Aliases for AEBP1 Gene
External Ids for AEBP1 Gene
Previous GeneCards Identifiers for AEBP1 Gene
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
GeneCards Summary for AEBP1 Gene
AEBP1 (AE Binding Protein 1) is a Protein Coding gene. Diseases associated with AEBP1 include Ehlers-Danlos Syndrome, Classic-Like, 2 and Gastroschisis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and calmodulin binding. An important paralog of this gene is CPXM2.
UniProtKB/Swiss-Prot Summary for AEBP1 Gene
Isoform 1: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellualr matrix.
Isoform 2: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.