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This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. Diseases associated with AGTRAP include Juvenile Astrocytoma and Hypertension, Essential. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include angiotensin type II receptor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004945 | angiotensin type II receptor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Life Cycle |
.45
|
|
2 | Oncogenic MAPK signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEA | -- |
GO:0008217 | regulation of blood pressure | IEA,IBA | 21873635 |
GO:0038166 | angiotensin-activated signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Azilsartan medoxomil | Approved, Investigational | Pharma | Angiotensin II receptor type 1 antagonist | 55 | ||
Irbesartan | Approved, Investigational | Pharma | Antagonist | Angiotensin II inhibitor | 110 | |
Angiotensin II | Approved, Investigational | Pharma | Agonist, Full agonist | Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. | 1347 | |
Angiotensin 1-7 | Investigational | Pharma | Vasoconstriction peptide hormone | 0 | ||
Tranilast | Investigational | Pharma | Angiogenesis inhibitor | 11 |
Compound | Action | Cas Number |
---|---|---|
Angiotensin (1-7) | Vasoconstriction peptide hormone | 51833-78-4 |
Angiotensin 1/2 (1-5) | Vasoconstrictor | 58442-64-1 |
Angiotensin 1/2 (1-6) | Vasoconstrictor | 47896-63-9 |
Angiotensin 1/2 + A (2 - 8) | 51833-76-2 | |
Angiotensin III (human, mouse) | Aldosterone stimulator | 13602-53-4 |
AVE 0991 | Agonist of angiotensin-(1-7) receptor | 304462-19-9 |
AVE 0991 sodium salt | Ang-(1-7) receptor Mas agonist | 306288-04-0 |
Azilsartan | 147403-03-0 | |
Azilsartan Medoxomil | Angiotensin II receptor type 1 antagonist | 863031-21-4 |
Eprosartan Mesylate | 144143-96-4 | |
Irbesartan | Angiotensin II inhibitor | 138402-11-6 |
PD123319 | Angiotensin AT2 receptor antagonist | 130663-39-7 |
Tranilast | Angiogenesis inhibitor | 53902-12-8 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AGTRAP 30 |
|
||
Dog (Canis familiaris) |
Mammalia | AGTRAP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AGTRAP 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Agtrap 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Agtrap 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | AGTRAP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | AGTRAP 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | agtrap 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | agtrap 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10899 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17875960 | - | p.Ala143Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
juvenile astrocytoma |
|
|
hypertension, essential |
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|