Aliases for ADRA2B Gene
External Ids for ADRA2B Gene
Previous HGNC Symbols for ADRA2B Gene
Previous GeneCards Identifiers for ADRA2B Gene
This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
GeneCards Summary for ADRA2B Gene
ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. Diseases associated with ADRA2B include Benign Adult Familial Myoclonic Epilepsy and Epilepsy, Familial Adult Myoclonic, 2. Among its related pathways are Monoamine GPCRs and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and alpha2-adrenergic receptor activity. An important paralog of this gene is ADRA2A.
UniProtKB/Swiss-Prot Summary for ADRA2B Gene
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.