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Aliases for AGAP9 Gene

Aliases for AGAP9 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 9 2 3 5
  • Centaurin-Gamma-Like Family Member 6 3 4
  • CTGLF6 3 4
  • AGAP-9 3 4
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 9 3
  • Centaurin, Gamma-Like Family, Member 6 2
  • BA301J7.2 3

External Ids for AGAP9 Gene

Previous HGNC Symbols for AGAP9 Gene

  • CTGLF6

Previous GeneCards Identifiers for AGAP9 Gene

  • GC10P047809
  • GC10P047834
  • GC10P048214
  • GC10P048189

Summaries for AGAP9 Gene

GeneCards Summary for AGAP9 Gene

AGAP9 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is AGAP6.

UniProtKB/Swiss-Prot for AGAP9 Gene

  • Putative GTPase-activating protein.

Additional gene information for AGAP9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP9 Gene

Genomics for AGAP9 Gene

GeneHancer (GH) Regulatory Elements for AGAP9 Gene

Promoters and enhancers for AGAP9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J047523 Promoter 0.5 EPDnew 650.7 -0.3 -268 0.1 AGAP9 RNA5SP312 ENSG00000254929 ANXA8
GH10J048010 Promoter 0.5 EPDnew 650 -486.9 -486850 0.1 AGAP9 GC10P048000 AGAP12P
GH10J046522 Enhancer 1.3 Ensembl ENCODE 136.6 +998.9 998940 3.6 HDGF ARNT SIN3A YBX1 ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 FOS PARGP1 AGAP4 BMS1P1 AGAP9 WASHC2C LOC105378289 AGAP10P FAM21FP ZFAND4 FAM35BP
GH10J047552 Promoter 1.2 Ensembl 70 -29.9 -29863 1.8 HDAC1 PKNOX1 ZNF493 ZFP64 ZBTB40 ZNF335 ZNF121 POLR2B ZNF213 ZNF202 BMS1P2 ENSG00000254929 BMS1P1 AGAP9 LOC105378289 MAPK8 RNA5SP312 ANXA8
GH10J046555 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 37.5 +966.9 966949 2.9 HDGF MXI1 USF1 BACH1 ZNF175 SIN3A GLI4 ZIC2 ZFHX2 ZNF791 GPRIN2 NPY4R PARGP1 BMS1P1 BMS1P2 AGAP9 AGAP4 WASHC2C AGAP10P LOC105378289
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AGAP9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGAP9 gene promoter:

Genomic Locations for AGAP9 Gene

Genomic Locations for AGAP9 Gene
chr10:47,501,854-47,523,638
(GRCh38/hg38)
Size:
21,785 bases
Orientation:
Minus strand
chr10:48,189,612-48,237,508
(GRCh37/hg19)

Genomic View for AGAP9 Gene

Genes around AGAP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP9 Gene

Proteins for AGAP9 Gene

  • Protein details for AGAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTM2-AGAP9_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
    Protein Accession:
    Q5VTM2
    Secondary Accessions:
    • D3YTF3

    Protein attributes for AGAP9 Gene

    Size:
    703 amino acids
    Molecular mass:
    77972 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
    SequenceCaution:
    • Sequence=CAH72201.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGAP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGAP9 Gene

Post-translational modifications for AGAP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGAP9 Gene

Domains & Families for AGAP9 Gene

Suggested Antigen Peptide Sequences for AGAP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VTM2

UniProtKB/Swiss-Prot:

AGAP9_HUMAN :
  • Belongs to the centaurin gamma-like family.
Family:
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP9: view

Function for AGAP9 Gene

Molecular function for AGAP9 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Gene Ontology (GO) - Molecular Function for AGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP9: view
genes like me logo Genes that share phenotypes with AGAP9: view

Animal Model Products

miRNA for AGAP9 Gene

miRTarBase miRNAs that target AGAP9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGAP9 Gene

Localization for AGAP9 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AGAP9 Gene

Pathways & Interactions for AGAP9 Gene

SuperPathways for AGAP9 Gene

No Data Available

Interacting Proteins for AGAP9 Gene

Selected Interacting proteins: Q5VTM2-AGAP9_HUMAN for AGAP9 Gene via IID

Symbol External ID(s) Details
HSPB1

Gene Ontology (GO) - Biological Process for AGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP9: view

No data available for Pathways by source and SIGNOR curated interactions for AGAP9 Gene

Drugs & Compounds for AGAP9 Gene

No Compound Related Data Available

Transcripts for AGAP9 Gene

mRNA/cDNA for AGAP9 Gene

(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGAP9 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP9 Gene

No ASD Table

Relevant External Links for AGAP9 Gene

GeneLoc Exon Structure for
AGAP9
ECgene alternative splicing isoforms for
AGAP9

Expression for AGAP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGAP9 Gene

Protein differential expression in normal tissues from HIPED for AGAP9 Gene

This gene is overexpressed in Cerebrospinal fluid (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGAP9 Gene



Protein tissue co-expression partners for AGAP9 Gene

NURSA nuclear receptor signaling pathways regulating expression of AGAP9 Gene:

AGAP9

SOURCE GeneReport for Unigene cluster for AGAP9 Gene:

Hs.645346
genes like me logo Genes that share expression patterns with AGAP9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP9 Gene

Orthologs for AGAP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTGLF2 33
  • 97.44 (n)
-- 34
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
ManyToMany
-- 34
  • 8 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii agap1 34
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnt-2 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToMany
Species where no ortholog for AGAP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP9 Gene

ENSEMBL:
Gene Tree for AGAP9 (if available)
TreeFam:
Gene Tree for AGAP9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AGAP9: view image

Paralogs for AGAP9 Gene

(17) SIMAP similar genes for AGAP9 Gene using alignment to 1 proteins:

  • AGAP9_HUMAN
genes like me logo Genes that share paralogs with AGAP9: view

Variants for AGAP9 Gene

Sequence variations from dbSNP and Humsavar for AGAP9 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1047435 -- 47,502,436(-) A/G coding_sequence_variant, missense_variant
rs1047447 -- 47,502,343(-) T/C coding_sequence_variant, missense_variant
rs1047466 -- 47,502,248(-) T/C coding_sequence_variant, synonymous_variant
rs1047615 -- 47,501,918(-) A/G 3_prime_UTR_variant
rs1047621 -- 47,501,913(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP9 Gene

Variant ID Type Subtype PubMed ID
dgv137e199 CNV deletion 23128226
nsv1068309 CNV deletion 25765185
nsv1118173 CNV deletion 24896259
nsv982761 CNV duplication 23825009

Additional Variant Information for AGAP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGAP9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for AGAP9 Gene

Disorders for AGAP9 Gene

Additional Disease Information for AGAP9

No disorders were found for AGAP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP9 Gene

Publications for AGAP9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for AGAP9 Gene

Sources for AGAP9 Gene

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