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Aliases for AGAP9 Gene

Aliases for AGAP9 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 9 2 3 5
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 9 3 4
  • Centaurin-Gamma-Like Family Member 6 3 4
  • CTGLF6 3 4
  • AGAP-9 3 4
  • Centaurin, Gamma-Like Family, Member 6 2
  • BA301J7.2 3

External Ids for AGAP9 Gene

Previous HGNC Symbols for AGAP9 Gene

  • CTGLF6

Previous GeneCards Identifiers for AGAP9 Gene

  • GC10P047809
  • GC10P047834
  • GC10P048214
  • GC10P048189

Summaries for AGAP9 Gene

GeneCards Summary for AGAP9 Gene

AGAP9 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is AGAP6.

UniProtKB/Swiss-Prot for AGAP9 Gene

Additional gene information for AGAP9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP9 Gene

Genomics for AGAP9 Gene

GeneHancer (GH) Regulatory Elements for AGAP9 Gene

Promoters and enhancers for AGAP9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J047523 Promoter 0.5 EPDnew 600.7 -0.3 -268 0.1 AGAP9 RNA5SP312 ENSG00000254929 ANXA8
GH10J048010 Promoter 0.5 EPDnew 600 -486.9 -486850 0.1 AGAP9 GC10P048000 AGAP12P
GH10J046522 Enhancer 1.3 Ensembl ENCODE 136.6 +998.7 998667 4.4 ZNF473 MTA3 ZKSCAN8 MLLT1 ZNF121 GTF2F1 CSDE1 ZSCAN21 CDC5L BACH1 PARGP1 AGAP4 BMS1P1 AGAP9 WASHC2C ENSG00000229227 AGAP10P FAM21FP ZFAND4 SHLD2P1
GH10J047552 Promoter 1.2 Ensembl 70 -29.8 -29763 2.4 CC2D1A MLLT1 ZNF121 TRIM24 ZNF404 ZNF680 ZNF560 ZNF547 PKNOX1 ZBTB8A BMS1P2 ENSG00000254929 BMS1P1 AGAP9 ENSG00000229227 MAPK8 RNA5SP312 ANXA8
GH10J046555 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 25.6 +967.4 967437 2 HDGF ZNF680 ZNF560 ZIC2 KLF7 POLR2A KLF9 AEBP2 ZNF274 ZFHX2 GPRIN2 NPY4R PARGP1 BMS1P1 BMS1P2 AGAP4 AGAP9 WASHC2C ENSG00000229227 AGAP10P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGAP9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGAP9 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • Egr-4
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • HFH-1
  • Pax-4a
  • Sox5

Genomic Locations for AGAP9 Gene

Genomic Locations for AGAP9 Gene
21,785 bases
Minus strand
47,897 bases
Plus strand

Genomic View for AGAP9 Gene

Genes around AGAP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP9 Gene

Proteins for AGAP9 Gene

  • Protein details for AGAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • D3YTF3

    Protein attributes for AGAP9 Gene

    703 amino acids
    Molecular mass:
    77972 Da
    Quaternary structure:
    No Data Available
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

    Alternative splice isoforms for AGAP9 Gene


neXtProt entry for AGAP9 Gene

Post-translational modifications for AGAP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGAP9 Gene

Domains & Families for AGAP9 Gene

Suggested Antigen Peptide Sequences for AGAP9 Gene

GenScript: Design optimal peptide antigens:
  • Centaurin-gamma-like family member 6 (AGAP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the centaurin gamma-like family.
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP9: view

Function for AGAP9 Gene

Molecular function for AGAP9 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Phenotypes From GWAS Catalog for AGAP9 Gene

Gene Ontology (GO) - Molecular Function for AGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP9: view
genes like me logo Genes that share phenotypes with AGAP9: view

Animal Model Products

CRISPR Products

miRNA for AGAP9 Gene

miRTarBase miRNAs that target AGAP9

Clone Products

  • Applied Biological Materials (abm): Clones for AGAP9 - Now 50% OFF >
  • * AGAP9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * AGAP9 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGAP9 Gene

Localization for AGAP9 Gene

Gene Ontology (GO) - Cellular Components for AGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with AGAP9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for AGAP9 Gene

Pathways & Interactions for AGAP9 Gene

PathCards logo

SuperPathways for AGAP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP9: view

No data available for Pathways by source and SIGNOR curated interactions for AGAP9 Gene

Drugs & Compounds for AGAP9 Gene

No Compound Related Data Available

Transcripts for AGAP9 Gene

mRNA/cDNA for AGAP9 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for AGAP9 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 9:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for AGAP9 - Now 50% OFF >
  • * AGAP9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * AGAP9 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP9 Gene

No ASD Table

Relevant External Links for AGAP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGAP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGAP9 Gene

Protein differential expression in normal tissues from HIPED for AGAP9 Gene

This gene is overexpressed in Cerebrospinal fluid (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGAP9 Gene

Protein tissue co-expression partners for AGAP9 Gene

NURSA nuclear receptor signaling pathways regulating expression of AGAP9 Gene:


SOURCE GeneReport for Unigene cluster for AGAP9 Gene:

genes like me logo Genes that share expression patterns with AGAP9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP9 Gene

Orthologs for AGAP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTGLF2 34
  • 97.44 (n)
-- 35
  • 76 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
(Gallus gallus)
Aves -- 35
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
-- 35
  • 8 (a)
(Danio rerio)
Actinopterygii agap1 35
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 35
  • 23 (a)
(Caenorhabditis elegans)
Secernentea cnt-2 35
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
Species where no ortholog for AGAP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP9 Gene

Gene Tree for AGAP9 (if available)
Gene Tree for AGAP9 (if available)
Evolutionary constrained regions (ECRs) for AGAP9: view image

Paralogs for AGAP9 Gene

(17) SIMAP similar genes for AGAP9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AGAP9: view

Variants for AGAP9 Gene

Sequence variations from dbSNP and Humsavar for AGAP9 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1047435 -- 47,502,436(-) A/G coding_sequence_variant, missense_variant
rs1047447 -- 47,502,343(-) T/C coding_sequence_variant, missense_variant
rs1047466 -- 47,502,248(-) T/C coding_sequence_variant, synonymous_variant
rs1047615 -- 47,501,918(-) A/G 3_prime_UTR_variant
rs1047621 -- 47,501,913(-) T/C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP9 Gene

Variant ID Type Subtype PubMed ID
dgv137e199 CNV deletion 23128226
nsv1068309 CNV deletion 25765185
nsv1118173 CNV deletion 24896259
nsv982761 CNV duplication 23825009

Additional Variant Information for AGAP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for AGAP9 Gene

Disorders for AGAP9 Gene

Additional Disease Information for AGAP9

No disorders were found for AGAP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP9 Gene

Publications for AGAP9 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for AGAP9 Gene

Sources for AGAP9 Gene

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