Aliases for AGAP5 Gene

Aliases for AGAP5 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5 2 3 5
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 5 3 4
  • Centaurin, Gamma-Like Family, Member 2 2 3
  • CTGLF2 3 4
  • AGAP-5 3 4
  • Centaurin-Gamma-Like Family Member 2 4
  • Em:AC073389.1 2
  • AGAP5 5

External Ids for AGAP5 Gene

Previous HGNC Symbols for AGAP5 Gene

  • CTGLF2

Previous GeneCards Identifiers for AGAP5 Gene

  • GC10M075108
  • GC10M075435

Summaries for AGAP5 Gene

GeneCards Summary for AGAP5 Gene

AGAP5 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 5) is a Protein Coding gene. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is AGAP6.

UniProtKB/Swiss-Prot Summary for AGAP5 Gene

Additional gene information for AGAP5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGAP5 Gene

Genomics for AGAP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AGAP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGAP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGAP5

Top Transcription factor binding sites by QIAGEN in the AGAP5 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • HFH-1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • Sox5

Genomic Locations for AGAP5 Gene

Genomic Locations for AGAP5 Gene
chr10:73,674,275-73,701,328
(GRCh38/hg38)
Size:
27,054 bases
Orientation:
Minus strand
chr10:75,434,033-75,457,639
(GRCh37/hg19)
Size:
23,607 bases
Orientation:
Minus strand

Genomic View for AGAP5 Gene

Genes around AGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP5 Gene

Proteins for AGAP5 Gene

  • Protein details for AGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIR3-AGAP5_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
    Protein Accession:
    A6NIR3
    Secondary Accessions:
    • A8MSN5

    Protein attributes for AGAP5 Gene

    Size:
    686 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

neXtProt entry for AGAP5 Gene

Post-translational modifications for AGAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP5 Gene

No data available for DME Specific Peptides for AGAP5 Gene

Domains & Families for AGAP5 Gene

Gene Families for AGAP5 Gene

Suggested Antigen Peptide Sequences for AGAP5 Gene

GenScript: Design optimal peptide antigens:
  • Centaurin-gamma-like family member 2 (AGAP5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NIR3

UniProtKB/Swiss-Prot:

AGAP5_HUMAN :
  • Belongs to the centaurin gamma-like family.
Family:
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP5: view

Function for AGAP5 Gene

Molecular function for AGAP5 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Phenotypes From GWAS Catalog for AGAP5 Gene

Gene Ontology (GO) - Molecular Function for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP5: view
genes like me logo Genes that share phenotypes with AGAP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGAP5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP5 Gene

Localization for AGAP5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP5 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with AGAP5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for AGAP5 Gene

Pathways & Interactions for AGAP5 Gene

PathCards logo

SuperPathways for AGAP5 Gene

SuperPathway Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with AGAP5: view

Pathways by source for AGAP5 Gene

1 KEGG pathway for AGAP5 Gene

Gene Ontology (GO) - Biological Process for AGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP5: view

No data available for SIGNOR curated interactions for AGAP5 Gene

Drugs & Compounds for AGAP5 Gene

No Compound Related Data Available

Transcripts for AGAP5 Gene

mRNA/cDNA for AGAP5 Gene

1 REFSEQ mRNAs :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGAP5

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP5 Gene

No ASD Table

Relevant External Links for AGAP5 Gene

GeneLoc Exon Structure for
AGAP5

Expression for AGAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGAP5 Gene

Protein differential expression in normal tissues from HIPED for AGAP5 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGAP5 Gene



Protein tissue co-expression partners for AGAP5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGAP5

SOURCE GeneReport for Unigene cluster for AGAP5 Gene:

Hs.651147
genes like me logo Genes that share expression patterns with AGAP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP5 Gene

Orthologs for AGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CTGLF2 30
  • 98.34 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 46 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 58 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 63 (a)
ManyToMany
-- 31
  • 13 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii agap1 31
  • 48 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta cenG1A 31
  • 26 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cnt-2 31
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for AGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for AGAP5 Gene

ENSEMBL:
Gene Tree for AGAP5 (if available)
TreeFam:
Gene Tree for AGAP5 (if available)

Paralogs for AGAP5 Gene

(16) SIMAP similar genes for AGAP5 Gene using alignment to 3 proteins:

  • AGAP5_HUMAN
  • J3KQL4_HUMAN
  • U3KQ60_HUMAN

Pseudogenes.org Pseudogenes for AGAP5 Gene

genes like me logo Genes that share paralogs with AGAP5: view

Variants for AGAP5 Gene

Additional dbSNP identifiers (rs#s) for AGAP5 Gene

Structural Variations from Database of Genomic Variants (DGV) for AGAP5 Gene

Variant ID Type Subtype PubMed ID
esv24583 CNV loss 19812545
nsv831912 CNV gain 17160897
nsv8688 CNV loss 18304495
nsv948068 CNV duplication 23825009
nsv971764 CNV duplication 23825009
nsv971766 CNV duplication 23825009
nsv974949 CNV duplication 23825009
nsv975705 CNV duplication 23825009

Variation tolerance for AGAP5 Gene

Gene Damage Index Score: 4.04; 60.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGAP5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGAP5 Gene

Disorders for AGAP5 Gene

No disorders were found for AGAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP5 Gene

Publications for AGAP5 Gene

  1. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. (PMID: 30652415) Liu Y … Chen L (Cancer medicine 2019) 3
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for AGAP5 Gene

Sources for AGAP5 Gene