Aliases for AGPAT2 Gene
- 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 2 3 4 5
- 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) 2 3
- 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Beta 3 4
- Lysophosphatidic Acid Acyltransferase-Beta 2 3
- 1-AGP Acyltransferase 2 3 4
- LPAAT-Beta 3 4
- 1-AGPAT 2 3 4
External Ids for AGPAT2 Gene
Previous HGNC Symbols for AGPAT2 Gene
Previous GeneCards Identifiers for AGPAT2 Gene
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGPAT2 Gene
AGPAT2 (1-Acylglycerol-3-Phosphate O-Acyltransferase 2) is a Protein Coding gene. Diseases associated with AGPAT2 include Lipodystrophy, Congenital Generalized, Type 1 and Berardinelli-Seip Congenital Lipodystrophy. Among its related pathways are Innate Immune System and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT1.
UniProtKB/Swiss-Prot Summary for AGPAT2 Gene
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.