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This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] See more...
Aliases for AGTRAP Gene
Aliases for AGTRAP Gene
External Ids for AGTRAP Gene
- HGNC: 13539
- Entrez Gene: 57085
- Ensembl: ENSG00000177674
- OMIM: 608729
- UniProtKB: Q6RW13
Previous GeneCards Identifiers for AGTRAP Gene
- GC00U990804
- GC01P011639
- GC01P011405
- GC01P011505
- GC01P011730
- GC01P011796
- GC01P010950
Summaries for AGTRAP Gene
-
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGTRAP Gene
AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. Diseases associated with AGTRAP include Juvenile Astrocytoma and Hypertension, Essential. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include angiotensin type II receptor activity.
UniProtKB/Swiss-Prot Summary for AGTRAP Gene
-
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Additional gene information for AGTRAP Gene
- HGNC(13539)
- Entrez Gene(57085)
- Ensembl(ENSG00000177674)
- OMIM(608729)
- UniProtKB(Q6RW13)
- Open Targets Platform(ENSG00000177674)
- Search for AGTRAP at DataMed
- Search for AGTRAP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGTRAP Gene
Genomics for AGTRAP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for AGTRAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AGTRAP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGTRAP
- Top Transcription factor binding sites by QIAGEN in the AGTRAP gene promoter:
-
- FOXJ2
- FOXJ2 (long isoform)
- ITF-2
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- SRY
- Tal-1beta
- USF-1
- USF1
Genomic Locations for AGTRAP Gene
Genomic Locations for AGTRAP Gene
- chr1:11,736,084-11,754,802
- (GRCh38/hg38)
- Size:
- 18,719 bases
- Orientation:
- Plus strand
- chr1:11,796,141-11,814,859
- (GRCh37/hg19)
- Size:
- 18,719 bases
- Orientation:
- Plus strand
Genomic View for AGTRAP Gene
Genes around AGTRAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.22 by HGNC
- 1p36.22 by Entrez Gene
- 1p36.22 by Ensembl
AGTRAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AGTRAP Gene
Proteins for AGTRAP Gene
-
Protein details for AGTRAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6RW13-ATRAP_HUMAN
- Recommended name:
- Type-1 angiotensin II receptor-associated protein
- Protein Accession:
- Q6RW13
- A8MVQ5
- Q5SNV4
- Q5SNV5
- Q96AC0
- Q96PL4
- Q9NRW9
Protein attributes for AGTRAP Gene
- Size:
- 159 amino acids
- Molecular mass:
- 17419 Da
- Quaternary structure:
-
- Interacts with RACK1, and with the C-terminal region of AGTR1.
Protein Expression for AGTRAP Gene
Post-translational modifications for AGTRAP Gene
Other Protein References for AGTRAP Gene
Antibody Products
- LifeSpan BioSciences AGTRAP / ATRAP Monoclonal Antibody
- Creative Diagnostics Anti-AGTRAP monoclonal antibody, clone 2H3
- Creative Biolabs Recombinant Mouse Anti-Human AGTRAP Antibody and Mouse Anti-AGTRAP Recombinant Antibody (1G2)
-
Custom Antibody ServicesOriGene Antibodies for AGTRAP
- Novus Biologicals Antibodies for AGTRAP
-
Abcam antibodies for AGTRAP
- Invitrogen Antibodies for AGTRAP (AFLGC-AGTRAP)
-
Boster Bio Antibodies for AGTRAP
-
Santa Cruz Biotechnology (SCBT) Antibodies for AGTRAP
Protein Products
-
OriGene Purified Proteins for AGTRAP
- Search Origene for MassSpec and Protein Over-expression Lysates for AGTRAP
- Origene Custom Protein Services for AGTRAP
- antibodies-online: Show 4 available AGTRAP Proteins ranked by validation data
- Compare Top AGTRAP Proteins
-
Quality Products:
-
Abcam proteins for AGTRAP
Assay Products
- Creative Diagnostics Human AGTRAP ELISA Matched Antibody Pair (ABPR-0021) and Human AGTRAP ELISA Matched Antibody Pair (ABPR-0020)
No data available for DME Specific Peptides for AGTRAP Gene
Domains & Families for AGTRAP Gene
Gene Families for AGTRAP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for AGTRAP Gene
- GenScript: Design optimal peptide antigens:
-
- AT1 receptor-associated protein (ATRAP_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AGTRAP Gene
Function for AGTRAP Gene
Molecular function for AGTRAP Gene
- UniProtKB/Swiss-Prot Function:
- Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Phenotypes From GWAS Catalog for AGTRAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004945 | angiotensin type II receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for AGTRAP Gene
- MGI mutant phenotypes for AGTRAP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for AGTRAP:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased epidermal growth factor (EGF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased Sindbis virus (SINV) infection
- Increased shRNA abundance (Z-score > 2)
- Increased HPV18 LCR reporter activity
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability (cell death)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for AGTRAP - Select products 50% OFF >
- * AGTRAP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for AGTRAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AGTRAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for AGTRAP
miRNA for AGTRAP Gene
- miRTarBase miRNAs that target AGTRAP
-
- hsa-miR-1-3p (MIRT023506)
- hsa-miR-125a-5p (MIRT045764)
- mmu-miR-155-5p (MIRT054576)
- hsa-miR-216a-3p (MIRT129681)
- hsa-miR-128-3p (MIRT129682)
- hsa-miR-155-5p (MIRT129684)
- hsa-miR-377-5p (MIRT129689)
- hsa-miR-766-3p (MIRT129699)
- hsa-miR-940 (MIRT129701)
- hsa-miR-3681-3p (MIRT129716)
- hsa-miR-6086 (MIRT129736)
- hsa-miR-6512-3p (MIRT129738)
- hsa-miR-6720-5p (MIRT129740)
- hsa-miR-6733-3p (MIRT129743)
- hsa-miR-6808-5p (MIRT129749)
- hsa-miR-6893-5p (MIRT129755)
- hsa-miR-30e-3p (MIRT455179)
- hsa-miR-30d-3p (MIRT455180)
- hsa-miR-30a-3p (MIRT455181)
- hsa-miR-3942-3p (MIRT455182)
- hsa-miR-3915 (MIRT455183)
- hsa-miR-5100 (MIRT455184)
- hsa-miR-1294 (MIRT455185)
- hsa-miR-7160-5p (MIRT455186)
- hsa-miR-655-5p (MIRT455187)
- hsa-miR-1827 (MIRT455188)
- hsa-miR-3928-3p (MIRT455189)
- hsa-miR-4649-3p (MIRT455190)
- hsa-miR-1250-3p (MIRT455191)
- hsa-miR-1245b-3p (MIRT455192)
- hsa-miR-5582-5p (MIRT455193)
- mmu-miR-5098 (MIRT579409)
- mmu-miR-466f (MIRT579410)
- mmu-miR-466d-5p (MIRT579411)
- mmu-miR-466k (MIRT579412)
- mmu-miR-466i-5p (MIRT579413)
- mmu-miR-466n-5p (MIRT579414)
- mmu-miR-466m-5p (MIRT579415)
- mmu-miR-466j (MIRT579416)
- mmu-miR-466h-5p (MIRT579417)
- mmu-miR-669m-5p (MIRT579418)
- mmu-miR-210-3p (MIRT579419)
- mmu-miR-696 (MIRT579420)
- mmu-miR-3064-3p (MIRT579421)
- mmu-miR-105 (MIRT579422)
- mmu-miR-290a-3p (MIRT579423)
- mmu-miR-292a-3p (MIRT579424)
- mmu-miR-467a-5p (MIRT579425)
- mmu-miR-129-5p (MIRT588081)
- mmu-miR-670-5p (MIRT588082)
- mmu-miR-339-5p (MIRT588083)
- mmu-miR-1896 (MIRT588084)
- mmu-miR-129-1-3p (MIRT588085)
- mmu-miR-129-2-3p (MIRT588086)
- mmu-miR-3085-3p (MIRT588087)
- mmu-miR-3064-5p (MIRT588088)
- mmu-miR-3110-5p (MIRT599813)
- mmu-miR-5125 (MIRT599814)
- hsa-miR-6749-3p (MIRT610343)
- hsa-miR-6069 (MIRT610344)
- hsa-miR-4469 (MIRT610345)
- hsa-miR-532-3p (MIRT610346)
- hsa-miR-8073 (MIRT610347)
- hsa-miR-221-5p (MIRT610348)
- hsa-miR-660-3p (MIRT610349)
- hsa-miR-4667-3p (MIRT610350)
- hsa-miR-1470 (MIRT610351)
- hsa-miR-662 (MIRT610352)
- hsa-miR-664a-5p (MIRT615511)
- hsa-miR-4794 (MIRT615512)
- hsa-miR-5195-3p (MIRT618781)
- hsa-miR-145-5p (MIRT618782)
- hsa-miR-6820-5p (MIRT618783)
- hsa-miR-4660 (MIRT618784)
- hsa-miR-6849-3p (MIRT618785)
- hsa-miR-6736-3p (MIRT618786)
- hsa-miR-3614-3p (MIRT618787)
- hsa-miR-7108-5p (MIRT645302)
- hsa-miR-6818-3p (MIRT645303)
- hsa-miR-6873-3p (MIRT645304)
- hsa-miR-663b (MIRT645305)
- hsa-miR-593-3p (MIRT645306)
- hsa-miR-6895-3p (MIRT645307)
- hsa-miR-6744-3p (MIRT645308)
- hsa-miR-4757-5p (MIRT645309)
- hsa-miR-874-5p (MIRT645310)
- hsa-miR-7110-3p (MIRT645311)
- hsa-miR-6845-3p (MIRT645312)
- hsa-miR-1976 (MIRT645313)
- hsa-miR-3653-5p (MIRT645314)
- hsa-miR-199b-5p (MIRT645315)
- hsa-miR-199a-5p (MIRT645316)
- hsa-miR-6513-5p (MIRT692340)
- hsa-miR-887-5p (MIRT692341)
- hsa-miR-3913-5p (MIRT692342)
- hsa-miR-3122 (MIRT692343)
- hsa-miR-450a-1-3p (MIRT692344)
- hsa-miR-6788-5p (MIRT692345)
- hsa-miR-30c-2-3p (MIRT692346)
- hsa-miR-30c-1-3p (MIRT692347)
- hsa-miR-7977 (MIRT692348)
- hsa-miR-513b-5p (MIRT692349)
- hsa-miR-3165 (MIRT692350)
- hsa-miR-6799-5p (MIRT692351)
- hsa-miR-6883-5p (MIRT692352)
- hsa-miR-6785-5p (MIRT692353)
- hsa-miR-4728-5p (MIRT692354)
- hsa-miR-149-3p (MIRT692355)
- hsa-miR-7106-5p (MIRT692356)
- hsa-miR-4736 (MIRT692357)
- hsa-miR-3665 (MIRT692358)
- hsa-miR-6089 (MIRT692359)
- hsa-miR-383-3p (MIRT692360)
- hsa-miR-125b-2-3p (MIRT692361)
- hsa-miR-4457 (MIRT692362)
- hsa-miR-624-3p (MIRT692363)
- hsa-miR-3974 (MIRT692364)
- hsa-miR-340-3p (MIRT741378)
- hsa-miR-3613-3p (MIRT741634)
- hsa-miR-371a-5p (MIRT742586)
- hsa-miR-371b-5p (MIRT742599)
- hsa-miR-372-5p (MIRT742610)
- hsa-miR-373-5p (MIRT742623)
- hsa-miR-4668-5p (MIRT746814)
- hsa-miR-616-5p (MIRT752526)
- hsa-miR-6827-3p (MIRT757040)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AGTRAP
- Browse OriGene Inhibitory RNA Products For AGTRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGTRAP
Clone Products
- Applied Biological Materials (abm): Clones for AGTRAP - Select products 50% OFF >
- * AGTRAP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201251
- MR201251
- MR201251L3
- MR201251L4
- MR227864
- RC205705
- RC205705L1
- RC205705L2
- RC205705L3
- RC205705L4
- RC212155
- RC212155L1
- RC212155L2
- RC212155L3
- RC212155L4
- RC212269
- RC212269L3
- RC212269L4
- RC212327
- RC212327L3
- RC212327L4
- RC223005
- RC223005L3
- RC223005L4
- RG205705
- RG212155
- RG212269
- RG212327
- RG223005
- RR206078
- RR206078L3
- RR206078L4
- MR201251L3V
- MR201251L4V
- RC205705L1V
- RC205705L2V
- RC205705L3V
- RC205705L4V
- RC212155L1V
- RC212155L2V
- RC212155L3V
- RC212155L4V
- RC212269L3V
- RC212269L4V
- RC212327L3V
- RC212327L4V
- RC223005L3V
- RC223005L4V
- RR206078L3V
- RR206078L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AGTRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AGTRAP
Cell Line Products
-
Horizon Cell Lines for AGTRAP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGTRAP Gene
Localization for AGTRAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for AGTRAP Gene
- Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Cytoplasmic vesicle membrane. Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 4 |
| cytosol | 4 |
| endoplasmic reticulum | 3 |
| golgi apparatus | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| lysosome | 0 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
Pathways & Interactions for AGTRAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.45
|
|
| 2 | Oncogenic MAPK signaling | ||
Pathways by source for AGTRAP Gene
4 Reactome pathways for AGTRAP Gene
Interacting Proteins for AGTRAP Gene
Selected Interacting proteins:
Q6RW13-ATRAP_HUMAN
ENSP00000319713
for AGTRAP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for AGTRAP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0008217 | regulation of blood pressure | IEA,IBA | 21873635 |
| GO:0038166 | angiotensin-activated signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for AGTRAP Gene
Drugs & Compounds for AGTRAP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Azilsartan medoxomil | Approved, Investigational | Pharma | Angiotensin II receptor type 1 antagonist | 55 | ||
| Irbesartan | Approved, Investigational | Pharma | Antagonist | Angiotensin II inhibitor | 110 | |
| Angiotensin II | Approved, Investigational | Pharma | Agonist, Full agonist | Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. | 1347 | |
| Angiotensin 1-7 | Investigational | Pharma | Vasoconstriction peptide hormone | 0 | ||
| Tranilast | Investigational | Pharma | Angiogenesis inhibitor | 11 |
(13) ApexBio Compounds for AGTRAP Gene
| Compound | Action | Cas Number |
|---|---|---|
| Angiotensin (1-7) | Vasoconstriction peptide hormone | 51833-78-4 |
| Angiotensin 1/2 (1-5) | Vasoconstrictor | 58442-64-1 |
| Angiotensin 1/2 (1-6) | Vasoconstrictor | 47896-63-9 |
| Angiotensin 1/2 + A (2 - 8) | 51833-76-2 | |
| Angiotensin III (human, mouse) | Aldosterone stimulator | 13602-53-4 |
| AVE 0991 | Agonist of angiotensin-(1-7) receptor | 304462-19-9 |
| AVE 0991 sodium salt | Ang-(1-7) receptor Mas agonist | 306288-04-0 |
| Azilsartan | 147403-03-0 | |
| Azilsartan Medoxomil | Angiotensin II receptor type 1 antagonist | 863031-21-4 |
| Eprosartan Mesylate | 144143-96-4 | |
| Irbesartan | Angiotensin II inhibitor | 138402-11-6 |
| PD123319 | Angiotensin AT2 receptor antagonist | 130663-39-7 |
| Tranilast | Angiogenesis inhibitor | 53902-12-8 |
Transcripts for AGTRAP Gene
mRNA/cDNA for AGTRAP Gene
- 5 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000376637 1067 nts (view in UCSC)
- ENST00000476512 942 nts (view in UCSC)
- ENST00000400895 786 nts (view in UCSC)
- ENST00000494437 976 nts (view in UCSC)
- ENST00000491346 1116 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for AGTRAP - Select products 50% OFF >
- * AGTRAP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for AGTRAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AGTRAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for AGTRAP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AGTRAP
- Browse OriGene Inhibitory RNA Products For AGTRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGTRAP
Clone Products
- Applied Biological Materials (abm): Clones for AGTRAP - Select products 50% OFF >
- * AGTRAP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201251
- MR201251
- MR201251L3
- MR201251L4
- MR227864
- RC205705
- RC205705L1
- RC205705L2
- RC205705L3
- RC205705L4
- RC212155
- RC212155L1
- RC212155L2
- RC212155L3
- RC212155L4
- RC212269
- RC212269L3
- RC212269L4
- RC212327
- RC212327L3
- RC212327L4
- RC223005
- RC223005L3
- RC223005L4
- RG205705
- RG212155
- RG212269
- RG212327
- RG223005
- RR206078
- RR206078L3
- RR206078L4
- MR201251L3V
- MR201251L4V
- RC205705L1V
- RC205705L2V
- RC205705L3V
- RC205705L4V
- RC212155L1V
- RC212155L2V
- RC212155L3V
- RC212155L4V
- RC212269L3V
- RC212269L4V
- RC212327L3V
- RC212327L4V
- RC223005L3V
- RC223005L4V
- RR206078L3V
- RR206078L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AGTRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AGTRAP
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - |
Relevant External Links for AGTRAP Gene
- GeneLoc Exon Structure for
- AGTRAP
Expression for AGTRAP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for AGTRAP Gene
This gene is overexpressed in Whole Blood (x17.8).
This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Monocytes (11.9), NK cells (7.2), and Gallbladder (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AGTRAP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGTRAP
SOURCE GeneReport for Unigene cluster for AGTRAP Gene:
Hs.464438mRNA Expression by UniProt/SwissProt for AGTRAP Gene:
Q6RW13-ATRAP_HUMAN
Tissue specificity:
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
Evidence on tissue expression from TISSUES for AGTRAP Gene
- Kidney(4.5)
- Nervous system(4.5)
- Intestine(4.4)
- Eye(4.2)
- Muscle(2.4)
- Heart(2.4)
- Lung(2.4)
- Skin(2.3)
- Blood(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for AGTRAP
-
OriGene qPCR primer pairs and template standards for AGTRAP
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AGTRAP Gene
Orthologs for AGTRAP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | AGTRAP 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | AGTRAP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | AGTRAP 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Agtrap 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Agtrap 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | AGTRAP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | AGTRAP 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | agtrap 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | agtrap 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10899 30 |
|
- Species where no ortholog for AGTRAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for AGTRAP Gene
- ENSEMBL:
- Gene Tree for AGTRAP (if available)
- TreeFam:
- Gene Tree for AGTRAP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AGTRAP: view image
Paralogs for AGTRAP Gene
No data available for Paralogs for AGTRAP Gene
Variants for AGTRAP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGTRAP Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17875960 | - | p.Ala143Val |
Residual Variation Intolerance Score:
82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.46;
9.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AGTRAP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AGTRAP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTRAP Gene
Disorders for AGTRAP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| juvenile astrocytoma |
|
|
| hypertension, essential |
|
|
Search AGTRAP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AGTRAP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for AGTRAP Gene
Publications for AGTRAP Gene
- Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap). (PMID: 11733189) Wang W … Mao Y (The international journal of biochemistry & cell biology 2002) 2 3 4 23
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C … Munroe PB (Nature genetics 2009) 3 41
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for AGTRAP Gene
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- Invitrogen Antibodies for AGTRAP (AFLGC-AGTRAP)
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- VectorBuilder Viral vectors for AGTRAP (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for AGTRAP
- antibodies-online: Show 16 available AGTRAP Antibodies ranked by validation data
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- antibodies-online: Show 4 available AGTRAP Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for AGTRAP
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- Horizon Cell Lines for AGTRAP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AGTRAP
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- Boster Bio Antibodies for AGTRAP
- Browse Boster Bio ELISA Kits
Sources for AGTRAP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB