The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq... See more...

Aliases for AGAP2 Gene

Aliases for AGAP2 Gene

  • ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2 2 3 5
  • Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 2 3 4
  • Phosphatidylinositol 3-Kinase Enhancer 3 4
  • Centaurin, Gamma 1 2 3
  • Cnt-G1 3 4
  • CENTG1 3 4
  • GGAP2 3 4
  • PIKE 3 4
  • Arf GAP With GTP-Binding Protein-Like, ANK Repeat And PH Domains 2 3
  • GTP-Binding And GTPase Activating Protein 2 3
  • GTP-Binding And GTPase-Activating Protein 2 4
  • Phosphoinositide 3-Kinase Enhancer 3
  • Centaurin-Gamma-1 4
  • KIAA0167 4
  • AGAP-2 4

External Ids for AGAP2 Gene

Previous HGNC Symbols for AGAP2 Gene

  • CENTG1

Previous GeneCards Identifiers for AGAP2 Gene

  • GC12M056406
  • GC12M058118
  • GC12M055156

Summaries for AGAP2 Gene

Entrez Gene Summary for AGAP2 Gene

  • The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for AGAP2 Gene

AGAP2 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Diseases associated with AGAP2 include Diphyllobothriasis and Capillariasis. Among its related pathways are Netrin-1 signaling and Endocytosis. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is AGAP1.

UniProtKB/Swiss-Prot Summary for AGAP2 Gene

  • GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Gene Wiki entry for AGAP2 Gene

Additional gene information for AGAP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AGAP2 Gene

Genomics for AGAP2 Gene

GeneHancer (GH) Regulatory Elements for AGAP2 Gene

Promoters and enhancers for AGAP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGAP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AGAP2

Top Transcription factor binding sites by QIAGEN in the AGAP2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for AGAP2 Gene

Genomic Locations for AGAP2 Gene
chr12:57,723,761-57,742,201
(GRCh38/hg38)
Size:
18,441 bases
Orientation:
Minus strand
chr12:58,118,980-58,135,940
(GRCh37/hg19)
Size:
16,961 bases
Orientation:
Minus strand

Genomic View for AGAP2 Gene

Genes around AGAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGAP2 Gene

Proteins for AGAP2 Gene

  • Protein details for AGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99490-AGAP2_HUMAN
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q99490
    Secondary Accessions:
    • A8K9F7
    • O00578
    • Q548E0
    • Q8IWU3

    Protein attributes for AGAP2 Gene

    Size:
    1192 amino acids
    Molecular mass:
    124674 Da
    Quaternary structure:
    • Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex.
    SequenceCaution:
    • Sequence=BAA11484.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AGAP2 Gene

    Alternative splice isoforms for AGAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGAP2 Gene

Post-translational modifications for AGAP2 Gene

  • Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGAP2 Gene

Antibody Products

  • Boster Bio Antibodies for AGAP2
  • Santa Cruz Biotechnology (SCBT) Antibodies for AGAP2

No data available for DME Specific Peptides for AGAP2 Gene

Domains & Families for AGAP2 Gene

Gene Families for AGAP2 Gene

Protein Domains for AGAP2 Gene

Blocks:
  • Ankyrin repeat signature
  • Pleckstrin-like
  • HIV Rev interacting protein signature
  • Miro-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGAP2 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidylinositol-3-kinase enhancer (AGAP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99490

UniProtKB/Swiss-Prot:

AGAP2_HUMAN :
  • G domain binds GTP and has GTPase activity.
  • Belongs to the centaurin gamma-like family.
Domain:
  • G domain binds GTP and has GTPase activity.
  • Arf-GAP domain interacts with G domain and may regulate its GTPase activity.
  • Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1.
Family:
  • Belongs to the centaurin gamma-like family.
genes like me logo Genes that share domains with AGAP2: view

Function for AGAP2 Gene

Molecular function for AGAP2 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation.

Phenotypes From GWAS Catalog for AGAP2 Gene

Gene Ontology (GO) - Molecular Function for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,TAS 18374643
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA,IPI 21720388
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with AGAP2: view
genes like me logo Genes that share phenotypes with AGAP2: view

Animal Models for AGAP2 Gene

MGI Knock Outs for AGAP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGAP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AGAP2 Gene

Localization for AGAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGAP2 Gene

[Isoform 1]: Cytoplasm. Nucleus.
[Isoform 2]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGAP2 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Midbody ring (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 18374643
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm TAS,IEA 18374643
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with AGAP2: view

Pathways & Interactions for AGAP2 Gene

PathCards logo

SuperPathways for AGAP2 Gene

genes like me logo Genes that share pathways with AGAP2: view

Pathways by source for AGAP2 Gene

2 KEGG pathways for AGAP2 Gene
1 GeneGo (Thomson Reuters) pathway for AGAP2 Gene
  • Apoptosis and survival NGF signaling pathway

SIGNOR curated interactions for AGAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA --
GO:0015031 protein transport IEA --
GO:0032147 activation of protein kinase activity IEA --
GO:0033601 positive regulation of mammary gland epithelial cell proliferation IEA --
GO:0042177 negative regulation of protein catabolic process IDA 18374643
genes like me logo Genes that share ontologies with AGAP2: view

Drugs & Compounds for AGAP2 Gene

(1) Drugs for AGAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(12) Additional Compounds for AGAP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
PA(16:0/18:1(9Z))
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
PA(16:0/18:2(9Z,12Z))
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with AGAP2: view

Transcripts for AGAP2 Gene

mRNA/cDNA for AGAP2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AGAP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGAP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3: - - -

Relevant External Links for AGAP2 Gene

GeneLoc Exon Structure for
AGAP2

Expression for AGAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGAP2 Gene

This gene is overexpressed in Brain - Cortex (x5.7), Brain - Cerebellum (x5.4), Brain - Nucleus accumbens (basal ganglia) (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.7), Brain - Hippocampus (x4.6), Brain - Cerebellar Hemisphere (x4.6), Brain - Amygdala (x4.3), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for AGAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.8), Stomach (11.1), and Brain (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AGAP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AGAP2

SOURCE GeneReport for Unigene cluster for AGAP2 Gene:

Hs.302435

mRNA Expression by UniProt/SwissProt for AGAP2 Gene:

Q99490-AGAP2_HUMAN
Tissue specificity: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.

Evidence on tissue expression from TISSUES for AGAP2 Gene

  • Blood(4.1)
  • Bone marrow(4.1)
  • Heart(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with AGAP2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGAP2 Gene

Orthologs for AGAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGAP2 31 30
  • 98.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AGAP2 31 30
  • 92.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AGAP2 31
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agap2 17 31 30
  • 88.81 (n)
rat
(Rattus norvegicus)
Mammalia Agap2 30
  • 88.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AGAP2 31
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGAP2 31
  • 14 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 15 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia AGAP2 31
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496997 30
  • 61.38 (n)
zebrafish
(Danio rerio)
Actinopterygii agap2 31 30
  • 60.14 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Asap1 31
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5006 31
  • 15 (a)
OneToMany
Species where no ortholog for AGAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGAP2 Gene

ENSEMBL:
Gene Tree for AGAP2 (if available)
TreeFam:
Gene Tree for AGAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AGAP2: view image

Paralogs for AGAP2 Gene

(17) SIMAP similar genes for AGAP2 Gene using alignment to 4 proteins:

  • AGAP2_HUMAN
  • F8VVT9_HUMAN
  • H0YHB1_HUMAN
  • J3KNM6_HUMAN
genes like me logo Genes that share paralogs with AGAP2: view

Variants for AGAP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AGAP2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
VAR_026438 A glioblastoma cell line p.Val455Ala
VAR_026439 A sarcoma cell line p.Arg518Gly
VAR_026441 A glioblastoma cell line p.Ala651Val
VAR_026442 A glioblastoma cell line p.Glu767Val
VAR_026443 A glioblastoma cell line p.Asn939Asp

Additional dbSNP identifiers (rs#s) for AGAP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for AGAP2 Gene

Variant ID Type Subtype PubMed ID
nsv1071036 CNV deletion 25765185
nsv1143566 CNV deletion 24896259
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559045 CNV loss 21841781
nsv826383 CNV gain 20364138
nsv826384 CNV gain 20364138
nsv826385 CNV gain 20364138
nsv826386 CNV gain 20364138

Variation tolerance for AGAP2 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGAP2 Gene

Human Gene Mutation Database (HGMD)
AGAP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGAP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGAP2 Gene

Disorders for AGAP2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for AGAP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diphyllobothriasis
  • diphyllobothrium infection
capillariasis
  • capillaria infection
spinal canal intradural extramedullary neoplasm
  • intradural extramedullary spinal tumors
fragile x syndrome
  • fxs
anisakiasis
  • infection by anisakis larva
- elite association - COSMIC cancer census association via MalaCards
Search AGAP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AGAP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AGAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGAP2 Gene

Publications for AGAP2 Gene

  1. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. (PMID: 16079295) Nie Z … Randazzo PA (Journal of cell science 2005) 2 3 4 23 54
  2. The centaurin gamma-1 GTPase-like domain functions as an NTPase. (PMID: 17037982) Soundararajan M … Doyle DA (The Biochemical journal 2007) 3 4 23 54
  3. Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. (PMID: 16150119) Knobbe CB … Reifenberger G (Neuropathology and applied neurobiology 2005) 3 4 23 54
  4. PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PMID: 14761976) Ahn JY … Ye K (The Journal of biological chemistry 2004) 3 4 23 54
  5. Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling. (PMID: 19318351) Zhu Y … Nie Z (The Journal of biological chemistry 2009) 3 23 54

Products for AGAP2 Gene

Sources for AGAP2 Gene