Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADRM1 Gene

Aliases for ADRM1 Gene

  • Adhesion Regulating Molecule 1 2 3 5
  • Proteasome Regulatory Particle Non-ATPase 13 3 4
  • 110 KDa Cell Membrane Glycoprotein 3 4
  • Rpn13 Homolog 3 4
  • ARM-1 3 4
  • GP110 3 4
  • Proteasomal Ubiquitin Receptor ADRM1 3
  • Adhesion-Regulating Molecule 1 4
  • M(R) 110,000 Surface Antigen 3
  • HRpn13 4
  • Gp110 4
  • ARM1 3

External Ids for ADRM1 Gene

Previous GeneCards Identifiers for ADRM1 Gene

  • GC20P060641
  • GC20P061516
  • GC20P061563
  • GC20P060311
  • GC20P060877
  • GC20P057653

Summaries for ADRM1 Gene

Entrez Gene Summary for ADRM1 Gene

  • This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for ADRM1 Gene

ADRM1 (Adhesion Regulating Molecule 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include protease binding and endopeptidase activator activity.

UniProtKB/Swiss-Prot for ADRM1 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.

Gene Wiki entry for ADRM1 Gene

Additional gene information for ADRM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRM1 Gene

Genomics for ADRM1 Gene

GeneHancer (GH) Regulatory Elements for ADRM1 Gene

Promoters and enhancers for ADRM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J062300 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665.3 +1.7 1734 5.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ADRM1 DIDO1 TAF4 MRGBP ENSG00000226332 GID8 RPS21 YTHDF1 LAMA5 LAMA5-AS1
GH20J062140 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -159.2 -159151 4.3 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF207 SS18L1 PIR42263 PSMA7 MRGBP TAF4 DIDO1 ADRM1 MTG2
GH20J062236 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -63.7 -63735 4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 OSBPL2 DIDO1 TAF4 MRGBP MTG2 ADRM1 LAMA5-AS1 CABLES2 GATA5 GC20M062290
GH20J063271 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.1 +971.3 971297 2.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B SLC30A9 ZNF143 NKAIN4 ARFGAP1 GMEB2 MRGBP DIDO1 PRPF6 RTEL1 ARFRP1 YTHDF1 TNFRSF6B
GH20J062641 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.1 +343.3 343326 8 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 SLCO4A1 MRGBP TAF4 GMEB2 SLCO4A1-AS1 OGFR OGFR-AS1 MIR1-1 MIR1-1HG MIR1-1HG-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADRM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADRM1 gene promoter:

Genomic Locations for ADRM1 Gene

Genomic Locations for ADRM1 Gene
chr20:62,302,056-62,308,862
(GRCh38/hg38)
Size:
6,807 bases
Orientation:
Plus strand
chr20:60,877,149-60,883,918
(GRCh37/hg19)

Genomic View for ADRM1 Gene

Genes around ADRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRM1 Gene

Proteins for ADRM1 Gene

  • Protein details for ADRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16186-ADRM1_HUMAN
    Recommended name:
    Proteasomal ubiquitin receptor ADRM1
    Protein Accession:
    Q16186
    Secondary Accessions:
    • A0PKB1
    • Q96FJ7
    • Q9H1P2

    Protein attributes for ADRM1 Gene

    Size:
    407 amino acids
    Molecular mass:
    42153 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (PubMed:16990800). Interacts with the proteasomal scaffolding protein PSMD1 (PubMed:16990800,PubMed:16815440, PubMed:16906146, PubMed:20471946). Interacts with deubiquitinase UCHL5; this interaction activates the auto-inhibited UCHL5 by deoligomerizing it (PubMed:17139257, PubMed:24752541, PubMed:25702870, PubMed:25702872). Interacts with UBQLN2 and ubiquitin (PubMed:27396824).

    Three dimensional structures from OCA and Proteopedia for ADRM1 Gene

neXtProt entry for ADRM1 Gene

Post-translational modifications for ADRM1 Gene

  • Ubiquitination at Lys379, posLast=6262, Lys34, and posLast=2121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADRM1 Gene

Domains & Families for ADRM1 Gene

Gene Families for ADRM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ADRM1 Gene

Suggested Antigen Peptide Sequences for ADRM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16186

UniProtKB/Swiss-Prot:

ADRM1_HUMAN :
  • The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit.
  • Belongs to the ADRM1 family.
Domain:
  • The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit.
Family:
  • Belongs to the ADRM1 family.
genes like me logo Genes that share domains with ADRM1: view

Function for ADRM1 Gene

Molecular function for ADRM1 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.

Gene Ontology (GO) - Molecular Function for ADRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 18922472
GO:0005515 protein binding IPI 16713569
GO:0043130 ubiquitin binding IBA --
GO:0061133 endopeptidase activator activity IDA 16990800
GO:0070628 proteasome binding IDA 18162577
genes like me logo Genes that share ontologies with ADRM1: view
genes like me logo Genes that share phenotypes with ADRM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADRM1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRM1

Clone Products

  • Addgene plasmids for ADRM1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADRM1 Gene

Localization for ADRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRM1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRM1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 16990800
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADRM1: view

Pathways & Interactions for ADRM1 Gene

genes like me logo Genes that share pathways with ADRM1: view

Pathways by source for ADRM1 Gene

Gene Ontology (GO) - Biological Process for ADRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006368 transcription elongation from RNA polymerase II promoter IMP 11818576
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0010950 positive regulation of endopeptidase activity IEA --
GO:0016579 protein deubiquitination TAS --
GO:0043248 proteasome assembly IDA 16990800
genes like me logo Genes that share ontologies with ADRM1: view

No data available for SIGNOR curated interactions for ADRM1 Gene

Drugs & Compounds for ADRM1 Gene

No Compound Related Data Available

Transcripts for ADRM1 Gene

Unigene Clusters for ADRM1 Gene

Adhesion regulating molecule 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRM1

Clone Products

  • Addgene plasmids for ADRM1

Alternative Splicing Database (ASD) splice patterns (SP) for ADRM1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - - - - - - -
SP10: -
SP11: - - - -
SP12: -
SP13: -

ExUns: 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ADRM1 Gene

GeneLoc Exon Structure for
ADRM1
ECgene alternative splicing isoforms for
ADRM1

Expression for ADRM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADRM1 Gene

mRNA differential expression in normal tissues according to GTEx for ADRM1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for ADRM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.6), Breast (7.5), and Bone (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADRM1 Gene



Protein tissue co-expression partners for ADRM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADRM1 Gene:

ADRM1

SOURCE GeneReport for Unigene cluster for ADRM1 Gene:

Hs.90107

Evidence on tissue expression from TISSUES for ADRM1 Gene

  • Nervous system(4.8)
  • Skin(4.7)
  • Liver(4.4)
  • Pancreas(4.3)
  • Lung(3.6)
  • Intestine(2.7)
  • Muscle(2.5)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with ADRM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRM1 Gene

Orthologs for ADRM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADRM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRM1 34 33
  • 96.34 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRM1 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADRM1 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9774 34
  • 90 (a)
OneToMany
Adrm1 16 34 33
  • 87.31 (n)
dog
(Canis familiaris)
Mammalia ADRM1 34 33
  • 89.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADRM1 34 33
  • 88.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adrm1 33
  • 87.47 (n)
chicken
(Gallus gallus)
Aves ADRM1 34 33
  • 78.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRM1 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adrm1 33
  • 76.51 (n)
MGC75897 33
African clawed frog
(Xenopus laevis)
Amphibia Xoom 33
zebrafish
(Danio rerio)
Actinopterygii adrm1 34 33
  • 74.8 (n)
OneToOne
zgc56107 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8622 33
fruit fly
(Drosophila melanogaster)
Insecta CG13349 34 35
  • 41 (a)
OneToMany
CG6789 34
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C56G2.7 34 35
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons RPN13 33
  • 47.86 (n)
rice
(Oryza sativa)
Liliopsida Os05g0594800 33
  • 46.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8586 34
  • 51 (a)
OneToOne
Cin.4565 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn1301 33
  • 44.85 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4565 33
Species where no ortholog for ADRM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRM1 Gene

ENSEMBL:
Gene Tree for ADRM1 (if available)
TreeFam:
Gene Tree for ADRM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRM1: view image

Paralogs for ADRM1 Gene

(1) SIMAP similar genes for ADRM1 Gene using alignment to 1 proteins:

  • ADRM1_HUMAN
genes like me logo Genes that share paralogs with ADRM1: view

No data available for Paralogs for ADRM1 Gene

Variants for ADRM1 Gene

Sequence variations from dbSNP and Humsavar for ADRM1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs193921052 uncertain-significance, Malignant tumor of prostate 62,307,625(+) C/A/T coding_sequence_variant, missense_variant
rs1000405216 -- 62,304,266(+) C/G intron_variant
rs1000471418 -- 62,302,400(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000561190 -- 62,308,847(+) T/G 3_prime_UTR_variant
rs1000627913 -- 62,307,956(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADRM1 Gene

Variant ID Type Subtype PubMed ID
esv2422398 CNV duplication 17116639
nsv1160689 CNV deletion 26073780
nsv3441 CNV insertion 18451855
nsv470556 CNV loss 18288195
nsv518296 CNV loss 19592680
nsv586485 CNV loss 21841781
nsv834024 CNV gain 17160897
nsv953301 CNV deletion 24416366

Variation tolerance for ADRM1 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRM1 Gene

Disorders for ADRM1 Gene

Additional Disease Information for ADRM1

No disorders were found for ADRM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADRM1 Gene

Publications for ADRM1 Gene

  1. Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon. (PMID: 8033103) Shimada S … Greiner JW (Cancer research 1994) 2 3 4 58
  2. Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome. (PMID: 27396824) Chen X … Walters KJ (Structure (London, England : 1993) 2016) 3 4 58
  3. Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G. (PMID: 25702870) Sahtoe DD … Sixma TK (Molecular cell 2015) 3 4 58
  4. Structural basis for the activation and inhibition of the UCH37 deubiquitylase. (PMID: 25702872) Vander Linden RT … Hill CP (Molecular cell 2015) 3 4 58
  5. Mechanism of the Rpn13-induced activation of Uch37. (PMID: 24752541) Jiao L … Liu ZJ (Protein & cell 2014) 3 4 58

Products for ADRM1 Gene

Sources for ADRM1 Gene

Content
Loading form....