Aliases for ADTRP Gene

Aliases for ADTRP Gene

  • Androgen Dependent TFPI Regulating Protein 2 3 5
  • Androgen-Dependent TFPI-Regulating Protein 2 3 4
  • Fatty Acid Esters Of Hydroxy Fatty Acids Hydrolase ADTRP 3 4
  • FAHFA Hydrolase ADTRP 3 4
  • C6orf105 3 4
  • Androgen-Dependent TPF1-Regulating Protein 3
  • Chromosome 6 Open Reading Frame 105 2
  • Androgen-Induced 1-Like 2
  • EC 3.1.-.- 4
  • DJ413H6.1 3
  • AIG1L 3

External Ids for ADTRP Gene

Previous HGNC Symbols for ADTRP Gene

  • C6orf105

Summaries for ADTRP Gene

GeneCards Summary for ADTRP Gene

ADTRP (Androgen Dependent TFPI Regulating Protein) is a Protein Coding gene. An important paralog of this gene is AIG1.

UniProtKB/Swiss-Prot Summary for ADTRP Gene

  • Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574).

Additional gene information for ADTRP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADTRP Gene

Genomics for ADTRP Gene

GeneHancer (GH) Regulatory Elements for ADTRP Gene

Promoters and enhancers for ADTRP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J011777 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 769.3 +27.9 27934 2.3 ZBTB40 SMARCE1 ELF1 HLF L3MBTL2 TEAD4 GTF2F1 ZFX CBFA2T2 BACH1 ADTRP MF281480-002 RF00017-5271
GH06J011804 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 764.9 +1.1 1140 3 SREBF1 MYC MAX SP1 CBFA2T2 EGR1 PKNOX1 KLF4 ZFHX2 PBX2 ADTRP MF281480-002 RF00017-5271
GH06J011728 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 750.2 +78.3 78256 2.8 TEAD4 EP300 TAL1 CBFA2T3 ADTRP HIVEP1 ENSG00000287593 piR-48209-606 lnc-NEDD9-3 RF00017-5271
GH06J011765 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +37.7 37681 8.7 POLR2A USF2 HLF L3MBTL2 ZKSCAN8 ZNF148 ZFX SP1 MAFK MLLT1 HIVEP1 ADTRP RPL15P3 ERVFRD-1 ENSG00000271897 TMEM170B NEDD9 MF281480-002 lnc-NEDD9-3 RF00017-5271
GH06J011827 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -21.3 -21255 1.8 ZNF24 ETV6 RELA MLLT1 ZNF687 CREM ZBTB33 IKZF1 TRIM22 IKZF2 ADTRP TMEM170B piR-35858-006 ENSG00000234427 RF00017-5271
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADTRP on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADTRP Gene

Genomic Locations for ADTRP Gene
94,993 bases
Minus strand
94,993 bases
Minus strand

Genomic View for ADTRP Gene

Genes around ADTRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADTRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADTRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADTRP Gene

Proteins for ADTRP Gene

  • Protein details for ADTRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Androgen-dependent TFPI-regulating protein
    Protein Accession:
    Secondary Accessions:
    • B2R7T9
    • B4DV39
    • Q5THW1

    Protein attributes for ADTRP Gene

    230 amino acids
    Molecular mass:
    26842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADTRP Gene


neXtProt entry for ADTRP Gene

Post-translational modifications for ADTRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADTRP Gene

Domains & Families for ADTRP Gene

Gene Families for ADTRP Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ADTRP Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AIG1 family.
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with ADTRP: view

No data available for Suggested Antigen Peptide Sequences for ADTRP Gene

Function for ADTRP Gene

Molecular function for ADTRP Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52052, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83670, ChEBI:CHEBI:136286; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52053; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52056, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83677, ChEBI:CHEBI:84201; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52057; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52068, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136286, ChEBI:CHEBI:136309; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52069; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:84201, ChEBI:CHEBI:136312; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52073; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52076, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136304, ChEBI:CHEBI:136315; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52077; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52096, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136286, ChEBI:CHEBI:136373; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52097; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:84201, ChEBI:CHEBI:136330; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52081; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136304, ChEBI:CHEBI:136335; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52085; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52048, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136282, ChEBI:CHEBI:136286; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52049; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84201, ChEBI:CHEBI:136302; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52061; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136303, ChEBI:CHEBI:136304; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52065; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136370, ChEBI:CHEBI:136389; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52101; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-hydroxyhydantoin carbamate JJH260 and beta-lactone KC01.
UniProtKB/Swiss-Prot Induction:
By androgens.

Enzyme Numbers (IUBMB) for ADTRP Gene

Phenotypes From GWAS Catalog for ADTRP Gene

Gene Ontology (GO) - Molecular Function for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IMP 27018888
genes like me logo Genes that share ontologies with ADTRP: view
genes like me logo Genes that share phenotypes with ADTRP: view

Animal Model Products

CRISPR Products

miRNA for ADTRP Gene

miRTarBase miRNAs that target ADTRP

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADTRP Gene

Localization for ADTRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADTRP Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts. {ECO:0000269 PubMed:21868574}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADTRP gene
Compartment Confidence
plasma membrane 5
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005901 caveola IDA 21868574
GO:0009986 cell surface IDA 21868574
GO:0016020 membrane IEA,IDA 27018888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADTRP: view

Pathways & Interactions for ADTRP Gene

PathCards logo

SuperPathways for ADTRP Gene

No Data Available

Interacting Proteins for ADTRP Gene

Gene Ontology (GO) - Biological Process for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 28341552
GO:0002042 cell migration involved in sprouting angiogenesis IMP 28341552
GO:0002686 negative regulation of leukocyte migration IMP 28341552
GO:0003332 negative regulation of extracellular matrix constituent secretion IMP 28341552
GO:0010628 positive regulation of gene expression IMP 21868574
genes like me logo Genes that share ontologies with ADTRP: view

No data available for Pathways by source and SIGNOR curated interactions for ADTRP Gene

Drugs & Compounds for ADTRP Gene

No Compound Related Data Available

Transcripts for ADTRP Gene

mRNA/cDNA for ADTRP Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADTRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -

Relevant External Links for ADTRP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADTRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADTRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADTRP Gene

This gene is overexpressed in Colon - Transverse (x15.0), Small Intestine - Terminal Ileum (x7.4), Stomach (x5.3), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of ADTRP Gene:


SOURCE GeneReport for Unigene cluster for ADTRP Gene:


mRNA Expression by UniProt/SwissProt for ADTRP Gene:

Tissue specificity: Expressed in cultured endothelial cells and in placenta.

Evidence on tissue expression from TISSUES for ADTRP Gene

  • Intestine(4.3)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with ADTRP: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADTRP Gene

Orthologs for ADTRP Gene

This gene was present in the common ancestor of animals.

Orthologs for ADTRP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADTRP 33 32
  • 98.84 (n)
(Canis familiaris)
Mammalia ADTRP 33 32
  • 82.46 (n)
(Bos Taurus)
Mammalia ADTRP 32
  • 80.87 (n)
C23H6ORF105 33
  • 72 (a)
(Rattus norvegicus)
Mammalia Adtrp 32
  • 75.07 (n)
(Mus musculus)
Mammalia Adtrp 17 33 32
  • 74.2 (n)
(Ornithorhynchus anatinus)
Mammalia ADTRP 33
  • 53 (a)
(Monodelphis domestica)
Mammalia ADTRP 33
  • 46 (a)
(Gallus gallus)
Aves C2H6ORF105 32
  • 61.01 (n)
  • 48 (a)
(Anolis carolinensis)
Reptilia ADTRP 33
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adtrp 32
  • 55.02 (n)
(Danio rerio)
Actinopterygii LOC100537455 32
  • 51.5 (n)
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3625 33
  • 30 (a)
CG6149 33
  • 29 (a)
CG11601 33
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 30 (a)
Species where no ortholog for ADTRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADTRP Gene

Gene Tree for ADTRP (if available)
Gene Tree for ADTRP (if available)
Evolutionary constrained regions (ECRs) for ADTRP: view image

Paralogs for ADTRP Gene

Paralogs for ADTRP Gene

(1) SIMAP similar genes for ADTRP Gene using alignment to 6 proteins:

  • D6R9A9_HUMAN
  • D6R9E5_HUMAN
  • H0Y9P4_HUMAN
genes like me logo Genes that share paralogs with ADTRP: view

Variants for ADTRP Gene

Sequence variations from dbSNP and Humsavar for ADTRP Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000032607 -- 11,781,287(-) C/T upstream_transcript_variant
rs1000099334 -- 11,746,190(-) A/C intron_variant
rs1000102807 -- 11,769,441(-) A/T intron_variant
rs1000116663 -- 11,775,315(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000133498 -- 11,733,657(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADTRP Gene

Variant ID Type Subtype PubMed ID
esv2759407 CNV loss 17122850
nsv522039 CNV gain 19592680
nsv600990 CNV loss 21841781

Variation tolerance for ADTRP Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADTRP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADTRP Gene

Disorders for ADTRP Gene

Additional Disease Information for ADTRP

No disorders were found for ADTRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADTRP Gene

Publications for ADTRP Gene

  1. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. (PMID: 21868574) Lupu C … Lupu F (Blood 2011) 2 3 4 56
  2. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. (PMID: 27018888) Parsons WH … Cravatt BF (Nature chemical biology 2016) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56

Products for ADTRP Gene

Sources for ADTRP Gene