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This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
AGRP (Agouti Related Neuropeptide) is a Protein Coding gene. Diseases associated with AGRP include Body Mass Index Quantitative Trait Locus 11 and Anorexia Nervosa. Among its related pathways are Adipocytokine signaling pathway and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuropeptide hormone activity. An important paralog of this gene is ASIP.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 10318826 |
GO:0005184 | neuropeptide hormone activity | TAS,IDA | 15927146 |
GO:0031779 | melanocortin receptor binding | IBA | 21873635 |
GO:0070996 | type 1 melanocortin receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IEA,IDA | 15927146 |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005796 | Golgi lumen | IEA,IDA | 15927146 |
GO:0043025 | neuronal cell body | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Adipocytokine signaling pathway | ||
2 | Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics | ||
3 | Circadian rythm related genes | ||
4 | Syndecan-3-mediated signaling events |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007218 | neuropeptide signaling pathway | TAS,IDA | 15927146 |
GO:0007623 | circadian rhythm | IEA | -- |
GO:0007631 | feeding behavior | TAS | 9751529 |
GO:0008343 | adult feeding behavior | IEA,IBA | 21873635 |
GO:0009755 | hormone-mediated signaling pathway | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AGRP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AGRP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Agrp 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Agrp 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AGRP 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AGRP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | AGRP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LOC100859622 30 |
|
||
AGRP 31 31 |
|
OneToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | agrp 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
body mass index quantitative trait locus 11 |
|
|
anorexia nervosa |
|
|
overnutrition |
|
|
leptin deficiency or dysfunction |
|
|
prader-willi syndrome |
|