Free for academic non-profit institutions. Other users need a Commercial license

AGTR2 Gene(Protein Coding)

Angiotensin II Receptor Type 2

GCID:
GC0XP116170
GIFtS:
54
Genes Participants
UDN Logo

Aliases for AGTR2 Gene

Aliases for AGTR2 Gene

  • Angiotensin II Receptor Type 2 2 3 5
  • Angiotensin II Type-2 Receptor 3 4
  • AT2 3 4
  • Type-2 Angiotensin II Receptor 3
  • Angiotensin Receptor 2 2
  • ATGR2 3
  • MRX88 3

External Ids for AGTR2 Gene

Previous GeneCards Identifiers for AGTR2 Gene

  • GC0XP110072
  • GC0XP112376
  • GC0XP113316
  • GC0XP114086
  • GC0XP115113
  • GC0XP115216
  • GC0XP104838

Summaries for AGTR2 Gene

Entrez Gene Summary for AGTR2 Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. [provided by RefSeq, Jan 2010]

GeneCards Summary for AGTR2 Gene

AGTR2 (Angiotensin II Receptor Type 2) is a Protein Coding gene. Diseases associated with AGTR2 include X-Linked Non-Specific Intellectual Disability and Multicystic Dysplastic Kidney. Among its related pathways are Peptide ligand-binding receptors and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is AGTR1.

UniProtKB/Swiss-Prot for AGTR2 Gene

  • Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Tocris Summary for AGTR2 Gene

  • The angiotensin2 receptor (AT2) is a member of the angiotensin receptor group of G-protein-coupled receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart and uterus where they counterbalance the effects of AT1.

Gene Wiki entry for AGTR2 Gene

Additional gene information for AGTR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTR2 Gene

Genomics for AGTR2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for AGTR2 Gene

Promoters and enhancers for AGTR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XI116170 Promoter 0.5 EPDnew 550.8 +0.0 27 0.1 AGTR2 GC0XP116203
GH0XI116229 Enhancer 0.7 ENCODE 5.4 +60.4 60390 3.6 FOXA2 CEBPB REST CEBPG EP300 FOXA1 SP1 CTBP1 JUND GATA3 AGTR2 SLC6A14 GC0XP116203 GC0XM116401 RNU6-154P
GH0XI116279 Enhancer 0.2 ENCODE 4.4 +106.9 106869 0.7 AGTR2 GC0XP116203 RNU6-154P GC0XM116401
GH0XI116172 Enhancer 0.2 ENCODE 0.8 +2.3 2285 1.8 SLC6A14 AGTR2 GC0XP116203
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AGTR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGTR2 gene promoter:

Genomic Locations for AGTR2 Gene

Genomic Locations for AGTR2 Gene
chrX:116,170,705-116,174,972
(GRCh38/hg38)
Size:
4,268 bases
Orientation:
Plus strand
chrX:115,301,958-115,306,225
(GRCh37/hg19)

Genomic View for AGTR2 Gene

Genes around AGTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AGTR2 Gene

Proteins for AGTR2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AGTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50052-AGTR2_HUMAN
    Recommended name:
    Type-2 angiotensin II receptor
    Protein Accession:
    P50052
    Secondary Accessions:
    • B2R9V1
    • Q13016
    • Q6FGY7

    Protein attributes for AGTR2 Gene

    Size:
    363 amino acids
    Molecular mass:
    41184 Da
    Quaternary structure:
    • Interacts with MTUS1.

    Three dimensional structures from OCA and Proteopedia for AGTR2 Gene

neXtProt entry for AGTR2 Gene

Post-translational modifications for AGTR2 Gene

  • Glycosylation at posLast=44, Asn13, Asn24, posLast=2929, and Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for AGTR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGTR2 Gene

Domains & Families for AGTR2 Gene

Gene Families for AGTR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for AGTR2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AGTR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50052

UniProtKB/Swiss-Prot:

AGTR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with AGTR2: view

Function for AGTR2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for AGTR2 Gene

GENATLAS Biochemistry:
angiotensin II (type-2) receptor,abundantly expressed during embryonic development in fetal tissues,in adrenal glands,heart and brain,G protein coupled receptor superfamily,involved in the activation of dephosphorylating enzymes,stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase (involved in blood pressure regulation)
UniProtKB/Swiss-Prot Function:
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Phenotypes From GWAS Catalog for AGTR2 Gene

Gene Ontology (GO) - Molecular Function for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004945 angiotensin type II receptor activity IPI 10406457
GO:0005515 protein binding IPI 10406457
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with AGTR2: view
genes like me logo Genes that share phenotypes with AGTR2: view

Human Phenotype Ontology for AGTR2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGTR2 Gene

MGI Knock Outs for AGTR2:

Animal Model Products

Clone Products

  • Addgene plasmids for AGTR2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGTR2 Gene

Localization for AGTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGTR2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 10406457
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGTR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AGTR2 Gene

Pathways & Interactions for AGTR2 Gene

genes like me logo Genes that share pathways with AGTR2: view

SIGNOR curated interactions for AGTR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling TAS 17159080
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin IEA,ISS --
GO:0002018 renin-angiotensin regulation of aldosterone production IEA --
GO:0002033 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA --
GO:0002035 brain renin-angiotensin system IEA --
genes like me logo Genes that share ontologies with AGTR2: view

Drugs & Compounds for AGTR2 Gene

Products:

  1. Drug

(62) Drugs for AGTR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Angiotensin II Approved, Investigational Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1217
Tasosartan Approved Pharma Target, antagonist 0
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 102
Losartan Approved Pharma Antagonist 295
Azilsartan medoxomil Approved, Investigational Pharma Angiotensin II receptor type 1 antagonist 0

(14) Additional Compounds for AGTR2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
angiotensin I
Full agonist, Agonist

(3) Tocris Compounds for AGTR2 Gene

Compound Action Cas Number
CGP 42112 Selective, high affinity AT2 ligand 127060-75-7
Novokinin Orally active AT2 agonist 358738-77-9
PD 123319 ditrifluoroacetate Potent, selective non-peptide AT2 antagonist 130663-39-7

(29) ApexBio Compounds for AGTR2 Gene

Compound Action Cas Number
Acetyl Angiotensinogen (1-14), porcine Angiotensinogen precursor 66641-26-7
Angiotensin (1-7) Vasoconstriction peptide hormone 51833-78-4
Angiotensin 1/2 (1-5) Vasoconstrictor 58442-64-1
Angiotensin 1/2 (1-6) Vasoconstrictor 47896-63-9
Angiotensin 1/2 (1-9) Vasoconstrictor 34273-12-6
Angiotensin 1/2 + A (2 - 8) 51833-76-2
Angiotensin I (human, mouse, rat) Precursor of angiotensin II 484-42-4
Angiotensin II Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 68521-88-0
Angiotensin II human 4474-91-3
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
AVE 0991 Agonist of angiotensin-(1-7) receptor 304462-19-9
AVE 0991 sodium salt Ang-(1-7) receptor Mas agonist 306288-04-0
Azilsartan 147403-03-0
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist 863031-21-4
Biapenem 120410-24-4
Candesartan Cilexetil 145040-37-5
CGP 42112 127060-75-7
EMD 66684 1216884-39-7
Eprosartan Mesylate 144143-96-4
Fimasartan 247257-48-3
Irbesartan Angiotensin II inhibitor 138402-11-6
LCZ696 936623-90-4
Losartan 114798-26-4
Novokinin 358738-77-9
PD 123319 ditrifluoroacetate Angiotensin AT2 receptor antagonist 136676-91-0
PD123319 Angiotensin AT2 receptor antagonist 130663-39-7
Telmisattan Angiotensin II receptor antagonist 144701-48-4
Tranilast Angiogenesis inhibitor 53902-12-8
ZD 7155 hydrochloride 146709-78-6
genes like me logo Genes that share compounds with AGTR2: view

Drug Products

Transcripts for AGTR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for AGTR2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGTR2 Gene

Angiotensin II receptor, type 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for AGTR2

Alternative Splicing Database (ASD) splice patterns (SP) for AGTR2 Gene

No ASD Table

Relevant External Links for AGTR2 Gene

GeneLoc Exon Structure for
AGTR2
ECgene alternative splicing isoforms for
AGTR2

Expression for AGTR2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGTR2 Gene

mRNA expression in normal human tissues for AGTR2 Gene
mRNA expression by GTEx for AGTR2 GenemRNA expression by BioGPS for AGTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTR2 Gene

This gene is overexpressed in Lung (x22.1), Fallopian Tube (x8.4), and Uterus (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of AGTR2 Gene:

AGTR2

SOURCE GeneReport for Unigene cluster for AGTR2 Gene:

Hs.405348

mRNA Expression by UniProt/SwissProt for AGTR2 Gene:

P50052-AGTR2_HUMAN
Tissue specificity: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.

Evidence on tissue expression from TISSUES for AGTR2 Gene

  • Kidney(4.6)
  • Blood(4.5)
  • Lung(4.5)
  • Liver(4.4)
  • Adrenal gland(2.6)
  • Heart(2.6)
  • Nervous system(2.6)
  • Muscle(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AGTR2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
  • testicle
  • urinary bladder
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with AGTR2: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for AGTR2 Gene

Orthologs for AGTR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia AGTR2 33 34
  • 99.72 (n)
cow
(Bos Taurus)
 Mammalia AT2 34
  • 94 (a)
 OneToOne
AGTR2 33
  • 91.9 (n)
dog
(Canis familiaris)
 Mammalia AGTR2 33 34
  • 92.63 (n)
rat
(Rattus norvegicus)
 Mammalia Agtr2 33
  • 89.35 (n)
mouse
(Mus musculus)
 Mammalia Agtr2 33 16 34
  • 89.16 (n)
oppossum
(Monodelphis domestica)
 Mammalia AGTR2 34
  • 62 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves AGTR2 33 34
  • 62.62 (n)
lizard
(Anolis carolinensis)
 Reptilia AGTR2 34
  • 47 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia agtr2 33
  • 58.53 (n)
zebrafish
(Danio rerio)
 Actinopterygii agtr2 33 34
  • 53.41 (n)
Species where no ortholog for AGTR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTR2 Gene

ENSEMBL:
Gene Tree for AGTR2 (if available)
TreeFam:
Gene Tree for AGTR2 (if available)

Paralogs for AGTR2 Gene

Variants for AGTR2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for AGTR2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs121917810 uncertain-significance, benign, not provided, not specified 116,172,342(+) G/T coding_sequence_variant, missense_variant
rs387906503 uncertain-significance, likely-benign, not provided, not specified 116,172,675(+) TTTTTTTT/TTTTTTT/TTTTTTTTT coding_sequence_variant, frameshift
rs121917811 uncertain-significance, not provided 116,173,289(+) A/G coding_sequence_variant, missense_variant
rs121917813 uncertain-significance, not provided 116,172,437(+) A/T coding_sequence_variant, missense_variant
rs35474657 uncertain-significance, not provided 116,173,251(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for AGTR2 Gene

Variant ID Type Subtype PubMed ID
esv2758886 CNV gain 17122850
nsv9965 CNV gain 18304495

Variation tolerance for AGTR2 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGTR2 Gene

Human Gene Mutation Database (HGMD)
AGTR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGTR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTR2 Gene

Disorders for AGTR2 Gene

MalaCards: The human disease database

(14) MalaCards diseases for AGTR2 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
x-linked non-specific intellectual disability
  • x-linked non-syndromic intellectual disability
multicystic dysplastic kidney
  • mcdk
malignant secondary hypertension
malignant essential hypertension
  • accelerated essential hypertension
familial vesicoureteral reflux
  • familial vur
- elite association - COSMIC cancer census association via MalaCards
Search AGTR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AGTR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AGTR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGTR2 Gene

Publications for AGTR2 Gene

  1. Role of the angiotensin II type 2 receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients. (PMID: 20467270) Huber M … Kreutz R (Journal of hypertension 2010) 3 22 44 58
  2. The environmental and genetic evidence for the association of hyperlipidemia and hypertension. (PMID: 19155782) Ruixing Y … Shangling P (Journal of hypertension 2009) 3 22 44 58
  3. Angiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tract. (PMID: 17515833) Siomou E … Siamopoulou A (Pediatric research 2007) 3 22 44 58
  4. The AT2 gene may have a gender-specific effect on kidney function and pulse pressure in type I diabetic patients. (PMID: 16598200) Pettersson-Fernholm K … FinnDiane Study Group (Kidney international 2006) 3 22 44 58
  5. Implication of genetic variations in congenital obstructive nephropathy. (PMID: 16133060) Hahn H … Cheong HI (Pediatric nephrology (Berlin, Germany) 2005) 3 22 44 58

Products for AGTR2 Gene

  • Addgene plasmids for AGTR2

Sources for AGTR2 Gene

Content
Loading form....