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Aliases for AFG3L2 Gene

Aliases for AFG3L2 Gene

  • AFG3 Like Matrix AAA Peptidase Subunit 2 2 3 5
  • Paraplegin-Like Protein 3 4
  • AFG3 Like AAA ATPase 2 2 3
  • AFG3 ATPase Family Member 3-Like 2 (S. Cerevisiae) 2
  • AFG3 (ATPase Family Gene 3, Yeast)-Like 2 2
  • AFG3 ATPase Family Member 3-Like 2 3
  • AFG3 ATPase Family Gene 3-Like 2 3
  • ATPase Family Gene 3, Yeast 3
  • Spinocerebellar Ataxia 28 2
  • AFG3-Like Protein 2 3
  • EC 3.4.24.- 4
  • SPAX5 3
  • SCA28 3

External Ids for AFG3L2 Gene

Previous HGNC Symbols for AFG3L2 Gene

  • SCA28

Previous GeneCards Identifiers for AFG3L2 Gene

  • GC18P012541
  • GC18M012385
  • GC18M012319
  • GC18M012282

Summaries for AFG3L2 Gene

Entrez Gene Summary for AFG3L2 Gene

  • This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for AFG3L2 Gene

AFG3L2 (AFG3 Like Matrix AAA Peptidase Subunit 2) is a Protein Coding gene. Diseases associated with AFG3L2 include Spinocerebellar Ataxia 28 and Spastic Ataxia 5, Autosomal Recessive. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and unfolded protein binding. An important paralog of this gene is SPG7.

UniProtKB/Swiss-Prot for AFG3L2 Gene

  • ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form (By similarity).

Gene Wiki entry for AFG3L2 Gene

Additional gene information for AFG3L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AFG3L2 Gene

Genomics for AFG3L2 Gene

GeneHancer (GH) Regulatory Elements for AFG3L2 Gene

Promoters and enhancers for AFG3L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J012375 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.5 476 3.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 FOS AFG3L2 ENSG00000267199 TUBB6 CEP192 PRELID3A ENSG00000267108
GH18J012306 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 +68.7 68658 5.2 SMAD1 ATF1 SIN3A DMAP1 ZBTB7B IRF4 ZNF48 ZNF766 GLIS2 ZNF143 TUBB6 PRELID3A CEP192 PTPN2 MPPE1 AFG3L2 PSMG2 RNU7-129P CHMP1B
GH18J012419 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.9 -43.4 -43356 2.2 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 ZNF207 ATF7 PRELID3A SPIRE1 AFG3L2 CEP192 ENSG00000267199 PSMG2 PTPN2 CEP76 GC18P012639
GH18J012605 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -230.1 -230092 3.3 ELF3 PKNOX1 FOXA2 ZSCAN4 RAD21 RFX5 ZNF366 FOS ATF7 ZNF362 SPIRE1 PSMG2 PRELID3A ENSG00000267199 CEP192 RNU7-129P ENSG00000266969 AFG3L2 CEP76 PTPN2
GH18J012313 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +61.4 61350 5.8 SCRT1 SRF RFX1 MAFG EBF1 MEF2B ZIC2 NR2F2 ZNF121 ZNF316 TUBB6 AFG3L2 RNU7-129P PRELID3A IMPA2 CHMP1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AFG3L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AFG3L2 gene promoter:

Genomic Locations for AFG3L2 Gene

Genomic Locations for AFG3L2 Gene
chr18:12,328,944-12,377,314
(GRCh38/hg38)
Size:
48,371 bases
Orientation:
Minus strand
chr18:12,328,943-12,377,313
(GRCh37/hg19)

Genomic View for AFG3L2 Gene

Genes around AFG3L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AFG3L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AFG3L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFG3L2 Gene

Proteins for AFG3L2 Gene

  • Protein details for AFG3L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4W6-AFG32_HUMAN
    Recommended name:
    AFG3-like protein 2
    Protein Accession:
    Q9Y4W6
    Secondary Accessions:
    • Q6P1L0

    Protein attributes for AFG3L2 Gene

    Size:
    797 amino acids
    Molecular mass:
    88584 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homooligomer. Forms heterooligomers with SPG7 and AFG3L1 (PubMed:17101804). Interacts with SPG7; the interaction is required for the efficient assembly of mitochondrial complex I (PubMed:14623864, PubMed:26387735). Interacts with AFG3L1 (By similarity). Interacts with MAIP1 (PubMed:27499296, PubMed:27642048).

    Three dimensional structures from OCA and Proteopedia for AFG3L2 Gene

neXtProt entry for AFG3L2 Gene

Post-translational modifications for AFG3L2 Gene

  • Upon import into the mitochondrion, the N-terminal transit peptide is cleaved to generate an intermediate form which undergoes autocatalytic proteolytic processing to generate the proteolytically active mature form.
  • Ubiquitination at posLast=611611, Lys481, posLast=342342, Lys182, and posLast=173173
  • Modification sites at PhosphoSitePlus

Other Protein References for AFG3L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AFG3L2 Gene

Domains & Families for AFG3L2 Gene

Gene Families for AFG3L2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for AFG3L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4W6

UniProtKB/Swiss-Prot:

AFG32_HUMAN :
  • In the N-terminal section; belongs to the AAA ATPase family.
Family:
  • In the N-terminal section; belongs to the AAA ATPase family.
  • In the C-terminal section; belongs to the peptidase M41 family.
genes like me logo Genes that share domains with AFG3L2: view

Function for AFG3L2 Gene

Molecular function for AFG3L2 Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form (By similarity).
GENATLAS Biochemistry:
ATPases yeast AFG3 and RCA1 gene homolog,family gene 3-like 2,paraplegin related gene,highly expressed in heart and skeletal muscle

Enzyme Numbers (IUBMB) for AFG3L2 Gene

Phenotypes From GWAS Catalog for AFG3L2 Gene

Gene Ontology (GO) - Molecular Function for AFG3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 14623864
GO:0005524 ATP binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IMP 27642048
genes like me logo Genes that share ontologies with AFG3L2: view
genes like me logo Genes that share phenotypes with AFG3L2: view

Human Phenotype Ontology for AFG3L2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for AFG3L2

miRNA for AFG3L2 Gene

miRTarBase miRNAs that target AFG3L2

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for AFG3L2 Gene

Localization for AFG3L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AFG3L2 Gene

Mitochondrion. Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AFG3L2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
plasma membrane 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AFG3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,TAS --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005745 m-AAA complex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AFG3L2: view

Pathways & Interactions for AFG3L2 Gene

SuperPathways for AFG3L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AFG3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IMP 27642048
GO:0006851 mitochondrial calcium ion transmembrane transport TAS --
GO:0007005 mitochondrion organization IEA --
GO:0007409 axonogenesis IEA,IMP 27642048
GO:0007528 neuromuscular junction development IEA --
genes like me logo Genes that share ontologies with AFG3L2: view

No data available for Pathways by source and SIGNOR curated interactions for AFG3L2 Gene

Drugs & Compounds for AFG3L2 Gene

(1) Drugs for AFG3L2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker, Target 0
genes like me logo Genes that share compounds with AFG3L2: view

Transcripts for AFG3L2 Gene

mRNA/cDNA for AFG3L2 Gene

Unigene Clusters for AFG3L2 Gene

AFG3 ATPase family member 3-like 2 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AFG3L2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2: -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for AFG3L2 Gene

GeneLoc Exon Structure for
AFG3L2
ECgene alternative splicing isoforms for
AFG3L2

Expression for AFG3L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AFG3L2 Gene

mRNA differential expression in normal tissues according to GTEx for AFG3L2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for AFG3L2 Gene

This gene is overexpressed in Heart (8.1), Nasal epithelium (7.4), and Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AFG3L2 Gene



Protein tissue co-expression partners for AFG3L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AFG3L2 Gene:

AFG3L2

SOURCE GeneReport for Unigene cluster for AFG3L2 Gene:

Hs.726355

mRNA Expression by UniProt/SwissProt for AFG3L2 Gene:

Q9Y4W6-AFG32_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in the cerebellar Purkinje cells.

Evidence on tissue expression from TISSUES for AFG3L2 Gene

  • Eye(4.6)
  • Liver(4.3)
  • Nervous system(4.1)
  • Skin(2.8)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AFG3L2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • eyelid
  • face
  • head
  • mouth
  • pharynx
Thorax:
  • esophagus
Abdomen:
  • stomach
Limb:
  • foot
  • lower limb
  • upper limb
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with AFG3L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AFG3L2 Gene

Orthologs for AFG3L2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AFG3L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AFG3L2 34 33
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AFG3L2 34 33
  • 91.22 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AFG3L2 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AFG3L2 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Afg3l2 33
  • 86.2 (n)
cow
(Bos Taurus)
Mammalia AFG3L2 34 33
  • 86.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Afg3l2 16 34 33
  • 85.18 (n)
chicken
(Gallus gallus)
Aves AFG3L2 34 33
  • 76.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AFG3L2 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia afg3l2 33
  • 74.4 (n)
zebrafish
(Danio rerio)
Actinopterygii afg3l2 34 33
  • 71.71 (n)
OneToOne
Dr.14054 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10435 33
fruit fly
(Drosophila melanogaster)
Insecta CG6512 34 35 33
  • 61.38 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006949 33
  • 59.87 (n)
worm
(Caenorhabditis elegans)
Secernentea spg-7 34 33
  • 60.9 (n)
OneToMany
Y47C4A.1 34 35
  • 44 (a)
OneToMany
Y108F1.1 34
  • 44 (a)
OneToMany
Y73B3A.21 34
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AFG3 33
  • 58.25 (n)
YTA12 36 34
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR025C 33
  • 57.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ftsh10 33
  • 59.12 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7456 33
rice
(Oryza sativa)
Liliopsida Os01g0842600 33
  • 59.59 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.4858 33
wheat
(Triticum aestivum)
Liliopsida Ta.1329 33
corn
(Zea mays)
Liliopsida Zm.5595 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 65 (a)
OneToOne
Species where no ortholog for AFG3L2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AFG3L2 Gene

ENSEMBL:
Gene Tree for AFG3L2 (if available)
TreeFam:
Gene Tree for AFG3L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AFG3L2: view image

Paralogs for AFG3L2 Gene

Paralogs for AFG3L2 Gene

(13) SIMAP similar genes for AFG3L2 Gene using alignment to 3 proteins:

  • AFG32_HUMAN
  • D3DUJ0_HUMAN
  • K7EP56_HUMAN

Pseudogenes.org Pseudogenes for AFG3L2 Gene

genes like me logo Genes that share paralogs with AFG3L2: view

Variants for AFG3L2 Gene

Sequence variations from dbSNP and Humsavar for AFG3L2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1057522195 uncertain-significance, not specified, not provided 12,356,794(-) G/A coding_sequence_variant, missense_variant
rs11080572 conflicting-interpretations-of-pathogenicity, benign, not specified, Spinocerebellar Ataxia, Dominant 12,351,343(-) C/T coding_sequence_variant, synonymous_variant
rs1129115 benign, Spinocerebellar Ataxia, Dominant 12,329,537(-) C/G 3_prime_UTR_variant
rs113981080 benign, likely-benign, not specified, Spinocerebellar Ataxia, Dominant 12,329,563(-) C/A/G/T 3_prime_UTR_variant
rs114203162 likely-benign, Spinocerebellar Ataxia, Dominant 12,329,456(-) T/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for AFG3L2 Gene

Variant ID Type Subtype PubMed ID
esv2758714 CNV loss 17122850
esv3641836 CNV loss 21293372
nsv1060808 CNV gain 25217958
nsv1063125 CNV loss 25217958
nsv576496 CNV gain 21841781
nsv819744 CNV loss 19587683

Variation tolerance for AFG3L2 Gene

Residual Variation Intolerance Score: 5.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AFG3L2 Gene

Human Gene Mutation Database (HGMD)
AFG3L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AFG3L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AFG3L2 Gene

Disorders for AFG3L2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for AFG3L2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 28
  • sca28
spastic ataxia 5, autosomal recessive
  • spax5
spastic ataxia 5
spastic ataxia
  • ataxia, spastic
hereditary spastic paraplegia
  • spastic paraplegia 3, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

AFG32_HUMAN
  • Spinocerebellar ataxia 28 (SCA28) [MIM:610246]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA28 is an autosomal dominant cerebellar ataxia (ADCA) with a slow progressive course and no evidence of sensory involvement or cognitive impairment. {ECO:0000269 PubMed:20208537, ECO:0000269 PubMed:20354562, ECO:0000269 PubMed:20725928, ECO:0000269 PubMed:24293060, ECO:0000269 PubMed:26677414}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Spastic ataxia 5, autosomal recessive (SPAX5) [MIM:614487]: A neurodegenerative disorder characterized by early onset spasticity, peripheral neuropathy, ptosis, oculomotor apraxia, dystonia, cerebellar atrophy, and progressive myoclonic epilepsy. {ECO:0000269 PubMed:22022284}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for AFG3L2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AFG3L2: view

No data available for Genatlas for AFG3L2 Gene

Publications for AFG3L2 Gene

  1. Identification and characterization of AFG3L2, a novel paraplegin-related gene. (PMID: 10395799) Banfi S … Franco B (Genomics 1999) 2 3 4 22 58
  2. Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia. (PMID: 14623864) Atorino L … Casari G (The Journal of cell biology 2003) 3 4 22 58
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 4 58
  4. The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria. (PMID: 27642048) König T … Langer T (Molecular cell 2016) 3 4 58
  5. SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore. (PMID: 26387735) Shanmughapriya S … Madesh M (Molecular cell 2015) 3 4 58

Products for AFG3L2 Gene

Sources for AFG3L2 Gene

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