The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain poly... See more...

Aliases for ADRB3 Gene

Aliases for ADRB3 Gene

  • Adrenoceptor Beta 3 2 3 5
  • Adrenergic, Beta-3-, Receptor 2 3
  • Beta-3 Adrenergic Receptor 3 4
  • Beta-3 Adrenoreceptor 3 4
  • Beta-3 Adrenoceptor 3 4
  • BETA3AR 3
  • ADRB3R 4
  • ADRB3 5
  • B3AR 4

External Ids for ADRB3 Gene

Previous GeneCards Identifiers for ADRB3 Gene

  • GC08P037473
  • GC08M038084
  • GC08M9E0062
  • GC08M037939
  • GC08M037822
  • GC08M036354

Summaries for ADRB3 Gene

Entrez Gene Summary for ADRB3 Gene

  • The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]

GeneCards Summary for ADRB3 Gene

ADRB3 (Adrenoceptor Beta 3) is a Protein Coding gene. Diseases associated with ADRB3 include Body Mass Index Quantitative Trait Locus 11 and Obesity Due To Melanocortin 4 Receptor Deficiency. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and epinephrine binding. An important paralog of this gene is ENSG00000285880.

UniProtKB/Swiss-Prot Summary for ADRB3 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Tocris Summary for ADRB3 Gene

  • The adrenergic beta3 receptor (beta3-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta2. They are located primarily in the small intestine, adipose tissue and vascular endothelium.

Gene Wiki entry for ADRB3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADRB3 Gene

Genomics for ADRB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADRB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J037964 Promoter/Enhancer 0.8 Ensembl ENCODE 250.7 +0.9 874 1.5 ZBTB33 HDAC2 EZH2 BACH1 ADRB3 ENSG00000285880 piR-43325-091 GOT1L1 RF00017-6412
GH08J037966 Promoter 0.6 EPDnew 250.7 +0.1 79 0.1 ZFP91 ZBTB33 BACH1 EZH2 ADRB3 ENSG00000285880 piR-57460-636 RAB11FIP1 RF00017-6412
GH08J037967 Promoter 0.5 EPDnew 250.7 -0.3 -348 0.1 ZFP91 EZH2 ADRB3 ENSG00000285880 piR-57460-636 RF00017-6412 EIF4EBP1
GH08J038070 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -105.3 -105321 3.5 NCOR1 IKZF1 ZNF580 ZNF592 NFIC TAL1 NUFIP1 RBM22 RELA ZBTB33 ADRB3 NSD3 HSALNG0064606 HSALNG0064608 RF00017-6416 HSALNG0064607-001 ASH2L EIF4EBP1 RF00017-6413 RF00017-6415
GH08J037960 Enhancer 0.9 Ensembl ENCODE 0.7 +4.8 4787 3.6 NCOR1 IKZF1 NFIC TAL1 BHLHE40 SPI1 HDAC2 BATF NRF1 TCF12 ADRB3 ENSG00000285880 piR-43325-091 GOT1L1 RF00017-6412
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRB3

Top Transcription factor binding sites by QIAGEN in the ADRB3 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A

Genomic Locations for ADRB3 Gene

Latest Assembly
chr8:37,962,990-37,966,599
(GRCh38/hg38)
Size:
3,610 bases
Orientation:
Minus strand

Previous Assembly
chr8:37,820,508-37,824,117
(GRCh37/hg19 by Entrez Gene)
Size:
3,610 bases
Orientation:
Minus strand

chr8:37,820,516-37,824,483
(GRCh37/hg19 by Ensembl)
Size:
3,968 bases
Orientation:
Minus strand

Genomic View for ADRB3 Gene

Genes around ADRB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB3 Gene

Proteins for ADRB3 Gene

  • Protein details for ADRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13945-ADRB3_HUMAN
    Recommended name:
    Beta-3 adrenergic receptor
    Protein Accession:
    P13945
    Secondary Accessions:
    • Q4JFT4

    Protein attributes for ADRB3 Gene

    Size:
    408 amino acids
    Molecular mass:
    43519 Da
    Quaternary structure:
    • Interacts with ARRDC3.

    Three dimensional structures from OCA and Proteopedia for ADRB3 Gene

neXtProt entry for ADRB3 Gene

Post-translational modifications for ADRB3 Gene

  • Glycosylation at Asn8 and Asn26
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRB3 Gene

Domains & Families for ADRB3 Gene

Gene Families for ADRB3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADRB3 Gene

InterPro:
Blocks:
  • Adrenergic receptor signature
  • Beta-3 adrenergic receptor signature

Suggested Antigen Peptide Sequences for ADRB3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94487, Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA (A8KAG8_HUMAN)
  • Beta-3 adrenoreceptor (ADRB3_HUMAN)
  • Beta3 adrenoceptor (B8X6N0_HUMAN)
  • Beta3 adrenoceptor (B8X6N1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13945

UniProtKB/Swiss-Prot:

ADRB3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
genes like me logo Genes that share domains with ADRB3: view

Function for ADRB3 Gene

Molecular function for ADRB3 Gene

UniProtKB/Swiss-Prot Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
GENATLAS Biochemistry:
adrenergic,beta-3-,receptor,G protein coupled receptor superfamily,mostly expressed in brown and white adipose tissue,activating adenylate cyclase,susceptibility gene for hypertension in the Sardinian population (polymorphism W64R) and for obesity in Mexican-American population

Gene Ontology (GO) - Molecular Function for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004935 adrenergic receptor activity IEA --
GO:0004939 beta-adrenergic receptor activity IDA 15123695
GO:0005515 protein binding IPI 15123695
GO:0015052 beta3-adrenergic receptor activity IMP 9892244
genes like me logo Genes that share ontologies with ADRB3: view
genes like me logo Genes that share phenotypes with ADRB3: view

Human Phenotype Ontology for ADRB3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADRB3 Gene

MGI Knock Outs for ADRB3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRB3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for ADRB3 Gene

Localization for ADRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRB3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
extracellular 2
cytoskeleton 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 15123695
genes like me logo Genes that share ontologies with ADRB3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRB3 Gene

Pathways & Interactions for ADRB3 Gene

PathCards logo

SuperPathways for ADRB3 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
2 Activation of cAMP-Dependent PKA
.77
.77
.71
3 Monoamine GPCRs
4 Signaling by GPCR
5 DAG and IP3 signaling
.50
.32
genes like me logo Genes that share pathways with ADRB3: view

Pathways by source for ADRB3 Gene

5 GeneGo (Thomson Reuters) pathways for ADRB3 Gene
  • Beta-2 adrenergic-dependent CFTR expression
  • Development Beta-adrenergic receptors regulation of ERK
  • Development Beta-adrenergic receptors signaling via cAMP
  • Development Ligand-independent activation of ESR1 and ESR2
  • Transcription CREB pathway
3 Qiagen pathways for ADRB3 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • cAMP Pathway

SIGNOR curated interactions for ADRB3 Gene

Activates:

Gene Ontology (GO) - Biological Process for ADRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA 21873635
GO:0002032 NOT desensitization of G protein-coupled receptor signaling pathway by arrestin IDA 15123695
GO:0005975 carbohydrate metabolic process TAS 2570461
GO:0006091 generation of precursor metabolites and energy TAS 2570461
GO:0006112 energy reserve metabolic process TAS 1718744
genes like me logo Genes that share ontologies with ADRB3: view

Drugs & Compounds for ADRB3 Gene

(90) Drugs for ADRB3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoproterenol Approved, Investigational Pharma Agonist, Full agonist, Target 31
Propranolol Approved, Investigational Pharma Antagonist, Target Beta blocker 314
Nadolol Approved Pharma Antagonist 24
Norepinephrine Approved Pharma Target, agonist 1019
Mirabegron Approved Pharma Target, agonist 126

(14) Additional Compounds for ADRB3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
bunolol
Antagonist
SR58611A
Agonist, Full agonist
(S)-(-)-Pindolol
26328-11-0
Octopamine hydrochloride
770-05-8

(3) Tocris Compounds for ADRB3 Gene

Compound Action Cas Number
(S)-(-)-Pindolol beta3 partial agonist. More active enantiomer of pindolol (Cat. No. 0994) 26328-11-0
Octopamine hydrochloride Invertebrate biogenic amine: activates beta3 adrenoceptors 770-05-8
Pindolol beta3 partial agonist 13523-86-9

(7) ApexBio Compounds for ADRB3 Gene

Compound Action Cas Number
Betaxolol βadrenergic receptor blocker 659-18-7
BRL 37344, sodium salt β3-adrenoceptor agonist,potent and selective 127299-93-8
CL 316243 disodium salt murine-selective β3 adrenoceptor agonist 151126-84-0
Esmolol HCl 81161-17-3
ICI 118,551 hydrochloride 72795-01-8
L-755,507 β3 adrenergic receptor agonist 159182-43-1
Sotalol hydrochloride β-adrenergic receptor antagonist 959-24-0
genes like me logo Genes that share compounds with ADRB3: view

Drug products for research

Transcripts for ADRB3 Gene

mRNA/cDNA for ADRB3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRB3

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB3 Gene

No ASD Table

Relevant External Links for ADRB3 Gene

GeneLoc Exon Structure for
ADRB3

Expression for ADRB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB3 Gene

This gene is overexpressed in Ovary (x14.6), Fallopian Tube (x6.9), Esophagus - Muscularis (x6.5), Bladder (x5.9), and Esophagus - Gastroesophageal Junction (x4.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRB3

SOURCE GeneReport for Unigene cluster for ADRB3 Gene:

Hs.2549

mRNA Expression by UniProt/SwissProt for ADRB3 Gene:

P13945-ADRB3_HUMAN
Tissue specificity: Expressed mainly in adipose tissues.

Evidence on tissue expression from TISSUES for ADRB3 Gene

  • Nervous system(2.7)
  • Muscle(2.4)
  • Heart(2.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ADRB3: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRB3 Gene

Orthologs for ADRB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADRB3 29 30
  • 99.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADRB3 29 30
  • 86.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADRB3 29 30
  • 86.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Adrb3 29 16 30
  • 81.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adrb3 29
  • 80.9 (n)
Oppossum
(Monodelphis domestica)
Mammalia ADRB3 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC430991 29
  • 71.31 (n)
ADRB3 30
  • 45 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADRB3 30
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100487086 29
  • 61.81 (n)
Zebrafish
(Danio rerio)
Actinopterygii adrb3a 29 30
  • 56.57 (n)
OneToMany
adrb3b 30
  • 39 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7431 31
  • 40 (a)
CG6989 31
  • 37 (a)
CG6919 31
  • 36 (a)
DopR 31
  • 34 (a)
Octbeta2R 30
  • 23 (a)
ManyToMany
oa2 30
  • 23 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea M03F4.3 31
  • 39 (a)
Species where no ortholog for ADRB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADRB3 Gene

ENSEMBL:
Gene Tree for ADRB3 (if available)
TreeFam:
Gene Tree for ADRB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRB3: view image
Alliance of Genome Resources:
Additional Orthologs for ADRB3

Paralogs for ADRB3 Gene

(15) SIMAP similar genes for ADRB3 Gene using alignment to 4 proteins:

  • ADRB3_HUMAN
  • A8KAG8_HUMAN
  • B8X6N0_HUMAN
  • B8X6N1_HUMAN
genes like me logo Genes that share paralogs with ADRB3: view

Variants for ADRB3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB3 Gene

ADRB3_HUMAN-P13945
The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRB3 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs202143668 Benign: not provided 37,966,416(-) G/C
NM_000025.3(ADRB3):c.54C>G (p.Pro18=)
SYNONYMOUS
rs36031925 Benign: not provided 37,965,413(-) G/Ap.Arg353Cys
NM_000025.3(ADRB3):c.1057C>T (p.Arg353Cys)
MISSENSE
rs4994 Risk Factor: Obesity 37,966,280(-) A/Gp.Trp64Arg
NM_000025.3(ADRB3):c.190T>C (p.Trp64Arg)
MISSENSE
rs780502227 Likely Benign: not provided 37,965,492(-) C/A
NM_000025.3(ADRB3):c.978G>T (p.Pro326=)
SYNONYMOUS
rs28364012 -- p.Glu249Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ADRB3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ADRB3 Gene

Variant ID Type Subtype PubMed ID
nsv474345 CNV novel sequence insertion 20440878
nsv610947 CNV loss 21841781
nsv610948 CNV loss 21841781
nsv610949 CNV gain+loss 21841781
nsv951127 CNV deletion 24416366

Variation tolerance for ADRB3 Gene

Gene Damage Index Score: 5.83; 73.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRB3 Gene

Human Gene Mutation Database (HGMD)
ADRB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRB3
Leiden Open Variation Database (LOVD)
ADRB3

SNP Genotyping and Copy Number Assays for research

Disorders for ADRB3 Gene

MalaCards: The human disease database

(22) MalaCards diseases for ADRB3 Gene - From: OMI, CVR, GTR, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ADRB3 in MalaCards View complete list of genes associated with diseases

Genatlas disease for ADRB3 Gene

excess capacity to gain weight in patients with insulin resistance,early onset non insulin dependent diabetes and/or morbid obesity,with fatty liver

Additional Disease Information for ADRB3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ADRB3: view

No data available for UniProtKB/Swiss-Prot for ADRB3 Gene

Publications for ADRB3 Gene

  1. Effects of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates. (PMID: 15472194) Wang X … Li S (The Journal of clinical endocrinology and metabolism 2004) 3 22 40 72
  2. Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor. (PMID: 11095426) Walston J … Shuldiner AR (The Journal of clinical endocrinology and metabolism 2000) 3 22 40 72
  3. Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects. (PMID: 10999801) Urhammer SA … Pedersen O (The Journal of clinical endocrinology and metabolism 2000) 3 22 40 72
  4. Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. (PMID: 8721782) Fujisawa T … Ogihara T (Diabetologia 1996) 3 4 22 40
  5. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. (PMID: 7609752) Clément K … Strosberg AD (The New England journal of medicine 1995) 3 4 22 72

Products for ADRB3 Gene

  • Addgene plasmids for ADRB3

Sources for ADRB3 Gene