Aliases for AGO4 Gene
External Ids for AGO4 Gene
Previous HGNC Symbols for AGO4 Gene
Previous GeneCards Identifiers for AGO4 Gene
This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]
GeneCards Summary for AGO4 Gene
AGO4 (Argonaute RISC Component 4) is a Protein Coding gene. Diseases associated with AGO4 include Cartilage-Hair Hypoplasia. Among its related pathways are RET signaling and Pre-NOTCH Expression and Processing. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and double-stranded RNA binding. An important paralog of this gene is AGO1.
UniProtKB/Swiss-Prot Summary for AGO4 Gene
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).