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Aliases for ADTRP Gene

Aliases for ADTRP Gene

  • Androgen Dependent TFPI Regulating Protein 2 3 5
  • Androgen-Dependent TFPI-Regulating Protein 2 3
  • C6orf105 3 4
  • Androgen-Dependent TPF1-Regulating Protein 3
  • Chromosome 6 Open Reading Frame 105 2
  • Androgen-Induced 1-Like 2
  • DJ413H6.1 3
  • AIG1L 3

External Ids for ADTRP Gene

Previous HGNC Symbols for ADTRP Gene

  • C6orf105

Summaries for ADTRP Gene

GeneCards Summary for ADTRP Gene

ADTRP (Androgen Dependent TFPI Regulating Protein) is a Protein Coding gene. An important paralog of this gene is AIG1.

UniProtKB/Swiss-Prot for ADTRP Gene

  • Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).

Additional gene information for ADTRP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADTRP Gene

Genomics for ADTRP Gene

GeneHancer (GH) Regulatory Elements for ADTRP Gene

Promoters and enhancers for ADTRP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J011728 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.2 +77.9 77921 2.1 MEIS2 TEAD4 TAL1 CBFA2T3 EP300 SPI1 ADTRP HIVEP1 GC06P011709 GC06M011750
GH06J011777 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 669.3 +27.9 27934 2.3 ATF1 FOXA2 ARNT TCF12 POLR2B ZNF766 ATF7 ZNF592 SMARCA4 KLF1 ADTRP GC06P011785 GC06M011750
GH06J011804 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 665 +1.1 1140 3 PKNOX1 MAX CBFA2T3 KLF4 SREBF1 SP1 ZFHX2 POLR2A EGR1 PBX2 ADTRP GC06P011785 GC06M011802
GH06J011765 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +37.7 37681 8.7 FOXA2 ARNT SIN3A ZNF766 FOS ATF7 RUNX3 DEK RXRA REST ADTRP HIVEP1 ENSG00000271897 TMEM170B NEDD9 GC06P011785 GC06M011750
GH06J011744 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +62.1 62107 1.1 SP1 ZNF766 ZSCAN4 NR2F2 ADTRP HIVEP1 TMEM170B GC06M011750 GC06P011709
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADTRP on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADTRP Gene

Genomic Locations for ADTRP Gene
chr6:11,712,054-11,807,046
(GRCh38/hg38)
Size:
94,993 bases
Orientation:
Minus strand
chr6:11,712,287-11,807,279
(GRCh37/hg19)

Genomic View for ADTRP Gene

Genes around ADTRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADTRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADTRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADTRP Gene

Proteins for ADTRP Gene

  • Protein details for ADTRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ2-ADTRP_HUMAN
    Recommended name:
    Androgen-dependent TFPI-regulating protein
    Protein Accession:
    Q96IZ2
    Secondary Accessions:
    • B2R7T9
    • B4DV39
    • Q5THW1

    Protein attributes for ADTRP Gene

    Size:
    230 amino acids
    Molecular mass:
    26842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADTRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADTRP Gene

Post-translational modifications for ADTRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADTRP Gene

Domains & Families for ADTRP Gene

Gene Families for ADTRP Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ADTRP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IZ2

UniProtKB/Swiss-Prot:

ADTRP_HUMAN :
  • Belongs to the AIG1 family.
Family:
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with ADTRP: view

No data available for Suggested Antigen Peptide Sequences for ADTRP Gene

Function for ADTRP Gene

Molecular function for ADTRP Gene

UniProtKB/Swiss-Prot Function:
Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).
UniProtKB/Swiss-Prot Induction:
By androgens.

Phenotypes From GWAS Catalog for ADTRP Gene

Gene Ontology (GO) - Molecular Function for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IMP 27018888
genes like me logo Genes that share ontologies with ADTRP: view
genes like me logo Genes that share phenotypes with ADTRP: view

Animal Model Products

miRNA for ADTRP Gene

miRTarBase miRNAs that target ADTRP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADTRP Gene

Localization for ADTRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADTRP Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADTRP gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005901 caveola IDA 21868574
GO:0009986 cell surface IDA 21868574
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IDA,IEA 27018888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADTRP: view

Pathways & Interactions for ADTRP Gene

SuperPathways for ADTRP Gene

No Data Available

Interacting Proteins for ADTRP Gene

Gene Ontology (GO) - Biological Process for ADTRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IMP 21868574
GO:0030195 negative regulation of blood coagulation IMP 21868574
GO:0042758 long-chain fatty acid catabolic process IMP 27018888
GO:0071383 cellular response to steroid hormone stimulus IEP 21868574
genes like me logo Genes that share ontologies with ADTRP: view

No data available for Pathways by source and SIGNOR curated interactions for ADTRP Gene

Drugs & Compounds for ADTRP Gene

No Compound Related Data Available

Transcripts for ADTRP Gene

Unigene Clusters for ADTRP Gene

Androgen-dependent TFPI-regulating protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADTRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for ADTRP Gene

GeneLoc Exon Structure for
ADTRP
ECgene alternative splicing isoforms for
ADTRP

Expression for ADTRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADTRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADTRP Gene

This gene is overexpressed in Colon - Transverse (x15.0), Small Intestine - Terminal Ileum (x7.4), Stomach (x5.3), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of ADTRP Gene:

ADTRP

SOURCE GeneReport for Unigene cluster for ADTRP Gene:

Hs.126409

mRNA Expression by UniProt/SwissProt for ADTRP Gene:

Q96IZ2-ADTRP_HUMAN
Tissue specificity: Expressed in cultured endothelial cells and in placenta.

Evidence on tissue expression from TISSUES for ADTRP Gene

  • Intestine(4.3)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with ADTRP: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADTRP Gene

Orthologs for ADTRP Gene

This gene was present in the common ancestor of animals.

Orthologs for ADTRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADTRP 34 33
  • 98.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADTRP 34 33
  • 82.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADTRP 33
  • 80.87 (n)
C23H6ORF105 34
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adtrp 33
  • 75.07 (n)
mouse
(Mus musculus)
Mammalia Adtrp 16 34 33
  • 74.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADTRP 34
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADTRP 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H6ORF105 33
  • 61.01 (n)
ADTRP 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADTRP 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adtrp 33
  • 55.02 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537455 33
  • 51.5 (n)
ADTRP 34
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3625 34
  • 30 (a)
ManyToMany
CG6149 34
  • 29 (a)
ManyToMany
CG11601 34
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for ADTRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADTRP Gene

ENSEMBL:
Gene Tree for ADTRP (if available)
TreeFam:
Gene Tree for ADTRP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADTRP: view image

Paralogs for ADTRP Gene

Paralogs for ADTRP Gene

(1) SIMAP similar genes for ADTRP Gene using alignment to 6 proteins:

  • ADTRP_HUMAN
  • D6R9A9_HUMAN
  • D6R9E5_HUMAN
  • D6RDG9_HUMAN
  • H0Y9P4_HUMAN
  • H0YAA5_HUMAN
genes like me logo Genes that share paralogs with ADTRP: view

Variants for ADTRP Gene

Sequence variations from dbSNP and Humsavar for ADTRP Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000032607 -- 11,781,287(-) C/T upstream_transcript_variant
rs1000099334 -- 11,746,190(-) A/C intron_variant
rs1000102807 -- 11,769,441(-) A/T intron_variant
rs1000116663 -- 11,775,315(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000133498 -- 11,733,657(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADTRP Gene

Variant ID Type Subtype PubMed ID
esv2759407 CNV loss 17122850
nsv522039 CNV gain 19592680
nsv600990 CNV loss 21841781

Variation tolerance for ADTRP Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADTRP Gene

Human Gene Mutation Database (HGMD)
ADTRP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADTRP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADTRP Gene

Disorders for ADTRP Gene

Additional Disease Information for ADTRP

No disorders were found for ADTRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADTRP Gene

Publications for ADTRP Gene

  1. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. (PMID: 21868574) Lupu C … Lupu F (Blood 2011) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by global gene expression regulation. (PMID: 27235449) Luo C … Wang QK (Physiological genomics 2016) 3 58

Products for ADTRP Gene

Sources for ADTRP Gene

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