Aliases for AGGF1 Gene
External Ids for AGGF1 Gene
Previous GeneCards Identifiers for AGGF1 Gene
This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]
GeneCards Summary for AGGF1 Gene
AGGF1 (Angiogenic Factor With G-Patch And FHA Domains 1) is a Protein Coding gene. Diseases associated with AGGF1 include Klippel-Trenaunay-Weber Syndrome and Venous Malformations, Multiple Cutaneous And Mucosal. Among its related pathways are HIV Life Cycle and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000285000.
UniProtKB/Swiss-Prot Summary for AGGF1 Gene
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.