This gene produces a long non-coding RNA that is overexpressed in tumor cells and may promote cancer cell metastasis. [provided by RefSeq, Dec 2017] See more...

Aliases for AFAP1-AS1 Gene

Subcategory (RNA class) for AFAP1-AS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for AFAP1-AS1 Gene

  • AFAP1 Antisense RNA 1 2 3 5
  • AFAP1 Antisense RNA 1 (Non-Protein Coding) 2 3
  • AFAP1 Antisense RNA (Non-Protein Coding) 2
  • HSALNG0032699 167
  • NONHSAG037420 92
  • Lnc-SORCS2-1 168
  • AFAP1-AS1 2
  • AFAP1-AS 3
  • AFAP1AS 3

External Ids for AFAP1-AS1 Gene

Previous HGNC Symbols for AFAP1-AS1 Gene

  • AFAP1AS
  • AFAP1-AS

Summaries for AFAP1-AS1 Gene

Entrez Gene Summary for AFAP1-AS1 Gene

  • This gene produces a long non-coding RNA that is overexpressed in tumor cells and may promote cancer cell metastasis. [provided by RefSeq, Dec 2017]

GeneCards Summary for AFAP1-AS1 Gene

AFAP1-AS1 (AFAP1 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AFAP1-AS1 include Esophagus Adenocarcinoma and Esophagus Squamous Cell Carcinoma.

Additional gene information for AFAP1-AS1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AFAP1-AS1 Gene

Genomics for AFAP1-AS1 Gene

GeneHancer (GH) Regulatory Elements for AFAP1-AS1 Gene

Promoters and enhancers for AFAP1-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J007754 Promoter 0.9 Ensembl 500.7 +0.7 723 1.6 MYC CREB3L1 POLR2A MAX POLR2H TBP SKIL MNT ELF1 SUPT5H AFAP1-AS1 AFAP1 piR-52875
GH04J007753 Enhancer 0.6 ENCODE 500.7 -0.4 -406 0.6 CREB3L1 FOS MAX POLR2A POLR2H TBP SKIL MNT ELF1 EP400 AFAP1-AS1 HSALNG0032693
GH04J007778 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 8 +28.1 28056 8.1 EP300 MEF2C MXI1 GATA3 GABPA IRF1 POLR2A IRF2 ZFHX2 FOS AFAP1 AFAP1-AS1 ENSG00000287164 piR-37613
GH04J007803 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.7 +56.5 56518 18.4 EP300 FOXK2 ZNF217 CTCF TCF12 NRF1 NCOR1 JUND FOS TEAD4 AFAP1 AFAP1-AS1 ACOX3 lnc-SORCS2-3 ENSG00000287164 piR-50852-103
GH04J007770 Enhancer 1 Ensembl ENCODE 8.8 +18.4 18415 4.2 CTCF SP1 NCOR1 ZIC2 MEF2C BCL11A TCF12 NFIC SMC3 CBFB AFAP1 AFAP1-AS1 piR-37613 ENSG00000287164
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AFAP1-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AFAP1-AS1 Gene

Genomic Locations for AFAP1-AS1 Gene
chr4:7,754,077-7,778,928
(GRCh38/hg38)
Size:
24,852 bases
Orientation:
Plus strand
chr4:7,755,817-7,780,655
(GRCh37/hg19)
Size:
24,839 bases
Orientation:
Plus strand

Genomic View for AFAP1-AS1 Gene

Genes around AFAP1-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AFAP1-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AFAP1-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFAP1-AS1 Gene

Proteins for AFAP1-AS1 Gene

Post-translational modifications for AFAP1-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for AFAP1-AS1 Gene

Domains & Families for AFAP1-AS1 Gene

Gene Families for AFAP1-AS1 Gene

genes like me logo Genes that share domains with AFAP1-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AFAP1-AS1 Gene

Function for AFAP1-AS1 Gene

Phenotypes From GWAS Catalog for AFAP1-AS1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AFAP1-AS1 Gene

Localization for AFAP1-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AFAP1-AS1 gene
Compartment Confidence
cytoskeleton 2
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AFAP1-AS1 Gene

Pathways & Interactions for AFAP1-AS1 Gene

PathCards logo

SuperPathways for AFAP1-AS1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for AFAP1-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for AFAP1-AS1 Gene

Drugs & Compounds for AFAP1-AS1 Gene

No Compound Related Data Available

Transcripts for AFAP1-AS1 Gene

mRNA/cDNA for AFAP1-AS1 Gene

6 RNACentral transcripts :
2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 NONCODE transcripts :
1 LncBook transcripts :
1 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for AFAP1-AS1 Gene

No ASD Table

Relevant External Links for AFAP1-AS1 Gene

GeneLoc Exon Structure for
AFAP1-AS1

Expression for AFAP1-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AFAP1-AS1

SOURCE GeneReport for Unigene cluster for AFAP1-AS1 Gene:

Hs.663029
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AFAP1-AS1 Gene

Orthologs for AFAP1-AS1 Gene

Evolution for AFAP1-AS1 Gene

ENSEMBL:
Gene Tree for AFAP1-AS1 (if available)
TreeFam:
Gene Tree for AFAP1-AS1 (if available)

No data available for Orthologs for AFAP1-AS1 Gene

Paralogs for AFAP1-AS1 Gene

No data available for Paralogs for AFAP1-AS1 Gene

Variants for AFAP1-AS1 Gene

Additional dbSNP identifiers (rs#s) for AFAP1-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AFAP1-AS1 Gene

Variant ID Type Subtype PubMed ID
esv2727074 CNV deletion 23290073
esv2727075 CNV deletion 23290073
esv2727076 CNV deletion 23290073
esv2727077 CNV deletion 23290073
esv2727078 CNV deletion 23290073
esv2727079 CNV deletion 23290073
esv34196 OTHER inversion 12058347
nsv1117961 CNV deletion 24896259
nsv1121623 CNV deletion 24896259
nsv1126034 CNV deletion 24896259
nsv1130812 CNV deletion 24896259
nsv1139213 CNV deletion 24896259
nsv822468 CNV gain 20364138

Additional Variant Information for AFAP1-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AFAP1-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for AFAP1-AS1 Gene

Disorders for AFAP1-AS1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for AFAP1-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophagus adenocarcinoma
  • oesophageal adenocarcinoma
esophagus squamous cell carcinoma
  • scc of esophagus
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
nasopharyngeal carcinoma
  • npc
gallbladder cancer
  • gallbladder ca
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AFAP1-AS1

genes like me logo Genes that share disorders with AFAP1-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AFAP1-AS1 Gene

Publications for AFAP1-AS1 Gene

  1. Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling. (PMID: 26892468) Zhang JY … Xu JM (International journal of oncology 2016) 2 3 54
  2. Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. (PMID: 23333711) Wu W … Meltzer SJ (Gastroenterology 2013) 2 3 54
  3. Cross-talk among AFAP1-AS1, ACVR1 and microRNA-384 regulates the stemness of pancreatic cancer cells and tumorigenicity in nude mice. (PMID: 30819221) Wu XB … Liu XQ (Journal of experimental & clinical cancer research : CR 2019) 3 54
  4. Silencing of lncRNA AFAP1-AS1 Inhibits Cell Growth and Metastasis in Clear Cell Renal Cell Carcinoma. (PMID: 30832752) Mu Z … Zhao C (Oncology research 2019) 3 54
  5. LncRNA GAS8-AS inhibits colorectal cancer (CRC) cell proliferation by downregulating lncRNA AFAP1-AS1. (PMID: 31132513) Zhao Y … Xu F (Gene 2019) 3 54

Products for AFAP1-AS1 Gene

Sources for AFAP1-AS1 Gene