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Aliases for ADRA2C Gene

Aliases for ADRA2C Gene

  • Adrenoceptor Alpha 2C 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C4 3 4
  • Adrenergic, Alpha-2C-, Receptor 2 3
  • Alpha-2C Adrenoreceptor 3 4
  • Alpha-2C Adrenoceptor 3 4
  • Alpha-2CAR 3 4
  • ADRA2RL2 3 4
  • ADRA2L2 3 4
  • Alpha-2C Adrenergic Receptor 3
  • Alpha2-AR-C4 3
  • ALPHA2CAR 3
  • ADRARL2 3

External Ids for ADRA2C Gene

Previous HGNC Symbols for ADRA2C Gene

  • ADRA2L2
  • ADRA2RL2

Previous GeneCards Identifiers for ADRA2C Gene

  • GC04U990002
  • GC04M9J0040
  • GC04P003798

Summaries for ADRA2C Gene

Entrez Gene Summary for ADRA2C Gene

  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA2C Gene

ADRA2C (Adrenoceptor Alpha 2C) is a Protein Coding gene. Diseases associated with ADRA2C include Raynaud Phenomenon and Orthostatic Intolerance. Among its related pathways are Integrin alphaIIb beta3 signaling and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is ADRA2A.

UniProtKB/Swiss-Prot for ADRA2C Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Tocris Summary for ADRA2C Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2C Gene

Additional gene information for ADRA2C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2C Gene

Genomics for ADRA2C Gene

GeneHancer (GH) Regulatory Elements for ADRA2C Gene

Promoters and enhancers for ADRA2C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J003765 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 650.7 -0.4 -413 1.7 CTCF SAP130 ARID4B ZNF48 RBPJ ZEB1 HIC1 ZNF335 ZFHX2 CTBP1 ADRA2C ENSG00000250986
GH04J003767 Enhancer 0.5 ENCODE 650.7 +0.9 871 0.2 CTCF MBD1 PRPF4 ZBTB33 ZBTB26 EZH2 ADRA2C GC04P003863
GH04J003745 Enhancer 0.9 ENCODE 16.1 -20.0 -19968 1.3 PKNOX1 ARNT GLI4 ZNF2 GLIS2 ZNF213 ZNF416 FOS ZNF518A ZNF658 ADRA2C ENSG00000250986 GC04M003763 PIR54762 GC04M003694
GH04J003792 Enhancer 0.9 ENCODE 12.6 +25.8 25781 0.1 MLX ZFP64 ARID4B SIN3A ZNF48 SLC30A9 ZNF143 NFKBIZ NFYC MXD4 ENSG00000250986 ADRA2C GC04P003863
GH04J004327 Enhancer 1.1 Ensembl ENCODE 5.6 +561.6 561572 0.8 HDAC1 ATF1 ARID4B SIN3A DMAP1 RAD21 ZNF48 RARA CHAMP1 ZNF614 LYAR TMEM128 ADRA2C NSG1 ENSG00000248516 PIR59167
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADRA2C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADRA2C gene promoter:
  • E2F-1
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • Bach1
  • E2F
  • aMEF-2
  • MEF-2A
  • STAT1beta

Genomic Locations for ADRA2C Gene

Genomic Locations for ADRA2C Gene
chr4:3,766,348-3,768,526
(GRCh38/hg38)
Size:
2,179 bases
Orientation:
Plus strand
chr4:3,768,075-3,770,253
(GRCh37/hg19)
Size:
2,179 bases
Orientation:
Plus strand

Genomic View for ADRA2C Gene

Genes around ADRA2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2C Gene

Proteins for ADRA2C Gene

  • Protein details for ADRA2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18825-ADA2C_HUMAN
    Recommended name:
    Alpha-2C adrenergic receptor
    Protein Accession:
    P18825
    Secondary Accessions:
    • P35369
    • Q9HB49

    Protein attributes for ADRA2C Gene

    Size:
    462 amino acids
    Molecular mass:
    49522 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35513.1; Type=Frameshift; Positions=270, 296, 300; Evidence={ECO:0000305}; Sequence=AAC78723.1; Type=Frameshift; Positions=270, 296, 300; Evidence={ECO:0000305};

neXtProt entry for ADRA2C Gene

Post-translational modifications for ADRA2C Gene

  • Glycosylation at Asn33 and Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2C Gene

Domains & Families for ADRA2C Gene

Gene Families for ADRA2C Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADRA2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18825

UniProtKB/Swiss-Prot:

ADA2C_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
genes like me logo Genes that share domains with ADRA2C: view

Function for ADRA2C Gene

Molecular function for ADRA2C Gene

UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
GENATLAS Biochemistry:
adrenergic,alpha-2C-,receptor,G protein coupled receptor superfamily,without action on ion channels

Gene Ontology (GO) - Molecular Function for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IBA,IEA --
GO:0004938 alpha2-adrenergic receptor activity TAS,IDA 17215105
GO:0005515 protein binding IPI 16531006
GO:0031694 alpha-2A adrenergic receptor binding IPI 16605244
genes like me logo Genes that share ontologies with ADRA2C: view
genes like me logo Genes that share phenotypes with ADRA2C: view

Animal Models for ADRA2C Gene

MGI Knock Outs for ADRA2C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA2C

Clone Products

  • R&D Systems cDNA Clones for ADRA2C (alpha-2C Adrenergic R/ADRA2C)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADRA2C Gene

Localization for ADRA2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2C Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA2C gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16605244
GO:0005768 endosome TAS 10196213
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 16605244
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADRA2C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRA2C Gene

Pathways & Interactions for ADRA2C Gene

genes like me logo Genes that share pathways with ADRA2C: view

Gene Ontology (GO) - Biological Process for ADRA2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007267 cell-cell signaling TAS 9371698
genes like me logo Genes that share ontologies with ADRA2C: view

No data available for SIGNOR curated interactions for ADRA2C Gene

Drugs & Compounds for ADRA2C Gene

(155) Drugs for ADRA2C Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved, Investigational, Vet_approved Pharma Antagonist, antagonist, Target 28
Clonidine Approved Pharma Partial agonist, Agonist, agonist, Target 250
Apomorphine Approved, Investigational Pharma Antagonist, Partial agonist, Agonist, Full agonist, Activation, Activator, agonist, Target 40
Brimonidine Approved Pharma Partial agonist, Agonist, Full agonist, agonist, Target 0
Bromocriptine Approved, Investigational Pharma Antagonist, Full agonist, Agonist, Partial agonist, agonist, Target 33

(4) Additional Compounds for ADRA2C Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-adrenaline
Full agonist, Agonist, Partial agonist
Clonidine hydrochloride
4205-91-8
Rilmenidine hemifumarate
207572-68-7

(5) Tocris Compounds for ADRA2C Gene

Compound Action Cas Number
Clonidine hydrochloride alpha2 agonist. Also I1 ligand 4205-91-8
Guanabenz acetate alpha2 agonist. Also I2 selective ligand 23256-50-0
Rilmenidine hemifumarate alpha2 agonist. Also I1 ligand 207572-68-7
Spiroxatrine Potent alpha2C antagonist 1054-88-2
UK 14,304 alpha2 agonist 59803-98-4

(57) ApexBio Compounds for ADRA2C Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Moxonidine hydrochloride α2AR/I1R agonist 75536-04-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Setiptiline Serotonin receptor antagonist 57262-94-9
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine α2-adrenoceptor agonist 7361-61-7
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
genes like me logo Genes that share compounds with ADRA2C: view

Drug Products

Transcripts for ADRA2C Gene

mRNA/cDNA for ADRA2C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2C Gene

Adrenoceptor alpha 2C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA2C

Clone Products

  • R&D Systems cDNA Clones for ADRA2C (alpha-2C Adrenergic R/ADRA2C)

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2C Gene

No ASD Table

Relevant External Links for ADRA2C Gene

GeneLoc Exon Structure for
ADRA2C
ECgene alternative splicing isoforms for
ADRA2C

Expression for ADRA2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADRA2C Gene

mRNA differential expression in normal tissues according to GTEx for ADRA2C Gene

This gene is overexpressed in Artery - Aorta (x8.2), Cervix - Endocervix (x6.7), and Artery - Tibial (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA2C Gene



NURSA nuclear receptor signaling pathways regulating expression of ADRA2C Gene:

ADRA2C

SOURCE GeneReport for Unigene cluster for ADRA2C Gene:

Hs.123022

Evidence on tissue expression from TISSUES for ADRA2C Gene

  • Kidney(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ADRA2C: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA2C Gene

Orthologs for ADRA2C Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA2C 34 33
  • 98.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADRA2C 34 33
  • 89.71 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adra2c 33
  • 84.6 (n)
mouse
(Mus musculus)
Mammalia Adra2c 16 34 33
  • 84.3 (n)
oppossum
(Monodelphis domestica)
Mammalia ADRA2C 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRA2C 34 33
  • 72.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adra2c 33
  • 68.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26396 33
zebrafish
(Danio rerio)
Actinopterygii adra2c 34 33
  • 64.38 (n)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta DopR2 35
  • 44 (a)
5-HT7 35
  • 33 (a)
Oct-TyrR 34
  • 24 (a)
ManyToMany
CG18208 34 35
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea sca-1 35
  • 31 (a)
ser-1 35
  • 31 (a)
ser-2 34
  • 30 (a)
ManyToMany
octr-1 34
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for ADRA2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA2C Gene

ENSEMBL:
Gene Tree for ADRA2C (if available)
TreeFam:
Gene Tree for ADRA2C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRA2C: view image

Paralogs for ADRA2C Gene

(18) SIMAP similar genes for ADRA2C Gene using alignment to 3 proteins:

  • ADA2C_HUMAN
  • D6RGL0_HUMAN
  • Q4W594_HUMAN
genes like me logo Genes that share paralogs with ADRA2C: view

Variants for ADRA2C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2C Gene

ADA2C_HUMAN-P18825
The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040).

Sequence variations from dbSNP and Humsavar for ADRA2C Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000062728 -- 3,764,662(+) A/C upstream_transcript_variant
rs1003723943 -- 3,768,304(+) G/A 3_prime_UTR_variant
rs1004276565 -- 3,765,324(+) T/C upstream_transcript_variant
rs1004290318 -- 3,764,937(+) C/T upstream_transcript_variant
rs1006563297 -- 3,769,008(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA2C Gene

Variant ID Type Subtype PubMed ID
nsv998670 CNV gain 25217958
nsv997647 CNV gain 25217958
nsv949772 CNV deletion 24416366
nsv593470 CNV gain+loss 21841781
nsv593469 CNV gain 21841781
nsv593468 CNV loss 21841781
nsv519631 CNV loss 19592680
nsv1133576 CNV deletion 24896259
nsv1074138 CNV deletion 25765185
nsv1005210 CNV gain 25217958
esv3575674 CNV gain 25503493
esv2759219 CNV gain 17122850
esv26274 CNV loss 19812545
dgv8929n54 CNV loss 21841781
dgv8928n54 CNV loss 21841781
dgv854n67 CNV gain 20364138

Variation tolerance for ADRA2C Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA2C Gene

Human Gene Mutation Database (HGMD)
ADRA2C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRA2C

Disorders for ADRA2C Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADRA2C Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
raynaud phenomenon
  • raynaud disease
orthostatic intolerance
  • neurocirculatory asthenia
attention deficit-hyperactivity disorder
  • adhd
long qt syndrome
  • romano-ward syndrome
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADRA2C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADRA2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA2C Gene

Publications for ADRA2C Gene

  1. Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. (PMID: 1849485) Chhajlani V … Wikberg JE (FEBS letters 1991) 2 3 4 22 58
  2. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. (PMID: 19880803) Bristow MR … Liggett SB (Circulation. Heart failure 2010) 3 22 44 58
  3. The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction. (PMID: 19444546) Friedman EA … Kurnik D (Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2009) 3 22 44 58
  4. Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade. (PMID: 18794726) Kurnik D … Stein CM (Pharmacogenetics and genomics 2008) 3 22 44 58
  5. The alpha 2C Del322-325 adrenergic receptor polymorphism is not associated with heart failure due to idiopathic dilated cardiomyopathy in black Africans. (PMID: 18320080) Du Preez J … Mayosi BM (Cardiovascular journal of Africa 2008) 3 22 44 58

Products for ADRA2C Gene

Sources for ADRA2C Gene

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