AGTR2 Gene (Protein Coding)

Angiotensin II Receptor Type 2

GC0XP116170
GIFtS:
43
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may p... See more...

Aliases for AGTR2 Gene

Aliases for AGTR2 Gene

  • Angiotensin II Receptor Type 2 2 3 5
  • AT2 2 3 4
  • Type-2 Angiotensin II Receptor 3 4
  • Angiotensin II Type-2 Receptor 3 4
  • MRX88 2 3
  • Angiotensin Receptor 2 2
  • ATGR2 3
  • AGTR2 5

External Ids for AGTR2 Gene

Previous GeneCards Identifiers for AGTR2 Gene

  • GC0XP110072
  • GC0XP112376
  • GC0XP113316
  • GC0XP114086
  • GC0XP115113
  • GC0XP115216
  • GC0XP104838

Summaries for AGTR2 Gene

Entrez Gene Summary for AGTR2 Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and SARS-CoV-2 infection result in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors which triggers serious inflammatory lesions, primarily in the lungs, an effect mediated by angiotensin II derivatives. However, while the ACE2-angiotensin II-angiotensin AT1 receptor pathway contributes to the pathophysiology of acute respiratory distress syndrome (ARDS), the activation of the ACE-2-angiotensin(1-7)-angiotensin AT2 receptor and the ACE-2-angiotensin(1-7)-Mas receptor pathways have been shown to be protective. [provided by RefSeq, Jun 2020]

GeneCards Summary for AGTR2 Gene

AGTR2 (Angiotensin II Receptor Type 2) is a Protein Coding gene. Diseases associated with AGTR2 include Non-Syndromic X-Linked Intellectual Disability and Obstructive Nephropathy. Among its related pathways are Signaling by GPCR and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide hormone binding. An important paralog of this gene is AGTR1.

UniProtKB/Swiss-Prot Summary for AGTR2 Gene

  • Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Tocris Summary for AGTR2 Gene

  • The angiotensin2 receptor (AT2) is a member of the angiotensin receptor group of G-protein-coupled receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart and uterus where they counterbalance the effects of AT1.

Gene Wiki entry for AGTR2 Gene

Additional gene information for AGTR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGTR2 Gene

Genomics for AGTR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for AGTR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ116170 Promoter 0.3 EPDnew 600.7 0.0 -12 0.1 AGTR2 NONHSAG055155.2 PLS3
GH0XJ116229 Enhancer 0.8 Ensembl ENCODE 5.5 +60.7 60716 4.3 CEBPG ZHX2 REST CEBPB SP1 CTBP1 NR3C1 FOXA2 JUND CUX1 AGTR2 SLC6A14 piR-36921-040
GH0XJ116284 Enhancer 0.9 Ensembl ENCODE 4.8 +114.4 114363 1.8 ATF7 ESR1 CTBP1 CEBPB PKNOX1 ZNF217 CUX1 EP300 MBD2 RFX5 lnc-CT83-3 AGTR2 SLC6A14 HSALNG0139676
GH0XJ116290 Enhancer 0.2 Ensembl 5.6 +119.8 119757 1 AGTR2 lnc-CT83-3 piR-37656-309 SLC6A14
GH0XJ116283 Enhancer 0.2 Ensembl 4.8 +112.3 112257 0.4 AGTR2 lnc-CT83-3 HSALNG0139676 SLC6A14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGTR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGTR2

Top Transcription factor binding sites by QIAGEN in the AGTR2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • IRF-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for AGTR2 Gene

Genomic Locations for AGTR2 Gene
chrX:116,170,744-116,174,974
(GRCh38/hg38)
Size:
4,231 bases
Orientation:
Plus strand
chrX:115,301,958-115,306,225
(GRCh37/hg19)
Size:
4,268 bases
Orientation:
Plus strand

Genomic View for AGTR2 Gene

Genes around AGTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AGTR2 Gene

Proteins for AGTR2 Gene

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  • Protein details for AGTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50052-AGTR2_HUMAN
    Recommended name:
    Type-2 angiotensin II receptor
    Protein Accession:
    P50052
    Secondary Accessions:
    • B2R9V1
    • Q13016
    • Q6FGY7

    Protein attributes for AGTR2 Gene

    Size:
    363 amino acids
    Molecular mass:
    41184 Da
    Quaternary structure:
    • Interacts with MTUS1.

    Three dimensional structures from OCA and Proteopedia for AGTR2 Gene

neXtProt entry for AGTR2 Gene

Post-translational modifications for AGTR2 Gene

  • Glycosylation at Asn4, Asn13, Asn24, Asn29, and Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for AGTR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGTR2 Gene

Domains & Families for AGTR2 Gene

Gene Families for AGTR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for AGTR2 Gene

InterPro:
Blocks:
  • Angiotensin II receptor signature
  • AT2 angiotensin II receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for AGTR2 Gene

GenScript: Design optimal peptide antigens:
  • Angiotensin II type-2 receptor (AGTR2_HUMAN)
  • ATGR2 (Q6UVH2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50052

UniProtKB/Swiss-Prot:

AGTR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with AGTR2: view

Function for AGTR2 Gene

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Molecular function for AGTR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
GENATLAS Biochemistry:
angiotensin II (type-2) receptor,abundantly expressed during embryonic development in fetal tissues,in adrenal glands,heart and brain,G protein coupled receptor superfamily,involved in the activation of dephosphorylating enzymes,stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase (involved in blood pressure regulation)

Phenotypes From GWAS Catalog for AGTR2 Gene

Gene Ontology (GO) - Molecular Function for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004945 angiotensin type II receptor activity IBA,IPI 10406457
GO:0005515 protein binding IPI 10406457
GO:0008134 transcription factor binding IEA --
GO:0048019 receptor antagonist activity TAS 17159079
genes like me logo Genes that share ontologies with AGTR2: view
genes like me logo Genes that share phenotypes with AGTR2: view

Human Phenotype Ontology for AGTR2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGTR2 Gene

MGI Knock Outs for AGTR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGTR2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGTR2 Gene

Localization for AGTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTR2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGTR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 10406457
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGTR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AGTR2 Gene

Pathways & Interactions for AGTR2 Gene

genes like me logo Genes that share pathways with AGTR2: view

Pathways by source for AGTR2 Gene

3 Qiagen pathways for AGTR2 Gene
  • JAK-STAT Pathway
  • Renin-Angiotensin Pathway
  • Signaling Involved in Cardiac Hypertrophy

SIGNOR curated interactions for AGTR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0001974 blood vessel remodeling TAS 17159080
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin IEA,ISS --
GO:0002018 renin-angiotensin regulation of aldosterone production IEA --
GO:0002033 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA --
genes like me logo Genes that share ontologies with AGTR2: view

Drugs & Compounds for AGTR2 Gene

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(60) Drugs for AGTR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Angiotensin II Approved, Investigational Pharma Agonist, Full agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1347
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 110
Losartan Approved Pharma Antagonist 345
Azilsartan medoxomil Approved, Investigational Pharma Angiotensin II receptor type 1 antagonist 55
Candesartan cilexetil Approved Pharma 176

(13) Additional Compounds for AGTR2 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
angiotensin I
  • I, angiotensin
 Agonist, Full agonist

(3) Tocris Compounds for AGTR2 Gene

Compound Action Cas Number
CGP 42112 Selective, high affinity AT2 ligand 127060-75-7
Novokinin Orally active AT2 agonist 358738-77-9
PD 123319 ditrifluoroacetate Potent, selective non-peptide AT2 antagonist 130663-39-7

(26) ApexBio Compounds for AGTR2 Gene

Compound Action Cas Number
Acetyl Angiotensinogen (1-14), porcine Angiotensinogen precursor 66641-26-7
Angiotensin (1-7) Vasoconstriction peptide hormone 51833-78-4
Angiotensin 1/2 (1-5) Vasoconstrictor 58442-64-1
Angiotensin 1/2 (1-6) Vasoconstrictor 47896-63-9
Angiotensin 1/2 (1-9) Vasoconstrictor 34273-12-6
Angiotensin 1/2 + A (2 - 8) 51833-76-2
Angiotensin I (human, mouse, rat) Precursor of angiotensin II 484-42-4
Angiotensin II Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 68521-88-0
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
AVE 0991 Agonist of angiotensin-(1-7) receptor 304462-19-9
AVE 0991 sodium salt Ang-(1-7) receptor Mas agonist 306288-04-0
Azilsartan 147403-03-0
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist 863031-21-4
Biapenem 120410-24-4
Candesartan Cilexetil 145040-37-5
CGP 42112 127060-75-7
EMD 66684 1216884-39-7
Eprosartan Mesylate 144143-96-4
Irbesartan Angiotensin II inhibitor 138402-11-6
LCZ696 936623-90-4
Losartan 114798-26-4
Novokinin 358738-77-9
PD 123319 ditrifluoroacetate Angiotensin AT2 receptor antagonist 136676-91-0
PD123319 Angiotensin AT2 receptor antagonist 130663-39-7
Telmisattan Angiotensin II receptor antagonist 144701-48-4
Tranilast Angiogenesis inhibitor 53902-12-8
genes like me logo Genes that share compounds with AGTR2: view

Drug Products

Transcripts for AGTR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for AGTR2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGTR2

Alternative Splicing Database (ASD) splice patterns (SP) for AGTR2 Gene

No ASD Table

Relevant External Links for AGTR2 Gene

GeneLoc Exon Structure for
AGTR2

Expression for AGTR2 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGTR2 Gene

mRNA expression in normal human tissues for AGTR2 Gene
mRNA expression by BioGPS for AGTR2 GenemRNA expression by GTEx for AGTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTR2 Gene

This gene is overexpressed in Lung (x22.1), Fallopian Tube (x8.4), and Uterus (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGTR2

SOURCE GeneReport for Unigene cluster for AGTR2 Gene:

Hs.405348

mRNA Expression by UniProt/SwissProt for AGTR2 Gene:

P50052-AGTR2_HUMAN
Tissue specificity: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.

Evidence on tissue expression from TISSUES for AGTR2 Gene

  • Kidney(4.6)
  • Blood(4.6)
  • Liver(4.5)
  • Lung(4.5)
  • Nervous system(2.9)
  • Heart(2.8)
  • Muscle(2.7)
  • Adrenal gland(2.6)
  • Skin(2.4)
  • Intestine(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AGTR2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
  • testicle
  • urinary bladder
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with AGTR2: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for AGTR2 Gene

Orthologs for AGTR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia AGTR2 30 31
  • 99.72 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia AT2 31
  • 94 (a)
 OneToOne
AGTR2 30
  • 91.9 (n)
Dog
(Canis familiaris)
 Mammalia AGTR2 30 31
  • 92.63 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Agtr2 30
  • 89.35 (n)
Mouse
(Mus musculus)
 Mammalia Agtr2 30 17 31
  • 89.16 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia AGTR2 31
  • 62 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves AGTR2 30 31
  • 62.62 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia AGTR2 31
  • 47 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia agtr2 30
  • 58.53 (n)
Zebrafish
(Danio rerio)
 Actinopterygii agtr2 30 31
  • 53.41 (n)
 OneToOne
Species where no ortholog for AGTR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AGTR2 Gene

ENSEMBL:
Gene Tree for AGTR2 (if available)
TreeFam:
Gene Tree for AGTR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AGTR2: view image

Paralogs for AGTR2 Gene

Paralogs for AGTR2 Gene

(47) SIMAP similar genes for AGTR2 Gene using alignment to 1 proteins:

  • AGTR2_HUMAN
genes like me logo Genes that share paralogs with AGTR2: view

Variants for AGTR2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGTR2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
727625 Benign: not provided 116,172,971(+) T/C MISSENSE_VARIANT
738653 Benign: not provided 116,172,658(+) G/A SYNONYMOUS_VARIANT
rs1057522135 Uncertain Significance: not provided 116,172,839(+) A/G MISSENSE_VARIANT
rs1163188247 Uncertain Significance: not provided 116,173,151(+) G/A MISSENSE_VARIANT
rs121917810 Benign/Likely Benign: X-Linked Mental Retardation 88; History of neurodevelopmental disorder; not specified; not provided. - 116,172,342(+) G/Tp.Gly21Val MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for AGTR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for AGTR2 Gene

Variant ID Type Subtype PubMed ID
esv2758886 CNV gain 17122850
nsv9965 CNV gain 18304495

Variation tolerance for AGTR2 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGTR2 Gene

Human Gene Mutation Database (HGMD)
AGTR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGTR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTR2 Gene

Disorders for AGTR2 Gene

MalaCards: The human disease database

(30) MalaCards diseases for AGTR2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
obstructive nephropathy
  • con
cakut
  • renal hypodysplasia, nonsyndromic, 1
angioedema
  • angioneurotic edema
myocardial stunning
- elite association - COSMIC cancer census association via MalaCards
Search AGTR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AGTR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AGTR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGTR2 Gene

Publications for AGTR2 Gene

  1. Role of the angiotensin II type 2 receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients. (PMID: 20467270) Huber M … Kreutz R (Journal of hypertension 2010) 3 23 41
  2. The environmental and genetic evidence for the association of hyperlipidemia and hypertension. (PMID: 19155782) Ruixing Y … Shangling P (Journal of hypertension 2009) 3 23 41
  3. Angiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tract. (PMID: 17515833) Siomou E … Siamopoulou A (Pediatric research 2007) 3 23 41
  4. [Mutation screening in Angiotensin II receptors, AGTR1 and AGTR2, and evaluation of AGTR1 polymorphisms C573T and A1166C in patients with premature adrenarche]. (PMID: 17160213) Moura MS … Monte O (Arquivos brasileiros de endocrinologia e metabologia 2006) 3 23 41
  5. The AT2 gene may have a gender-specific effect on kidney function and pulse pressure in type I diabetic patients. (PMID: 16598200) Pettersson-Fernholm K … FinnDiane Study Group (Kidney international 2006) 3 23 41

ExternalLinks

View latest publications for AGTR2 gene in Mastermind

Products for AGTR2 Gene

  • Addgene plasmids for AGTR2

Sources for AGTR2 Gene