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Aliases for AGPAT4 Gene

Aliases for AGPAT4 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 4 2 3 4 5
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 4 (Lysophosphatidic Acid Acyltransferase, Delta) 2 3
  • Lysophosphatidic Acid Acyltransferase Delta 3 4
  • 1-AGP Acyltransferase 4 3 4
  • LPAAT-Delta 3 4
  • EC 2.3.1.51 4 56
  • 1-AGPAT 4 3 4
  • Lysophosphatidic Acid Acyltransferase-Delta (LPAAT-Delta) 3
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta 3
  • Lysophosphatidic Acid Acyltransferase, Delta 2
  • DJ473J16.2 3
  • 1-AGPAT4 3

External Ids for AGPAT4 Gene

Previous GeneCards Identifiers for AGPAT4 Gene

  • GC06M161466
  • GC06M161527
  • GC06M161471
  • GC06M159006

Summaries for AGPAT4 Gene

Entrez Gene Summary for AGPAT4 Gene

  • This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGPAT4 Gene

AGPAT4 (1-Acylglycerol-3-Phosphate O-Acyltransferase 4) is a Protein Coding gene. Among its related pathways are Metabolism and triacylglycerol biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT3.

UniProtKB/Swiss-Prot for AGPAT4 Gene

  • Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Additional gene information for AGPAT4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT4 Gene

Genomics for AGPAT4 Gene

GeneHancer (GH) Regulatory Elements for AGPAT4 Gene

Promoters and enhancers for AGPAT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I161272 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 555.1 +0.4 393 2.3 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF213 E2F8 AGPAT4 GC06P161252
GH06I161225 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.5 +46.4 46369 4.7 HDGF PKNOX1 ATF1 TCF12 GATA2 FOS NCOA1 ZNF592 ZNF184 SMARCA4 AGPAT4 MAP3K4 GC06P161252 PIR49622
GH06I161214 Enhancer 1.2 Ensembl ENCODE dbSUPER 21.1 +58.4 58418 2.6 ARNT CHAMP1 NCOA2 TCF12 GATA2 FOS CREM PHF21A CEBPB USF2 AGPAT4 GC06P161252 PIR49622
GH06I161226 Enhancer 0.8 ENCODE 21.3 +49.0 48991 0.2 HDAC1 YBX3 PKNOX1 ARNT NFRKB YBX1 NFXL1 CHAMP1 ZNF280A FOS MAP3K4 AGPAT4 GC06P161252 PIR49622
GH06I161242 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +31.0 31000 2 BCOR PKNOX1 RFX1 CEBPB ZMYM3 CEBPG ATF4 POLR2A BRD9 ZFP36 AGPAT4 MAP3K4 GC06P161252 PIR49622
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AGPAT4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGPAT4 gene promoter:

Genomic Locations for AGPAT4 Gene

Genomic Locations for AGPAT4 Gene
chr6:161,129,979-161,274,075
(GRCh38/hg38)
Size:
144,097 bases
Orientation:
Minus strand
chr6:161,551,011-161,695,107
(GRCh37/hg19)

Genomic View for AGPAT4 Gene

Genes around AGPAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGPAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGPAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGPAT4 Gene

Proteins for AGPAT4 Gene

  • Protein details for AGPAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRZ5-PLCD_HUMAN
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta
    Protein Accession:
    Q9NRZ5
    Secondary Accessions:
    • B4DSF9
    • Q5TEF0

    Protein attributes for AGPAT4 Gene

    Size:
    378 amino acids
    Molecular mass:
    44021 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AGPAT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGPAT4 Gene

Selected DME Specific Peptides for AGPAT4 Gene

Q9NRZ5:
  • SGSSLTLASF
  • WLHKLYQEKDA
  • WPINKQLFRKIN
  • NKQLFRKINCRLSYC
  • VPPRRPW
  • RTGTFPETP
  • SQLVMLLEWWS
  • AVYDCTLNFRNNENPTLLGVLNGKKYHAD
  • LYPFFQFLVSM
  • SKVLAKKEL
  • GLLKSQFLCHLVFCYVFIASGLI
  • FEIDFLCGW

Post-translational modifications for AGPAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGPAT4 Gene

Domains & Families for AGPAT4 Gene

Gene Families for AGPAT4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for AGPAT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRZ5

UniProtKB/Swiss-Prot:

PLCD_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with AGPAT4: view

Function for AGPAT4 Gene

Molecular function for AGPAT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Enzyme Numbers (IUBMB) for AGPAT4 Gene

Phenotypes From GWAS Catalog for AGPAT4 Gene

Gene Ontology (GO) - Molecular Function for AGPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with AGPAT4: view
genes like me logo Genes that share phenotypes with AGPAT4: view

Animal Models for AGPAT4 Gene

MGI Knock Outs for AGPAT4:

Animal Model Products

  • Taconic Biosciences Mouse Models for AGPAT4

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGPAT4 Gene

Localization for AGPAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGPAT4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
nucleus 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AGPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGPAT4: view

Pathways & Interactions for AGPAT4 Gene

genes like me logo Genes that share pathways with AGPAT4: view

UniProtKB/Swiss-Prot Q9NRZ5-PLCD_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Gene Ontology (GO) - Biological Process for AGPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008152 metabolic process IEA --
GO:0008654 phospholipid biosynthetic process NAS 15367102
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
genes like me logo Genes that share ontologies with AGPAT4: view

No data available for SIGNOR curated interactions for AGPAT4 Gene

Drugs & Compounds for AGPAT4 Gene

(3) Drugs for AGPAT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0

(52) Additional Compounds for AGPAT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AGPAT4: view

Transcripts for AGPAT4 Gene

Unigene Clusters for AGPAT4 Gene

1-acylglycerol-3-phosphate O-acyltransferase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - - -
SP6:
SP7:

Relevant External Links for AGPAT4 Gene

GeneLoc Exon Structure for
AGPAT4
ECgene alternative splicing isoforms for
AGPAT4

Expression for AGPAT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGPAT4 Gene

mRNA differential expression in normal tissues according to GTEx for AGPAT4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.2).

Protein differential expression in normal tissues from HIPED for AGPAT4 Gene

This gene is overexpressed in Cerebrospinal fluid (33.1), Spinal cord (9.0), and Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGPAT4 Gene



Protein tissue co-expression partners for AGPAT4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGPAT4 Gene:

AGPAT4

SOURCE GeneReport for Unigene cluster for AGPAT4 Gene:

Hs.353175

mRNA Expression by UniProt/SwissProt for AGPAT4 Gene:

Q9NRZ5-PLCD_HUMAN
Tissue specificity: Widely expressed with highest levels in skeletal muscle, followed by heart, liver, prostate and thymus.

Evidence on tissue expression from TISSUES for AGPAT4 Gene

  • Nervous system(4.9)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with AGPAT4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGPAT4 Gene

Orthologs for AGPAT4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AGPAT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPAT4 34 33
  • 98.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AGPAT4 33 34
  • 88.18 (n)
cow
(Bos Taurus)
Mammalia AGPAT4 33 34
  • 86.6 (n)
rat
(Rattus norvegicus)
Mammalia Agpat4 33
  • 84.13 (n)
mouse
(Mus musculus)
Mammalia Agpat4 16 34 33
  • 83.69 (n)
oppossum
(Monodelphis domestica)
Mammalia AGPAT4 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT4 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGPAT4 33 34
  • 75.64 (n)
lizard
(Anolis carolinensis)
Reptilia AGPAT4 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat4 33
  • 71.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5695 33
zebrafish
(Danio rerio)
Actinopterygii agpat4 33 34
  • 66.76 (n)
map3k4 33
fruit fly
(Drosophila melanogaster)
Insecta CG4729 34
  • 36 (a)
ManyToMany
CG4753 34
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CST26 36 34
  • 19 (a)
-- 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
Species where no ortholog for AGPAT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGPAT4 Gene

ENSEMBL:
Gene Tree for AGPAT4 (if available)
TreeFam:
Gene Tree for AGPAT4 (if available)

Paralogs for AGPAT4 Gene

Paralogs for AGPAT4 Gene

(2) SIMAP similar genes for AGPAT4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with AGPAT4: view

Variants for AGPAT4 Gene

Sequence variations from dbSNP and Humsavar for AGPAT4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000011781 -- 161,250,843(-) A/G intron_variant
rs1000035192 -- 161,162,074(-) A/G intron_variant
rs1000038096 -- 161,236,181(-) T/A intron_variant
rs1000038327 -- 161,130,474(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000076288 -- 161,256,724(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AGPAT4 Gene

Variant ID Type Subtype PubMed ID
esv1221310 CNV deletion 17803354
esv2311013 CNV deletion 18987734
esv2659009 CNV deletion 23128226
esv2733072 CNV deletion 23290073
esv2733074 CNV deletion 23290073
esv2733075 CNV deletion 23290073
esv2733076 CNV deletion 23290073
esv2752091 CNV gain 17911159
esv27949 CNV loss 19812545
esv3094151 CNV deletion 24192839
esv3308076 CNV mobile element insertion 20981092
esv3357862 CNV insertion 20981092
esv33824 CNV gain+loss 17666407
esv3540782 CNV deletion 23714750
esv3576242 CNV gain 25503493
esv3576243 CNV gain 25503493
esv3576244 CNV gain 25503493
esv3611453 CNV gain 21293372
esv3611455 CNV loss 21293372
nsv1026543 CNV gain 25217958
nsv1029727 CNV gain 25217958
nsv1030045 CNV gain 25217958
nsv1030852 CNV gain 25217958
nsv1031234 CNV gain 25217958
nsv1074031 CNV deletion 25765185
nsv1137173 CNV deletion 24896259
nsv1142645 CNV deletion 24896259
nsv349803 CNV insertion 16902084
nsv507371 OTHER sequence alteration 20534489
nsv520807 CNV loss 19592680
nsv526643 CNV loss 19592680
nsv527098 CNV loss 19592680
nsv528938 CNV loss 19592680
nsv5574 CNV insertion 18451855
nsv5575 CNV deletion 18451855

Variation tolerance for AGPAT4 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGPAT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGPAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPAT4 Gene

Disorders for AGPAT4 Gene

Additional Disease Information for AGPAT4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AGPAT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGPAT4 Gene

Publications for AGPAT4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. The structure and functions of human lysophosphatidic acid acyltransferases. (PMID: 11487472) Leung DW (Frontiers in bioscience : a journal and virtual library 2001) 3 4 58

Products for AGPAT4 Gene

Sources for AGPAT4 Gene

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