRAP Gene
- miRTarBase miRNAs that target AGTRAP
-
- hsa-mir-1-3p (MIRT023506)
- hsa-mir-125a-5p (MIRT045764)
- hsa-mir-216a-3p (MIRT129681)
- hsa-mir-128-3p (MIRT129682)
- hsa-mir-155-5p (MIRT129684)
- hsa-mir-377-5p (MIRT129689)
- hsa-mir-766-3p (MIRT129699)
- hsa-mir-940 (MIRT129701)
- hsa-mir-3681-3p (MIRT129716)
- hsa-mir-6086 (MIRT129736)
- hsa-mir-6512-3p (MIRT129738)
- hsa-mir-6720-5p (MIRT129740)
- hsa-mir-6733-3p (MIRT129743)
- hsa-mir-6808-5p (MIRT129749)
- hsa-mir-6893-5p (MIRT129755)
- hsa-mir-30e-3p (MIRT455179)
- hsa-mir-30d-3p (MIRT455180)
- hsa-mir-30a-3p (MIRT455181)
- hsa-mir-3942-3p (MIRT455182)
- hsa-mir-3915 (MIRT455183)
- hsa-mir-5100 (MIRT455184)
- hsa-mir-1294 (MIRT455185)
- hsa-mir-7160-5p (MIRT455186)
- hsa-mir-655-5p (MIRT455187)
- hsa-mir-1827 (MIRT455188)
- hsa-mir-3928-3p (MIRT455189)
- hsa-mir-4649-3p (MIRT455190)
- hsa-mir-1250-3p (MIRT455191)
- hsa-mir-1245b-3p (MIRT455192)
- hsa-mir-5582-5p (MIRT455193)
- hsa-mir-6749-3p (MIRT610343)
- hsa-mir-6069 (MIRT610344)
- hsa-mir-4469 (MIRT610345)
- hsa-mir-532-3p (MIRT610346)
- hsa-mir-8073 (MIRT610347)
- hsa-mir-221-5p (MIRT610348)
- hsa-mir-660-3p (MIRT610349)
- hsa-mir-4667-3p (MIRT610350)
- hsa-mir-1470 (MIRT610351)
- hsa-mir-662 (MIRT610352)
- hsa-mir-664a-5p (MIRT615511)
- hsa-mir-4794 (MIRT615512)
- hsa-mir-5195-3p (MIRT618781)
- hsa-mir-145-5p (MIRT618782)
- hsa-mir-6820-5p (MIRT618783)
- hsa-mir-4660 (MIRT618784)
- hsa-mir-6849-3p (MIRT618785)
- hsa-mir-6736-3p (MIRT618786)
- hsa-mir-3614-3p (MIRT618787)
- hsa-mir-7108-5p (MIRT645302)
- hsa-mir-6818-3p (MIRT645303)
- hsa-mir-6873-3p (MIRT645304)
- hsa-mir-663b (MIRT645305)
- hsa-mir-593-3p (MIRT645306)
- hsa-mir-6895-3p (MIRT645307)
- hsa-mir-6744-3p (MIRT645308)
- hsa-mir-4757-5p (MIRT645309)
- hsa-mir-874-5p (MIRT645310)
- hsa-mir-7110-3p (MIRT645311)
- hsa-mir-6845-3p (MIRT645312)
- hsa-mir-1976 (MIRT645313)
- hsa-mir-3653-5p (MIRT645314)
- hsa-mir-199b-5p (MIRT645315)
- hsa-mir-199a-5p (MIRT645316)
- hsa-mir-6513-5p (MIRT692340)
- hsa-mir-887-5p (MIRT692341)
- hsa-mir-3913-5p (MIRT692342)
- hsa-mir-3122 (MIRT692343)
- hsa-mir-450a-1-3p (MIRT692344)
- hsa-mir-6788-5p (MIRT692345)
- hsa-mir-30c-2-3p (MIRT692346)
- hsa-mir-30c-1-3p (MIRT692347)
- hsa-mir-7977 (MIRT692348)
- hsa-mir-513b-5p (MIRT692349)
- hsa-mir-3165 (MIRT692350)
- hsa-mir-6799-5p (MIRT692351)
- hsa-mir-6883-5p (MIRT692352)
- hsa-mir-6785-5p (MIRT692353)
- hsa-mir-4728-5p (MIRT692354)
- hsa-mir-149-3p (MIRT692355)
- hsa-mir-7106-5p (MIRT692356)
- hsa-mir-4736 (MIRT692357)
- hsa-mir-3665 (MIRT692358)
- hsa-mir-6089 (MIRT692359)
- hsa-mir-383-3p (MIRT692360)
- hsa-mir-125b-2-3p (MIRT692361)
- hsa-mir-4457 (MIRT692362)
- hsa-mir-624-3p (MIRT692363)
- hsa-mir-3974 (MIRT692364)
- hsa-mir-340-3p (MIRT741378)
- hsa-mir-3613-3p (MIRT741634)
- hsa-mir-371a-5p (MIRT742586)
- hsa-mir-371b-5p (MIRT742599)
- hsa-mir-372-5p (MIRT742610)
- hsa-mir-373-5p (MIRT742623)
- hsa-mir-4668-5p (MIRT746814)
- hsa-mir-616-5p (MIRT752526)
- hsa-mir-6827-3p (MIRT757040)
miRNA Products
- Search ViGene Biosciences for AGTRAP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for AGTRAP
- Browse OriGene Inhibitory RNA Products For AGTRAP
- genomics-online: shRNA clones - Search results for available AGTRAP gene related products
Clone Products
-
OriGene ORF clones in human for AGTRAP
- RC205705L1V
- RG212155
- RC212155L2
- RC212155L1
- RC212155
- RG212327
- RC212327L2
- RC212327L1
- RC212327
- RG212269
- RC212269L2
- RC212269L1
- RC212269
- RG223005
- RC223005L2
- RC223005L1
- RC223005
- RG205705
- RC205705L2
- RC205705L1
- RC205705
- RC212155L2V
- RC212155L1V
- RC212327L2V
- RC212327L1V
- RC212269L2V
- RC212269L1V
- RC223005L2V
- RC223005L1V
- RC205705L2V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AGTRAP
- VectorBuilder custom plasmid, inducible vectors for AGTRAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AGTRAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available AGTRAP gene related products
- orf clones - Search results for available AGTRAP gene related products
- Applied Biological Materials Clones for AGTRAP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for AGTRAP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGTRAP Gene
Localization for AGTRAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for AGTRAP Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 3 |
| golgi apparatus | 3 |
| extracellular | 1 |
| lysosome | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
Pathways & Interactions for AGTRAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.45
|
|
| 2 | Oncogenic MAPK signaling | ||
Pathways by source for AGTRAP Gene
4 Reactome pathways for AGTRAP Gene
Interacting Proteins for AGTRAP Gene
Selected Interacting proteins:
Q6RW13-ATRAP_HUMAN
ENSP00000319713
for AGTRAP Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0008217 | regulation of blood pressure | IEA | -- |
| GO:0038166 | angiotensin-activated signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for AGTRAP Gene
Drugs & Compounds for AGTRAP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Azilsartan medoxomil | Approved, Investigational | Pharma | Angiotensin II receptor type 1 antagonist | 0 | ||
| Irbesartan | Approved, Investigational | Pharma | Antagonist | Angiotensin II inhibitor | 102 | |
| Tranilast | Approved, Investigational | Pharma | Angiogenesis inhibitor | 7 | ||
| Angiotensin II | Approved, Investigational | Pharma | Full agonist, Agonist | Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. | 1217 | |
| Angiotensin (1-7) | Pharma | Vasoconstriction peptide hormone | 0 |
(13) ApexBio Compounds for AGTRAP Gene
| Compound | Action | Cas Number |
|---|---|---|
| Angiotensin (1-7) | Vasoconstriction peptide hormone | 51833-78-4 |
| Angiotensin 1/2 (1-5) | Vasoconstrictor | 58442-64-1 |
| Angiotensin 1/2 (1-6) | Vasoconstrictor | 47896-63-9 |
| Angiotensin 1/2 + A (2 - 8) | 51833-76-2 | |
| Angiotensin III (human, mouse) | Aldosterone stimulator | 13602-53-4 |
| AVE 0991 | Agonist of angiotensin-(1-7) receptor | 304462-19-9 |
| AVE 0991 sodium salt | Ang-(1-7) receptor Mas agonist | 306288-04-0 |
| Azilsartan | 147403-03-0 | |
| Azilsartan Medoxomil | Angiotensin II receptor type 1 antagonist | 863031-21-4 |
| Eprosartan Mesylate | 144143-96-4 | |
| Irbesartan | Angiotensin II inhibitor | 138402-11-6 |
| PD123319 | Angiotensin AT2 receptor antagonist | 130663-39-7 |
| Tranilast | Angiogenesis inhibitor | 53902-12-8 |
Transcripts for AGTRAP Gene
mRNA/cDNA for AGTRAP Gene
- (8) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (246) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AGTRAP Gene
CRISPR Products
-
OriGene CRISPR knockouts for AGTRAP
- genomics-online: gRNA clones - Search results for available AGTRAP gene related products
- Applied Biological Materials CRISPR for AGTRAP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AGTRAP
- GenScript: Design CRISPR guide RNA sequences for AGTRAP
miRNA Products
- Search ViGene Biosciences for AGTRAP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for AGTRAP
- Browse OriGene Inhibitory RNA Products For AGTRAP
- genomics-online: shRNA clones - Search results for available AGTRAP gene related products
Clone Products
-
OriGene ORF clones in human for AGTRAP
- RC205705L1V
- RG212155
- RC212155L2
- RC212155L1
- RC212155
- RG212327
- RC212327L2
- RC212327L1
- RC212327
- RG212269
- RC212269L2
- RC212269L1
- RC212269
- RG223005
- RC223005L2
- RC223005L1
- RC223005
- RG205705
- RC205705L2
- RC205705L1
- RC205705
- RC212155L2V
- RC212155L1V
- RC212327L2V
- RC212327L1V
- RC212269L2V
- RC212269L1V
- RC223005L2V
- RC223005L1V
- RC205705L2V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AGTRAP
- VectorBuilder custom plasmid, inducible vectors for AGTRAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AGTRAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available AGTRAP gene related products
- orf clones - Search results for available AGTRAP gene related products
- Applied Biological Materials Clones for AGTRAP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - |
Expression for AGTRAP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for AGTRAP Gene
This gene is overexpressed in Whole Blood (x17.8).
This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Monocytes (11.9), NK cells (7.2), and Gallbladder (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGTRAP Gene
NURSA nuclear receptor signaling pathways regulating expression of AGTRAP Gene:
AGTRAPSOURCE GeneReport for Unigene cluster for AGTRAP Gene:
Hs.464438mRNA Expression by UniProt/SwissProt for AGTRAP Gene:
Q6RW13-ATRAP_HUMAN
Tissue specificity:
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
Evidence on tissue expression from TISSUES for AGTRAP Gene
- Kidney(4.5)
- Intestine(4.3)
- Nervous system(4.3)
- Eye(4.1)
- Lung(2.4)
- Heart(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for AGTRAP
-
OriGene qPCR primer pairs and template standards for AGTRAP
- genomics-online: primer clones - Search results for available AGTRAP gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AGTRAP Gene
Orthologs for AGTRAP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AGTRAP 33 |
|
||
| dog (Canis familiaris) |
Mammalia | AGTRAP 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | AGTRAP 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Agtrap 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Agtrap 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AGTRAP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | AGTRAP 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | agtrap 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | agtrap 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10899 33 |
|
- Species where no ortholog for AGTRAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for AGTRAP Gene
No data available for Paralogs for AGTRAP Gene
Variants for AGTRAP Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000148201 | -- | 11,739,766(+) | G/A | intron_variant | |
| rs1000175147 | -- | 11,745,213(+) | C/T | intron_variant | |
| rs1000218063 | -- | 11,751,211(+) | C/T | downstream_transcript_variant | |
| rs1000272543 | -- | 11,737,842(+) | C/G | intron_variant | |
| rs1000365655 | -- | 11,749,544(+) | G/C | intron_variant |
Residual Variation Intolerance Score:
82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.46;
9.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AGTRAP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AGTRAP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTRAP Gene
Disorders for AGTRAP Gene
Additional Disease Information for AGTRAP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for AGTRAP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGTRAP Gene
Publications for AGTRAP Gene
- Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap). (PMID: 11733189) Wang W … Mao Y (The international journal of biochemistry & cell biology 2002) 2 3 4 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C … Munroe PB (Nature genetics 2009) 3 44 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for AGTRAP Gene
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- ApexBio compounds for AGTRAP
- Cyagen custom Knockout/knockin (KOKI) mouse models for AGTRAP
- VectorBuilder custom plasmid, inducible vectors for AGTRAP
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available AGTRAP Antibodies ranked by validation data
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- Search GeneTex for Antibodies for AGTRAP
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- Search ViGene Biosciences for AGTRAP
- Santa Cruz Biotechnology (SCBT) Antibodies for AGTRAP
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- Santa Cruz Biotechnology (SCBT) CRISPR for AGTRAP
- Horizon Cell Lines for AGTRAP
- genomics-online: cdna clones - Search results for available AGTRAP gene related products
- orf clones - Search results for available AGTRAP gene related products
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Sources for AGTRAP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems