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Aliases for ADRA2B Gene

Aliases for ADRA2B Gene

  • Adrenoceptor Alpha 2B 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C2 3 4
  • Alpha-2B Adrenoreceptor 3 4
  • Alpha-2BAR 3 4
  • ADRA2RL1 3 4
  • ADRA2L1 3 4
  • ADRA2B Adrenergic, Alpha-2B-, Receptor 3
  • Alpha-2-Adrenergic Receptor-Like 1 3
  • Adrenergic, Alpha-2B-, Receptor 2
  • Alpha-2B Adrenergic Receptor 3
  • G-Protein Coupled Receptor 3
  • Alpha-2B Adrenoceptor 4
  • ALPHA2BAR 3
  • ADRARL1 3
  • FAME2 3

External Ids for ADRA2B Gene

Previous HGNC Symbols for ADRA2B Gene

  • ADRA2L1
  • ADRA2RL1

Previous GeneCards Identifiers for ADRA2B Gene

  • GC02M094650
  • GC02M095232
  • GC02M096246
  • GC02M096263
  • GC02M096200
  • GC02M096142
  • GC02M096778
  • GC02M090739

Summaries for ADRA2B Gene

Entrez Gene Summary for ADRA2B Gene

  • This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

GeneCards Summary for ADRA2B Gene

ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. Diseases associated with ADRA2B include Epilepsy, Familial Adult Myoclonic, 2 and Benign Adult Familial Myoclonic Epilepsy. Among its related pathways are Integrin alphaIIb beta3 signaling and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and alpha2-adrenergic receptor activity. An important paralog of this gene is ADRA2A.

UniProtKB/Swiss-Prot for ADRA2B Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Tocris Summary for ADRA2B Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2B Gene

Additional gene information for ADRA2B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA2B Gene

Genomics for ADRA2B Gene

GeneHancer (GH) Regulatory Elements for ADRA2B Gene

Promoters and enhancers for ADRA2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J096116 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 650.7 -0.6 -581 0.9 RB1 SIN3A KLF5 RAD21 ZNF335 GLIS2 ZNF207 ZNF143 EGR2 SMARCA5 ADRA2B FAHD2CP ASTL
GH02J096155 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -41.8 -41795 4.2 HDGF PKNOX1 ATF1 SMAD1 YBX1 IRF4 POLR2B ZNF766 ZNF207 ZNF143 ADRA2B KANSL3 SNRNP200 GPAT2 GPAT2P1 ARID5A ZNF514 LMAN2L DUSP2 TMEM127
GH02J095990 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12.5 +124.2 124184 2.9 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 ZNF213 PIR48420 ANKRD36C ADRA2B GPAT2
GH02J096240 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.2 -125.7 -125658 3.1 CTCF PKNOX1 BACH1 EBF1 BATF KLF5 IRF4 POLR2A EED ZNF143 ADRA2B GC02M096251 PIR52980 STARD7-AS1
GH02J096161 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -47.2 -47195 4.1 HDGF PKNOX1 SMAD1 STAT5A BATF KLF5 IRF4 ZNF143 ATF7 FOS ASTL ADRA2B ITPRIPL1 STARD7-AS1 STARD7 ENSG00000230747 KCNIP3 DUSP2 ARID5A KANSL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRA2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADRA2B gene promoter:
  • Max1
  • c-Myc
  • GR-beta
  • GR
  • GR-alpha
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • NF-YB

Genomic Locations for ADRA2B Gene

Genomic Locations for ADRA2B Gene
chr2:96,112,875-96,116,245
(GRCh38/hg38)
Size:
3,371 bases
Orientation:
Minus strand
chr2:96,778,623-96,781,984
(GRCh37/hg19)
Size:
3,362 bases
Orientation:
Minus strand

Genomic View for ADRA2B Gene

Genes around ADRA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2B Gene

Proteins for ADRA2B Gene

  • Protein details for ADRA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18089-ADA2B_HUMAN
    Recommended name:
    Alpha-2B adrenergic receptor
    Protein Accession:
    P18089
    Secondary Accessions:
    • A2RUS0
    • Q4TUH9
    • Q53RF2
    • Q9BZK0

    Protein attributes for ADRA2B Gene

    Size:
    450 amino acids
    Molecular mass:
    49954 Da
    Quaternary structure:
    • Interacts with RAB26 (PubMed:23105096). Interacts with PPP1R9B (PubMed:24114805).

    Three dimensional structures from OCA and Proteopedia for ADRA2B Gene

neXtProt entry for ADRA2B Gene

Post-translational modifications for ADRA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADRA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2B Gene

Domains & Families for ADRA2B Gene

Gene Families for ADRA2B Gene

Suggested Antigen Peptide Sequences for ADRA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18089

UniProtKB/Swiss-Prot:

ADA2B_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
genes like me logo Genes that share domains with ADRA2B: view

Function for ADRA2B Gene

Molecular function for ADRA2B Gene

UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
GENATLAS Biochemistry:
adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+ channels,contributing to the patho genesis of obesity

Phenotypes From GWAS Catalog for ADRA2B Gene

Gene Ontology (GO) - Molecular Function for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IBA,IEA --
GO:0004938 alpha2-adrenergic receptor activity TAS,IDA 17215105
GO:0005515 protein binding IPI 16531006
genes like me logo Genes that share ontologies with ADRA2B: view
genes like me logo Genes that share phenotypes with ADRA2B: view

Human Phenotype Ontology for ADRA2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADRA2B Gene

MGI Knock Outs for ADRA2B:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for ADRA2B (alpha-2B Adrenergic R/ADRA2B)

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADRA2B Gene

Localization for ADRA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2B Gene

Cell membrane; Multi-pass membrane protein. Note=Interaction with RAB26 mediates transport from the Golgi to the cell membrane. {ECO:0000269 PubMed:23105096}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA2B gene
Compartment Confidence
plasma membrane 5
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2164221
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRA2B Gene

Pathways & Interactions for ADRA2B Gene

genes like me logo Genes that share pathways with ADRA2B: view

Interacting Proteins for ADRA2B Gene

Gene Ontology (GO) - Biological Process for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0003056 regulation of vascular smooth muscle contraction IEA --
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADRA2B: view

No data available for SIGNOR curated interactions for ADRA2B Gene

Drugs & Compounds for ADRA2B Gene

(160) Drugs for ADRA2B Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved, Investigational, Vet_approved Pharma Antagonist, antagonist, Target 28
Apomorphine Approved, Investigational Pharma Antagonist, Partial agonist, Agonist, Full agonist, Activation, Activator, agonist, Target 40
Brimonidine Approved Pharma Partial agonist, Agonist, Full agonist, agonist, Target 0
Bromocriptine Approved, Investigational Pharma Antagonist, Full agonist, Agonist, Partial agonist, agonist, Target 33
Cabergoline Approved Pharma Antagonist, Full agonist, Agonist, Partial agonist, agonist, Target, antagonist 50

(5) Additional Compounds for ADRA2B Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-adrenaline
Full agonist, Agonist, Partial agonist
p-Octopamine
  • 4-(2R-amino-1-HYDROXYETHYL)phenol
  • Octopamine
  • P-Hydroxyphenylethanolamine
  • (RS)-Octopamine
  • 1-(P-Hydroxyphenyl)-2-aminoethanol
104-14-3
Clonidine hydrochloride
4205-91-8
Rilmenidine hemifumarate
207572-68-7

(5) Tocris Compounds for ADRA2B Gene

Compound Action Cas Number
Clonidine hydrochloride alpha2 agonist. Also I1 ligand 4205-91-8
Guanabenz acetate alpha2 agonist. Also I2 selective ligand 23256-50-0
Rilmenidine hemifumarate alpha2 agonist. Also I1 ligand 207572-68-7
Spiroxatrine Potent alpha2C antagonist 1054-88-2
UK 14,304 alpha2 agonist 59803-98-4
genes like me logo Genes that share compounds with ADRA2B: view

Transcripts for ADRA2B Gene

mRNA/cDNA for ADRA2B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA2B Gene

Adrenoceptor alpha 2B:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for ADRA2B (alpha-2B Adrenergic R/ADRA2B)

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2B Gene

No ASD Table

Relevant External Links for ADRA2B Gene

GeneLoc Exon Structure for
ADRA2B
ECgene alternative splicing isoforms for
ADRA2B

Expression for ADRA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADRA2B Gene

Protein differential expression in normal tissues from HIPED for ADRA2B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA2B Gene



Protein tissue co-expression partners for ADRA2B Gene

NURSA nuclear receptor signaling pathways regulating expression of ADRA2B Gene:

ADRA2B

SOURCE GeneReport for Unigene cluster for ADRA2B Gene:

Hs.247686

Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA2B Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cerebellum
  • eye
  • eyelid
  • face
  • head
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with ADRA2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for ADRA2B Gene

Orthologs for ADRA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA2B 33
  • 98.48 (n)
dog
(Canis familiaris)
Mammalia ADRA2B 33
  • 89.11 (n)
cow
(Bos Taurus)
Mammalia ADRA2B 33
  • 87.72 (n)
rat
(Rattus norvegicus)
Mammalia Adra2b 33
  • 84.79 (n)
mouse
(Mus musculus)
Mammalia Adra2b 16 33
  • 83.97 (n)
chicken
(Gallus gallus)
Aves LOC101751513 33
  • 75.45 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia adra2b 33
  • 60.48 (n)
zebrafish
(Danio rerio)
Actinopterygii adra2b 33
  • 58.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000606 33
  • 57.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7431 35
  • 46 (a)
CG18208 35
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea dop-1 33
  • 47.49 (n)
Species where no ortholog for ADRA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA2B Gene

ENSEMBL:
Gene Tree for ADRA2B (if available)
TreeFam:
Gene Tree for ADRA2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRA2B: view image

Paralogs for ADRA2B Gene

(6) SIMAP similar genes for ADRA2B Gene using alignment to 3 proteins:

  • ADA2B_HUMAN
  • A2RUS0_HUMAN
  • L8E8D5_HUMAN
genes like me logo Genes that share paralogs with ADRA2B: view

Variants for ADRA2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2B Gene

ADA2B_HUMAN-P18089
A rare polymorphic frameshift in position 451 produces a protein of 545 residues.

Sequence variations from dbSNP and Humsavar for ADRA2B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs879255577 pathogenic, Epilepsy, familial adult myoclonic 2 96,115,464(-) AAAGCCCCACCA/CTGCCAAAC coding_sequence_variant, inframe_indel
rs786205528 likely-pathogenic, not provided 96,115,486(-) G/A coding_sequence_variant, stop_gained
rs1057520077 uncertain-significance, not provided 96,115,874(-) G/C coding_sequence_variant, missense_variant
rs1000169652 -- 96,117,940(-) A/G upstream_transcript_variant
rs1000231137 -- 96,113,141(-) C/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA2B Gene

Variant ID Type Subtype PubMed ID
dgv4009n100 CNV gain 25217958
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591652 OTHER inversion 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv2834 CNV deletion 18451855

Variation tolerance for ADRA2B Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA2B Gene

Human Gene Mutation Database (HGMD)
ADRA2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRA2B

Disorders for ADRA2B Gene

MalaCards: The human disease database

(7) MalaCards diseases for ADRA2B Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADA2B_HUMAN
  • Epilepsy, familial adult myoclonic, 2 (FAME2) [MIM:607876]: A form of cortical myoclonic tremor with epilepsy, a syndrome characterized by cortical myoclonus and variable occurrence of epileptic seizures. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom; both complex partial as well as generalized tonic clonic seizures are described. Some patients exhibit mild cognitive impairment. {ECO:0000269 PubMed:24114805}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ADRA2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADRA2B: view

No data available for Genatlas for ADRA2B Gene

Publications for ADRA2B Gene

  1. Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. (PMID: 20051907) Muszkat M … Stein CM (Journal of hypertension 2010) 3 22 44 58
  2. Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome. (PMID: 19593211) Fava C … Melander O (Journal of hypertension 2009) 3 22 44 58
  3. A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. (PMID: 19826083) Rasch B … de Quervain DJ (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 44 58
  4. Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism. (PMID: 17277585) Laaksonen DE … Finnish Diabetes Prevention Study Group (Medicine and science in sports and exercise 2007) 3 22 44 58
  5. Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men. (PMID: 17620957) Ohlin B … Melander O (Journal of hypertension 2007) 3 22 44 58

Products for ADRA2B Gene

Sources for ADRA2B Gene

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