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Aliases for AFAP1-AS1 Gene

Subcategory (RNA class) for AFAP1-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for AFAP1-AS1 Gene

  • AFAP1 Antisense RNA 1 2 3 5
  • AFAP1 Antisense RNA 1 (Non-Protein Coding) 2 3
  • AFAP1 Antisense RNA (Non-Protein Coding) 2
  • AFAP1-AS 3
  • AFAP1AS 3

External Ids for AFAP1-AS1 Gene

Previous HGNC Symbols for AFAP1-AS1 Gene

  • AFAP1-AS

Summaries for AFAP1-AS1 Gene

Entrez Gene Summary for AFAP1-AS1 Gene

  • This gene produces a long non-coding RNA that is overexpressed in tumor cells and may promote cancer cell metastasis. [provided by RefSeq, Dec 2017]

GeneCards Summary for AFAP1-AS1 Gene

AFAP1-AS1 (AFAP1 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with AFAP1-AS1 include Esophagus Adenocarcinoma and Esophagus Squamous Cell Carcinoma.

Additional gene information for AFAP1-AS1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AFAP1-AS1 Gene

Genomics for AFAP1-AS1 Gene

GeneHancer (GH) Regulatory Elements for AFAP1-AS1 Gene

Promoters and enhancers for AFAP1-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J007753 Promoter/Enhancer 1.2 Ensembl ENCODE 600.7 +0.3 306 2 ZFX HDAC1 MGA ZNF766 POLR2A MNT SKIL SUPT5H ELF1 NRF1 AFAP1-AS1 AFAP1 GC04M007761 PIR46874
GH04J007778 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 8 +28.0 28043 8.1 CREM EGR1 ZBED1 POLR2A RUNX3 GABPA JUNB ZFHX2 RCOR1 IRF2 AFAP1 AFAP1-AS1 PIR60658 GC04M007832
GH04J007802 Enhancer 1.4 Ensembl ENCODE dbSUPER 7.7 +57.3 57294 16.8 CTCF ELF3 ZKSCAN8 CEBPG RERE NFIB TFE3 HNF1A PPARG RAD21 AFAP1 AFAP1-AS1 ACOX3 PIR60658 GC04M007832
GH04J007770 Enhancer 1 Ensembl ENCODE 8.8 +18.3 18264 4 SP1 CTCF CEBPG SP5 CREM ZNF384 ZBED1 PKNOX1 ZIC2 CEBPA AFAP1 AFAP1-AS1 PIR60658 GC04M007832
GH04J007758 Enhancer 0.6 ENCODE 14.2 +5.7 5650 2.2 MAFK ZNF316 NFE2 MAFG POLR2A IRF2 NFE2L2 EMSY GC04M007761 PIR46874 AFAP1 AFAP1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AFAP1-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AFAP1-AS1 Gene

Genomic Locations for AFAP1-AS1 Gene
24,839 bases
Plus strand
24,839 bases
Plus strand

Genomic View for AFAP1-AS1 Gene

Genes around AFAP1-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AFAP1-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AFAP1-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFAP1-AS1 Gene

Proteins for AFAP1-AS1 Gene

Post-translational modifications for AFAP1-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for AFAP1-AS1 Gene

Domains & Families for AFAP1-AS1 Gene

Gene Families for AFAP1-AS1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AFAP1-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for AFAP1-AS1 Gene

Function for AFAP1-AS1 Gene

Phenotypes From GWAS Catalog for AFAP1-AS1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AFAP1-AS1 Gene

Localization for AFAP1-AS1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AFAP1-AS1 gene
Compartment Confidence
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AFAP1-AS1 Gene

Pathways & Interactions for AFAP1-AS1 Gene

PathCards logo

SuperPathways for AFAP1-AS1 Gene

No Data Available

Interacting Proteins for AFAP1-AS1 Gene

Gene Ontology (GO) - Biological Process for AFAP1-AS1 Gene


No data available for Pathways by source and SIGNOR curated interactions for AFAP1-AS1 Gene

Drugs & Compounds for AFAP1-AS1 Gene

No Compound Related Data Available

Transcripts for AFAP1-AS1 Gene

mRNA/cDNA for AFAP1-AS1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

Unigene Clusters for AFAP1-AS1 Gene

AFAP1 antisense RNA 1:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1-AS1 Gene

No ASD Table

Relevant External Links for AFAP1-AS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AFAP1-AS1 Gene

SOURCE GeneReport for Unigene cluster for AFAP1-AS1 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AFAP1-AS1 Gene

Orthologs for AFAP1-AS1 Gene

Evolution for AFAP1-AS1 Gene

Gene Tree for AFAP1-AS1 (if available)
Gene Tree for AFAP1-AS1 (if available)

No data available for Orthologs for AFAP1-AS1 Gene

Paralogs for AFAP1-AS1 Gene

No data available for Paralogs for AFAP1-AS1 Gene

Variants for AFAP1-AS1 Gene

Sequence variations from dbSNP and Humsavar for AFAP1-AS1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000041405 -- 7,773,609(+) T/G non_coding_transcript_variant
rs1000059153 -- 7,770,203(+) A/G intron_variant
rs1000136565 -- 7,766,981(+) G/C intron_variant
rs1000155005 -- 7,755,525(+) A/G intron_variant
rs1000345550 -- 7,756,479(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AFAP1-AS1 Gene

Variant ID Type Subtype PubMed ID
esv2727074 CNV deletion 23290073
esv2727075 CNV deletion 23290073
esv2727076 CNV deletion 23290073
esv2727077 CNV deletion 23290073
esv2727078 CNV deletion 23290073
esv2727079 CNV deletion 23290073
esv34196 OTHER inversion 12058347
nsv1117961 CNV deletion 24896259
nsv1121623 CNV deletion 24896259
nsv1126034 CNV deletion 24896259
nsv1130812 CNV deletion 24896259
nsv1139213 CNV deletion 24896259
nsv822468 CNV gain 20364138

Additional Variant Information for AFAP1-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for AFAP1-AS1 Gene

Disorders for AFAP1-AS1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for AFAP1-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophagus adenocarcinoma
  • oesophageal adenocarcinoma
esophagus squamous cell carcinoma
  • scc of esophagus
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
tongue squamous cell carcinoma
  • squamous cell carcinoma of tongue
gallbladder cancer
  • gallbladder ca
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AFAP1-AS1

genes like me logo Genes that share disorders with AFAP1-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AFAP1-AS1 Gene

Publications for AFAP1-AS1 Gene

  1. Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling. (PMID: 26892468) Zhang JY … Xu JM (International journal of oncology 2016) 2 3 58
  2. Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. (PMID: 23333711) Wu W … Meltzer SJ (Gastroenterology 2013) 2 3 58
  3. Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis and promotes carcinogenesis of breast cancer. (PMID: 29974352) Ma D … Wu D (Breast cancer (Tokyo, Japan) 2019) 3 58
  4. AFAP1-AS1: A novel oncogenic long non-coding RNA in human cancers. (PMID: 29057544) Zhang F … Huang W (Cell proliferation 2018) 3 58
  5. Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/β-catenin signaling pathway. (PMID: 29310682) Wang ZY … Gong ZJ (Molecular cancer 2018) 3 58

Products for AFAP1-AS1 Gene

Sources for AFAP1-AS1 Gene

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