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This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014] See more...
Aliases for ADRA2B Gene
Aliases for ADRA2B Gene
External Ids for ADRA2B Gene
- HGNC: 282
- Entrez Gene: 151
- Ensembl: ENSG00000274286
- OMIM: 104260
- UniProtKB: P18089
Previous HGNC Symbols for ADRA2B Gene
- ADRA2L1
- ADRA2RL1
Previous GeneCards Identifiers for ADRA2B Gene
- GC02M094650
- GC02M095232
- GC02M096246
- GC02M096263
- GC02M096200
- GC02M096142
- GC02M096778
- GC02M090739
Summaries for ADRA2B Gene
-
This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
GeneCards Summary for ADRA2B Gene
ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. Diseases associated with ADRA2B include Familial Adult Myoclonic Epilepsy and Epilepsy, Familial Adult Myoclonic, 2. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and alpha2-adrenergic receptor activity. An important paralog of this gene is ADRA2A.
UniProtKB/Swiss-Prot Summary for ADRA2B Gene
-
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
-
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.
Additional gene information for ADRA2B Gene
- HGNC(282)
- Entrez Gene(151)
- Ensembl(ENSG00000274286)
- OMIM(104260)
- UniProtKB(P18089)
- Open Targets Platform(ENSG00000274286)
- Monarch Initiative
- Search for ADRA2B at DataMed
- Search for ADRA2B at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADRA2B Gene
Genomics for ADRA2B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADRA2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADRA2B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRA2B
- Top Transcription factor binding sites by QIAGEN in the ADRA2B gene promoter:
-
- c-Myc
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- GR
- GR-alpha
- GR-beta
- Max1
- NF-YB
Genomic Locations for ADRA2B Gene
Genomic Locations for ADRA2B Gene
- chr2:96,112,876-96,116,571
- (GRCh38/hg38)
- Size:
- 3,696 bases
- Orientation:
- Minus strand
- chr2:96,778,623-96,781,984
- (GRCh37/hg19)
- Size:
- 3,362 bases
- Orientation:
- Minus strand
Genomic View for ADRA2B Gene
Genes around ADRA2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by HGNC
- 2q11.2 by Entrez Gene
- 2q11.2 by Ensembl
ADRA2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADRA2B Gene
Proteins for ADRA2B Gene
-
Protein details for ADRA2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18089-ADA2B_HUMAN
- Recommended name:
- Alpha-2B adrenergic receptor
- Protein Accession:
- P18089
- A2RUS0
- Q4TUH9
- Q53RF2
- Q9BZK0
Protein attributes for ADRA2B Gene
- Size:
- 450 amino acids
- Molecular mass:
- 49954 Da
- Quaternary structure:
-
- Interacts with RAB26 (PubMed:23105096). Interacts with PPP1R9B (PubMed:24114805). Interacts with GGA1, GGA2 and GGA3 (PubMed:27901063, PubMed:26811329).
Protein Expression for ADRA2B Gene
Post-translational modifications for ADRA2B Gene
Other Protein References for ADRA2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ AR a2B Polyclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for ADRA2B
- Novus Biologicals Antibodies for ADRA2B
-
Abcam antibodies for ADRA2B
- Invitrogen Antibodies for ADRA2B (AFLGC-ADRA2B)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADRA2B
- Sino Biological Antibodies for ADRA2B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADRA2B
- Origene Custom Protein Services for ADRA2B
- Novus Biologicals proteins for ADRA2B
No data available for DME Specific Peptides for ADRA2B Gene
Domains & Families for ADRA2B Gene
Gene Families for ADRA2B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for ADRA2B Gene
- InterPro:
- Blocks:
-
- Adrenergic receptor signature
- Alpha-2B adrenergic receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for ADRA2B Gene
- GenScript: Design optimal peptide antigens:
-
- HCG37297 (A2RUS0_HUMAN)
- Alpha-2B adrenoreceptor (ADA2B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P18089UniProtKB/Swiss-Prot:
ADA2B_HUMAN :- Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
- Family:
-
- Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
Function for ADRA2B Gene
Molecular function for ADRA2B Gene
- UniProtKB/Swiss-Prot Function:
- Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
- GENATLAS Biochemistry:
- adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+ channels,contributing to the patho genesis of obesity
Phenotypes From GWAS Catalog for ADRA2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA,IBA | 21873635 |
| GO:0004935 | adrenergic receptor activity | IBA | -- |
| GO:0004938 | alpha2-adrenergic receptor activity | TAS,IDA | 17215105 |
| GO:0005515 | protein binding | IPI | 16531006 |
| GO:0051379 | epinephrine binding | IDA | 17215105 |
Phenotypes for ADRA2B Gene
- MGI mutant phenotypes for ADRA2B:
-
inferred from 1 alleles
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for ADRA2B:
Animal Models for ADRA2B Gene
- MGI Knock Outs for ADRA2B:
-
- Adra2b Adra2b<tm1Gsb>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADRA2B - Select products 50% OFF >
- * ADRA2B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ADRA2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADRA2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADRA2B
miRNA for ADRA2B Gene
- miRTarBase miRNAs that target ADRA2B
-
- hsa-miR-6763-5p (MIRT527157)
- hsa-miR-3150a-3p (MIRT527158)
- hsa-miR-6825-5p (MIRT527159)
- hsa-miR-939-5p (MIRT527160)
- hsa-miR-1343-5p (MIRT527161)
- hsa-miR-3175 (MIRT527162)
- hsa-miR-4700-5p (MIRT527163)
- hsa-miR-8089 (MIRT527164)
- hsa-miR-4667-5p (MIRT527165)
- hsa-miR-361-3p (MIRT527166)
- hsa-miR-4286 (MIRT527167)
- mmu-miR-377-3p (MIRT601222)
- mmu-miR-706 (MIRT601223)
- mmu-miR-1192 (MIRT601224)
- mmu-miR-495-3p (MIRT601225)
- mmu-miR-10b-5p (MIRT601226)
- mmu-miR-10a-5p (MIRT601227)
- mmu-miR-339-5p (MIRT601228)
- mmu-miR-290a-5p (MIRT601229)
- mmu-miR-292a-5p (MIRT601230)
- hsa-miR-4659b-3p (MIRT616454)
- hsa-miR-4659a-3p (MIRT616455)
- hsa-miR-6875-3p (MIRT616456)
- hsa-miR-6749-3p (MIRT616457)
- hsa-miR-6792-3p (MIRT616458)
- hsa-miR-4691-5p (MIRT616459)
- hsa-miR-4291 (MIRT616460)
- hsa-miR-761 (MIRT616461)
- hsa-miR-3619-5p (MIRT616462)
- hsa-miR-214-3p (MIRT616463)
- hsa-miR-922 (MIRT616464)
- hsa-miR-6838-5p (MIRT616465)
- hsa-miR-497-5p (MIRT616466)
- hsa-miR-424-5p (MIRT616467)
- hsa-miR-195-5p (MIRT616468)
- hsa-miR-16-5p (MIRT616469)
- hsa-miR-15b-5p (MIRT616470)
- hsa-miR-15a-5p (MIRT616471)
- hsa-miR-542-5p (MIRT713036)
- hsa-miR-6889-5p (MIRT713037)
- hsa-miR-6777-5p (MIRT713038)
- hsa-miR-1247-5p (MIRT713039)
- hsa-miR-8079 (MIRT713040)
- hsa-miR-1245a (MIRT713041)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADRA2B
- Browse OriGene Inhibitory RNA Products For ADRA2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA2B
Clone Products
- Applied Biological Materials (abm): Clones for ADRA2B - Select products 50% OFF >
- * ADRA2B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ADRA2B
- Addgene plasmids for ADRA2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADRA2B
Cell Line Products
-
Horizon Cell Lines for ADRA2B
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADRA2B Gene
Localization for ADRA2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADRA2B Gene
- Cell membrane. Multi-pass membrane protein. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000269 PubMed:23105096, ECO:0000269 PubMed:26811329, ECO:0000269 PubMed:27901063}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
| GO:0009986 | cell surface | IDA | 27901063 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRA2B Gene
Pathways & Interactions for ADRA2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Monoamine GPCRs |
.75
|
.01
|
| 3 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
|
| 4 | Signaling by GPCR | ||
| 5 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for ADRA2B Gene
2 BioSystems pathways for ADRA2B Gene
13 Reactome pathways for ADRA2B Gene
1 PharmGKB pathway for ADRA2B Gene
2 KEGG pathways for ADRA2B Gene
1 GeneGo (Thomson Reuters) pathway for ADRA2B Gene
- Development Alpha-2 adrenergic receptor activation of ERK
5 Qiagen pathways for ADRA2B Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- AMPK Enzyme Complex Pathway
- cAMP Pathway
- Signaling Involved in Cardiac Hypertrophy
Interacting Proteins for ADRA2B Gene
Selected Interacting proteins:
P18089-ADA2B_HUMAN
ENSP00000480573
for ADRA2B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ADRA2B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0003056 | regulation of vascular smooth muscle contraction | IEA | -- |
| GO:0006940 | regulation of smooth muscle contraction | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IDA,TAS | -- |
Drugs & Compounds for ADRA2B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Yohimbine | Approved, Investigational, Vet_approved | Pharma | Antagonist, Target, antagonist | 36 | ||
| Apomorphine | Approved, Investigational | Pharma | Agonist, Partial agonist, Antagonist, Full agonist, Activator, Activation, Target, agonist | 48 | ||
| Brimonidine | Approved | Pharma | Agonist, Full agonist, Partial agonist, Target, agonist | 0 | ||
| Bromocriptine | Approved, Investigational | Pharma | Antagonist, Agonist, Partial agonist, Full agonist, Target, agonist | 44 | ||
| Cabergoline | Approved | Pharma | Antagonist, Agonist, Full agonist, Partial agonist, Target, antagonist, agonist | 60 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Clonidine hydrochloride |
|
4205-91-8 |
|
|
||
| Rilmenidine hemifumarate |
|
207572-68-7 |
|
|
(5) Tocris Compounds for ADRA2B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Clonidine hydrochloride | alpha2 agonist. Also I1 ligand | 4205-91-8 |
| Guanabenz acetate | alpha2 agonist. Also I2 selective ligand | 23256-50-0 |
| Rilmenidine hemifumarate | alpha2 agonist. Also I1 ligand | 207572-68-7 |
| Spiroxatrine | Potent alpha2C antagonist | 1054-88-2 |
| UK 14,304 | alpha2 agonist | 59803-98-4 |
(61) ApexBio Compounds for ADRA2B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Acebutolol HCl | 34381-68-5 | |
| Adrenalone HCl | 62-13-5 | |
| Alfuzosin HCl | α1 adrenoceptor antagonist,functionally uro-selective | 81403-68-1 |
| ARC 239 dihydrochloride | α2B adrenoceptor antagonist | 55974-42-0 |
| Bambuterol | 81732-65-2 | |
| Betaxolol | βadrenergic receptor blocker | 659-18-7 |
| Betaxolol HCl | 63659-19-8 | |
| Bisoprolol fumarate | 104344-23-2 | |
| Brimonidine Tartrate | 70359-46-5 | |
| Carvedilol | 72956-09-3 | |
| Cisatracurium Besylate | Neuromuscular-blocking drug | 96946-42-8 |
| Clonidine HCl | 4205-91-8 | |
| Detomidine HCl | 90038-01-0 | |
| Dexmedetomidine | 113775-47-6 | |
| Dexmedetomidine HCl | 145108-58-3 | |
| DL-Adrenaline | 329-65-7 | |
| Doxazosin Mesylate | α1-adrenergic receptor antagonist | 77883-43-3 |
| Droxidopa | 23651-95-8 | |
| Epinephrine Bitartrate | 51-42-3 | |
| Epinephrine HCl | 55-31-2 | |
| Formoterol Hemifumarate | 43229-80-7 | |
| Guanabenz Acetate | 23256-50-0 | |
| Indacaterol Maleate | 753498-25-8 | |
| Isoprenaline HCl | 51-30-9 | |
| Ivabradine HCl | 148849-67-6 | |
| Labetalol HCl | 32780-64-6 | |
| L-Adrenaline | 51-43-4 | |
| Maprotiline HCl | 10347-81-6 | |
| Medetomidine HCl | 86347-15-1 | |
| Methyldopa | 555-30-6 | |
| Metoprolol Tartrate | β1-adrenergic blocking agent | 392-17-7 |
| Mirabegron (YM178) | 223673-61-8 | |
| Moxonidine | I1R/α2AR agonist | 75438-57-2 |
| Naftopidil | α1-adrenergic receptor antagonist | 57149-07-2 |
| Naftopidil DiHCl | 57149-08-3 | |
| Naphazoline HCl | 550-99-2 | |
| Nebivolol | 152520-56-4 | |
| Nedaplatin | 95734-82-0 | |
| Noradrenaline bitartrate monohydrate | 108341-18-0 | |
| Oxymetazoline HCl | Alpha-1/alpha-2 agonist | 2315-02-8 |
| Phenoxybenzamine HCl | 63-92-3 | |
| Phentolamine Mesylate | Alpha 1/2-blocking agent | 65-28-1 |
| Phenylephrine HCl | 61-76-7 | |
| Prazosin HCl | α1 and α2B-adrenoceptor antagonist | 19237-84-4 |
| Propranolol HCl | 318-98-9 | |
| Ritodrine HCl | β-2 adrenergic receptor agonist | 23239-51-2 |
| Salbutamol Sulfate | β-2 adrenergic receptor agonist | 51022-70-9 |
| Salmeterol xinafoate | β2-adrenergic receptor agonist | 94749-08-3 |
| Scopine | 498-45-3 | |
| Setiptiline | Serotonin receptor antagonist | 57262-94-9 |
| Silodosin | α1-adrenoceptor antagonist | 160970-54-7 |
| Synephrine HCl | 5985-28-4 | |
| Terazosin HCl | 70024-40-7 | |
| Terbutaline Sulfate | 23031-32-5 | |
| Tetrahydrozoline HCl | 522-48-5 | |
| Timolol Maleate | 26921-17-5 | |
| Tizanidine HCl | 64461-82-1 | |
| Tolazoline HCl | 59-97-2 | |
| Xylazine | α2-adrenoceptor agonist | 7361-61-7 |
| Xylazine HCl | α2 Adrenoceptor agonist | 23076-35-9 |
| Xylometazoline HCl | 1218-35-5 |
Transcripts for ADRA2B Gene
mRNA/cDNA for ADRA2B Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000620793 3696 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADRA2B - Select products 50% OFF >
- * ADRA2B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ADRA2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADRA2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADRA2B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADRA2B
- Browse OriGene Inhibitory RNA Products For ADRA2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA2B
Clone Products
- Applied Biological Materials (abm): Clones for ADRA2B - Select products 50% OFF >
- * ADRA2B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ADRA2B
- Addgene plasmids for ADRA2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADRA2B
Relevant External Links for ADRA2B Gene
- GeneLoc Exon Structure for
- ADRA2B
Expression for ADRA2B Gene
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA2B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRA2B
SOURCE GeneReport for Unigene cluster for ADRA2B Gene:
Hs.247686Evidence on tissue expression from TISSUES for ADRA2B Gene
- Nervous system(3.5)
- Muscle(3.2)
- Heart(3.2)
- Blood(2.9)
- Kidney(2.4)
- Adrenal gland(2.3)
- Intestine(2.2)
- Liver(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA2B Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- cerebellum
- eye
- eyelid
- face
- head
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for ADRA2B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADRA2B Gene
Orthologs for ADRA2B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADRA2B 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | ADRA2B 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | ADRA2B 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Adra2b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Adra2b 30 17 |
|
||
| Chicken (Gallus gallus) |
Aves | LOC101751513 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adra2b 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | adra2b 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000606 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7431 32 |
|
|
|
| CG18208 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | dop-1 30 |
|
- Species where no ortholog for ADRA2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ADRA2B Gene
- ENSEMBL:
- Gene Tree for ADRA2B (if available)
- TreeFam:
- Gene Tree for ADRA2B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADRA2B: view image
Paralogs for ADRA2B Gene
Paralogs for ADRA2B Gene
(6) SIMAP similar genes for ADRA2B Gene using alignment to 3 proteins:
- ADA2B_HUMAN
- A2RUS0_HUMAN
- L8E8D5_HUMAN
Variants for ADRA2B Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2B Gene
- ADA2B_HUMAN-P18089
- A rare polymorphic frameshift in position 451 produces a protein of 545 residues.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRA2B Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 655730 | Uncertain Significance: not provided | 96,115,455(-) | G/C | MISSENSE_VARIANT | |
| 706992 | Likely Benign: not provided | 96,115,238(-) | C/CTCCTCT | INFRAME_INSERTION | |
| 707066 | Likely Benign: not provided | 96,115,015(-) | C/T | MISSENSE_VARIANT | |
| 707706 | Likely Benign: not provided | 96,115,207(-) | C/T | MISSENSE_VARIANT | |
| 713934 | Likely Benign: not provided | 96,116,005(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4009n100 | CNV | gain | 25217958 |
| dgv607e201 | CNV | deletion | 23290073 |
| esv3425717 | CNV | duplication | 20981092 |
| esv3591652 | OTHER | inversion | 21293372 |
| esv5003 | OTHER | complex | 18987735 |
| nsv1135873 | CNV | deletion | 24896259 |
| nsv2834 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.62;
31.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADRA2B Gene
SNP Genotyping and Copy Number Assay Products
Disorders for ADRA2B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial adult myoclonic epilepsy |
|
|
| epilepsy, familial adult myoclonic, 2 |
|
|
| resting heart rate, variation in |
|
|
| perinephritis |
|
|
| ocular hypotension |
|
|
Search ADRA2B in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ADA2B_HUMAN- Epilepsy, familial adult myoclonic, 2 (FAME2) [MIM:607876]: A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME2 inheritance is autosomal dominant. {ECO:0000269 PubMed:24114805}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ADRA2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for ADRA2B Gene
Publications for ADRA2B Gene
- Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. (PMID: 20051907) Muszkat M … Stein CM (Journal of hypertension 2010) 3 23 41
- A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. (PMID: 19826083) Rasch B … de Quervain DJ (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23 41
- Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome. (PMID: 19593211) Fava C … Melander O (Journal of hypertension 2009) 3 23 41
- Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism. (PMID: 17277585) Laaksonen DE … Finnish Diabetes Prevention Study Group (Medicine and science in sports and exercise 2007) 3 23 41
- Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men. (PMID: 17620957) Ohlin B … Melander O (Journal of hypertension 2007) 3 23 41
ExternalLinks
Products for ADRA2B Gene
- View all 9 R&D Systems ADRA2B (alpha-2B Adrenergic R/ADRA2B) Products
- View all 8 R&D Systems ADRA2B (alpha-2B Adrenergic R/ADRA2B) Primary Antibodies
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Sources for ADRA2B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (64) Proteopedia
- (65) MOPED
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
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