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Aliases for AGAP4 Gene

Aliases for AGAP4 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 4 2 3 5
  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 8 2 3
  • Centaurin, Gamma-Like Family, Member 1 2 3
  • Centaurin, Gamma-Like Family, Member 5 2 3
  • CTGLF1 3 4
  • CTGLF5 3 4
  • AGAP-4 3 4
  • AGAP8 3 4
  • MRIP2 3 4
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 4 3
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 8 3
  • Centaurin-Gamma-Like Family Member 1 4
  • Centaurin-Gamma-Like Family Member 5 4
  • ARF GTPase-Activating Protein 3
  • AGAP-8 3

External Ids for AGAP4 Gene

Previous HGNC Symbols for AGAP4 Gene

  • CTGLF1
  • AGAP8
  • CTGLF5

Previous GeneCards Identifiers for AGAP4 Gene

  • GC10M045643
  • GC10M046322
  • GC10M045375

Summaries for AGAP4 Gene

GeneCards Summary for AGAP4 Gene

AGAP4 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is AGAP6.

UniProtKB/Swiss-Prot for AGAP4 Gene

  • Putative GTPase-activating protein.

Additional gene information for AGAP4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGAP4 Gene

Genomics for AGAP4 Gene

GeneHancer (GH) Regulatory Elements for AGAP4 Gene

Promoters and enhancers for AGAP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J045971 Promoter/Enhancer 1.3 EPDnew Ensembl dbSUPER 650.1 -118.6 -118624 2.2 E4F1 PARGP1 TIMM23 AGAP4 SNORA74C-1
GH10J046522 Enhancer 1.3 Ensembl ENCODE 183.3 -670.8 -670821 3.6 HDGF ARNT SIN3A YBX1 ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 FOS PARGP1 AGAP4 BMS1P1 AGAP9 WASHC2C LOC105378289 AGAP10P FAM21FP ZFAND4 FAM35BP
GH10J046017 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 52.8 -168.0 -167959 8.4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 NCOA4 AGAP4 AGAP7P MSMB PARGP1 LOC105378289 ZFAND4 GC10M046012 PIR52076
GH10J046028 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 48.9 -176.5 -176535 4.8 CLOCK ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 PPARGC1A MEF2D SSRP1 LOC105378287 NCOA4 MARCH8 AGAP4 AGAP7P FAM21FP PARGP1 AGAP10P WASHC2C ZFAND4
GH10J045726 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 26.8 +126.5 126491 1.6 CLOCK MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 WASHC2C ENSG00000228702 FAM21FP PARGP1 AGAP4 LOC105378289 ZFAND4 ENSG00000273363 AGAP10P DEPP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AGAP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGAP4 gene promoter:
  • AML1a
  • FOXJ2 (long isoform)
  • FOXJ2
  • FOXL1
  • Pax-4a
  • HFH-1
  • Tal-1beta
  • ITF-2

Genomic Locations for AGAP4 Gene

Genomic Locations for AGAP4 Gene
28,286 bases
Minus strand
28,282 bases
Minus strand

Genomic View for AGAP4 Gene

Genes around AGAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP4 Gene

Proteins for AGAP4 Gene

  • Protein details for AGAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
    Protein Accession:

    Protein attributes for AGAP4 Gene

    663 amino acids
    Molecular mass:
    73070 Da
    Quaternary structure:
    No Data Available
    • Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

neXtProt entry for AGAP4 Gene

Post-translational modifications for AGAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP4 Gene

No data available for DME Specific Peptides for AGAP4 Gene

Domains & Families for AGAP4 Gene

Suggested Antigen Peptide Sequences for AGAP4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the centaurin gamma-like family.
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP4: view

Function for AGAP4 Gene

Molecular function for AGAP4 Gene

UniProtKB/Swiss-Prot Function:
Putative GTPase-activating protein.

Phenotypes From GWAS Catalog for AGAP4 Gene

Gene Ontology (GO) - Molecular Function for AGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA --
GO:0031267 small GTPase binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGAP4: view
genes like me logo Genes that share phenotypes with AGAP4: view

Animal Model Products

CRISPR Products

miRNA for AGAP4 Gene

miRTarBase miRNAs that target AGAP4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGAP4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGAP4 Gene

Localization for AGAP4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP4 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IBA --
GO:0016020 membrane IBA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with AGAP4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for AGAP4 Gene

Pathways & Interactions for AGAP4 Gene

SuperPathways for AGAP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IBA --
GO:0032012 regulation of ARF protein signal transduction IBA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with AGAP4: view

No data available for Pathways by source and SIGNOR curated interactions for AGAP4 Gene

Drugs & Compounds for AGAP4 Gene

No Compound Related Data Available

Transcripts for AGAP4 Gene

Unigene Clusters for AGAP4 Gene

ArfGAP with GTPase domain, ankyrin repeat and PH domain 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGAP4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP4 Gene

No ASD Table

Relevant External Links for AGAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGAP4 Gene

Protein differential expression in normal tissues from HIPED for AGAP4 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGAP4 Gene

Protein tissue co-expression partners for AGAP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGAP4 Gene:


SOURCE GeneReport for Unigene cluster for AGAP4 Gene:


Evidence on tissue expression from TISSUES for AGAP4 Gene

  • Liver(2.5)
  • Nervous system(2.4)
  • Intestine(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with AGAP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP4 Gene

Orthologs for AGAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTGLF2 33
  • 98.18 (n)
-- 34
  • 92 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
(Gallus gallus)
Aves -- 34
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
-- 34
  • 10 (a)
(Danio rerio)
Actinopterygii agap1 34
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta cenG1A 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea cnt-2 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for AGAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AGAP4 Gene

Gene Tree for AGAP4 (if available)
Gene Tree for AGAP4 (if available)

Paralogs for AGAP4 Gene

(19) SIMAP similar genes for AGAP4 Gene using alignment to 3 proteins:

  • K7ER91_HUMAN
  • Q86XV2_HUMAN Pseudogenes for AGAP4 Gene

genes like me logo Genes that share paralogs with AGAP4: view

Variants for AGAP4 Gene

Sequence variations from dbSNP and Humsavar for AGAP4 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1045725 -- 45,853,613(-) G/C genic_upstream_transcript_variant, intron_variant
rs1057791 -- 45,855,951(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant
rs10666313 -- 45,857,168(-) C/CCC 5_prime_UTR_variant, genic_upstream_transcript_variant
rs111351178 -- 45,830,503(-) T/G intron_variant
rs11239607 -- 45,825,275(-) G/A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for AGAP4 Gene

Variant ID Type Subtype PubMed ID
nsv1118165 CNV deletion 24896259
nsv8630 CNV loss 18304495
nsv947917 CNV duplication 23825009
nsv971743 CNV duplication 23825009
nsv974928 CNV duplication 23825009
nsv974930 CNV duplication 23825009
nsv975686 CNV duplication 23825009
nsv982752 CNV duplication 23825009

Variation tolerance for AGAP4 Gene

Gene Damage Index Score: 1.98; 36.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGAP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP4 Gene

Disorders for AGAP4 Gene

Additional Disease Information for AGAP4

No disorders were found for AGAP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGAP4 Gene

Publications for AGAP4 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 58
  5. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 3 58

Products for AGAP4 Gene

Sources for AGAP4 Gene

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