Aliases for AFF3 Gene
External Ids for AFF3 Gene
Previous HGNC Symbols for AFF3 Gene
Previous GeneCards Identifiers for AFF3 Gene
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for AFF3 Gene
AFF3 (AF4/FMR2 Family Member 3) is a Protein Coding gene. Diseases associated with AFF3 include Childhood T-Cell Acute Lymphoblastic Leukemia and Leukemia, Acute Lymphoblastic. Gene Ontology (GO) annotations related to this gene include double-stranded DNA binding. An important paralog of this gene is AFF2.
UniProtKB/Swiss-Prot Summary for AFF3 Gene
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.