The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been sh... See more...

Aliases for ADRB1 Gene

Aliases for ADRB1 Gene

  • Adrenoceptor Beta 1 2 3 5
  • Adrenergic, Beta-1-, Receptor 2 3
  • Beta-1 Adrenergic Receptor 3 4
  • Beta-1 Adrenoreceptor 3 4
  • Beta-1 Adrenoceptor 3 4
  • ADRB1R 3 4
  • B1AR 3 4
  • BETA1AR 3
  • FNSS2 3
  • ADRB1 5
  • RHR 3

External Ids for ADRB1 Gene

Previous HGNC Symbols for ADRB1 Gene

  • ADRB1R

Previous GeneCards Identifiers for ADRB1 Gene

  • GC10P114711
  • GC10P115037
  • GC10P115935
  • GC10P115468
  • GC10P115793
  • GC10P109429

Summaries for ADRB1 Gene

Entrez Gene Summary for ADRB1 Gene

  • The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019]

GeneCards Summary for ADRB1 Gene

ADRB1 (Adrenoceptor Beta 1) is a Protein Coding gene. Diseases associated with ADRB1 include Resting Heart Rate, Variation In and Short Sleep, Familial Natural, 2. Among its related pathways are Neuroscience and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is ADRB2.

UniProtKB/Swiss-Prot Summary for ADRB1 Gene

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062).

Tocris Summary for ADRB1 Gene

  • The adrenergic beta1 receptor (beta1-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta2 and beta3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle.

Gene Wiki entry for ADRB1 Gene

PharmGKB "VIP" Summary for ADRB1 Gene

No data available for CIViC Summary , Rfam classification and piRNA Summary for ADRB1 Gene

Genomics for ADRB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADRB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J114042 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 607.8 +1.7 1676 6.1 PRDM10 KDM1A ZNF692 POLR2A FOXA1 PATZ1 EZH2 ZNF600 ZNF341 EED ADRB1 lnc-CCDC186-1 lnc-ADRB1-3 CCDC186 lnc-ADRB1-1
GH10J113956 Enhancer 1.1 ENCODE dbSUPER 11.4 -84.2 -84166 5.8 CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST RFX1 ZNF7 JUND PRDM1 HSALNG0080770 ADRB1 CASP7 HSALNG0080771 NHLRC2
GH10J114064 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.7 +20.4 20435 2.6 FOXA2 YY1 JUND RAD21 HNF4A RXRA MAX HLF SP1 ADRB1 HSALNG0080779 lnc-ADRB1-3 CCDC186
GH10J113946 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.4 -96.5 -96465 2 IKZF1 PKNOX1 MNT PBX2 NR2F1 TCF7L2 TAL1 EBF1 NR2F6 MEIS2 RNU6-709P ADRB1 TDRD1 PLEKHS1 HSALNG0080771 piR-42491-025 NHLRC2
GH10J113788 Enhancer 1 Ensembl ENCODE 10 -255.1 -255105 1.5 IKZF1 BACH1 JUND RELA TCF12 IKZF2 TRIM22 DPF2 EP300 EED CASP7 ENSG00000234393 RNU6-709P PLEKHS1 ADRB1 NRAP lnc-DCLRE1A-1 HSALNG0080763 DCLRE1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRB1

Top Transcription factor binding sites by QIAGEN in the ADRB1 gene promoter:
  • AP-1
  • ATF
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • CREB
  • deltaCREB
  • FOXI1
  • HFH-3
  • Pax-3

Genomic Locations for ADRB1 Gene

Genomic Locations for ADRB1 Gene
chr10:114,043,866-114,046,904
(GRCh38/hg38)
Size:
3,039 bases
Orientation:
Plus strand
chr10:115,803,806-115,806,667
(GRCh37/hg19)
Size:
2,862 bases
Orientation:
Plus strand

Genomic View for ADRB1 Gene

Genes around ADRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRB1 Gene

Proteins for ADRB1 Gene

  • Protein details for ADRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08588-ADRB1_HUMAN
    Recommended name:
    Beta-1 adrenergic receptor
    Protein Accession:
    P08588
    Secondary Accessions:
    • B0LPE2
    • Q5T5Y4
    • Q9UKG7
    • Q9UKG8

    Protein attributes for ADRB1 Gene

    Size:
    477 amino acids
    Molecular mass:
    51323 Da
    Quaternary structure:
    • Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4.

    Three dimensional structures from OCA and Proteopedia for ADRB1 Gene

neXtProt entry for ADRB1 Gene

Post-translational modifications for ADRB1 Gene

  • Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
  • Glycosylation at Asn15
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADRB1 Gene

Domains & Families for ADRB1 Gene

Gene Families for ADRB1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for ADRB1 Gene

InterPro:
Blocks:
  • Adrenergic receptor signature
  • Beta-1 adrenergic receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for ADRB1 Gene

GenScript: Design optimal peptide antigens:
  • Beta-1 adrenoreceptor (ADRB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08588

UniProtKB/Swiss-Prot:

ADRB1_HUMAN :
  • The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
Domain:
  • The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
genes like me logo Genes that share domains with ADRB1: view

Function for ADRB1 Gene

Molecular function for ADRB1 Gene

UniProtKB/Swiss-Prot Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
GENATLAS Biochemistry:
adrenergic,beta-1-,receptor,G protein coupled receptor superfamily,mostly expressed in heart,activating adenylate cyclase,lung,placenta,cerebral cortex,and in other organs mediating the action of catecholamines and sympathetic nervous system,with no apparent association of the C1165G variant with idiopathic cardiomyopathy

Phenotypes From GWAS Catalog for ADRB1 Gene

Gene Ontology (GO) - Molecular Function for ADRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0004935 adrenergic receptor activity IBA --
GO:0004939 beta-adrenergic receptor activity TAS 8892658
GO:0004940 beta1-adrenergic receptor activity IBA 21873635
GO:0005088 Ras guanyl-nucleotide exchange factor activity IDA 12391161
genes like me logo Genes that share ontologies with ADRB1: view
genes like me logo Genes that share phenotypes with ADRB1: view

Animal Models for ADRB1 Gene

MGI Knock Outs for ADRB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRB1 Gene

Localization for ADRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRB1 Gene

Cell membrane. Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRB1 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 21540189
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADRB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRB1 Gene

Pathways & Interactions for ADRB1 Gene

genes like me logo Genes that share pathways with ADRB1: view

Pathways by source for ADRB1 Gene

7 GeneGo (Thomson Reuters) pathways for ADRB1 Gene
  • Beta-2 adrenergic-dependent CFTR expression
  • Development Beta-adrenergic receptors regulation of ERK
  • Development Beta-adrenergic receptors signaling via cAMP
  • Development Ligand-independent activation of ESR1 and ESR2
  • G-protein signaling_H-RAS regulation pathway
6 Qiagen pathways for ADRB1 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Beta-Adrenergic Signaling
  • cAMP Pathway
  • Signaling in Gap Junctions
2 Cell Signaling Technology pathways for ADRB1 Gene

SIGNOR curated interactions for ADRB1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ADRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IBA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IBA 21873635
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
GO:0002024 diet induced thermogenesis IEA --
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA,IBA 21873635
genes like me logo Genes that share ontologies with ADRB1: view

Drugs & Compounds for ADRB1 Gene

(241) Drugs for ADRB1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metoprolol Approved, Investigational Pharma Antagonist, Target, antagonist 255
Carvedilol Approved, Investigational Pharma Antagonist, Target, antagonist 199
Atenolol Approved Pharma Antagonist, Target, antagonist 114
Betaxolol Approved, Investigational Pharma Antagonist, Target, antagonist βadrenergic receptor blocker 6
Dobutamine Approved Pharma Agonist, Partial agonist, Target, agonist 158

(18) Additional Compounds for ADRB1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Hydroxycarvedilol
(RS)-Atenolol
29122-68-7
(S)-(-)-Atenolol
93379-54-5
(S)-Timolol maleate
26921-17-5
Betaxolol hydrochloride
63659-19-8

(5) Tocris Compounds for ADRB1 Gene

Compound Action Cas Number
(RS)-Atenolol beta1 antagonist 29122-68-7
(S)-(-)-Atenolol beta1-antagonist. Active isomer of atenolol (Cat. No. 0387) 93379-54-5
(S)-Timolol maleate beta1 antagonist 26921-17-5
Betaxolol hydrochloride Selective beta1 antagonist 63659-19-8
Xamoterol hemifumarate beta1 selective partial agonist 73210-73-8

(99) ApexBio Compounds for ADRB1 Gene

Compound Action Cas Number
(R)-(-)-Niguldipine hydrochloride
(S)-(-)-Propranolol hydrochloride 4199-10-4
(S)-(+)-Niguldipine hydrochloride 113145-69-0
2-PMDQ 139047-55-5
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Agmatine sulfate 2482-00-0
Alfuzosin 81403-80-7
Alprenolol hydrochloride 13707-88-5
Atipamezole hydrochloride 104075-48-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Bucindolol 71119-11-4
Carteolol HCl Non-selective beta-adrenoceptor antagonist 51781-21-6
Carvedilol 72956-09-3
CGP 12177 hydrochloride β1/β2-AR antagonist,β3 AR partial agonist 64208-32-8
CGP 20712 dihydrochloride β1 antagonist,highly potent and selective 1216905-73-5
Cimaterol 54239-37-1
Cirazoline hydrochloride 40600-13-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine 76631-46-4
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
Dihydroergocristine mesylate 24730-10-7
DL-Adrenaline 329-65-7
Doxazosin 74191-85-8
DSP-4 40616-75-9
Efaroxan hydrochloride 89197-00-2
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Esmolol HCl 81161-17-3
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Guanfacine 29110-47-2
HEAT hydrochloride 30007-39-7
ICI 118,551 hydrochloride 72795-01-8
ICI 89406 53671-71-9
Idazoxan hydrochloride 79944-56-2
Imiloxan hydrochloride 81167-22-8
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
JP 1302 dihydrochloride 1259314-65-2
L-748,337 244192-94-7
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Levobetaxolol HCl 116209-55-3
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Succinate 98418-47-4
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Oxprenolol hydrochloride 6452-73-9
Phenoxybenzamine HCl 63-92-3
Phenylephrine HCl 61-76-7
Pindolol 13523-86-9
Prazosin 19216-56-9
Procaterol hydrochloride 62929-91-3
Pronethalol hydrochloride 1951-02-5
Propranolol HCl 318-98-9
Rauwolscine hydrochloride 6211-32-1
Rec 15/2615 dihydrochloride 173059-17-1
RS 100329 hydrochloride 1215654-26-4
RS 79948 hydrochloride 186002-54-0
RWJ 52353 245744-10-9
RX 821002 hydrochloride 109544-45-8
Scopine 498-45-3
SDZ 21009 39731-05-0
SKF 86466 hydrochloride 86129-54-6
SNAP 5089 157066-77-8
Sotalol 959-24-0
Sotalol hydrochloride β-adrenergic receptor antagonist 959-24-0
Spiroxatrine 1054-88-2
SR 58611A hydrochloride 121524-09-2
SR 59230A hydrochloride 1135278-41-9
ST 91 4749-61-5
Synephrine HCl 5985-28-4
TC-G 1000 245744-18-7
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine 51322-75-9
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
WB 4101 hydrochloride 2170-58-3
Xamoterol hemifumarate 73210-73-8
ZD 2079 178600-17-4
ZD 7114 hydrochloride 129689-28-7
Zinterol hydrochloride 37000-20-7
genes like me logo Genes that share compounds with ADRB1: view

Drug Products

Transcripts for ADRB1 Gene

mRNA/cDNA for ADRB1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRB1

Alternative Splicing Database (ASD) splice patterns (SP) for ADRB1 Gene

No ASD Table

Relevant External Links for ADRB1 Gene

GeneLoc Exon Structure for
ADRB1

Expression for ADRB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRB1 Gene

This gene is overexpressed in Heart - Left Ventricle (x9.1) and Heart - Atrial Appendage (x5.4).

Protein differential expression in normal tissues from HIPED for ADRB1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRB1 Gene



Protein tissue co-expression partners for ADRB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRB1

SOURCE GeneReport for Unigene cluster for ADRB1 Gene:

Hs.99913

Evidence on tissue expression from TISSUES for ADRB1 Gene

  • Heart(3.9)
  • Nervous system(3.7)
  • Muscle(3.5)
  • Blood(3)
  • Kidney(2.5)
  • Lung(2.5)
  • Intestine(2.3)
  • Adrenal gland(2.3)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with ADRB1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRB1 Gene

Orthologs for ADRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADRB1 30 31
  • 96.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADRB1 30 31
  • 89.66 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADRB1 30 31
  • 89.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Adrb1 30 17 31
  • 88.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adrb1 30
  • 88.75 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ADRB1 31
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADRB1 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADRB1 30 31
  • 75.32 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADRB1 31
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14992 30
Zebrafish
(Danio rerio)
Actinopterygii adrb1 30 31 31
  • 66.03 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta DopR2 30 32
  • 56.98 (n)
CG6919 32
  • 36 (a)
oa2 31
  • 26 (a)
ManyToMany
Octbeta2R 31
  • 25 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDOP2 30
  • 48.47 (n)
Worm
(Caenorhabditis elegans)
Secernentea M03F4.3 32
  • 39 (a)
Species where no ortholog for ADRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ADRB1 Gene

ENSEMBL:
Gene Tree for ADRB1 (if available)
TreeFam:
Gene Tree for ADRB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRB1: view image

Paralogs for ADRB1 Gene

(20) SIMAP similar genes for ADRB1 Gene using alignment to 1 proteins:

  • ADRB1_HUMAN
genes like me logo Genes that share paralogs with ADRB1: view

Variants for ADRB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRB1 Gene

ADRB1_HUMAN-P08588
Genetic variations in ADRB1 are associated with inter-individual variability in the resting heart rate. This quantitative trait has been significantly correlated with cardiovascular morbidity and mortality [MIM:607276].
ADRB1_HUMAN-P08588
Genetic variations in ADRB1 are associated with the familial natural short sleep 2 (FNSS2) phenotype, an autosomal dominant trait [MIM:618591]. Individuals with this trait require less sleep in any 24-hour period than is typical for their age group.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRB1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
717168 Benign: not provided 114,044,146(+) T/C MISSENSE_VARIANT
735162 Benign: not provided 114,045,298(+) G/T MISSENSE_VARIANT
760055 Benign: not provided 114,045,277(+) A/G MISSENSE_VARIANT
776545 Benign: not provided 114,044,447(+) G/T SYNONYMOUS_VARIANT
778968 Likely Benign: not provided 114,045,449(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ADRB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADRB1 Gene

Variant ID Type Subtype PubMed ID
nsv1069516 CNV deletion 25765185
nsv552203 CNV loss 21841781
nsv7211 OTHER inversion 18451855
nsv951851 CNV deletion 24416366

Variation tolerance for ADRB1 Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRB1 Gene

Human Gene Mutation Database (HGMD)
ADRB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRB1

SNP Genotyping and Copy Number Assay Products

Disorders for ADRB1 Gene

MalaCards: The human disease database

(34) MalaCards diseases for ADRB1 Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
resting heart rate, variation in
  • rhr
short sleep, familial natural, 2
  • fnss2
ocular hypotension
  • hypotony of eye
congestive heart failure
  • cardiac failure congestive
heart disease
  • congenital heart disease
- elite association - COSMIC cancer census association via MalaCards
Search ADRB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADRB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRB1 Gene

Publications for ADRB1 Gene

  1. Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. (PMID: 15917856) Terra SG … Johnson JA (International journal of obesity (2005) 2005) 3 23 26 41
  2. A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. (PMID: 11854867) Ranade K … Risch N (American journal of human genetics 2002) 3 4 23 41
  3. Relationship between beta1-adrenergic receptor polymorphisms and cardiovascular disease in patients with diabetic nephropathy. (PMID: 20470286) Poon PY … Li PK (Nephrology (Carlton, Vic.) 2010) 3 23 41
  4. Association of ADRB1 gene polymorphism with atrial fibrillation. (PMID: 20384459) Nicoulina S … Voevoda M (Genetic testing and molecular biomarkers 2010) 3 23 41
  5. Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. (PMID: 20235788) Filigheddu F … Glorioso N (Pharmacogenomics 2010) 3 23 41

Products for ADRB1 Gene

  • Addgene plasmids for ADRB1

Sources for ADRB1 Gene