Aliases for AGBL4 Gene
External Ids for AGBL4 Gene
Previous GeneCards Identifiers for AGBL4 Gene
GeneCards Summary for AGBL4 Gene
AGBL4 (ATP/GTP Binding Protein Like 4) is a Protein Coding gene. Diseases associated with AGBL4 include Cardiofaciocutaneous Syndrome 3 and Cardiofaciocutaneous Syndrome 2. Gene Ontology (GO) annotations related to this gene include tubulin binding and metallocarboxypeptidase activity. An important paralog of this gene is AGTPBP1.
UniProtKB/Swiss-Prot Summary for AGBL4 Gene
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.