Aliases for AGTR1 Gene
External Ids for AGTR1 Gene
Previous HGNC Symbols for AGTR1 Gene
Previous GeneCards Identifiers for AGTR1 Gene
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for AGTR1 Gene
AGTR1 (Angiotensin II Receptor Type 1) is a Protein Coding gene. Diseases associated with AGTR1 include Renal Tubular Dysgenesis and Hypertension, Essential. Among its related pathways are Clathrin-mediated endocytosis and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and angiotensin type II receptor activity. An important paralog of this gene is AGTR2.
UniProtKB/Swiss-Prot Summary for AGTR1 Gene
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.