Aliases for AGBL5 Gene
External Ids for AGBL5 Gene
Previous GeneCards Identifiers for AGBL5 Gene
This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
GeneCards Summary for AGBL5 Gene
AGBL5 (ATP/GTP Binding Protein Like 5) is a Protein Coding gene. Diseases associated with AGBL5 include Retinitis Pigmentosa 75 and Retinitis Pigmentosa. Gene Ontology (GO) annotations related to this gene include tubulin binding and metallocarboxypeptidase activity. An important paralog of this gene is AGBL2.
UniProtKB/Swiss-Prot Summary for AGBL5 Gene
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.