Aliases for AEN Gene
External Ids for AEN Gene
Previous HGNC Symbols for AEN Gene
Previous GeneCards Identifiers for AEN Gene
GeneCards Summary for AEN Gene
AEN (Apoptosis Enhancing Nuclease) is a Protein Coding gene. Diseases associated with AEN include Benign Epilepsy With Centrotemporal Spikes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is ISG20L2.
UniProtKB/Swiss-Prot for AEN Gene
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.