Aliases for AGAP1 Gene
External Ids for AGAP1 Gene
Previous HGNC Symbols for AGAP1 Gene
Previous GeneCards Identifiers for AGAP1 Gene
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for AGAP1 Gene
AGAP1 (ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1) is a Protein Coding gene. Diseases associated with AGAP1 include Col4a1-Related Familial Vascular Leukoencephalopathy and Chromosome 1P36 Deletion Syndrome. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include GTP binding and phospholipid binding. An important paralog of this gene is AGAP3.
UniProtKB/Swiss-Prot Summary for AGAP1 Gene
GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.