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This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009] See more...
Aliases for AGRP Gene
Aliases for AGRP Gene
External Ids for AGRP Gene
- HGNC: 330
- Entrez Gene: 181
- Ensembl: ENSG00000159723
- OMIM: 602311
- UniProtKB: O00253
Previous GeneCards Identifiers for AGRP Gene
- GC16M058210
- GC16M067894
- GC16M067251
- GC16M067292
- GC16M066073
- GC16M067516
- GC16M053389
Summaries for AGRP Gene
-
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
GeneCards Summary for AGRP Gene
AGRP (Agouti Related Neuropeptide) is a Protein Coding gene. Diseases associated with AGRP include Body Mass Index Quantitative Trait Locus 11 and Anorexia Nervosa. Among its related pathways are Adipocytokine signaling pathway and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuropeptide hormone activity. An important paralog of this gene is ASIP.
UniProtKB/Swiss-Prot Summary for AGRP Gene
-
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Additional gene information for AGRP Gene
- HGNC(330)
- Entrez Gene(181)
- Ensembl(ENSG00000159723)
- OMIM(602311)
- UniProtKB(O00253)
- Open Targets Platform(ENSG00000159723)
- Monarch Initiative
- Search for AGRP at DataMed
- Search for AGRP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGRP Gene
Genomics for AGRP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for AGRP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AGRP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGRP
- Top Transcription factor binding sites by QIAGEN in the AGRP gene promoter:
-
- CREB
Genomic Locations for AGRP Gene
Genomic Locations for AGRP Gene
- chr16:67,482,571-67,483,547
- (GRCh38/hg38)
- Size:
- 977 bases
- Orientation:
- Minus strand
- chr16:67,516,474-67,517,716
- (GRCh37/hg19)
- Size:
- 1,243 bases
- Orientation:
- Minus strand
Genomic View for AGRP Gene
Genes around AGRP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by HGNC
- 16q22.1 by Entrez Gene
- 16q22.1 by Ensembl
AGRP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AGRP Gene
Proteins for AGRP Gene
-
Protein details for AGRP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00253-AGRP_HUMAN
- Recommended name:
- Agouti-related protein
- Protein Accession:
- O00253
- O15459
- Q2TBD9
Protein attributes for AGRP Gene
- Size:
- 132 amino acids
- Molecular mass:
- 14440 Da
- Quaternary structure:
-
- Interacts with melanocortin receptors MC3R, MC4R and MC5R.
Protein Expression for AGRP Gene
Post-translational modifications for AGRP Gene
No Post-translational modifications
Other Protein References for AGRP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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- 4 IHC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
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-
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Protein Products
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-
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Assay Products
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-
Boster Bio ELISA Kits for AGRP
No data available for DME Specific Peptides for AGRP Gene
Domains & Families for AGRP Gene
Gene Families for AGRP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for AGRP Gene
- InterPro:
- Blocks:
-
- Agouti
- ProtoNet:
Suggested Antigen Peptide Sequences for AGRP Gene
- GenScript: Design optimal peptide antigens:
-
- Agouti-related protein (AGRP_HUMAN)
- Agouti-related protein (C6SUN5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00253UniProtKB/Swiss-Prot:
AGRP_HUMAN :- The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
- Domain:
-
- The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Function for AGRP Gene
Molecular function for AGRP Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
- GENATLAS Biochemistry:
- mouse agouti related protein,primarily expressed in adrenal gland,subthalamic mucleus,hypothalamus,potent antagonist of melanocortin receptor MICR3,MICR4, implicated in body weight regulation
Phenotypes From GWAS Catalog for AGRP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 10318826 |
| GO:0005184 | neuropeptide hormone activity | TAS,IDA | 15927146 |
| GO:0031779 | melanocortin receptor binding | IBA | 21873635 |
| GO:0070996 | type 1 melanocortin receptor binding | IBA | 21873635 |
Phenotypes for AGRP Gene
- MGI mutant phenotypes for AGRP:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for AGRP:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Reduced mammosphere formation
- Decreased ionizing radiation sensitivity
- Decreased epidermal growth factor (EGF) endocytosis
Animal Models for AGRP Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for AGRP
CRISPR Products
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miRNA for AGRP Gene
- miRTarBase miRNAs that target AGRP
miRNA Products
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Clone Products
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Cell Line Products
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Horizon Cell Lines for AGRP
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGRP Gene
Localization for AGRP Gene
Subcellular locations from UniProtKB/Swiss-Prot for AGRP Gene
- Secreted. Golgi apparatus lumen.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA,IDA | 15927146 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005796 | Golgi lumen | IEA,IDA | 15927146 |
| GO:0043025 | neuronal cell body | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for AGRP Gene
Pathways & Interactions for AGRP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Adipocytokine signaling pathway | ||
| 2 | Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics | ||
| 3 | Circadian rythm related genes | ||
| 4 | Syndecan-3-mediated signaling events | ||
Pathways by source for AGRP Gene
2 BioSystems pathways for AGRP Gene
1 PharmGKB pathway for AGRP Gene
1 KEGG pathway for AGRP Gene
Interacting Proteins for AGRP Gene
GPS-Prot Interaction Network for AGRP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007218 | neuropeptide signaling pathway | TAS,IDA | 15927146 |
| GO:0007623 | circadian rhythm | IEA | -- |
| GO:0007631 | feeding behavior | TAS | 9751529 |
| GO:0008343 | adult feeding behavior | IEA,IBA | 21873635 |
| GO:0009755 | hormone-mediated signaling pathway | IEA | -- |
Transcripts for AGRP Gene
mRNA/cDNA for AGRP Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000290953 498 nts (view in UCSC)
CRISPR Products
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Clone Products
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Relevant External Links for AGRP Gene
- GeneLoc Exon Structure for
- AGRP
Expression for AGRP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for AGRP Gene
This gene is overexpressed in Brain - Hypothalamus (x27.3) and Adrenal Gland (x13.0).
This gene is overexpressed in Islet of Langerhans (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGRP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGRP
SOURCE GeneReport for Unigene cluster for AGRP Gene:
Hs.104633mRNA Expression by UniProt/SwissProt for AGRP Gene:
O00253-AGRP_HUMAN
Tissue specificity:
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Evidence on tissue expression from TISSUES for AGRP Gene
- Adrenal gland(4.5)
- Nervous system(3.6)
- Stomach(2.8)
- Skin(2.8)
- Muscle(2.6)
- Pancreas(2.5)
- Thyroid gland(2.5)
- Blood(2.5)
- Liver(2.4)
- Heart(2.3)
- Kidney(2.2)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for AGRP
-
OriGene qPCR primer pairs and template standards for AGRP
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AGRP Gene
Orthologs for AGRP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | AGRP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | AGRP 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Agrp 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Agrp 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | AGRP 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | AGRP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | AGRP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LOC100859622 30 |
|
||
| AGRP 31 31 |
|
OneToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | agrp 31 |
|
OneToOne |
- Species where no ortholog for AGRP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for AGRP Gene
- ENSEMBL:
- Gene Tree for AGRP (if available)
- TreeFam:
- Gene Tree for AGRP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AGRP: view image
Paralogs for AGRP Gene
Variants for AGRP Gene
Residual Variation Intolerance Score:
53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.96;
36.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AGRP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGRP Gene
Disorders for AGRP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| body mass index quantitative trait locus 11 |
|
|
| anorexia nervosa |
|
|
| overnutrition |
|
|
| leptin deficiency or dysfunction |
|
|
| prader-willi syndrome |
|
Search AGRP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
AGRP_HUMAN- Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for AGRP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for AGRP Gene
Publications for AGRP Gene
- Association between an agouti-related protein gene polymorphism and anorexia nervosa. (PMID: 11326303) Vink T … Adan RA (Molecular psychiatry 2001) 3 4 23 41
- Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI. (PMID: 19602223) Kalnina I … Klovins J (BMC medical genetics 2009) 3 23 41
- Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset. (PMID: 17197106) Dardennes RM … Epelbaum J (Psychoneuroendocrinology 2007) 3 23 41
- The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors. (PMID: 17041250) Breit A … Gudermann T (The Journal of biological chemistry 2006) 3 4 23
- Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults. (PMID: 16568137) van Rossum CT … Seidell JC (International journal of obesity (2005) 2006) 3 23 41
ExternalLinks
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- ABIN625264
- ABIN414612
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- ABIN1028028
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- ABIN1380008
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- ABIN2683371
- ABIN5669252
- ABIN827458
- ABIN424735
- ABIN1568238
- ABIN1558613
- ABIN5523966
- ABIN5670141
- ABIN627494
- ABIN5651526
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- antibodies-online: Show 30 available AGRP Proteins ranked by validation data
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Sources for AGRP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
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