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The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and SARS-CoV-2 infection result in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors which triggers serious inflammatory lesions, primarily in the lungs, an effect mediated by angiotensin II derivatives. However, while the ACE2-angiotensin II-angiotensin AT1 receptor pathway contributes to the pathophysiology of acute respiratory distress syndrome (ARDS), the activation of the ACE-2-angiotensin(1-7)-angiotensin AT2 receptor and the ACE-2-angiotensin(1-7)-Mas receptor pathways have been shown to be protective. [provided by RefSeq, Jun 2020]
AGTR2 (Angiotensin II Receptor Type 2) is a Protein Coding gene. Diseases associated with AGTR2 include Non-Syndromic X-Linked Intellectual Disability and Obstructive Nephropathy. Among its related pathways are Signaling by GPCR and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide hormone binding. An important paralog of this gene is AGTR1.
The angiotensin2 receptor (AT2) is a member of the angiotensin receptor group of G-protein-coupled receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart and uterus where they counterbalance the effects of AT1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ116170 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -12 | 0.1 | AGTR2 NONHSAG055155.2 PLS3 | ||
GH0XJ116229 | Enhancer | 0.8 | Ensembl ENCODE | 5.5 | +60.7 | 60716 | 4.3 | CEBPG ZHX2 REST CEBPB SP1 CTBP1 NR3C1 FOXA2 JUND CUX1 | AGTR2 SLC6A14 piR-36921-040 | |
GH0XJ116284 | Enhancer | 0.9 | Ensembl ENCODE | 4.8 | +114.4 | 114363 | 1.8 | ATF7 ESR1 CTBP1 CEBPB PKNOX1 ZNF217 CUX1 EP300 MBD2 RFX5 | lnc-CT83-3 AGTR2 SLC6A14 HSALNG0139676 | |
GH0XJ116290 | Enhancer | 0.2 | Ensembl | 5.6 | +119.8 | 119757 | 1 | AGTR2 lnc-CT83-3 piR-37656-309 SLC6A14 | ||
GH0XJ116283 | Enhancer | 0.2 | Ensembl | 4.8 | +112.3 | 112257 | 0.4 | AGTR2 lnc-CT83-3 HSALNG0139676 SLC6A14 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0004945 | angiotensin type II receptor activity | IBA,IPI | 10406457 |
GO:0005515 | protein binding | IPI | 10406457 |
GO:0008134 | transcription factor binding | IEA | -- |
GO:0048019 | receptor antagonist activity | TAS | 17159079 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IC | 10406457 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
.34
|
|
2 | Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics | ||
3 | Signaling by GPCR | ||
4 | cGMP-PKG signaling pathway | ||
5 | TGF-Beta Pathway |
JAK-STAT Pathway
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001822 | kidney development | IEA | -- |
GO:0001974 | blood vessel remodeling | TAS | 17159080 |
GO:0001991 | regulation of systemic arterial blood pressure by circulatory renin-angiotensin | IEA,ISS | -- |
GO:0002018 | renin-angiotensin regulation of aldosterone production | IEA | -- |
GO:0002033 | angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Angiotensin II | Approved, Investigational | Pharma | Agonist, Full agonist | Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. | 1347 | |
Irbesartan | Approved, Investigational | Pharma | Antagonist | Angiotensin II inhibitor | 110 | |
Losartan | Approved | Pharma | Antagonist | 345 | ||
Azilsartan medoxomil | Approved, Investigational | Pharma | Angiotensin II receptor type 1 antagonist | 55 | ||
Candesartan cilexetil | Approved | Pharma | 176 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
angiotensin I |
|
Agonist, Full agonist |
Compound | Action | Cas Number |
---|---|---|
CGP 42112 | Selective, high affinity AT2 ligand | 127060-75-7 |
Novokinin | Orally active AT2 agonist | 358738-77-9 |
PD 123319 ditrifluoroacetate | Potent, selective non-peptide AT2 antagonist | 130663-39-7 |
Compound | Action | Cas Number |
---|---|---|
Acetyl Angiotensinogen (1-14), porcine | Angiotensinogen precursor | 66641-26-7 |
Angiotensin (1-7) | Vasoconstriction peptide hormone | 51833-78-4 |
Angiotensin 1/2 (1-5) | Vasoconstrictor | 58442-64-1 |
Angiotensin 1/2 (1-6) | Vasoconstrictor | 47896-63-9 |
Angiotensin 1/2 (1-9) | Vasoconstrictor | 34273-12-6 |
Angiotensin 1/2 + A (2 - 8) | 51833-76-2 | |
Angiotensin I (human, mouse, rat) | Precursor of angiotensin II | 484-42-4 |
Angiotensin II | Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. | 68521-88-0 |
Angiotensin III (human, mouse) | Aldosterone stimulator | 13602-53-4 |
AVE 0991 | Agonist of angiotensin-(1-7) receptor | 304462-19-9 |
AVE 0991 sodium salt | Ang-(1-7) receptor Mas agonist | 306288-04-0 |
Azilsartan | 147403-03-0 | |
Azilsartan Medoxomil | Angiotensin II receptor type 1 antagonist | 863031-21-4 |
Biapenem | 120410-24-4 | |
Candesartan Cilexetil | 145040-37-5 | |
CGP 42112 | 127060-75-7 | |
EMD 66684 | 1216884-39-7 | |
Eprosartan Mesylate | 144143-96-4 | |
Irbesartan | Angiotensin II inhibitor | 138402-11-6 |
LCZ696 | 936623-90-4 | |
Losartan | 114798-26-4 | |
Novokinin | 358738-77-9 | |
PD 123319 ditrifluoroacetate | Angiotensin AT2 receptor antagonist | 136676-91-0 |
PD123319 | Angiotensin AT2 receptor antagonist | 130663-39-7 |
Telmisattan | Angiotensin II receptor antagonist | 144701-48-4 |
Tranilast | Angiogenesis inhibitor | 53902-12-8 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AGTR2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AT2 31 |
|
OneToOne | |
AGTR2 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | AGTR2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Agtr2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Agtr2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AGTR2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | AGTR2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | AGTR2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | agtr2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | agtr2 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
727625 | Benign: not provided | 116,172,971(+) | T/C | MISSENSE_VARIANT | |
738653 | Benign: not provided | 116,172,658(+) | G/A | SYNONYMOUS_VARIANT | |
rs1057522135 | Uncertain Significance: not provided | 116,172,839(+) | A/G | MISSENSE_VARIANT | |
rs1163188247 | Uncertain Significance: not provided | 116,173,151(+) | G/A | MISSENSE_VARIANT | |
rs121917810 | Benign/Likely Benign: X-Linked Mental Retardation 88; History of neurodevelopmental disorder; not specified; not provided. - | 116,172,342(+) | G/Tp.Gly21Val | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758886 | CNV | gain | 17122850 |
nsv9965 | CNV | gain | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
non-syndromic x-linked intellectual disability |
|
|
obstructive nephropathy |
|
|
cakut |
|
|
angioedema |
|
|
myocardial stunning |
|
|