Aliases for AFDN-DT Gene

Subcategory (RNA class) for AFDN-DT Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for AFDN-DT Gene

  • AFDN Divergent Transcript 2 3 4 5
  • AFDN-DT 2 5 165
  • MLLT4 Antisense RNA 1 (Non-Protein Coding) 2 3
  • MLLT4 Antisense RNA 1 (Head To Head) 2 3
  • AFDN Antisense RNA 1 (Head To Head) 2 3
  • DJ431P23.3 2 3
  • AFDN-AS1 3 4
  • C6orf124 3 4
  • HGC6.4 2 3
  • Putative Uncharacterized Protein AFDN-DT 4
  • Chromosome 6 Open Reading Frame 124 2
  • NONHSAG045430.2 91
  • Protein HGC6.4 4
  • HSALNG0055209 164
  • MLLT4-AS1 3

External Ids for AFDN-DT Gene

Previous HGNC Symbols for AFDN-DT Gene

  • C6orf124
  • MLLT4-AS1
  • AFDN-AS1

Summaries for AFDN-DT Gene

GeneCards Summary for AFDN-DT Gene

AFDN-DT (AFDN Divergent Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AFDN-DT include Astrocytoma and Gastric Cancer.

Additional gene information for AFDN-DT Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AFDN-DT Gene

Genomics for AFDN-DT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AFDN-DT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J167826 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -2.4 -2363 9.2 HNRNPL GATAD2A PRDM10 REST ZNF629 TFE3 ZNF512 LEF1 IKZF1 ZNF692 AFDN AFDN-DT LINC01558 LOC441179 ENSG00000285212 piR-46757 HGC6.3
GH06J167805 Enhancer 1 Ensembl ENCODE 12 +20.4 20433 2.3 GATAD2A NFKBIZ RCOR2 RXRB SP1 CEBPA SCRT2 SOX13 ETS1 TCF7 AFDN AFDN-DT ENSG00000285212 LINC01558 piR-31199-324 LOC105378132
GH06J167786 Enhancer 0.8 Ensembl ENCODE 11.2 +39.7 39669 1.3 RNF2 TFE3 PRDM1 SP1 ZNF316 NR2F2 POLR2A RAD21 HNF4A KLF11 AFDN AFDN-DT LINC02487 LOC441179 LINC01558 LOC100422263 LOC105378132
GH06J167782 Enhancer 0.7 ENCODE 11.2 +43.8 43791 1.2 TFE3 ZNF7 RXRB SP1 SOX13 ZBTB26 FOSL1 SAP130 SMAD4 BCL6 AFDN AFDN-DT LINC02487 LOC100422263 LOC441179 LOC105378132
GH06J168659 Enhancer 0.6 dbSUPER 11 -833.1 -833136 1.1 ZNF776 ZNF311 ZNF248 YBX1 MCM5 ZNF621 NFE2L2 ZNF571 EGR2 ZNF473 LINC02519 ENSG00000272848 AFDN-DT AFDN lnc-SMOC2-1 piR-44133-027 SMOC2 THBS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AFDN-DT on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for AFDN-DT Gene

Genomic Locations for AFDN-DT Gene
chr6:167,801,132-167,826,812
(GRCh38/hg38)
Size:
25,681 bases
Orientation:
Minus strand
chr6:168,224,556-168,227,476
(GRCh37/hg19)
Size:
2,921 bases
Orientation:
Minus strand

Genomic View for AFDN-DT Gene

Genes around AFDN-DT on UCSC Golden Path with GeneCards custom track
AFDN-DT in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
AFDN-DT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AFDN-DT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFDN-DT Gene

Proteins for AFDN-DT Gene

  • Protein details for AFDN-DT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Z5-AFDDT_HUMAN
    Recommended name:
    Putative uncharacterized protein AFDN-DT
    Protein Accession:
    Q9Y6Z5
    Secondary Accessions:
    • B4DW86
    • Q8NB23

    Protein attributes for AFDN-DT Gene

    Size:
    254 amino acids
    Molecular mass:
    26128 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AFDN-DT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AFDN-DT Gene

Post-translational modifications for AFDN-DT Gene

No Post-translational modifications

No data available for DME Specific Peptides for AFDN-DT Gene

Domains & Families for AFDN-DT Gene

Gene Families for AFDN-DT Gene

Protein Domains for AFDN-DT Gene

ProtoNet:

Suggested Antigen Peptide Sequences for AFDN-DT Gene

GenScript: Design optimal peptide antigens:
  • Protein HGC6.4 (CF124_HUMAN)
genes like me logo Genes that share domains with AFDN-DT: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AFDN-DT Gene

Function for AFDN-DT Gene

Gene Ontology (GO) - Molecular Function for AFDN-DT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with AFDN-DT: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AFDN-DT Gene

Localization for AFDN-DT Gene

Gene Ontology (GO) - Cellular Components for AFDN-DT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with AFDN-DT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for AFDN-DT Gene

Pathways & Interactions for AFDN-DT Gene

PathCards logo

SuperPathways for AFDN-DT Gene

No Data Available

Gene Ontology (GO) - Biological Process for AFDN-DT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with AFDN-DT: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for AFDN-DT Gene

Drugs & Compounds for AFDN-DT Gene

No Compound Related Data Available

Transcripts for AFDN-DT Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for AFDN-DT Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075BCEE_9606 lncRNA 2311 4

HGNC: 21236,

RefSeq: NR_027906,

LNCipedia: AFDN-DT:12,

NONCODE: NONHSAT116113.2,

URS0000783AA4_9606 lncRNA 311 3

Ensembl: ENST00000425438 (view in UCSC) ,

LNCipedia: AFDN-DT:21,

NONCODE: NONHSAT116114.2,

URS000195665E_9606 lncRNA 4011 1

Ensembl: ENST00000669546 (view in UCSC) ,

URS0000EEF114_9606 lncRNA 1639 1

Ensembl: ENST00000663809 (view in UCSC) ,

URS000076D944_9606 lncRNA 182 1

Ensembl: ENST00000417244 (view in UCSC) ,

AFDN-DT in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for AFDN-DT Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for AFDN-DT Gene

No ASD Table

Relevant External Links for AFDN-DT Gene

GeneLoc Exon Structure for
AFDN-DT

Expression for AFDN-DT Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AFDN-DT

mRNA Expression by UniProt/SwissProt for AFDN-DT Gene:

Q9Y6Z5-AFDDT_HUMAN
Tissue specificity: Ubiquitously expressed.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AFDN-DT Gene

Orthologs for AFDN-DT Gene

Evolution for AFDN-DT Gene

ENSEMBL:
Gene Tree for AFDN-DT (if available)
TreeFam:
Gene Tree for AFDN-DT (if available)

No data available for Orthologs for AFDN-DT Gene

Paralogs for AFDN-DT Gene

No data available for Paralogs for AFDN-DT Gene

Variants for AFDN-DT Gene

Additional dbSNP identifiers (rs#s) for AFDN-DT Gene

Structural Variations from Database of Genomic Variants (DGV) for AFDN-DT Gene

Variant ID Type Subtype PubMed ID
dgv217e55 CNV gain 17911159
dgv27e196 CNV duplication 17116639
esv2422263 CNV duplication 17116639
esv2761051 CNV gain 21179565
nsv1027114 CNV gain 25217958
nsv1074037 CNV deletion 25765185
nsv830864 CNV gain 17160897
nsv949897 CNV deletion 24416366

Additional Variant Information for AFDN-DT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AFDN-DT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for AFDN-DT Gene

Disorders for AFDN-DT Gene

MalaCards: The human disease database

(2) MalaCards diseases for AFDN-DT Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
astrocytoma
  • astrocytic tumor
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with AFDN-DT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AFDN-DT Gene

Publications for AFDN-DT Gene

  1. Complete DNA sequence and characterization of a 330-kb VNTR-rich region on chromosome 6q27 that is commonly deleted in ovarian cancer. (PMID: 10382971) Minaguchi T … Nakamura Y (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. Tumour suppressive long non-coding RNA AFDN-DT inhibits gastric cancer invasion via transcriptional regulation. (PMID: 31981317) Lai Y … Meng Y (Journal of cellular and molecular medicine 2020) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer. (PMID: 28927028) Lai Y … Wang J (Oncology letters 2017) 3
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4

Products for AFDN-DT Gene

Sources for AFDN-DT Gene