Aliases for AGRP Gene
External Ids for AGRP Gene
Previous GeneCards Identifiers for AGRP Gene
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
GeneCards Summary for AGRP Gene
AGRP (Agouti Related Neuropeptide) is a Protein Coding gene. Diseases associated with AGRP include Body Mass Index Quantitative Trait Locus 11 and Anorexia Nervosa. Among its related pathways are Circadian rythm related genes and Syndecan-3-mediated signaling events. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuropeptide hormone activity. An important paralog of this gene is ASIP.
UniProtKB/Swiss-Prot Summary for AGRP Gene
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.