Aliases for AGR3 Gene
External Ids for AGR3 Gene
Previous GeneCards Identifiers for AGR3 Gene
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]
GeneCards Summary for AGR3 Gene
AGR3 (Anterior Gradient 3, Protein Disulphide Isomerase Family Member) is a Protein Coding gene. Diseases associated with AGR3 include Breast Abscess and Ritter's Disease. Gene Ontology (GO) annotations related to this gene include dystroglycan binding. An important paralog of this gene is AGR2.
UniProtKB/Swiss-Prot Summary for AGR3 Gene
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.