Aliases for AGAP2-AS1 Gene

Subcategory (RNA class) for AGAP2-AS1 Gene

lncRNA

Number of RNA Genes sources:

1 / 14

Aliases for AGAP2-AS1 Gene

  • AGAP2 Antisense RNA 1 2 3 5
  • HSALNG0091650 167
  • AGAP2-AS1 2
  • PUNISHER 3

External Ids for AGAP2-AS1 Gene

Previous GeneCards Identifiers for AGAP2-AS1 Gene

  • GC12P058122
  • GC12P058123

Summaries for AGAP2-AS1 Gene

GeneCards Summary for AGAP2-AS1 Gene

AGAP2-AS1 (AGAP2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AGAP2-AS1 include Malignant Glioma and Lung Cancer.

Additional gene information for AGAP2-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGAP2-AS1 Gene

Genomics for AGAP2-AS1 Gene

GeneHancer (GH) Regulatory Elements for AGAP2-AS1 Gene

Promoters and enhancers for AGAP2-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057725 Promoter/Enhancer 1.3 Ensembl ENCODE 500.7 +0.2 206 2.5 ZNF217 CTCF USF1 PHF8 ZIC2 REST ZBTB10 POLR2A CLOCK ZNF423 AGAP2-AS1 lnc-AGAP2-1 ZBTB39 NAB2 PRIM1 NEMP1 ENSG00000224713 ATP23 TSPAN31 AGAP2
GH12J057727 Enhancer 0.6 ENCODE 500.7 +1.6 1574 0.2 REST SAP30 MIER1 YY1 EHMT2 SIN3A PCBP1 MIER2 ZNF143 EZH2 AGAP2-AS1 AGAP2 TSPAN31 RF00017-1166
GH12J057109 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 21.2 -614.9 -614938 4.2 EP300 FOXK2 ZNF217 CTCF TCF12 SIN3A POLR2G ZNF300 USF1 NCOR1 STAT6 lnc-LRP1-4 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A SMARCC2 CDK4 PAN2 ANKRD52
GH12J057085 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -634.2 -634172 14.1 HNRNPK ZBTB40 ZNF217 CTCF SIN3A TCF12 NRF1 POLR2G USF1 SP1 NAB2 lnc-LRP1-1 NEMP1 BAZ2A SMARCC2 AGAP2-AS1 PRIM1 PAN2 EEF1AKMT3 ENSG00000258317
GH12J057487 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -237.6 -237591 2.9 ZBTB40 ZNF217 CTCF SIN3A MYC POLR2G GTF2E2 PHF8 SIX5 PHB2 ARHGAP9 HSALNG0091627 NEMP1 BAZ2A RN7SL809P EEF1AKMT3 CDK4 CTDSP2 MBD6 NAB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGAP2-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AGAP2-AS1 Gene

Genomic Locations for AGAP2-AS1 Gene
chr12:57,726,239-57,728,356
(GRCh38/hg38)
Size:
2,118 bases
Orientation:
Plus strand
chr12:58,120,023-58,122,139
(GRCh37/hg19)
Size:
2,117 bases
Orientation:
Plus strand

Genomic View for AGAP2-AS1 Gene

Genes around AGAP2-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP2-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP2-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP2-AS1 Gene

Proteins for AGAP2-AS1 Gene

Post-translational modifications for AGAP2-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for AGAP2-AS1 Gene

Domains & Families for AGAP2-AS1 Gene

Gene Families for AGAP2-AS1 Gene

genes like me logo Genes that share domains with AGAP2-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AGAP2-AS1 Gene

Function for AGAP2-AS1 Gene

Phenotypes From GWAS Catalog for AGAP2-AS1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP2-AS1 Gene

Localization for AGAP2-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP2-AS1 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AGAP2-AS1 Gene

Pathways & Interactions for AGAP2-AS1 Gene

PathCards logo

SuperPathways for AGAP2-AS1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for AGAP2-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for AGAP2-AS1 Gene

Drugs & Compounds for AGAP2-AS1 Gene

No Compound Related Data Available

Transcripts for AGAP2-AS1 Gene

mRNA/cDNA for AGAP2-AS1 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
1 LncBook transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2-AS1 Gene

No ASD Table

Relevant External Links for AGAP2-AS1 Gene

GeneLoc Exon Structure for
AGAP2-AS1

Expression for AGAP2-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGAP2-AS1

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP2-AS1 Gene

Orthologs for AGAP2-AS1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for AGAP2-AS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGAP2-AS1 31
  • 100 (a)
OneToOne
Species where no ortholog for AGAP2-AS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AGAP2-AS1 Gene

ENSEMBL:
Gene Tree for AGAP2-AS1 (if available)
TreeFam:
Gene Tree for AGAP2-AS1 (if available)

Paralogs for AGAP2-AS1 Gene

No data available for Paralogs for AGAP2-AS1 Gene

Variants for AGAP2-AS1 Gene

Additional dbSNP identifiers (rs#s) for AGAP2-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AGAP2-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv559045 CNV loss 21841781
nsv826383 CNV gain 20364138

Variation tolerance for AGAP2-AS1 Gene

Gene Damage Index Score: 0.48; 10.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGAP2-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGAP2-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGAP2-AS1 Gene

Disorders for AGAP2-AS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for AGAP2-AS1 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
malignant glioma
  • glial cell tumor
lung cancer
  • adenocarcinoma of lung
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AGAP2-AS1

genes like me logo Genes that share disorders with AGAP2-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGAP2-AS1 Gene

Publications for AGAP2-AS1 Gene

  1. Long non-coding RNA AGAP2-AS1 exerts oncogenic properties in glioblastoma by epigenetically silencing TFPI2 through EZH2 and LSD1. (PMID: 31186379) Luo W … Zhao S (Aging 2019) 2 3 54
  2. Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells. (PMID: 27195672) Li W … Shu Y (Cell death & disease 2016) 2 3 54
  3. Co-expression Network Analysis of Human lncRNAs and Cancer Genes. (PMID: 25392693) Cogill SB … Wang L (Cancer informatics 2014) 2 3 54
  4. The Long Non-Coding RNA (lncRNA) AGAP2-AS1 is Upregulated in Ovarian Carcinoma and Negatively Regulates lncRNA MEG3. (PMID: 31233485) Chen J … Dai Y (Medical science monitor : international medical journal of experimental and clinical research 2019) 3 54
  5. Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma. (PMID: 31088485) Liu Z … Liu Q (Journal of experimental & clinical cancer research : CR 2019) 3 54

Products for AGAP2-AS1 Gene

Sources for AGAP2-AS1 Gene