Aliases for AGPAT5 Gene
- 1-Acylglycerol-3-Phosphate O-Acyltransferase 5 2 3 4 5
- 1-Acylglycerol-3-Phosphate O-Acyltransferase 5 (Lysophosphatidic Acid Acyltransferase, Epsilon) 2 3
- 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Epsilon 3 4
- Lysophosphatidic Acid Acyltransferase Epsilon 3 4
- 1-AGP Acyltransferase 5 3 4
- LPAAT-Epsilon 2 4
- 1-AGPAT 5 3 4
External Ids for AGPAT5 Gene
Previous GeneCards Identifiers for AGPAT5 Gene
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
GeneCards Summary for AGPAT5 Gene
AGPAT5 (1-Acylglycerol-3-Phosphate O-Acyltransferase 5) is a Protein Coding gene. Diseases associated with AGPAT5 include Keloid Formation and Dopamine Beta-Hydroxylase Deficiency. Among its related pathways are Acyl chain remodelling of PE and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is LCLAT1.
UniProtKB/Swiss-Prot Summary for AGPAT5 Gene
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190).