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Aliases for AGFG2 Gene

Aliases for AGFG2 Gene

  • ArfGAP With FG Repeats 2 2 3 5
  • Rev/Rex Activation Domain-Binding Protein Related 3 4
  • HIV-1 Rev-Binding Protein-Like Protein 3 4
  • HRBL 3 4
  • RABR 3 4
  • Arf-GAP Domain And FG Repeats-Containing Protein 2 3
  • Rev/Rex Activation Domain Binding Protein-Related 3
  • Arf-GAP Domain And FG Repeat-Containing Protein 2 3
  • HIV-1 Rev Binding Protein-Like 2
  • Nucleoporin 3
  • RAB-R 4

External Ids for AGFG2 Gene

Previous HGNC Symbols for AGFG2 Gene

  • HRBL

Previous GeneCards Identifiers for AGFG2 Gene

  • GC07P099976
  • GC07P100136
  • GC07P094769

Summaries for AGFG2 Gene

Entrez Gene Summary for AGFG2 Gene

  • This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]

GeneCards Summary for AGFG2 Gene

AGFG2 (ArfGAP With FG Repeats 2) is a Protein Coding gene. An important paralog of this gene is AGFG1.

Gene Wiki entry for AGFG2 Gene

Additional gene information for AGFG2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGFG2 Gene

Genomics for AGFG2 Gene

GeneHancer (GH) Regulatory Elements for AGFG2 Gene

Promoters and enhancers for AGFG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100538 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.4 +5.4 5402 12.6 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 AGFG2 SRRT PPP1R35 ZSCAN25 SAP25 GIGYF1 MEPCE AP4M1 LRCH4 ENSG00000242798
GH07J100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.6 -106.0 -106012 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE ZCWPW1 PIR54054 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF3 PILRA
GH07J100581 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 +45.5 45456 5.9 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 FBXO24 LRCH4 ZSCAN25 AP4M1 SRRT ZSCAN21 SAP25 MEPCE PPP1R35 GIGYF1
GH07J100672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.5 +137.8 137781 8.6 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 GNB2 GC07P100676 TRIM4 ZNF3 GIGYF1 SRRT PCOLCE STAG3L5P PPP1R35 ENSG00000242798
GH07J100124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.5 -412.5 -412538 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ENSG00000242798 MBLAC1 TAF6 GIGYF1 TRIM4 ZSCAN25 SRRT ZNF655 AP4M1 PPP1R35
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGFG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGFG2 gene promoter:
  • c-Jun
  • c-Fos
  • AP-1
  • Gfi-1
  • Egr-4
  • ATF-2
  • Tal-1
  • E47
  • AML1a
  • c-Myb

Genomic Locations for AGFG2 Gene

Genomic Locations for AGFG2 Gene
29,010 bases
Plus strand
29,010 bases
Plus strand

Genomic View for AGFG2 Gene

Genes around AGFG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGFG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGFG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGFG2 Gene

Proteins for AGFG2 Gene

  • Protein details for AGFG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP domain and FG repeat-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • O75429
    • Q96AB9
    • Q96GL4

    Protein attributes for AGFG2 Gene

    481 amino acids
    Molecular mass:
    48963 Da
    Quaternary structure:
    • Interacts with EPS15R.
    • Sequence=AAC78803.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGFG2 Gene


neXtProt entry for AGFG2 Gene

Post-translational modifications for AGFG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGFG2 Gene

No data available for DME Specific Peptides for AGFG2 Gene

Domains & Families for AGFG2 Gene

Gene Families for AGFG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AGFG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains FG repeats and 4 N-P-F repeats.
  • Contains FG repeats and 4 N-P-F repeats.
genes like me logo Genes that share domains with AGFG2: view

Function for AGFG2 Gene

Phenotypes From GWAS Catalog for AGFG2 Gene

Gene Ontology (GO) - Molecular Function for AGFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005096 GTPase activator activity IEA --
GO:0031267 small GTPase binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGFG2: view
genes like me logo Genes that share phenotypes with AGFG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGFG2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGFG2 Gene

Localization for AGFG2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGFG2 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for AGFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IBA --
GO:0016020 membrane HDA,IBA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with AGFG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for AGFG2 Gene

Pathways & Interactions for AGFG2 Gene

SuperPathways for AGFG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016192 vesicle-mediated transport IBA --
GO:0032012 regulation of ARF protein signal transduction IBA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGFG2: view

No data available for Pathways by source and SIGNOR curated interactions for AGFG2 Gene

Drugs & Compounds for AGFG2 Gene

No Compound Related Data Available

Transcripts for AGFG2 Gene

Unigene Clusters for AGFG2 Gene

ArfGAP with FG repeats 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGFG2

Alternative Splicing Database (ASD) splice patterns (SP) for AGFG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - -
SP3: -

Relevant External Links for AGFG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGFG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGFG2 Gene

Protein differential expression in normal tissues from HIPED for AGFG2 Gene

This gene is overexpressed in Skin (31.8), CD4 Tcells (9.0), and Cervix (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AGFG2 Gene

Protein tissue co-expression partners for AGFG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of AGFG2 Gene:


SOURCE GeneReport for Unigene cluster for AGFG2 Gene:


Evidence on tissue expression from TISSUES for AGFG2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with AGFG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGFG2 Gene

Orthologs for AGFG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGFG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AGFG2 34 33
  • 99.17 (n)
(Canis familiaris)
Mammalia AGFG2 34 33
  • 88.96 (n)
(Bos Taurus)
Mammalia AGFG2 34 33
  • 88.94 (n)
(Mus musculus)
Mammalia Agfg2 16 34 33
  • 82.56 (n)
(Monodelphis domestica)
Mammalia AGFG2 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia AGFG2 34
  • 61 (a)
(Anolis carolinensis)
Reptilia AGFG2 34
  • 54 (a)
(Danio rerio)
Actinopterygii AGFG2 34
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta drongo 34
  • 16 (a)
Species where no ortholog for AGFG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGFG2 Gene

Gene Tree for AGFG2 (if available)
Gene Tree for AGFG2 (if available)
Evolutionary constrained regions (ECRs) for AGFG2: view image

Paralogs for AGFG2 Gene

Paralogs for AGFG2 Gene

(2) SIMAP similar genes for AGFG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGFG2: view

Variants for AGFG2 Gene

Sequence variations from dbSNP and Humsavar for AGFG2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000191479 -- 100,555,006(+) C/T intron_variant
rs1000359324 -- 100,549,606(+) C/T intron_variant
rs1000365981 -- 100,547,065(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000387614 -- 100,563,592(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000503582 -- 100,568,173(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for AGFG2 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv831072 CNV loss 17160897
nsv951386 CNV deletion 24416366

Variation tolerance for AGFG2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGFG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGFG2 Gene

Disorders for AGFG2 Gene

Additional Disease Information for AGFG2

No disorders were found for AGFG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGFG2 Gene

Publications for AGFG2 Gene

  1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Glöckner G … Rosenthal A (Genome research 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. (PMID: 10613896) Doria M … Di Fiore PP (The Journal of cell biology 1999) 3 22 58
  4. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PMID: 9303539) Salcini AE … Di Fiore PP (Genes & development 1997) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for AGFG2 Gene

Sources for AGFG2 Gene

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