The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining bl... See more...

Aliases for AGT Gene

Aliases for AGT Gene

  • Angiotensinogen 2 3 4 5
  • Serpin Peptidase Inhibitor, Clade A, Member 8 2 3
  • Alpha-1 Antiproteinase, Antitrypsin 2 3
  • Serpin A8 3 4
  • SERPINA8 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor 3
  • Fetal-Liver Predominant Transporter 1 3
  • Pre-Angiotensinogen 3
  • Angiotensin II 3
  • Angiotensin I 3
  • HFLT1 3
  • ANHU 3
  • AGT 5

External Ids for AGT Gene

Previous HGNC Symbols for AGT Gene

  • SERPINA8

Previous GeneCards Identifiers for AGT Gene

  • GC01M229315
  • GC01M226566
  • GC01M227311
  • GC01M227873
  • GC01M227145
  • GC01M228904
  • GC01M230838
  • GC01M201323

Summaries for AGT Gene

Entrez Gene Summary for AGT Gene

  • The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]

GeneCards Summary for AGT Gene

AGT (Angiotensinogen) is a Protein Coding gene. Diseases associated with AGT include Renal Tubular Dysgenesis and Hypertension, Essential. Among its related pathways are Neuroscience and Monoamine Transport. Gene Ontology (GO) annotations related to this gene include growth factor activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA5.

UniProtKB/Swiss-Prot Summary for AGT Gene

  • Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
  • [Angiotensin-2]: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
  • [Angiotensin-3]: stimulates aldosterone release.
  • [Angiotensin 1-7]: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Wiki entry for AGT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGT Gene

Genomics for AGT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AGT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J230712 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 656.8 +31.4 31408 2.7 HNRNPL GATAD2A ATF7 REST TFE3 SOX13 NFKBIZ KDM1A RCOR2 RBFOX2 AGT lnc-CAPN9-2 ENSG00000286859 COG2 ENSG00000244137
GH01J230743 Enhancer 0.8 Ensembl dbSUPER 608.3 +0.9 882 2.2 ATF7 FOXA1 CEBPA CEBPB RFX1 ZSCAN5C FOXA2 ATF3 ZBTB17 ATF2 AGT CAPN9 lnc-AGT-2 ENSG00000244137 COG2
GH01J230681 Enhancer 1.1 Ensembl ENCODE 20.9 +63.0 63037 4.3 GATAD2A ZNF629 TFE3 SOX13 IKZF1 ZNF692 JUND FOXA1 PRDM1 ZIC2 AGT COG2 CAPN9 LOC107985358 ENSG00000286859
GH01J230707 Enhancer 1.1 Ensembl ENCODE 17.9 +36.5 36533 2.2 CEBPG HNRNPL GATAD2A REST TFE3 LEF1 SOX13 NFKBIZ RCOR2 JUND AGT ENSG00000286859 lnc-CAPN9-2 COG2
GH01J230641 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 6.8 +102.3 102255 3.5 SP1 HNRNPL GATAD2A CTCF PRDM10 ZNF629 ZNF512 SIX5 SOX13 KDM1A COG2 ENSG00000223393 C1orf198 AGT lnc-CAPN9-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGT

Top Transcription factor binding sites by QIAGEN in the AGT gene promoter:
  • C/EBPalpha
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1
  • STAT3

Genomic Locations for AGT Gene

Genomic Locations for AGT Gene
chr1:230,702,523-230,745,583
(GRCh38/hg38)
Size:
43,061 bases
Orientation:
Minus strand
chr1:230,838,269-230,850,336
(GRCh37/hg19)
Size:
12,068 bases
Orientation:
Minus strand

Genomic View for AGT Gene

Genes around AGT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGT Gene

Proteins for AGT Gene

  • Protein details for AGT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01019-ANGT_HUMAN
    Recommended name:
    Angiotensinogen
    Protein Accession:
    P01019
    Secondary Accessions:
    • Q16358
    • Q16359
    • Q96F91

    Protein attributes for AGT Gene

    Size:
    485 amino acids
    Molecular mass:
    53154 Da
    Quaternary structure:
    • During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.

    Three dimensional structures from OCA and Proteopedia for AGT Gene

neXtProt entry for AGT Gene

Post-translational modifications for AGT Gene

  • Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
  • In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).
  • The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
  • Glycosylation at Asn47, Asn170, Asn304, and Asn328
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ANGT_HUMAN (703)

Other Protein References for AGT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AGT Gene

Domains & Families for AGT Gene

Gene Families for AGT Gene

HGNC:
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for AGT Gene

InterPro:
Blocks:
  • Serpin
  • Angiotensinogen signature
ProtoNet:

Suggested Antigen Peptide Sequences for AGT Gene

GenScript: Design optimal peptide antigens:
  • Truncated angiotensinogen (A7L3A1_HUMAN)
  • Truncated angiotensinogen (A7L3A2_HUMAN)
  • Angiotensinogen (A7L3A3_HUMAN)
  • Angiotensinogen (A7L3A4_HUMAN)
  • Angiotensinogen (A7L3A5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01019

UniProtKB/Swiss-Prot:

ANGT_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with AGT: view

Function for AGT Gene

Molecular function for AGT Gene

UniProtKB/Swiss-Prot Function:
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
UniProtKB/Swiss-Prot Function:
[Angiotensin-2]: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
UniProtKB/Swiss-Prot Function:
[Angiotensin-3]: stimulates aldosterone release.
UniProtKB/Swiss-Prot Function:
[Angiotensin 1-7]: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
GENATLAS Biochemistry:
angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver

LifeMap Function Summary for AGT Gene

Phenotypes From GWAS Catalog for AGT Gene

Gene Ontology (GO) - Molecular Function for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity TAS,IBA 21873635
GO:0005179 hormone activity ISS --
GO:0005515 protein binding IPI 16237761
GO:0008083 growth factor activity TAS 10406457
GO:0031702 type 1 angiotensin receptor binding IPI 1378723
genes like me logo Genes that share ontologies with AGT: view
genes like me logo Genes that share phenotypes with AGT: view

Human Phenotype Ontology for AGT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGT Gene

MGI Knock Outs for AGT:
  • Agt Agt<tm1Afu>
  • Agt Agt<tm1Unc>
  • Agt Agt<tm1Ii>

Animal Model Products

CRISPR Products

miRNA for AGT Gene

miRTarBase miRNAs that target AGT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGT

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGT Gene

Localization for AGT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGT gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 3
nucleus 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005615 extracellular space IBA,ISS --
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AGT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AGT Gene

Pathways & Interactions for AGT Gene

genes like me logo Genes that share pathways with AGT: view

Pathways by source for AGT Gene

4 GeneGo (Thomson Reuters) pathways for AGT Gene
  • Cell adhesion Integrin inside-out signaling
  • Development Angiotensin activation of ERK
  • Development Angiotensin signaling via beta-Arrestin
  • Development Angiotensin signaling via PYK2
3 Qiagen pathways for AGT Gene
  • JAK-STAT Pathway
  • NFAT and Cardiac Hypertrophy
  • Renin-Angiotensin Pathway
1 Cell Signaling Technology pathway for AGT Gene

SIGNOR curated interactions for AGT Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IMP 28283184
GO:0001558 regulation of cell growth NAS 17159080
GO:0001819 positive regulation of cytokine production TAS 17906677
GO:0001822 kidney development IMP 16116425
GO:0001974 blood vessel remodeling TAS 10406457
genes like me logo Genes that share ontologies with AGT: view

Drugs & Compounds for AGT Gene

(96) Drugs for AGT Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lisinopril Approved, Investigational Pharma ACE inhibitor 131
Amlodipine Approved Pharma Calcium channel blocker 584
Atenolol Approved Pharma Antagonist 114
Benazepril Approved, Investigational Pharma 49
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 110

(51) Additional Compounds for AGT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for AGT Gene

Compound Action Cas Number
Acetyl Angiotensinogen (1-14), porcine Angiotensinogen precursor 66641-26-7
Angiotensin 1/2 (1-9) Vasoconstrictor 34273-12-6
genes like me logo Genes that share compounds with AGT: view

Transcripts for AGT Gene

mRNA/cDNA for AGT Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGT

Alternative Splicing Database (ASD) splice patterns (SP) for AGT Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for AGT Gene

GeneLoc Exon Structure for
AGT

Expression for AGT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGT Gene

This gene is overexpressed in Liver (x23.4).

Protein differential expression in normal tissues from HIPED for AGT Gene

This gene is overexpressed in Serum (18.0), Synovial fluid (9.7), Plasma (7.8), Cerebrospinal fluid (7.0), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AGT Gene



Protein tissue co-expression partners for AGT Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGT

SOURCE GeneReport for Unigene cluster for AGT Gene:

Hs.19383

mRNA Expression by UniProt/SwissProt for AGT Gene:

P01019-ANGT_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for AGT Gene

  • Nervous system(5)
  • Liver(5)
  • Heart(4.7)
  • Kidney(4.6)
  • Bone marrow(4.3)
  • Muscle(3.5)
  • Blood(3.4)
  • Adrenal gland(2.9)
  • Lung(2.7)
  • Urine(2.5)
  • Eye(2.5)
  • Pancreas(2.4)
  • Skin(2.3)
  • Intestine(2.3)
  • Gall bladder(2.1)
  • Thyroid gland(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AGT Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • face
  • head
  • skull
Thorax:
  • heart
  • lung
Abdomen:
  • kidney
Pelvis:
  • placenta
  • uterus
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood vessel
genes like me logo Genes that share expression patterns with AGT: view

Orthologs for AGT Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AGT 30
  • 98.63 (n)
REN 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia AGT 30 31
  • 77.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Agt 30
  • 72.89 (n)
Mouse
(Mus musculus)
Mammalia Agt 30 17 31
  • 71.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AGT 31
  • 60 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia AGT 31
  • 50 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia AGT 31
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves AGT 30 31
  • 52.77 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AGT 31
  • 34 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia agt 30
  • 48.08 (n)
Zebrafish
(Danio rerio)
Actinopterygii agt 30 31
  • 44.8 (n)
OneToOne
Species where no ortholog for AGT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AGT Gene

ENSEMBL:
Gene Tree for AGT (if available)
TreeFam:
Gene Tree for AGT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AGT: view image

Paralogs for AGT Gene

Variants for AGT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGT Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
713450 Likely Benign: not provided 230,703,204(-) A/G SYNONYMOUS_VARIANT
720905 Benign: Renal dysplasia; not provided 230,706,034(-) G/A SYNONYMOUS_VARIANT
723170 Likely Benign: not provided 230,710,542(-) G/A SYNONYMOUS_VARIANT
728571 Benign/Likely Benign: Renal dysplasia; not provided 230,706,145(-) G/A SYNONYMOUS_VARIANT
731749 Benign/Likely Benign: Renal dysplasia; not provided 230,710,441(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for AGT Gene

Structural Variations from Database of Genomic Variants (DGV) for AGT Gene

Variant ID Type Subtype PubMed ID
esv2657518 CNV deletion 23128226
esv3578466 CNV loss 25503493
esv3589093 CNV gain 21293372
esv3589098 CNV loss 21293372
nsv832836 CNV loss 17160897

Variation tolerance for AGT Gene

Residual Variation Intolerance Score: 90.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGT Gene

Human Gene Mutation Database (HGMD)
AGT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGT Gene

Disorders for AGT Gene

MalaCards: The human disease database

(62) MalaCards diseases for AGT Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal tubular dysgenesis
  • rtd
hypertension, essential
  • eht
renal dysplasia
  • renal cell dysplasia
anuria
  • suppression of urinary secretion
gitelman syndrome
  • gtlmns
- elite association - COSMIC cancer census association via MalaCards
Search AGT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ANGT_HUMAN
  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269 PubMed:1394429, ECO:0000269 PubMed:8513325}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for AGT Gene

hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced hypertension (preeclampsia),also increased risk of coronary heart disease (T174M and M235 variants),excluded at least in a population of Australian Anglo-Celtic Caucasians

Additional Disease Information for AGT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AGT: view

Publications for AGT Gene

  1. Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. (PMID: 19770777) Watkins WS … Jorde LB (Journal of hypertension 2010) 3 23 41
  2. Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue. (PMID: 19536167) Sarzani R … Rappelli A (Journal of human hypertension 2010) 3 23 41
  3. Lack of association between renin-angiotensin system (RAS) polymorphisms and hypertension in Tunisian type 2 diabetics. (PMID: 20415212) Arfa I … Abdelhak S (La Tunisie medicale 2010) 3 23 41
  4. Arterial properties in relation to genetic variation in alpha-adducin and the renin-angiotensin system in a White population. (PMID: 18800139) Seidlerová J … Filipovsk Ygrave J (Journal of human hypertension 2009) 3 23 41
  5. Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study. (PMID: 19057513) Suonsyrjä T … Hiltunen TP (American journal of hypertension 2009) 3 23 41

Products for AGT Gene

Sources for AGT Gene