This gene produces a long non-coding RNA that is overexpressed in tumor cells and may promote cancer cell metastasis. [provided by RefSeq, Dec 2017] See more...

Aliases for AFAP1-AS1 Gene

Subcategory (RNA class) for AFAP1-AS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for AFAP1-AS1 Gene

  • AFAP1 Antisense RNA 1 2 3 5
  • AFAP1 Antisense RNA 1 (Non-Protein Coding) 2 3
  • AFAP1-AS1 2 5
  • AFAP1 Antisense RNA (Non-Protein Coding) 2
  • NONHSAG037420.2 91
  • HSALNG0032699 164
  • Lnc-SORCS2-1 165
  • AFAP1-AS 3
  • MGC10981 2
  • AFAP1AS 3

External Ids for AFAP1-AS1 Gene

Previous HGNC Symbols for AFAP1-AS1 Gene

  • AFAP1AS
  • AFAP1-AS

Summaries for AFAP1-AS1 Gene

Entrez Gene Summary for AFAP1-AS1 Gene

  • This gene produces a long non-coding RNA that is overexpressed in tumor cells and may promote cancer cell metastasis. [provided by RefSeq, Dec 2017]

GeneCards Summary for AFAP1-AS1 Gene

AFAP1-AS1 (AFAP1 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AFAP1-AS1 include Esophagus Adenocarcinoma and Esophagus Squamous Cell Carcinoma.

Additional gene information for AFAP1-AS1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AFAP1-AS1 Gene

Genomics for AFAP1-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AFAP1-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J007754 Promoter 1.2 EPDnew Ensembl 600.7 +0.7 723 1.6 HDAC1 MGA ZNF766 POLR2A MNT MYC EP400 TBP ELF1 SKIL AFAP1-AS1 AFAP1 piR-52875 LOC389199 PSAPL1
GH04J007753 Enhancer 0.6 ENCODE 600.7 -0.4 -406 0.6 HDAC1 ZNF766 MNT EP400 TBP POLR2A ELF1 SKIL SMAD5 ZEB2 AFAP1-AS1 HSALNG0032693 LOC389199 PSAPL1
GH04J007803 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.7 +56.5 56518 18.4 CEBPG GATAD2A CTCF TEAD4 REST TFE3 SOX13 RCOR2 FOXA1 PRDM1 AFAP1 AFAP1-AS1 ACOX3 lnc-SORCS2-3 ENSG00000287164 piR-50852-103 LOC389199 PSAPL1
GH04J007778 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 8 +28.1 28056 8.1 POLR2A EGR1 RUNX3 GABPA ZFHX2 IRF2 JUNB RCOR1 JUND ATF2 AFAP1 AFAP1-AS1 ENSG00000287164 piR-37613 LOC389199 PSAPL1
GH04J007770 Enhancer 0.9 Ensembl ENCODE 8.8 +18.4 18415 4.2 SP1 CTCF ZIC2 PKNOX1 CEBPA EED MGA RUNX3 BCLAF1 CBFB AFAP1 AFAP1-AS1 piR-37613 ENSG00000287164 LOC389199 PSAPL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AFAP1-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for AFAP1-AS1 Gene

Genomic Locations for AFAP1-AS1 Gene
chr4:7,754,077-7,778,928
(GRCh38/hg38)
Size:
24,852 bases
Orientation:
Plus strand
chr4:7,755,817-7,780,655
(GRCh37/hg19)
Size:
24,839 bases
Orientation:
Plus strand

Genomic View for AFAP1-AS1 Gene

Genes around AFAP1-AS1 on UCSC Golden Path with GeneCards custom track
AFAP1-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
AFAP1-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AFAP1-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFAP1-AS1 Gene

Proteins for AFAP1-AS1 Gene

Post-translational modifications for AFAP1-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for AFAP1-AS1 Gene

Domains & Families for AFAP1-AS1 Gene

Gene Families for AFAP1-AS1 Gene

genes like me logo Genes that share domains with AFAP1-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AFAP1-AS1 Gene

Function for AFAP1-AS1 Gene

Phenotypes From GWAS Catalog for AFAP1-AS1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AFAP1-AS1 Gene

Localization for AFAP1-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AFAP1-AS1 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AFAP1-AS1 Gene

Pathways & Interactions for AFAP1-AS1 Gene

PathCards logo

SuperPathways for AFAP1-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AFAP1-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for AFAP1-AS1 Gene

Drugs & Compounds for AFAP1-AS1 Gene

No Compound Related Data Available

Transcripts for AFAP1-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for AFAP1-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E0F9_9606 lncRNA 6794 2

HGNC: 28141,

RefSeq: NR_026892,

URS0000D5CFA2_9606 lncRNA 6808 1

Ensembl: ENST00000608442 (view in UCSC) ,

URS0001987082_9606 lncRNA 5444 1

Ensembl: ENST00000674004 (view in UCSC) ,

URS0000EB558F_9606 lncRNA 6796 1

LncBook: HSALNT0289431,

URS00009B327F_9606 lncRNA 6794 1

NONCODE: NONHSAT095059.2,

AFAP1-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for AFAP1-AS1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1-AS1 Gene

No ASD Table

Relevant External Links for AFAP1-AS1 Gene

GeneLoc Exon Structure for
AFAP1-AS1

Expression for AFAP1-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AFAP1-AS1

SOURCE GeneReport for Unigene cluster for AFAP1-AS1 Gene:

Hs.663029
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AFAP1-AS1 Gene

Orthologs for AFAP1-AS1 Gene

Evolution for AFAP1-AS1 Gene

ENSEMBL:
Gene Tree for AFAP1-AS1 (if available)
TreeFam:
Gene Tree for AFAP1-AS1 (if available)

No data available for Orthologs for AFAP1-AS1 Gene

Paralogs for AFAP1-AS1 Gene

No data available for Paralogs for AFAP1-AS1 Gene

Variants for AFAP1-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AFAP1-AS1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
730676 Benign: not provided 7,772,958(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for AFAP1-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AFAP1-AS1 Gene

Variant ID Type Subtype PubMed ID
esv2727074 CNV deletion 23290073
esv2727075 CNV deletion 23290073
esv2727076 CNV deletion 23290073
esv2727077 CNV deletion 23290073
esv2727078 CNV deletion 23290073
esv2727079 CNV deletion 23290073
esv34196 OTHER inversion 12058347
nsv1117961 CNV deletion 24896259
nsv1121623 CNV deletion 24896259
nsv1126034 CNV deletion 24896259
nsv1130812 CNV deletion 24896259
nsv1139213 CNV deletion 24896259
nsv822468 CNV gain 20364138

Additional Variant Information for AFAP1-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AFAP1-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for AFAP1-AS1 Gene

Disorders for AFAP1-AS1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for AFAP1-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophagus adenocarcinoma
  • oesophageal adenocarcinoma
esophagus squamous cell carcinoma
  • oesophagus squamous cell carcinoma
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
gallbladder cancer
  • gallbladder ca
nasopharyngeal carcinoma
  • npc
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with AFAP1-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AFAP1-AS1 Gene

Publications for AFAP1-AS1 Gene

  1. Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling. (PMID: 26892468) Zhang JY … Xu JM (International journal of oncology 2016) 2 3
  2. Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. (PMID: 23333711) Wu W … Meltzer SJ (Gastroenterology 2013) 2 3
  3. Long non-coding RNA AFAP1-AS1 promotes proliferation and invasion in prostate cancer via targeting miR-512-3p. (PMID: 31669642) Wang K … Hu B (Gene 2020) 3
  4. Cross-talk among AFAP1-AS1, ACVR1 and microRNA-384 regulates the stemness of pancreatic cancer cells and tumorigenicity in nude mice. (PMID: 30819221) Wu XB … Liu XQ (Journal of experimental & clinical cancer research : CR 2019) 3
  5. LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway. (PMID: 31443665) Shi D … Shao Z (Journal of experimental & clinical cancer research : CR 2019) 3

Products for AFAP1-AS1 Gene

Sources for AFAP1-AS1 Gene