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Aliases for ADRB3 Gene

Aliases for ADRB3 Gene

  • Adrenoceptor Beta 3 2 3 5
  • Adrenergic, Beta-3-, Receptor 2 3
  • Beta-3 Adrenoreceptor 3 4
  • Beta-3 Adrenoceptor 3 4
  • Beta-3 Adrenergic Receptor 3
  • BETA3AR 3
  • ADRB3R 4
  • B3AR 4

External Ids for ADRB3 Gene

Previous GeneCards Identifiers for ADRB3 Gene

  • GC08P037473
  • GC08M038084
  • GC08M9E0062
  • GC08M037939
  • GC08M037822
  • GC08M036354

Summaries for ADRB3 Gene

Entrez Gene Summary for ADRB3 Gene

  • The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

GeneCards Summary for ADRB3 Gene

ADRB3 (Adrenoceptor Beta 3) is a Protein Coding gene. Diseases associated with ADRB3 include Body Mass Index Quantitative Trait Locus 11 and Morbid Obesity. Among its related pathways are G-protein signaling G-Protein alpha-i signaling cascades and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and epinephrine binding. An important paralog of this gene is ADRB1.

UniProtKB/Swiss-Prot for ADRB3 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Tocris Summary for ADRB3 Gene

  • The adrenergic beta3 receptor (beta3-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta2. They are located primarily in the small intestine, adipose tissue and vascular endothelium.

Gene Wiki entry for ADRB3 Gene

Additional gene information for ADRB3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRB3 Gene

Genomics for ADRB3 Gene

GeneHancer (GH) Regulatory Elements for ADRB3 Gene

Promoters and enhancers for ADRB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J037966 Promoter 0.7 EPDnew 650.7 +0.4 445 0.1 BACH1 ZFP91 EZH2 ADRB3 RAB11FIP1 GOT1L1
GH08J037967 Promoter 0.7 EPDnew 650.7 +0.0 18 0.1 ZFP91 EZH2 ADRB3 GOT1L1
GH08J037964 Enhancer 0.5 ENCODE 650.7 +1.2 1240 1.5 HDAC2 SUZ12 BACH1 CTBP2 ZBTB33 EZH2 ADRB3 GOT1L1
GH08J038070 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -104.5 -104514 2.6 TAL1 TCF12 ZNF766 NUFIP1 RBAK POLR2A NCOR1 CBFA2T2 ZNF280D CAVIN1 ADRB3 NSD3 ENSG00000260949 ENSG00000272128 GC08P038040 GC08M038027
GH08J037939 Promoter/Enhancer 1 EPDnew ENCODE 0.3 +26.6 26597 0.8 ZNF148 SP1 RFX1 VEZF1 REST GOT1L1 ADRB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADRB3 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A

Genomic Locations for ADRB3 Gene

Genomic Locations for ADRB3 Gene
chr8:37,962,991-37,966,965
(GRCh38/hg38)
Size:
3,975 bases
Orientation:
Minus strand
chr8:37,820,513-37,824,483
(GRCh37/hg19)
Size:
3,971 bases
Orientation:
Minus strand

Genomic View for ADRB3 Gene

Genes around ADRB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB3 Gene

Proteins for ADRB3 Gene

  • Protein details for ADRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13945-ADRB3_HUMAN
    Recommended name:
    Beta-3 adrenergic receptor
    Protein Accession:
    P13945
    Secondary Accessions:
    • Q4JFT4

    Protein attributes for ADRB3 Gene

    Size:
    408 amino acids
    Molecular mass:
    43519 Da
    Quaternary structure:
    • Interacts with ARRDC3.

    Three dimensional structures from OCA and Proteopedia for ADRB3 Gene

neXtProt entry for ADRB3 Gene

Post-translational modifications for ADRB3 Gene

  • Glycosylation at posLast=2626 and Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ADRB3 (beta-3 Adrenergic R/ADRB3)

No data available for DME Specific Peptides for ADRB3 Gene

Domains & Families for ADRB3 Gene

Gene Families for ADRB3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P13945

UniProtKB/Swiss-Prot:

ADRB3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
genes like me logo Genes that share domains with ADRB3: view

Function for ADRB3 Gene

Molecular function for ADRB3 Gene

UniProtKB/Swiss-Prot Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
GENATLAS Biochemistry:
adrenergic,beta-3-,receptor,G protein coupled receptor superfamily,mostly expressed in brown and white adipose tissue,activating adenylate cyclase,susceptibility gene for hypertension in the Sardinian population (polymorphism W64R) and for obesity in Mexican-American population

Gene Ontology (GO) - Molecular Function for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IBA,IEA --
GO:0004939 beta-adrenergic receptor activity IDA 15123695
GO:0005515 protein binding IPI 15123695
genes like me logo Genes that share ontologies with ADRB3: view
genes like me logo Genes that share phenotypes with ADRB3: view

Animal Models for ADRB3 Gene

MGI Knock Outs for ADRB3:

Clone Products

  • Addgene plasmids for ADRB3
  • R&D Systems cDNA Clones for ADRB3 (beta-3 Adrenergic R/ADRB3)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRB3 Gene

Localization for ADRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRB3 gene
Compartment Confidence
plasma membrane 5
nucleus 3
mitochondrion 2
peroxisome 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1718744
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRB3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRB3 Gene

Pathways & Interactions for ADRB3 Gene

genes like me logo Genes that share pathways with ADRB3: view

Gene Ontology (GO) - Biological Process for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IBA --
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA --
GO:0002032 NOT desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA 15123695
GO:0005975 carbohydrate metabolic process TAS 2570461
genes like me logo Genes that share ontologies with ADRB3: view

No data available for SIGNOR curated interactions for ADRB3 Gene

Drugs & Compounds for ADRB3 Gene

(91) Drugs for ADRB3 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bupranolol Approved Pharma Antagonist, Target, antagonist 0
Isoproterenol Approved, Investigational Pharma Full agonist, Agonist, Target, agonist 24
Propranolol Approved, Investigational Pharma Antagonist, Inhibition, Inhibitor, antagonist, Target Beta blocker 247
Nadolol Approved Pharma Antagonist, antagonist 22
Norepinephrine Approved Pharma Target, agonist 737

(13) Additional Compounds for ADRB3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-adrenaline
Full agonist, Agonist, Partial agonist
SR58611A
Full agonist, Agonist
Octopamine hydrochloride
770-05-8

(3) Tocris Compounds for ADRB3 Gene

Compound Action Cas Number
(S)-(-)-Pindolol beta3 partial agonist. More active enantiomer of pindolol (Cat. No. 0994) 26328-11-0
Octopamine hydrochloride Invertebrate biogenic amine: activates beta3 adrenoceptors 770-05-8
Pindolol beta3 partial agonist 13523-86-9
genes like me logo Genes that share compounds with ADRB3: view

Transcripts for ADRB3 Gene

mRNA/cDNA for ADRB3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRB3 Gene

Adrenoceptor beta 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for ADRB3
  • R&D Systems cDNA Clones for ADRB3 (beta-3 Adrenergic R/ADRB3)

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB3 Gene

No ASD Table

Relevant External Links for ADRB3 Gene

GeneLoc Exon Structure for
ADRB3
ECgene alternative splicing isoforms for
ADRB3

Expression for ADRB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADRB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB3 Gene

This gene is overexpressed in Ovary (x14.6), Fallopian Tube (x6.9), Esophagus - Muscularis (x6.5), Bladder (x5.9), and Esophagus - Gastroesophageal Junction (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of ADRB3 Gene:

ADRB3

SOURCE GeneReport for Unigene cluster for ADRB3 Gene:

Hs.2549

mRNA Expression by UniProt/SwissProt for ADRB3 Gene:

P13945-ADRB3_HUMAN
Tissue specificity: Expressed mainly in adipose tissues.

Evidence on tissue expression from TISSUES for ADRB3 Gene

  • Muscle(2.2)
  • Heart(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with ADRB3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRB3 Gene

Orthologs for ADRB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRB3 34 33
  • 99.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADRB3 34 33
  • 86.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADRB3 34 33
  • 86.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adrb3 16 34 33
  • 81.33 (n)
rat
(Rattus norvegicus)
Mammalia Adrb3 33
  • 80.9 (n)
oppossum
(Monodelphis domestica)
Mammalia ADRB3 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC430991 33
  • 71.31 (n)
ADRB3 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRB3 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487086 33
  • 61.81 (n)
zebrafish
(Danio rerio)
Actinopterygii adrb3a 34 33
  • 56.57 (n)
OneToMany
adrb3b 34
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7431 35
  • 40 (a)
CG6989 35
  • 37 (a)
CG6919 35
  • 36 (a)
DopR 35
  • 34 (a)
Octbeta2R 34
  • 23 (a)
ManyToMany
oa2 34
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 35
  • 39 (a)
Species where no ortholog for ADRB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRB3 Gene

ENSEMBL:
Gene Tree for ADRB3 (if available)
TreeFam:
Gene Tree for ADRB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRB3: view image

Paralogs for ADRB3 Gene

Paralogs for ADRB3 Gene

(15) SIMAP similar genes for ADRB3 Gene using alignment to 4 proteins:

  • ADRB3_HUMAN
  • A8KAG8_HUMAN
  • B8X6N0_HUMAN
  • B8X6N1_HUMAN
genes like me logo Genes that share paralogs with ADRB3: view

Variants for ADRB3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB3 Gene

ADRB3_HUMAN-P13945
The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).

Sequence variations from dbSNP and Humsavar for ADRB3 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs4994 risk-factor, Obesity 37,966,280(-) A/G coding_sequence_variant, missense_variant
rs1000149764 -- 37,965,295(-) G/C/T coding_sequence_variant, missense_variant
rs1000416960 -- 37,965,110(-) G/A intron_variant
rs1002283138 -- 37,964,546(-) T/G intron_variant
rs1003024920 -- 37,968,553(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADRB3 Gene

Variant ID Type Subtype PubMed ID
nsv474345 CNV novel sequence insertion 20440878
nsv610947 CNV loss 21841781
nsv610948 CNV loss 21841781
nsv610949 CNV gain+loss 21841781
nsv951127 CNV deletion 24416366

Variation tolerance for ADRB3 Gene

Gene Damage Index Score: 5.83; 73.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRB3 Gene

Human Gene Mutation Database (HGMD)
ADRB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRB3

SNP Genotyping and Copy Number Assay Products

Disorders for ADRB3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ADRB3 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ADRB3 in MalaCards View complete list of genes associated with diseases

Genatlas disease for ADRB3 Gene

excess capacity to gain weight in patients with insulin resistance,early onset non insulin dependent diabetes and/or morbid obesity,with fatty liver

Additional Disease Information for ADRB3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADRB3: view

No data available for UniProtKB/Swiss-Prot for ADRB3 Gene

Publications for ADRB3 Gene

  1. Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. (PMID: 20078877) Fan AZ … Mokdad AH (BMC medical genetics 2010) 3 22 44 58
  2. Trp64Arg polymorphism of the ADRB3 gene predicts hyperuricemia risk in a population from southern Spain. (PMID: 20008926) Morcillo S … Soriguer F (The Journal of rheumatology 2010) 3 22 44 58
  3. Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study. (PMID: 18249219) Kilpeläinen TO … Finnish Diabetes Prevention Study Group (Metabolism: clinical and experimental 2008) 3 22 44 58
  4. Genetic polymorphisms of beta2- and beta3-adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women. (PMID: 18393130) Rooyen JM … Schutte R (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008) 3 22 44 58
  5. Relation of Trp64Arg polymorphism of beta3-adrenoreceptor gene with cardiovascular risk factors in presurgical morbidly obese patients. (PMID: 18996293) de Luis DA … Conde R (Archives of medical research 2008) 3 22 44 58

Products for ADRB3 Gene

  • Addgene plasmids for ADRB3

Sources for ADRB3 Gene

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