Aliases for AGPAT4 Gene
- 1-Acylglycerol-3-Phosphate O-Acyltransferase 4 2 3 4 5
- LPAAT-Delta 2 3 4
- 1-Acylglycerol-3-Phosphate O-Acyltransferase 4 (Lysophosphatidic Acid Acyltransferase, Delta) 2 3
- 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta 3 4
- Lysophosphatidic Acid Acyltransferase Delta 3 4
- 1-AGP Acyltransferase 4 3 4
External Ids for AGPAT4 Gene
Previous GeneCards Identifiers for AGPAT4 Gene
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGPAT4 Gene
AGPAT4 (1-Acylglycerol-3-Phosphate O-Acyltransferase 4) is a Protein Coding gene. Diseases associated with AGPAT4 include Congenital Generalized Lipodystrophy. Among its related pathways are Acyl chain remodelling of PE and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT3.
UniProtKB/Swiss-Prot Summary for AGPAT4 Gene
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity).