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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
AGO2 (Argonaute RISC Catalytic Component 2) is a Protein Coding gene. Diseases associated with AGO2 include Colorectal Cancer and Eunuchism. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is AGO1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000340 | RNA 7-methylguanosine cap binding | IEA,IDA | 17524464 |
GO:0000993 | RNA polymerase II complex binding | IDA | 25336585 |
GO:0001046 | core promoter sequence-specific DNA binding | IMP | 25336585 |
GO:0001047 | core promoter binding | IMP | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IEA,IDA | 20616046 |
GO:0005634 | nucleus | IEA,IDA | 23985560 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA,IDA | 15260970 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | GAB1 signalosome |
.89
|
|
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.41
|
|
4 | Mitotic Prophase | ||
5 | Pre-NOTCH Expression and Processing |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006412 | translation | NAS | 10534406 |
GO:0006413 | translational initiation | IEA | -- |
GO:0006417 | regulation of translation | IEA | -- |
GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EIF2C2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AGO2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | AGO2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AGO2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | EIF2C2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ago2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ago2 30 |
|
||
Chicken (Gallus gallus) |
Aves | AGO2 31 |
|
OneToOne | |
LOC100858102 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | AGO2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ago2 30 |
|
||
Str.15011 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | CU929240.1 31 |
|
OneToOne | |
LOC570630 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011717 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | AGO1 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | alg-1 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AGO5 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.5747 30 |
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709067 | Benign: not provided | 140,541,269(-) | G/A | SYNONYMOUS_VARIANT | |
709179 | Likely Benign: not provided | 140,555,892(-) | G/A | INTRON_VARIANT | |
714622 | Benign: not provided | 140,560,414(-) | G/T | SYNONYMOUS_VARIANT | |
716646 | Likely Benign: not provided | 140,544,307(-) | C/T | INTRON_VARIANT | |
725082 | Benign: not provided | 140,544,243(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1712972 | CNV | deletion | 17803354 |
esv24351 | CNV | loss | 19812545 |
esv2539959 | CNV | deletion | 19546169 |
esv2737756 | CNV | deletion | 23290073 |
esv2737758 | CNV | deletion | 23290073 |
nsv1016282 | CNV | gain | 25217958 |
nsv1025478 | CNV | gain | 25217958 |
nsv1115144 | CNV | deletion | 24896259 |
nsv1126125 | CNV | deletion | 24896259 |
nsv1137621 | CNV | deletion | 24896259 |
nsv1144237 | CNV | deletion | 24896259 |
nsv465952 | CNV | loss | 19166990 |
nsv512075 | CNV | loss | 21212237 |
nsv526444 | CNV | gain | 19592680 |
nsv612568 | CNV | gain | 21841781 |
nsv612569 | CNV | loss | 21841781 |
nsv612570 | CNV | gain | 21841781 |
nsv6427 | CNV | insertion | 18451855 |
nsv824748 | CNV | gain | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
colorectal cancer |
|
|
eunuchism |
|
|
patau syndrome |
|
|
gum cancer |
|
|
chromosome 18p deletion syndrome |
|
|