Aliases for AFMID Gene
External Ids for AFMID Gene
Previous GeneCards Identifiers for AFMID Gene
GeneCards Summary for AFMID Gene
AFMID (Arylformamidase) is a Protein Coding gene. Diseases associated with AFMID include Hypertryptophanemia and Glaucomatocyclitic Crisis. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include hydrolase activity and arylformamidase activity. An important paralog of this gene is AADACL2.
UniProtKB/Swiss-Prot Summary for AFMID Gene
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.