This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009] See more...

Aliases for AGRP Gene

Aliases for AGRP Gene

  • Agouti Related Neuropeptide 2 3 5
  • Agouti-Related Protein 3 4
  • AGRT 3 4
  • ART 3 4
  • Agouti Related Protein Homolog (Mouse) 2
  • Agouti Related Protein Homolog 3
  • Agouti (Mouse) Related Protein 2
  • ASIP2 3

External Ids for AGRP Gene

Previous GeneCards Identifiers for AGRP Gene

  • GC16M058210
  • GC16M067894
  • GC16M067251
  • GC16M067292
  • GC16M066073
  • GC16M067516
  • GC16M053389

Summaries for AGRP Gene

Entrez Gene Summary for AGRP Gene

  • This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

GeneCards Summary for AGRP Gene

AGRP (Agouti Related Neuropeptide) is a Protein Coding gene. Diseases associated with AGRP include Body Mass Index Quantitative Trait Locus 11 and Anorexia Nervosa. Among its related pathways are Circadian rythm related genes and Syndecan-3-mediated signaling events. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuropeptide hormone activity. An important paralog of this gene is ASIP.

UniProtKB/Swiss-Prot Summary for AGRP Gene

  • Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

Gene Wiki entry for AGRP Gene

Additional gene information for AGRP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGRP Gene

Genomics for AGRP Gene

GeneHancer (GH) Regulatory Elements for AGRP Gene

Promoters and enhancers for AGRP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGRP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGRP

Top Transcription factor binding sites by QIAGEN in the AGRP gene promoter:
  • CREB

Genomic Locations for AGRP Gene

Genomic Locations for AGRP Gene
chr16:67,482,571-67,484,083
(GRCh38/hg38)
Size:
1,513 bases
Orientation:
Minus strand
chr16:67,516,474-67,517,716
(GRCh37/hg19)
Size:
1,243 bases
Orientation:
Minus strand

Genomic View for AGRP Gene

Genes around AGRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGRP Gene

Proteins for AGRP Gene

  • Protein details for AGRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00253-AGRP_HUMAN
    Recommended name:
    Agouti-related protein
    Protein Accession:
    O00253
    Secondary Accessions:
    • O15459
    • Q2TBD9

    Protein attributes for AGRP Gene

    Size:
    132 amino acids
    Molecular mass:
    14440 Da
    Quaternary structure:
    • Interacts with melanocortin receptors MC3R, MC4R and MC5R.

    Three dimensional structures from OCA and Proteopedia for AGRP Gene

neXtProt entry for AGRP Gene

Post-translational modifications for AGRP Gene

No Post-translational modifications

Other Protein References for AGRP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGRP Gene

Domains & Families for AGRP Gene

Gene Families for AGRP Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for AGRP Gene

Blocks:
  • Agouti
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGRP Gene

GenScript: Design optimal peptide antigens:
  • Agouti-related protein (AGRP_HUMAN)
  • Agouti-related protein (C6SUN5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00253

UniProtKB/Swiss-Prot:

AGRP_HUMAN :
  • The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Domain:
  • The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
genes like me logo Genes that share domains with AGRP: view

Function for AGRP Gene

Molecular function for AGRP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
GENATLAS Biochemistry:
mouse agouti related protein,primarily expressed in adrenal gland,subthalamic mucleus,hypothalamus,potent antagonist of melanocortin receptor MICR3,MICR4, implicated in body weight regulation

Phenotypes From GWAS Catalog for AGRP Gene

Gene Ontology (GO) - Molecular Function for AGRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 10318826
GO:0005184 neuropeptide hormone activity IDA,TAS 15927146
genes like me logo Genes that share ontologies with AGRP: view
genes like me logo Genes that share phenotypes with AGRP: view

Human Phenotype Ontology for AGRP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGRP Gene

MGI Knock Outs for AGRP:

Animal Model Products

CRISPR Products

miRNA for AGRP Gene

miRTarBase miRNAs that target AGRP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGRP Gene

Localization for AGRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGRP Gene

Secreted. Golgi apparatus lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGRP gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for AGRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 15927146
GO:0005794 Golgi apparatus IEA --
GO:0005796 Golgi lumen IEA,IDA 15927146
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with AGRP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AGRP Gene

Pathways & Interactions for AGRP Gene

genes like me logo Genes that share pathways with AGRP: view

Pathways by source for AGRP Gene

SIGNOR curated interactions for AGRP Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for AGRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway TAS,IDA 15927146
GO:0007623 circadian rhythm IEA --
GO:0007631 feeding behavior TAS 9751529
GO:0008343 adult feeding behavior IEA --
GO:0009755 hormone-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with AGRP: view

Drugs & Compounds for AGRP Gene

(10) Drugs for AGRP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for AGRP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AGRP: view

Transcripts for AGRP Gene

mRNA/cDNA for AGRP Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGRP Gene

No ASD Table

Relevant External Links for AGRP Gene

GeneLoc Exon Structure for
AGRP

Expression for AGRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGRP Gene

mRNA differential expression in normal tissues according to GTEx for AGRP Gene

This gene is overexpressed in Brain - Hypothalamus (x27.3) and Adrenal Gland (x13.0).

Protein differential expression in normal tissues from HIPED for AGRP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGRP Gene



Protein tissue co-expression partners for AGRP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGRP

SOURCE GeneReport for Unigene cluster for AGRP Gene:

Hs.104633

mRNA Expression by UniProt/SwissProt for AGRP Gene:

O00253-AGRP_HUMAN
Tissue specificity: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

Evidence on tissue expression from TISSUES for AGRP Gene

  • Adrenal gland(4.4)
  • Nervous system(3.3)
  • Skin(2)
genes like me logo Genes that share expression patterns with AGRP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AGRP Gene

Orthologs for AGRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGRP 31 30
  • 99.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AGRP 31 30
  • 86.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agrp 30
  • 82.68 (n)
mouse
(Mus musculus)
Mammalia Agrp 17 31 30
  • 82.44 (n)
cow
(Bos Taurus)
Mammalia AGRP 31 30
  • 82.07 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGRP 31
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGRP 31
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859622 30
  • 59.54 (n)
AGRP 31 31
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii agrp 31
  • 33 (a)
OneToOne
Species where no ortholog for AGRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGRP Gene

ENSEMBL:
Gene Tree for AGRP (if available)
TreeFam:
Gene Tree for AGRP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AGRP: view image

Paralogs for AGRP Gene

Paralogs for AGRP Gene

(1) SIMAP similar genes for AGRP Gene using alignment to 1 proteins:

  • AGRP_HUMAN
genes like me logo Genes that share paralogs with AGRP: view

Variants for AGRP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGRP Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs5030980 Pathogenic, Association: Leanness, inherited; Obesity, late-onset. - 67,483,042(-) C/Tp.Ala67Thr MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for AGRP Gene

Structural Variations from Database of Genomic Variants (DGV) for AGRP Gene

Variant ID Type Subtype PubMed ID
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv833266 CNV loss 17160897

Variation tolerance for AGRP Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGRP Gene

Human Gene Mutation Database (HGMD)
AGRP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGRP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGRP Gene

Disorders for AGRP Gene

MalaCards: The human disease database

(11) MalaCards diseases for AGRP Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search AGRP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AGRP_HUMAN
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for AGRP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AGRP: view

No data available for Genatlas for AGRP Gene

Publications for AGRP Gene

  1. Association between an agouti-related protein gene polymorphism and anorexia nervosa. (PMID: 11326303) Vink T … Adan RA (Molecular psychiatry 2001) 3 4 23 41 54
  2. Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI. (PMID: 19602223) Kalnina I … Klovins J (BMC medical genetics 2009) 3 23 41 54
  3. Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset. (PMID: 17197106) Dardennes RM … Epelbaum J (Psychoneuroendocrinology 2007) 3 23 41 54
  4. Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults. (PMID: 16568137) van Rossum CT … Seidell JC (International journal of obesity (2005) 2006) 3 23 41 54
  5. The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors. (PMID: 17041250) Breit A … Gudermann T (The Journal of biological chemistry 2006) 3 4 23 54

Products for AGRP Gene

  • Boster Bio Antibodies for AGRP
  • Boster Bio ELISA Kits for AGRP

Sources for AGRP Gene