Aliases for AGAP2-AS1 Gene

Subcategory (RNA class) for AGAP2-AS1 Gene

lncRNA

Number of RNA Genes sources:

1 / 17

Aliases for AGAP2-AS1 Gene

  • AGAP2 Antisense RNA 1 2 3 5
  • AGAP2-AS1 2 5
  • PUNISHER 2 3
  • HSALNG0091650 164
  • LOC100130776 2

External Ids for AGAP2-AS1 Gene

Previous GeneCards Identifiers for AGAP2-AS1 Gene

  • GC12P058122
  • GC12P058123

Summaries for AGAP2-AS1 Gene

GeneCards Summary for AGAP2-AS1 Gene

AGAP2-AS1 (AGAP2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AGAP2-AS1 include Malignant Glioma and Glioma Susceptibility 1.

Additional gene information for AGAP2-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGAP2-AS1 Gene

Genomics for AGAP2-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AGAP2-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGAP2-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for AGAP2-AS1 Gene

Genomic Locations for AGAP2-AS1 Gene
chr12:57,726,239-57,728,356
(GRCh38/hg38)
Size:
2,118 bases
Orientation:
Plus strand
chr12:58,120,023-58,122,139
(GRCh37/hg19)
Size:
2,117 bases
Orientation:
Plus strand

Genomic View for AGAP2-AS1 Gene

Genes around AGAP2-AS1 on UCSC Golden Path with GeneCards custom track
AGAP2-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
AGAP2-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP2-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP2-AS1 Gene

Proteins for AGAP2-AS1 Gene

Post-translational modifications for AGAP2-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for AGAP2-AS1 Gene

Domains & Families for AGAP2-AS1 Gene

Gene Families for AGAP2-AS1 Gene

genes like me logo Genes that share domains with AGAP2-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AGAP2-AS1 Gene

Function for AGAP2-AS1 Gene

Phenotypes From GWAS Catalog for AGAP2-AS1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP2-AS1 Gene

Localization for AGAP2-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP2-AS1 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AGAP2-AS1 Gene

Pathways & Interactions for AGAP2-AS1 Gene

PathCards logo

SuperPathways for AGAP2-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGAP2-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for AGAP2-AS1 Gene

Drugs & Compounds for AGAP2-AS1 Gene

No Compound Related Data Available

Transcripts for AGAP2-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for AGAP2-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E9B8_9606 lncRNA 1531 2

HGNC: 48633,

RefSeq: NR_027032,

URS000075FFE7_9606 lncRNA 1500 1

Ensembl: ENST00000542466 (view in UCSC) ,

URS0000EBBA69_9606 lncRNA 1533 1

LncBook: HSALNT0289464,

AGAP2-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for AGAP2-AS1 Gene

5 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2-AS1 Gene

No ASD Table

Relevant External Links for AGAP2-AS1 Gene

GeneLoc Exon Structure for
AGAP2-AS1

Expression for AGAP2-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGAP2-AS1

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP2-AS1 Gene

Orthologs for AGAP2-AS1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for AGAP2-AS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AGAP2-AS1 31
  • 100 (a)
OneToOne
Species where no ortholog for AGAP2-AS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for AGAP2-AS1 Gene

ENSEMBL:
Gene Tree for AGAP2-AS1 (if available)
TreeFam:
Gene Tree for AGAP2-AS1 (if available)

Paralogs for AGAP2-AS1 Gene

No data available for Paralogs for AGAP2-AS1 Gene

Variants for AGAP2-AS1 Gene

Additional dbSNP identifiers (rs#s) for AGAP2-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AGAP2-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv559045 CNV loss 21841781
nsv826383 CNV gain 20364138

Variation tolerance for AGAP2-AS1 Gene

Gene Damage Index Score: 0.48; 10.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGAP2-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGAP2-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGAP2-AS1 Gene

Disorders for AGAP2-AS1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for AGAP2-AS1 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
malignant glioma
  • glial cell tumor
glioma susceptibility 1
  • glm1
lung cancer
  • adenocarcinoma of lung
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with AGAP2-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGAP2-AS1 Gene

Publications for AGAP2-AS1 Gene

  1. Long non-coding RNA AGAP2-AS1 exerts oncogenic properties in glioblastoma by epigenetically silencing TFPI2 through EZH2 and LSD1. (PMID: 31186379) Luo W … Zhao S (Aging 2019) 2 3
  2. Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells. (PMID: 27195672) Li W … Shu Y (Cell death & disease 2016) 2 3
  3. Co-expression Network Analysis of Human lncRNAs and Cancer Genes. (PMID: 25392693) Cogill SB … Wang L (Cancer informatics 2014) 2 3
  4. RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4. (PMID: 30814490) Hui B … Zhou Y (Cell death & disease 2019) 3
  5. Increased Expression of Exosomal AGAP2-AS1 (AGAP2 Antisense RNA 1) In Breast Cancer Cells Inhibits Trastuzumab-Induced Cell Cytotoxicity. (PMID: 30910994) Zheng Z … Xie B (Medical science monitor : international medical journal of experimental and clinical research 2019) 3

Products for AGAP2-AS1 Gene

Sources for AGAP2-AS1 Gene