Aliases for AGMAT Gene

Aliases for AGMAT Gene

  • Agmatinase 2 3 5
  • Agmatine Ureohydrolase (Agmatinase) 2 3
  • Agmatinase, Mitochondrial 3 4
  • EC 3.5.3.11 4 51
  • AUH 3 4
  • Agmatine Ureohydrolase 4
  • FLJ23384 2
  • EC 3.5.3 51
  • AGMAT 5

External Ids for AGMAT Gene

Previous GeneCards Identifiers for AGMAT Gene

  • GC01M015296
  • GC01M015078
  • GC01M015050
  • GC01M015262
  • GC01M015261
  • GC01M015644
  • GC01M015772
  • GC01M015898
  • GC01M014418

Summaries for AGMAT Gene

GeneCards Summary for AGMAT Gene

AGMAT (Agmatinase) is a Protein Coding gene. Diseases associated with AGMAT include Dry Eye Syndrome and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Viral mRNA Translation and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include agmatinase activity. An important paralog of this gene is ARG2.

Gene Wiki entry for AGMAT Gene

Additional gene information for AGMAT Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGMAT Gene

Genomics for AGMAT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AGMAT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGMAT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGMAT

Top Transcription factor binding sites by QIAGEN in the AGMAT gene promoter:
  • AP-2gamma
  • Bach1
  • c-Ets-1
  • c-Myb
  • C/EBPalpha
  • En-1
  • S8
  • SEF-1 (1)
  • USF-1
  • USF1

Genomic Locations for AGMAT Gene

Genomic Locations for AGMAT Gene
chr1:15,571,699-15,585,051
(GRCh38/hg38)
Size:
13,353 bases
Orientation:
Minus strand
chr1:15,898,194-15,911,605
(GRCh37/hg19)
Size:
13,412 bases
Orientation:
Minus strand

Genomic View for AGMAT Gene

Genes around AGMAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGMAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGMAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGMAT Gene

Proteins for AGMAT Gene

  • Protein details for AGMAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSE5-SPEB_HUMAN
    Recommended name:
    Agmatinase, mitochondrial
    Protein Accession:
    Q9BSE5
    Secondary Accessions:
    • Q5TDH1
    • Q9H5J3

    Protein attributes for AGMAT Gene

    Size:
    352 amino acids
    Molecular mass:
    37660 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for AGMAT Gene

Selected DME Specific Peptides for AGMAT Gene

Q9BSE5:
  • ANLLFEMLC
  • RVVQIGIRGSS
  • LDPAYAPGTGTPEIAGLTP
  • RPGARFGP
  • QALEIIRGC

Post-translational modifications for AGMAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGMAT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for AGMAT

Domains & Families for AGMAT Gene

Gene Families for AGMAT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for AGMAT Gene

InterPro:
Blocks:
  • Arginase signature
  • Arginase/agmatinase/formiminoglutamase
ProtoNet:

Suggested Antigen Peptide Sequences for AGMAT Gene

GenScript: Design optimal peptide antigens:
  • Agmatine ureohydrolase (SPEB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BSE5

UniProtKB/Swiss-Prot:

SPEB_HUMAN :
  • Belongs to the arginase family. Agmatinase subfamily.
Family:
  • Belongs to the arginase family. Agmatinase subfamily.
genes like me logo Genes that share domains with AGMAT: view

Function for AGMAT Gene

Molecular function for AGMAT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=agmatine + H2O = putrescine + urea; Xref=Rhea:RHEA:13929, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:58145, ChEBI:CHEBI:326268; EC=3.5.3.11; Evidence={ECO:0000269|PubMed:11914032};.

Enzyme Numbers (IUBMB) for AGMAT Gene

Phenotypes From GWAS Catalog for AGMAT Gene

Gene Ontology (GO) - Molecular Function for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008783 agmatinase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGMAT: view
genes like me logo Genes that share phenotypes with AGMAT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AGMAT

CRISPR Products

miRNA for AGMAT Gene

miRTarBase miRNAs that target AGMAT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGMAT

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGMAT Gene

Localization for AGMAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGMAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGMAT gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS --
genes like me logo Genes that share ontologies with AGMAT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AGMAT Gene

Pathways & Interactions for AGMAT Gene

genes like me logo Genes that share pathways with AGMAT: view

Pathways by source for AGMAT Gene

UniProtKB/Swiss-Prot Q9BSE5-SPEB_HUMAN

  • Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.

Gene Ontology (GO) - Biological Process for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008295 spermidine biosynthetic process IEA --
GO:0009446 putrescine biosynthetic process IEA --
GO:0033388 putrescine biosynthetic process from arginine IEA --
GO:0033389 putrescine biosynthetic process from arginine, using agmatinase IBA 21873635
GO:0097055 agmatine biosynthetic process TAS --
genes like me logo Genes that share ontologies with AGMAT: view

No data available for SIGNOR curated interactions for AGMAT Gene

Drugs & Compounds for AGMAT Gene

(11) Drugs for AGMAT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 56
Guanidine Approved Pharma 0
Urea Approved, Investigational Pharma 0
Water Approved Pharma 0
agmatine Experimental Pharma Activator 0

(4) Additional Compounds for AGMAT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-acetylspermine
  • N'-monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-acetamide
  • N-Acetylspermine
25593-72-0
Norspermidine
  • 1,7-diamino-4-Azaheptane
  • 3,3'-Iminobis(propylamine)
  • 3,3'-Iminobispropylamine
  • 3,3'-Iminodi(propylamine)
  • 3,3-Diaminodipropylamine
56-18-8
genes like me logo Genes that share compounds with AGMAT: view

Transcripts for AGMAT Gene

mRNA/cDNA for AGMAT Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGMAT

Alternative Splicing Database (ASD) splice patterns (SP) for AGMAT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2: -

Relevant External Links for AGMAT Gene

GeneLoc Exon Structure for
AGMAT

Expression for AGMAT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGMAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGMAT Gene

This gene is overexpressed in Kidney - Cortex (x24.3) and Liver (x12.3).

Protein differential expression in normal tissues from HIPED for AGMAT Gene

This gene is overexpressed in Kidney (49.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AGMAT Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGMAT

SOURCE GeneReport for Unigene cluster for AGMAT Gene:

Hs.461532

mRNA Expression by UniProt/SwissProt for AGMAT Gene:

Q9BSE5-SPEB_HUMAN
Tissue specificity: Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord.

Evidence on tissue expression from TISSUES for AGMAT Gene

  • Kidney(4.7)
  • Liver(4.5)
genes like me logo Genes that share expression patterns with AGMAT: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGMAT Gene

Orthologs for AGMAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGMAT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AGMAT 30 31
  • 99.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AGMAT 30 31
  • 87.88 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AGMAT 30 31
  • 87.65 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia AGMAT 31
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Agmat 30 17 31
  • 82.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Agmat 30
  • 81.53 (n)
Oppossum
(Monodelphis domestica)
Mammalia AGMAT 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves AGMAT 30 31
  • 73.77 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia agmat 30
  • 70.99 (n)
Zebrafish
(Danio rerio)
Actinopterygii agmat 30 31
  • 65.51 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6064 30
Worm
(Caenorhabditis elegans)
Secernentea T21F4.1 31
  • 13 (a)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04235g 30
  • 44.98 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAR1 31
  • 18 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G08900 30
  • 45.93 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0106300 30
  • 46.16 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 65 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU01348 30
  • 47.96 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC11D3.09 30
  • 46.94 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.395 30
Species where no ortholog for AGMAT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for AGMAT Gene

ENSEMBL:
Gene Tree for AGMAT (if available)
TreeFam:
Gene Tree for AGMAT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AGMAT: view image

Paralogs for AGMAT Gene

Paralogs for AGMAT Gene

genes like me logo Genes that share paralogs with AGMAT: view

Variants for AGMAT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGMAT Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
767655 Benign: not provided 15,578,893(-) G/A MISSENSE_VARIANT
784932 Likely Benign: not provided 15,584,938(-) G/A SYNONYMOUS_VARIANT
788499 Benign: not provided 15,573,657(-) G/A SYNONYMOUS_VARIANT
rs11580170 - p.Arg140Gln
rs6429757 - p.Gly105Arg

Additional dbSNP identifiers (rs#s) for AGMAT Gene

Structural Variations from Database of Genomic Variants (DGV) for AGMAT Gene

Variant ID Type Subtype PubMed ID
esv3577747 CNV loss 25503493

Variation tolerance for AGMAT Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGMAT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGMAT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGMAT Gene

Disorders for AGMAT Gene

MalaCards: The human disease database

(2) MalaCards diseases for AGMAT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dry eye syndrome
  • xerophthalmia
renal cell carcinoma, nonpapillary
  • rcc
- elite association - COSMIC cancer census association via MalaCards
Search AGMAT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AGMAT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AGMAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGMAT Gene

Publications for AGMAT Gene

  1. Cloning and characterization of human agmatinase. (PMID: 11914032) Iyer RK … Cederbaum SD (Molecular genetics and metabolism 2002) 2 3 4 23
  2. Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus. (PMID: 11804860) Mistry SK … Morris SM (American journal of physiology. Gastrointestinal and liver physiology 2002) 2 3 4 23
  3. Human agmatinase is diminished in the clear cell type of renal cell carcinoma. (PMID: 14648699) Dallmann K … Walther R (International journal of cancer 2004) 2 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41

Products for AGMAT Gene

Sources for AGMAT Gene