This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The ass... See more...

Aliases for ADRB2 Gene

Aliases for ADRB2 Gene

  • Adrenoceptor Beta 2 2 3 5
  • B2AR 2 3 4
  • Adrenergic, Beta-2-, Receptor, Surface 2 3
  • Beta-2 Adrenergic Receptor 3 4
  • Beta-2 Adrenoreceptor 3 4
  • Beta-2 Adrenoceptor 3 4
  • ADRB2R 3 4
  • ADRBR 2 3
  • BAR 2 3
  • Adrenoceptor Beta 2, Surface 2
  • Adrenoceptor Beta 2 Surface 3
  • Catecholamine Receptor 3
  • BETA2AR 3
  • ADRB2 5

External Ids for ADRB2 Gene

Previous HGNC Symbols for ADRB2 Gene

  • ADRB2R

Previous GeneCards Identifiers for ADRB2 Gene

  • GC05P148250
  • GC05M148800
  • GC05P148187
  • GC05P148235
  • GC05P148236
  • GC05P148186
  • GC05P143352

Summaries for ADRB2 Gene

Entrez Gene Summary for ADRB2 Gene

  • This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

GeneCards Summary for ADRB2 Gene

ADRB2 (Adrenoceptor Beta 2) is a Protein Coding gene. Diseases associated with ADRB2 include Asthma and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Peptide ligand-binding receptors and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and enzyme binding. An important paralog of this gene is ADRB1.

UniProtKB/Swiss-Prot Summary for ADRB2 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Tocris Summary for ADRB2 Gene

  • The adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta3. They are located primarily in the CNS, heart, kidney and muscle.

Gene Wiki entry for ADRB2 Gene

PharmGKB "VIP" Summary for ADRB2 Gene

No data available for CIViC Summary , Rfam classification and piRNA Summary for ADRB2 Gene

Genomics for ADRB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADRB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRB2

Top Transcription factor binding sites by QIAGEN in the ADRB2 gene promoter:
  • CREB
  • deltaCREB
  • MyoD
  • p53
  • STAT3

Genomic Locations for ADRB2 Gene

Latest Assembly
2,013 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
2,013 bases
Plus strand

(GRCh37/hg19 by Ensembl)
2,041 bases
Plus strand

Genomic View for ADRB2 Gene

Genes around ADRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB2 Gene

Proteins for ADRB2 Gene

  • Protein details for ADRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-2 adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • B0LPE4
    • B2R7X2
    • O14823
    • O14824
    • O14825
    • O14826
    • Q4JG18
    • Q53GA6
    • Q6GMT4
    • Q6P4D8
    • Q8NEQ9
    • Q96EC3
    • Q9UCZ0
    • Q9UCZ1
    • Q9UCZ2
    • Q9UCZ3
    • Q9UH95
    • Q9UHA1
    • Q9UMZ5

    Protein attributes for ADRB2 Gene

    413 amino acids
    Molecular mass:
    46459 Da
    Quaternary structure:
    • Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262).
    • Sequence=BAD96745.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADRB2 Gene

neXtProt entry for ADRB2 Gene

Post-translational modifications for ADRB2 Gene

  • Palmitoylated (PubMed:2540197, PubMed:11146000, PubMed:27481942, PubMed:17962520, PubMed:18547522). Mainly palmitoylated at Cys-341 (PubMed:2540197, PubMed:17962520, PubMed:18547522). Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (PubMed:11146000). Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi (PubMed:27481942). Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor (PubMed:27481942). Could be depalmitoylated by LYPLA1 at the plasma membrane (PubMed:27481942).
  • Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
  • Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
  • Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.
  • Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
  • Glycosylation at Asn6 and Asn15
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for ADRB2 Gene

Domains & Families for ADRB2 Gene

Gene Families for ADRB2 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for ADRB2 Gene

  • Adrenergic receptor signature
  • Beta-2 adrenergic receptor signature

Suggested Antigen Peptide Sequences for ADRB2 Gene

GenScript: Design optimal peptide antigens:
  • Beta-2 adrenoreceptor (ADRB2_HUMAN)
  • Beta-2 adrenergic receptor (Q9BYZ0_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
genes like me logo Genes that share domains with ADRB2: view

Function for ADRB2 Gene

Molecular function for ADRB2 Gene

UniProtKB/Swiss-Prot Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
GENATLAS Biochemistry:
adrenergic,beta-2-,receptor,G protein coupled receptor superfamily,activating adenylate cyclase,major lipolytic receptor in human fat cell altered in obesity,also associated to susceptibility to hypertension (polymorphism,R16G)

Phenotypes From GWAS Catalog for ADRB2 Gene

Gene Ontology (GO) - Molecular Function for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding IDA 20395454
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004935 adrenergic receptor activity IEA --
GO:0004941 beta2-adrenergic receptor activity IBA,NAS 20395454
GO:0005515 protein binding IPI 9560162
genes like me logo Genes that share ontologies with ADRB2: view
genes like me logo Genes that share phenotypes with ADRB2: view

Human Phenotype Ontology for ADRB2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADRB2 Gene

MGI Knock Outs for ADRB2:

miRNA for ADRB2 Gene

miRTarBase miRNAs that target ADRB2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRB2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADRB2 Gene

Localization for ADRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB2 Gene

Cell membrane. Multi-pass membrane protein. Early endosome. Golgi apparatus. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). {ECO:0000269 PubMed:19584355, ECO:0000269 PubMed:20559325, ECO:0000269 PubMed:27481942}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRB2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
endosome 4
lysosome 4
extracellular 3
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005764 lysosome TAS 9507004
GO:0005768 endosome TAS 10734107
GO:0005769 early endosome IEA --
GO:0005794 Golgi apparatus IEA,IDA 27481942
genes like me logo Genes that share ontologies with ADRB2: view

Pathways & Interactions for ADRB2 Gene

genes like me logo Genes that share pathways with ADRB2: view

Pathways by source for ADRB2 Gene

7 GeneGo (Thomson Reuters) pathways for ADRB2 Gene
  • Beta-2 adrenergic-dependent CFTR expression
  • Development Beta-adrenergic receptors regulation of ERK
  • Development Beta-adrenergic receptors signaling via cAMP
  • Development Ligand-independent activation of ESR1 and ESR2
  • Regulation of CFTR activity (norm and CF)
5 Qiagen pathways for ADRB2 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Beta-Adrenergic Signaling
  • cAMP Pathway
  • Signaling Involved in Cardiac Hypertrophy
2 Cell Signaling Technology pathways for ADRB2 Gene

SIGNOR curated interactions for ADRB2 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for ADRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine IEA --
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA,IBA 21873635
GO:0002028 regulation of sodium ion transport IEA --
GO:0002032 desensitization of G protein-coupled receptor signaling pathway by arrestin IDA 15123695
genes like me logo Genes that share ontologies with ADRB2: view

Drugs & Compounds for ADRB2 Gene

(231) Drugs for ADRB2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoproterenol Approved, Investigational Pharma Agonist, Full agonist, Target 31
Carvedilol Approved, Investigational Pharma Antagonist, Target 207
Betaxolol Approved, Investigational Pharma Antagonist, Target βadrenergic receptor blocker 9
Propranolol Approved, Investigational Pharma Antagonist, Target Beta blocker 314
Salbutamol Approved, Vet_approved Pharma Agonist, Partial agonist, Target 0

(40) Additional Compounds for ADRB2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Salbutamol hemisulfate

(5) Tocris Compounds for ADRB2 Gene

Compound Action Cas Number
Formoterol hemifumarate Potent and selective beta2 agonist 43229-80-7
Procaterol hydrochloride Potent beta2 agonist 62929-91-3
Salbutamol hemisulfate beta agonist (beta2 > beta1) 51022-70-9
Salmeterol xinafoate Long-acting beta2 agonist; bronchodilator 94749-08-3
Zinterol hydrochloride Selective beta2 agonist 37000-20-7

(55) ApexBio Compounds for ADRB2 Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Carteolol HCl Non-selective beta-adrenoceptor antagonist 51781-21-6
Carvedilol 72956-09-3
CGP 12177 hydrochloride β1/β2-AR antagonist,β3 AR partial agonist 64208-32-8
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Clorprenaline HCL 6933-90-0
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Esmolol HCl 81161-17-3
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
HOKU-81 Bronchodilators,metabolite of tulobuterol 58020-43-2
ICI 118,551 hydrochloride 72795-01-8
Indacaterol β2-agonist 312753-06-3
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Levobetaxolol HCl 116209-55-3
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Mirabegron (YM178) 223673-61-8
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Phenoxybenzamine HCl 63-92-3
Phenylephrine HCl 61-76-7
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Sotalol hydrochloride β-adrenergic receptor antagonist 959-24-0
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Vilanterol β2-AR agonist 503068-34-6
Vilanterol trifenatate β2-AR agonist 503070-58-4
genes like me logo Genes that share compounds with ADRB2: view

Drug products for research

Transcripts for ADRB2 Gene

mRNA/cDNA for ADRB2 Gene

12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRB2

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB2 Gene

No ASD Table

Relevant External Links for ADRB2 Gene

GeneLoc Exon Structure for

Expression for ADRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x5.4) and Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for ADRB2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADRB2 Gene

Protein tissue co-expression partners for ADRB2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRB2

SOURCE GeneReport for Unigene cluster for ADRB2 Gene:


Evidence on tissue expression from TISSUES for ADRB2 Gene

  • Nervous system(4.6)
  • Heart(4.6)
  • Blood(4.6)
  • Thyroid gland(4.4)
  • Muscle(3.6)
  • Liver(3.2)
  • Lung(2.7)
  • Eye(2.7)
  • Skin(2.5)
  • Pancreas(2.4)
  • Kidney(2.4)
  • Intestine(2.4)
  • Spleen(2.2)
  • Bone marrow(2.1)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with ADRB2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRB2 Gene

Orthologs for ADRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADRB2 29 30
  • 99.6 (n)
(Canis familiaris)
Mammalia ADRB2 29 30
  • 90 (n)
(Bos Taurus)
Mammalia ADRB2 29 30
  • 89.99 (n)
(Rattus norvegicus)
Mammalia Adrb2 29
  • 87.09 (n)
(Mus musculus)
Mammalia Adrb2 29 16 30
  • 85.71 (n)
(Monodelphis domestica)
Mammalia ADRB2 30
  • 78 (a)
(Gallus gallus)
Aves ADRB2 29
  • 78.16 (n)
(Anolis carolinensis)
Reptilia ADRB2 30
  • 65 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adrb2 29
  • 67.43 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68724 29
(Danio rerio)
Actinopterygii adrb2b 29 30
  • 62.98 (n)
adrb2a 30
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA2 29
  • 51.13 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Octbeta2R 29 30
  • 50.3 (n)
DopR2 31
  • 45 (a)
CG6989 31
  • 40 (a)
CG6919 31
  • 39 (a)
DopR 31
  • 33 (a)
oa2 30
  • 25 (a)
(Caenorhabditis elegans)
Secernentea M03F4.3 31
  • 34 (a)
Species where no ortholog for ADRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADRB2 Gene

Gene Tree for ADRB2 (if available)
Gene Tree for ADRB2 (if available)
Evolutionary constrained regions (ECRs) for ADRB2: view image
Alliance of Genome Resources:
Additional Orthologs for ADRB2

Paralogs for ADRB2 Gene

(26) SIMAP similar genes for ADRB2 Gene using alignment to 3 proteins:

  • A2N4T7_HUMAN
genes like me logo Genes that share paralogs with ADRB2: view

Variants for ADRB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB2 Gene

The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRB2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs1042713 Benign: Asthma, nocturnal, susceptibility to; not provided. Drug Response: salbutamol response - Efficacy; salmeterol response - Efficacy 148,826,877(+) G/.G/Ap.Gly16Arg
NM_000024.5(ADRB2):c.46A>G (p.Arg16Gly)
rs1042714 Benign: ADRB2 POLYMORPHISM; not provided 148,826,910(+) G/.p.Glu27Gln
NM_000024.5(ADRB2):c.79C>G (p.Gln27Glu)
rs1262409100 Likely Benign: not provided 148,827,107(+) C/G
NM_000024.5(ADRB2):c.276C>G (p.Ala92=)
rs145066318 Likely Benign: not provided 148,827,821(+) A/C
NM_000024.5(ADRB2):c.990A>C (p.Pro330=)
rs1580822887 Likely Benign: not provided 148,827,323(+) C/A
NM_000024.5(ADRB2):c.492C>A (p.Thr164=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ADRB2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ADRB2 Gene

Variant ID Type Subtype PubMed ID
nsv599947 CNV loss 21841781

Variation tolerance for ADRB2 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.34; 88.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRB2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

Disorders for ADRB2 Gene

MalaCards: The human disease database

(55) MalaCards diseases for ADRB2 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
  • asthma, susceptibility to
body mass index quantitative trait locus 11
  • bmiq11
status asthmaticus
  • asthma with status asthmaticus
isoproterenol-mediated vasodilatation
acute mountain sickness
  • altitude anoxia
- elite association - COSMIC cancer census association via MalaCards
Search ADRB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADRB2

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ADRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRB2 Gene

Publications for ADRB2 Gene

  1. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. (PMID: 7706471) Turki J … Liggett SB (The Journal of clinical investigation 1995) 3 4 40 72
  2. GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. (PMID: 20335826) Choudhry S … Burchard EG (Pharmacogenetics and genomics 2010) 3 22 40
  3. Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure. (PMID: 20352314) Metra M … Dei Cas L (Cardiovascular drugs and therapy 2010) 3 22 40
  4. Adrenergic receptor polymorphisms and platelet reactivity after treatment with dual antiplatelet therapy with aspirin and clopidogrel in acute coronary syndrome. (PMID: 20135061) Cuisset T … Barbato E (Thrombosis and haemostasis 2010) 3 22 40
  5. Common genetic variation of beta1- and beta2-adrenergic receptor and response to four classes of antihypertensive treatment. (PMID: 20300048) Suonsyrjä T … Hiltunen TP (Pharmacogenetics and genomics 2010) 3 22 40

Products for ADRB2 Gene

  • Addgene plasmids for ADRB2

Sources for ADRB2 Gene