Aliases for AGTR2 Gene
External Ids for AGTR2 Gene
Previous GeneCards Identifiers for AGTR2 Gene
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and SARS-CoV-2 infection result in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors which triggers serious inflammatory lesions, primarily in the lungs, an effect mediated by angiotensin II derivatives. However, while the ACE2-angiotensin II-angiotensin AT1 receptor pathway contributes to the pathophysiology of acute respiratory distress syndrome (ARDS), the activation of the ACE-2-angiotensin(1-7)-angiotensin AT2 receptor and the ACE-2-angiotensin(1-7)-Mas receptor pathways have been shown to be protective. [provided by RefSeq, Jun 2020]
GeneCards Summary for AGTR2 Gene
AGTR2 (Angiotensin II Receptor Type 2) is a Protein Coding gene. Diseases associated with AGTR2 include Non-Syndromic X-Linked Intellectual Disability and Obstructive Nephropathy. Among its related pathways are Signaling by GPCR and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide hormone binding. An important paralog of this gene is AGTR1.
UniProtKB/Swiss-Prot Summary for AGTR2 Gene
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
The angiotensin2 receptor (AT2) is a member of the angiotensin receptor group of G-protein-coupled receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart and uterus where they counterbalance the effects of AT1.