Aliases for AFAP1 Gene
External Ids for AFAP1 Gene
Previous GeneCards Identifiers for AFAP1 Gene
The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for AFAP1 Gene
AFAP1 (Actin Filament Associated Protein 1) is a Protein Coding gene. Diseases associated with AFAP1 include Small Intestine Cancer and Open-Angle Glaucoma. Among its related pathways are Immune response IFN gamma signaling pathway. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is AFAP1L1.
UniProtKB/Swiss-Prot Summary for AFAP1 Gene
Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.