Aliases for AGAP9 Gene

Aliases for AGAP9 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 9 2 3 5
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 9 3 4
  • Centaurin-Gamma-Like Family Member 6 3 4
  • BA301J7.2 2 3
  • AGAP-9 3 4
  • CTGLF6 3 4
  • Centaurin, Gamma-Like Family, Member 6 2
  • FLJ00312 2
  • AGAP9 5

External Ids for AGAP9 Gene

Previous HGNC Symbols for AGAP9 Gene

  • CTGLF6

Previous GeneCards Identifiers for AGAP9 Gene

  • GC10P047809
  • GC10P047834
  • GC10P048214
  • GC10P048189

Summaries for AGAP9 Gene

GeneCards Summary for AGAP9 Gene

AGAP9 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 9) is a Protein Coding gene. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot Summary for AGAP9 Gene

Additional gene information for AGAP9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGAP9 Gene

Genomics for AGAP9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AGAP9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGAP9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGAP9

Top Transcription factor binding sites by QIAGEN in the AGAP9 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • Egr-4
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • HFH-1
  • Pax-4a
  • Sox5

Genomic Locations for AGAP9 Gene

Genomic Locations for AGAP9 Gene
21,785 bases
Minus strand
47,897 bases
Plus strand

Genomic View for AGAP9 Gene

Genes around AGAP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP9 Gene

Proteins for AGAP9 Gene

  • Protein details for AGAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • D3YTF3

    Protein attributes for AGAP9 Gene

    703 amino acids
    Molecular mass:
    77972 Da
    Quaternary structure:
    No Data Available
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

    Alternative splice isoforms for AGAP9 Gene


neXtProt entry for AGAP9 Gene

Post-translational modifications for AGAP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGAP9 Gene

Domains & Families for AGAP9 Gene

Gene Families for AGAP9 Gene

Suggested Antigen Peptide Sequences for AGAP9 Gene

GenScript: Design optimal peptide antigens:
  • Centaurin-gamma-like family member 6 (AGAP9_HUMAN)
  • FLJ00312 protein (Q6ZMK7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the centaurin gamma-like family.
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP9: view

Function for AGAP9 Gene

Molecular function for AGAP9 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Phenotypes From GWAS Catalog for AGAP9 Gene

Gene Ontology (GO) - Molecular Function for AGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP9: view
genes like me logo Genes that share phenotypes with AGAP9: view

Animal Model Products

CRISPR Products

miRNA for AGAP9 Gene

miRTarBase miRNAs that target AGAP9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGAP9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGAP9 Gene

Localization for AGAP9 Gene

Gene Ontology (GO) - Cellular Components for AGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with AGAP9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for AGAP9 Gene

Pathways & Interactions for AGAP9 Gene

PathCards logo

SuperPathways for AGAP9 Gene

SuperPathway Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with AGAP9: view

Pathways by source for AGAP9 Gene

1 KEGG pathway for AGAP9 Gene

Gene Ontology (GO) - Biological Process for AGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP9: view

No data available for SIGNOR curated interactions for AGAP9 Gene

Drugs & Compounds for AGAP9 Gene

No Compound Related Data Available

Transcripts for AGAP9 Gene

mRNA/cDNA for AGAP9 Gene

6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGAP9

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP9 Gene

No ASD Table

Relevant External Links for AGAP9 Gene

GeneLoc Exon Structure for

Expression for AGAP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGAP9 Gene

Protein differential expression in normal tissues from HIPED for AGAP9 Gene

This gene is overexpressed in Cerebrospinal fluid (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGAP9 Gene

Protein tissue co-expression partners for AGAP9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGAP9

SOURCE GeneReport for Unigene cluster for AGAP9 Gene:

genes like me logo Genes that share expression patterns with AGAP9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP9 Gene

Orthologs for AGAP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTGLF2 30
  • 97.44 (n)
-- 31
  • 76 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
(Gallus gallus)
Aves -- 31
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 56 (a)
-- 31
  • 8 (a)
(Danio rerio)
Actinopterygii agap1 31
  • 42 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta cenG1A 31
  • 23 (a)
(Caenorhabditis elegans)
Secernentea cnt-2 31
  • 18 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 31 (a)
Species where no ortholog for AGAP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for AGAP9 Gene

Gene Tree for AGAP9 (if available)
Gene Tree for AGAP9 (if available)
Evolutionary constrained regions (ECRs) for AGAP9: view image

Paralogs for AGAP9 Gene

(17) SIMAP similar genes for AGAP9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AGAP9: view

Variants for AGAP9 Gene

Additional dbSNP identifiers (rs#s) for AGAP9 Gene

Structural Variations from Database of Genomic Variants (DGV) for AGAP9 Gene

Variant ID Type Subtype PubMed ID
dgv137e199 CNV deletion 23128226
nsv1068309 CNV deletion 25765185
nsv1118173 CNV deletion 24896259
nsv982761 CNV duplication 23825009

Additional Variant Information for AGAP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for AGAP9 Gene

Disorders for AGAP9 Gene

No disorders were found for AGAP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP9 Gene

Publications for AGAP9 Gene

  1. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. (PMID: 30652415) Liu Y … Chen L (Cancer medicine 2019) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for AGAP9 Gene

Sources for AGAP9 Gene