This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014] See more...

Aliases for ADRA2B Gene

Aliases for ADRA2B Gene

  • Adrenoceptor Alpha 2B 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C2 3 4
  • Alpha-2B Adrenergic Receptor 3 4
  • Alpha-2B Adrenoreceptor 3 4
  • Alpha-2BAR 3 4
  • ADRA2RL1 3 4
  • ADRA2L1 3 4
  • ADRARL1 2 3
  • ADRA2B Adrenergic, Alpha-2B-, Receptor 3
  • Alpha-2-Adrenergic Receptor-Like 1 3
  • Adrenergic, Alpha-2B-, Receptor 2
  • G-Protein Coupled Receptor 3
  • Alpha-2B Adrenoceptor 4
  • ALPHA2BAR 3
  • ADRA2B 5
  • FAME2 3

External Ids for ADRA2B Gene

Previous HGNC Symbols for ADRA2B Gene

  • ADRA2L1
  • ADRA2RL1

Previous GeneCards Identifiers for ADRA2B Gene

  • GC02M094650
  • GC02M095232
  • GC02M096246
  • GC02M096263
  • GC02M096200
  • GC02M096142
  • GC02M096778
  • GC02M090739

Summaries for ADRA2B Gene

Entrez Gene Summary for ADRA2B Gene

  • This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

GeneCards Summary for ADRA2B Gene

ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. Diseases associated with ADRA2B include Familial Adult Myoclonic Epilepsy and Epilepsy, Familial Adult Myoclonic, 2. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and alpha2-adrenergic receptor activity. An important paralog of this gene is ADRA2A.

UniProtKB/Swiss-Prot Summary for ADRA2B Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Tocris Summary for ADRA2B Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADRA2B Gene

Genomics for ADRA2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADRA2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J096116 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 605 0.0 -30 3.2 CTCF HNRNPL BACH1 LARP7 ZNF143 REST RAD21 TRIM22 ZFX NONO ADRA2B GPAT2 FAHD2CP ASTL
GH02J096155 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -41.5 -41469 4.2 SP1 LEF1 POLR2A BACH1 LARP7 STAT3 ZNF143 MTA2 RELA ZIC2 ADRA2B GPAT2 GPAT2P1 ARID5A DUSP2 KANSL3 TMEM127 ASTL lnc-CIAO1-3 ENSG00000228873
GH02J096009 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 16.3 +106.0 106044 2.1 CREB1 CTCF ATF7 ZNF629 ZNF692 BACH1 PKNOX1 MTA1 PATZ1 ZNF501 FAHD2CP lnc-CIAO1-4 GPAT2 ADRA2B DUSP2 ASTL ENSG00000230747 ITPRIPL1 lnc-ANKRD36C-3 ANKRD36C
GH02J096240 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 19.2 -125.3 -125332 3.1 SP1 BACH1 GABPA ZNF143 IKZF2 POLR2A YY1 PKNOX1 EED DPF2 ADRA2B piR-44093-002 lnc-CIAO1-5 TMEM127 STARD7 STARD7-AS1
GH02J095990 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 12.5 +124.8 124810 3.5 GATAD2A CTCF ZNF629 IKZF1 ZNF692 LARP7 ZNF143 ZIC2 RBFOX2 PKNOX1 ANKRD36C lnc-GPAT2-3 piR-54421 ADRA2B GPAT2 TRIM43
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRA2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRA2B

Top Transcription factor binding sites by QIAGEN in the ADRA2B gene promoter:
  • c-Myc
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • GR
  • GR-alpha
  • GR-beta
  • Max1
  • NF-YB

Genomic Locations for ADRA2B Gene

Genomic Locations for ADRA2B Gene
chr2:96,112,876-96,116,571
(GRCh38/hg38)
Size:
3,696 bases
Orientation:
Minus strand
chr2:96,778,623-96,781,984
(GRCh37/hg19)
Size:
3,362 bases
Orientation:
Minus strand

Genomic View for ADRA2B Gene

Genes around ADRA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2B Gene

Proteins for ADRA2B Gene

  • Protein details for ADRA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18089-ADA2B_HUMAN
    Recommended name:
    Alpha-2B adrenergic receptor
    Protein Accession:
    P18089
    Secondary Accessions:
    • A2RUS0
    • Q4TUH9
    • Q53RF2
    • Q9BZK0

    Protein attributes for ADRA2B Gene

    Size:
    450 amino acids
    Molecular mass:
    49954 Da
    Quaternary structure:
    • Interacts with RAB26 (PubMed:23105096). Interacts with PPP1R9B (PubMed:24114805). Interacts with GGA1, GGA2 and GGA3 (PubMed:27901063, PubMed:26811329).

    Three dimensional structures from OCA and Proteopedia for ADRA2B Gene

neXtProt entry for ADRA2B Gene

Post-translational modifications for ADRA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADRA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA2B Gene

Domains & Families for ADRA2B Gene

Gene Families for ADRA2B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADRA2B Gene

InterPro:
Blocks:
  • Adrenergic receptor signature
  • Alpha-2B adrenergic receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for ADRA2B Gene

GenScript: Design optimal peptide antigens:
  • HCG37297 (A2RUS0_HUMAN)
  • Alpha-2B adrenoreceptor (ADA2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18089

UniProtKB/Swiss-Prot:

ADA2B_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
genes like me logo Genes that share domains with ADRA2B: view

Function for ADRA2B Gene

Molecular function for ADRA2B Gene

UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
GENATLAS Biochemistry:
adrenergic,alpha-2B-,receptor-like 1,G protein coupled receptor superfamily,inhibiting Ca2+ channels,contributing to the patho genesis of obesity

Phenotypes From GWAS Catalog for ADRA2B Gene

Gene Ontology (GO) - Molecular Function for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0004935 adrenergic receptor activity IBA --
GO:0004938 alpha2-adrenergic receptor activity TAS,IDA 17215105
GO:0005515 protein binding IPI 16531006
GO:0051379 epinephrine binding IDA 17215105
genes like me logo Genes that share ontologies with ADRA2B: view
genes like me logo Genes that share phenotypes with ADRA2B: view

Human Phenotype Ontology for ADRA2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADRA2B Gene

MGI Knock Outs for ADRA2B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA2B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADRA2B Gene

Localization for ADRA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2B Gene

Cell membrane. Multi-pass membrane protein. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000269 PubMed:23105096, ECO:0000269 PubMed:26811329, ECO:0000269 PubMed:27901063}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA2B gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0009986 cell surface IDA 27901063
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRA2B Gene

Pathways & Interactions for ADRA2B Gene

genes like me logo Genes that share pathways with ADRA2B: view

Pathways by source for ADRA2B Gene

1 GeneGo (Thomson Reuters) pathway for ADRA2B Gene
  • Development Alpha-2 adrenergic receptor activation of ERK
5 Qiagen pathways for ADRA2B Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • AMPK Enzyme Complex Pathway
  • cAMP Pathway
  • Signaling Involved in Cardiac Hypertrophy

SIGNOR curated interactions for ADRA2B Gene

Activates:

Gene Ontology (GO) - Biological Process for ADRA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0003056 regulation of vascular smooth muscle contraction IEA --
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IDA,TAS --
genes like me logo Genes that share ontologies with ADRA2B: view

Drugs & Compounds for ADRA2B Gene

(168) Drugs for ADRA2B Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved, Investigational, Vet_approved Pharma Antagonist, Target, antagonist 36
Apomorphine Approved, Investigational Pharma Agonist, Partial agonist, Antagonist, Full agonist, Activator, Activation, Target, agonist 48
Brimonidine Approved Pharma Agonist, Full agonist, Partial agonist, Target, agonist 0
Bromocriptine Approved, Investigational Pharma Antagonist, Agonist, Partial agonist, Full agonist, Target, agonist 44
Cabergoline Approved Pharma Antagonist, Agonist, Full agonist, Partial agonist, Target, antagonist, agonist 60

(4) Additional Compounds for ADRA2B Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Clonidine hydrochloride
4205-91-8
Rilmenidine hemifumarate
207572-68-7

(5) Tocris Compounds for ADRA2B Gene

Compound Action Cas Number
Clonidine hydrochloride alpha2 agonist. Also I1 ligand 4205-91-8
Guanabenz acetate alpha2 agonist. Also I2 selective ligand 23256-50-0
Rilmenidine hemifumarate alpha2 agonist. Also I1 ligand 207572-68-7
Spiroxatrine Potent alpha2C antagonist 1054-88-2
UK 14,304 alpha2 agonist 59803-98-4

(61) ApexBio Compounds for ADRA2B Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
ARC 239 dihydrochloride α2B adrenoceptor antagonist 55974-42-0
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Moxonidine I1R/α2AR agonist 75438-57-2
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Setiptiline Serotonin receptor antagonist 57262-94-9
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine α2-adrenoceptor agonist 7361-61-7
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
genes like me logo Genes that share compounds with ADRA2B: view

Drug Products

Transcripts for ADRA2B Gene

mRNA/cDNA for ADRA2B Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA2B

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2B Gene

No ASD Table

Relevant External Links for ADRA2B Gene

GeneLoc Exon Structure for
ADRA2B

Expression for ADRA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRA2B Gene

Protein differential expression in normal tissues from HIPED for ADRA2B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA2B Gene



Protein tissue co-expression partners for ADRA2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRA2B

SOURCE GeneReport for Unigene cluster for ADRA2B Gene:

Hs.247686

Evidence on tissue expression from TISSUES for ADRA2B Gene

  • Nervous system(3.5)
  • Muscle(3.2)
  • Heart(3.2)
  • Blood(2.9)
  • Kidney(2.4)
  • Adrenal gland(2.3)
  • Intestine(2.2)
  • Liver(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA2B Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cerebellum
  • eye
  • eyelid
  • face
  • head
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with ADRA2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADRA2B Gene

Orthologs for ADRA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADRA2B 30
  • 98.48 (n)
Dog
(Canis familiaris)
Mammalia ADRA2B 30
  • 89.11 (n)
Cow
(Bos Taurus)
Mammalia ADRA2B 30
  • 87.72 (n)
Rat
(Rattus norvegicus)
Mammalia Adra2b 30
  • 84.79 (n)
Mouse
(Mus musculus)
Mammalia Adra2b 30 17
  • 83.97 (n)
Chicken
(Gallus gallus)
Aves LOC101751513 30
  • 75.45 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adra2b 30
  • 60.48 (n)
Zebrafish
(Danio rerio)
Actinopterygii adra2b 30
  • 58.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000606 30
  • 57.28 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7431 32
  • 46 (a)
CG18208 32
  • 44 (a)
Worm
(Caenorhabditis elegans)
Secernentea dop-1 30
  • 47.49 (n)
Species where no ortholog for ADRA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADRA2B Gene

ENSEMBL:
Gene Tree for ADRA2B (if available)
TreeFam:
Gene Tree for ADRA2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRA2B: view image

Paralogs for ADRA2B Gene

(6) SIMAP similar genes for ADRA2B Gene using alignment to 3 proteins:

  • ADA2B_HUMAN
  • A2RUS0_HUMAN
  • L8E8D5_HUMAN
genes like me logo Genes that share paralogs with ADRA2B: view

Variants for ADRA2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2B Gene

ADA2B_HUMAN-P18089
A rare polymorphic frameshift in position 451 produces a protein of 545 residues.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRA2B Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
655730 Uncertain Significance: not provided 96,115,455(-) G/C MISSENSE_VARIANT
706992 Likely Benign: not provided 96,115,238(-) C/CTCCTCT INFRAME_INSERTION
707066 Likely Benign: not provided 96,115,015(-) C/T MISSENSE_VARIANT
707706 Likely Benign: not provided 96,115,207(-) C/T MISSENSE_VARIANT
713934 Likely Benign: not provided 96,116,005(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ADRA2B Gene

Structural Variations from Database of Genomic Variants (DGV) for ADRA2B Gene

Variant ID Type Subtype PubMed ID
dgv4009n100 CNV gain 25217958
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591652 OTHER inversion 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv2834 CNV deletion 18451855

Variation tolerance for ADRA2B Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA2B Gene

Human Gene Mutation Database (HGMD)
ADRA2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRA2B

Disorders for ADRA2B Gene

MalaCards: The human disease database

(24) MalaCards diseases for ADRA2B Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADA2B_HUMAN
  • Epilepsy, familial adult myoclonic, 2 (FAME2) [MIM:607876]: A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME2 inheritance is autosomal dominant. {ECO:0000269 PubMed:24114805}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ADRA2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADRA2B: view

No data available for Genatlas for ADRA2B Gene

Publications for ADRA2B Gene

  1. Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. (PMID: 20051907) Muszkat M … Stein CM (Journal of hypertension 2010) 3 23 41
  2. A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. (PMID: 19826083) Rasch B … de Quervain DJ (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23 41
  3. Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome. (PMID: 19593211) Fava C … Melander O (Journal of hypertension 2009) 3 23 41
  4. Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism. (PMID: 17277585) Laaksonen DE … Finnish Diabetes Prevention Study Group (Medicine and science in sports and exercise 2007) 3 23 41
  5. Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men. (PMID: 17620957) Ohlin B … Melander O (Journal of hypertension 2007) 3 23 41

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Sources for ADRA2B Gene