Aliases for AGPAT1 Gene
- 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 2 3 4 5
- LPAAT-Alpha 2 3 4
- 1-Acylglycerol-3-Phosphate O-Acyltransferase 1 (Lysophosphatidic Acid Acyltransferase, Alpha) 2 3
- 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha 3 4
- Lysophosphatidic Acid Acyltransferase Alpha 3 4
- 1-AGP Acyltransferase 1 3 4
- EC 184.108.40.206 4 50
- 1-AGPAT 1 3 4
External Ids for AGPAT1 Gene
Previous GeneCards Identifiers for AGPAT1 Gene
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGPAT1 Gene
AGPAT1 (1-Acylglycerol-3-Phosphate O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with AGPAT1 include Complete Generalized Lipodystrophy and Congenital Generalized Lipodystrophy. Among its related pathways are Acyl chain remodelling of PE and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT2.
UniProtKB/Swiss-Prot Summary for AGPAT1 Gene
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.