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Aliases for AGAP5 Gene

Aliases for AGAP5 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5 2 3 5
  • Centaurin, Gamma-Like Family, Member 2 2 3
  • CTGLF2 3 4
  • AGAP-5 3 4
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 5 3
  • Centaurin-Gamma-Like Family Member 2 4

External Ids for AGAP5 Gene

Previous HGNC Symbols for AGAP5 Gene

  • CTGLF2

Previous GeneCards Identifiers for AGAP5 Gene

  • GC10M075108
  • GC10M075435

Summaries for AGAP5 Gene

GeneCards Summary for AGAP5 Gene

AGAP5 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is AGAP6.

UniProtKB/Swiss-Prot for AGAP5 Gene

  • Putative GTPase-activating protein.

Additional gene information for AGAP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP5 Gene

Genomics for AGAP5 Gene

GeneHancer (GH) Regulatory Elements for AGAP5 Gene

Promoters and enhancers for AGAP5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J073741 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 671.5 -45.4 -45446 4.1 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SEC24C AGAP5 ENSG00000279088 GC10M073741 ECD FUT11 ENSG00000272140 GLUD1P3 NDST2 DUSP8P5
GH10J073109 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.1 +587.1 587102 2.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 IRF4 YY1 SLC30A9 NUDT13 ZSWIM8 NDST2 ZSWIM8-AS1 SEC24C DNAJB12 ECD AGAP5 CFAP70 DNAJC9
GH10J073930 Enhancer 1.1 Ensembl ENCODE 36.9 -232.6 -232649 1.2 HDGF PKNOX1 ATF1 ARNT TCF12 POLR2B ARID2 ATF7 CAVIN1 REST GC10P073930 GLUD1P3 ECD ENSG00000272140 AGAP5 DUSP8P5 SEC24C ZSWIM8 KAT6B AP3M1
GH10J073584 Enhancer 1.4 Ensembl ENCODE dbSUPER 26.8 +111.8 111818 2.9 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143 GC10P073587 ENSG00000272140 AGAP5 GLUD1P3 SEC24C NUDT13 DUSP8P5 ZSWIM8 ZSWIM8-AS1 ENSG00000242288
GH10J074417 Enhancer 1.9 VISTA UCNEbase Ensembl ENCODE 16.7 -720.5 -720464 1.4 PKNOX1 FEZF1 ZNF2 YY1 ZNF213 TSHZ1 ZNF610 ZSCAN16 GLIS1 HNF4A AGAP5 GLUD1P3 DUSP8P5 ENSG00000272791 ENSG00000272140 ZSWIM8 KAT6B ENSG00000268584 SEC24C ENSG00000227186
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGAP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGAP5 gene promoter:
  • POU2F1
  • Sox5
  • POU2F1a
  • AML1a
  • FOXJ2 (long isoform)
  • FOXJ2
  • FOXL1
  • Pax-4a
  • HFH-1

Genomic Locations for AGAP5 Gene

Genomic Locations for AGAP5 Gene
23,885 bases
Minus strand
23,607 bases
Minus strand

Genomic View for AGAP5 Gene

Genes around AGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP5 Gene

Proteins for AGAP5 Gene

  • Protein details for AGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • A8MSN5

    Protein attributes for AGAP5 Gene

    686 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    No Data Available
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

neXtProt entry for AGAP5 Gene

Post-translational modifications for AGAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP5 Gene

No data available for DME Specific Peptides for AGAP5 Gene

Domains & Families for AGAP5 Gene

Suggested Antigen Peptide Sequences for AGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the centaurin gamma-like family.
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP5: view

Function for AGAP5 Gene

Molecular function for AGAP5 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Phenotypes From GWAS Catalog for AGAP5 Gene

Gene Ontology (GO) - Molecular Function for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA --
GO:0031267 small GTPase binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP5: view
genes like me logo Genes that share phenotypes with AGAP5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP5 Gene

Localization for AGAP5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP5 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IBA --
GO:0016020 membrane IBA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with AGAP5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for AGAP5 Gene

Pathways & Interactions for AGAP5 Gene

SuperPathways for AGAP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IBA --
GO:0032012 regulation of ARF protein signal transduction IBA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP5: view

No data available for Pathways by source and SIGNOR curated interactions for AGAP5 Gene

Drugs & Compounds for AGAP5 Gene

No Compound Related Data Available

Transcripts for AGAP5 Gene

mRNA/cDNA for AGAP5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGAP5 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP5 Gene

No ASD Table

Relevant External Links for AGAP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGAP5 Gene

Protein differential expression in normal tissues from HIPED for AGAP5 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGAP5 Gene

Protein tissue co-expression partners for AGAP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGAP5 Gene:


SOURCE GeneReport for Unigene cluster for AGAP5 Gene:

genes like me logo Genes that share expression patterns with AGAP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP5 Gene

Orthologs for AGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTGLF2 33
  • 98.34 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
(Gallus gallus)
Aves -- 34
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
-- 34
  • 13 (a)
(Danio rerio)
Actinopterygii agap1 34
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea cnt-2 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for AGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP5 Gene

Gene Tree for AGAP5 (if available)
Gene Tree for AGAP5 (if available)

Paralogs for AGAP5 Gene

(16) SIMAP similar genes for AGAP5 Gene using alignment to 3 proteins:

  • U3KQ60_HUMAN Pseudogenes for AGAP5 Gene

genes like me logo Genes that share paralogs with AGAP5: view

Variants for AGAP5 Gene

Sequence variations from dbSNP and Humsavar for AGAP5 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000104499 -- 73,699,673(-) C/T upstream_transcript_variant
rs1000346048 -- 73,688,047(-) CTAACTA/CTA intron_variant
rs1000570137 -- 73,678,366(-) T/C intron_variant
rs1000581646 -- 73,677,788(-) T/G intron_variant
rs1000837625 -- 73,687,778(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP5 Gene

Variant ID Type Subtype PubMed ID
esv24583 CNV loss 19812545
nsv831912 CNV gain 17160897
nsv8688 CNV loss 18304495
nsv948068 CNV duplication 23825009
nsv971764 CNV duplication 23825009
nsv971766 CNV duplication 23825009
nsv974949 CNV duplication 23825009
nsv975705 CNV duplication 23825009

Variation tolerance for AGAP5 Gene

Gene Damage Index Score: 4.04; 60.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP5 Gene

Disorders for AGAP5 Gene

Additional Disease Information for AGAP5

No disorders were found for AGAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP5 Gene

Publications for AGAP5 Gene

  1. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for AGAP5 Gene

Sources for AGAP5 Gene

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