Aliases for AGR3 Gene
External Ids for AGR3 Gene
Previous GeneCards Identifiers for AGR3 Gene
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]
GeneCards Summary for AGR3 Gene
AGR3 (Anterior Gradient 3, Protein Disulphide Isomerase Family Member) is a Protein Coding gene. Diseases associated with AGR3 include Breast Abscess. Gene Ontology (GO) annotations related to this gene include dystroglycan binding. An important paralog of this gene is AGR2.
UniProtKB/Swiss-Prot for AGR3 Gene
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.