Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules... See more...

Aliases for ADRA2A Gene

Aliases for ADRA2A Gene

  • Adrenoceptor Alpha 2A 2 3 5
  • Alpha-2 Adrenergic Receptor Subtype C10 3 4
  • Adrenergic, Alpha-2A-, Receptor 2 3
  • Alpha-2A Adrenergic Receptor 3 4
  • Alpha-2A Adrenoreceptor 3 4
  • Alpha-2AAR Subtype C10 2 3
  • Alpha-2A Adrenoceptor 3 4
  • ADRA2R 3 4
  • ADRAR 3 4
  • Alpha-2-Adrenergic Receptor, Platelet Type 3
  • Alpha-2A-Adrenergic Receptor 2
  • Alpha-2AAR 4
  • ALPHA2AAR 3
  • ZNF32 3
  • ADRA2 3

External Ids for ADRA2A Gene

Previous HGNC Symbols for ADRA2A Gene

  • ADRA2
  • ADRA2R

Previous GeneCards Identifiers for ADRA2A Gene

  • GC10P111730
  • GC10P112070
  • GC10P112968
  • GC10P112501
  • GC10P112826
  • GC10P106465

Summaries for ADRA2A Gene

Entrez Gene Summary for ADRA2A Gene

  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]

GeneCards Summary for ADRA2A Gene

ADRA2A (Adrenoceptor Alpha 2A) is a Protein Coding gene. Diseases associated with ADRA2A include Gilles De La Tourette Syndrome and Motion Sickness. Among its related pathways are Monoamine GPCRs and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is ADRA2C.

UniProtKB/Swiss-Prot Summary for ADRA2A Gene

  • Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Tocris Summary for ADRA2A Gene

  • Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C.

Gene Wiki entry for ADRA2A Gene

Additional gene information for ADRA2A Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADRA2A Gene

Genomics for ADRA2A Gene

GeneHancer (GH) Regulatory Elements for ADRA2A Gene

Promoters and enhancers for ADRA2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J111076 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 504.9 +0.2 172 2.4 CTCF USF1 ZIC2 ZBTB10 ZNF423 GABPA ZBTB26 REST RAD21 ZBTB7A ADRA2A piR-35506 piR-43819
GH10J110855 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6 -211.2 -211228 19.2 FOXK2 ZBTB40 EP300 ZSCAN5C TCF12 SIN3A MYC NRF1 POLR2G USF1 PDCD4 SMNDC1 SHOC2 SMC3 BBIP1 ADRA2A ENSG00000270589 DUSP5 ENSG00000232470 lnc-BBIP1-4
GH10J110915 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 5.7 -157.7 -157701 6.9 ZBTB40 ZNF217 EP300 ZSCAN5C TCF12 SIN3A NRF1 POLR2G SP1 PHF8 BBIP1 SHOC2 lnc-SMNDC1-8 ENSG00000270589 SMC3 SMNDC1 XPNPEP1 ADRA2A PDCD4
GH10J110965 Enhancer 0.7 Ensembl 14.9 -112.1 -112128 9 RBM25 ZNF316 ZKSCAN1 BCOR BATF ADNP ZNF146 PRDM6 FEZF1 RXRA SHOC2 ADRA2A BBIP1 ENSG00000270589 MIR548E RPL13AP6
GH10J111136 Enhancer 0.8 Ensembl ENCODE 11.7 +60.4 60372 2.8 USF1 TEAD4 HDAC2 NANOG FOSL1 FOXP1 NR3C1 TAF1 CHD7 EP300 HSALNG0080639 ADRA2A BBIP1 HSALNG0080641
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRA2A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRA2A

Top Transcription factor binding sites by QIAGEN in the ADRA2A gene promoter:
  • AREB6
  • Arnt
  • Bach1
  • c-Myc
  • E2F
  • E2F-1
  • E47
  • Max1

Genomic Locations for ADRA2A Gene

Genomic Locations for ADRA2A Gene
chr10:111,077,029-111,080,907
(GRCh38/hg38)
Size:
3,879 bases
Orientation:
Plus strand
chr10:112,836,790-112,840,665
(GRCh37/hg19)
Size:
3,876 bases
Orientation:
Plus strand

Genomic View for ADRA2A Gene

Genes around ADRA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA2A Gene

Proteins for ADRA2A Gene

  • Protein details for ADRA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08913-ADA2A_HUMAN
    Recommended name:
    Alpha-2A adrenergic receptor
    Protein Accession:
    P08913
    Secondary Accessions:
    • B0LPF6
    • Q2I8G2
    • Q2XN99
    • Q86TH8
    • Q9BZK1

    Protein attributes for ADRA2A Gene

    Size:
    465 amino acids
    Molecular mass:
    50647 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA51664.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA51664.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA51665.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA51665.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAG00447.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH35047.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH50414.4; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAK26743.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAK51162.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAZ73101.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABB72683.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABY87535.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADRA2A Gene

neXtProt entry for ADRA2A Gene

Post-translational modifications for ADRA2A Gene

  • Glycosylation at Asn10 and Asn14
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADRA2A Gene

Domains & Families for ADRA2A Gene

Gene Families for ADRA2A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for ADRA2A Gene

Blocks:
  • Adrenergic receptor signature
  • Alpha-2A adrenergic receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADRA2A Gene

GenScript: Design optimal peptide antigens:
  • Alpha-2A adrenoreceptor (ADA2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08913

UniProtKB/Swiss-Prot:

ADA2A_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
genes like me logo Genes that share domains with ADRA2A: view

Function for ADRA2A Gene

Molecular function for ADRA2A Gene

UniProtKB/Swiss-Prot Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
GENATLAS Biochemistry:
adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP opening K+ channels,inhibiting Ca2+ channels

Phenotypes From GWAS Catalog for ADRA2A Gene

Gene Ontology (GO) - Molecular Function for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IBA 21873635
GO:0004938 alpha2-adrenergic receptor activity ISS 1354394
GO:0005515 protein binding IPI 16531006
GO:0019901 protein kinase binding IPI 15653687
genes like me logo Genes that share ontologies with ADRA2A: view
genes like me logo Genes that share phenotypes with ADRA2A: view

Animal Models for ADRA2A Gene

MGI Knock Outs for ADRA2A:

Animal Model Products

CRISPR Products

miRNA for ADRA2A Gene

miRTarBase miRNAs that target ADRA2A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA2A Gene

Localization for ADRA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA2A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA2A gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19477270
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 2823383
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRA2A Gene

Pathways & Interactions for ADRA2A Gene

genes like me logo Genes that share pathways with ADRA2A: view

Pathways by source for ADRA2A Gene

1 GeneGo (Thomson Reuters) pathway for ADRA2A Gene
  • Development Alpha-2 adrenergic receptor activation of ERK
6 Qiagen pathways for ADRA2A Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Alpha-Adrenergic Signaling
  • AMPK Enzyme Complex Pathway
  • cAMP Pathway

SIGNOR curated interactions for ADRA2A Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ADRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 17655843
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,ISS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with ADRA2A: view

Drugs & Compounds for ADRA2A Gene

(264) Drugs for ADRA2A Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexmedetomidine Approved, Vet_approved Pharma Full agonist, Agonist, Partial agonist, agonist, Target 893
Guanfacine Approved, Investigational Pharma Full agonist, Agonist, Partial agonist, agonist, Target 71
Norepinephrine Approved Pharma stimulator, Target, agonist 915
Prazosin Approved Pharma Antagonist, Inverse agonist, antagonist, Target, binder 76
Brimonidine Approved Pharma Partial agonist, Agonist, Full agonist, agonist, Target 0

(15) Additional Compounds for ADRA2A Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
HMA
Negative, Allosteric regulator
Clonidine hydrochloride
4205-91-8
Rilmenidine hemifumarate
207572-68-7

(5) Tocris Compounds for ADRA2A Gene

Compound Action Cas Number
Clonidine hydrochloride alpha2 agonist. Also I1 ligand 4205-91-8
Guanabenz acetate alpha2 agonist. Also I2 selective ligand 23256-50-0
Rilmenidine hemifumarate alpha2 agonist. Also I1 ligand 207572-68-7
Spiroxatrine Potent alpha2C antagonist 1054-88-2
UK 14,304 alpha2 agonist 59803-98-4

(127) ApexBio Compounds for ADRA2A Gene

Compound Action Cas Number
(R)-(-)-Niguldipine hydrochloride
(R)-(+)-m-Nitrobiphenyline oxalate 945618-97-3
(S)-(-)-Atenolol 93379-54-5
(S)-(-)-Pindolol 26328-11-0
(S)-(-)-Propranolol hydrochloride 4199-10-4
(S)-(+)-Niguldipine hydrochloride 113145-69-0
2-PMDQ 139047-55-5
3-MPPI 133399-65-2
A 80426 mesylate α2-adrenoceptor antagonist and 5-HT uptake inhibitor 152148-64-6
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Agmatine sulfate 2482-00-0
Alfuzosin 81403-80-7
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Alprenolol hydrochloride 13707-88-5
Atipamezole hydrochloride 104075-48-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
B-HT 933 dihydrochloride α2-adrenoceptor agonist 36067-72-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
BRL 44408 maleate Selective α2A-AR antagonist 681806-46-2
Bucindolol 71119-11-4
Carvedilol 72956-09-3
Cimaterol 54239-37-1
Cirazoline hydrochloride 40600-13-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine 76631-46-4
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
Dihydroergocristine mesylate 24730-10-7
DL-Adrenaline 329-65-7
Dobutamine hydrochloride 49745-95-1
Doxazosin 74191-85-8
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
DSP-4 40616-75-9
Efaroxan hydrochloride 89197-00-2
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Guanfacine 29110-47-2
Guanfacine hydrochloride α2A-adrenoceptor agonist 29110-48-3
HEAT hydrochloride 30007-39-7
ICI 215,001 hydrochloride 140850-02-8
ICI 89406 53671-71-9
Idazoxan hydrochloride 79944-56-2
Imiloxan hydrochloride 81167-22-8
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
JP 1302 dihydrochloride 1259314-65-2
L-(-)-α-Methyldopa hydrochloride Alpha-adrenergic agonist 884-39-9
L-748,337 244192-94-7
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Levalbuterol tartrate 661464-94-4
Maprotiline HCl 10347-81-6
Medetomidine α2-adrenoceptor agonist 86347-14-0
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Succinate 98418-47-4
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Moxonidine I1R/α2AR agonist 75438-57-2
Moxonidine hydrochloride α2AR/I1R agonist 75536-04-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
NPEC-caged-noradrenalin 1257323-83-3
Oxprenolol hydrochloride 6452-73-9
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Pindolol 13523-86-9
Prazosin 19216-56-9
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Procaterol hydrochloride 62929-91-3
Pronethalol hydrochloride 1951-02-5
Propranolol HCl 318-98-9
Rauwolscine hydrochloride 6211-32-1
Rec 15/2615 dihydrochloride 173059-17-1
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
RS 100329 hydrochloride 1215654-26-4
RS 79948 hydrochloride 186002-54-0
RWJ 52353 245744-10-9
RX 821002 hydrochloride 109544-45-8
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmefamol 18910-65-1
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
SDZ 21009 39731-05-0
Setiptiline Serotonin receptor antagonist 57262-94-9
Silodosin α1-adrenoceptor antagonist 160970-54-7
SKF 86466 hydrochloride 86129-54-6
SNAP 5089 157066-77-8
Sotalol 959-24-0
Spiroxatrine 1054-88-2
SR 58611A hydrochloride 121524-09-2
SR 59230A hydrochloride 1135278-41-9
ST 91 4749-61-5
Synephrine 1994-07-5
Synephrine HCl 5985-28-4
TC-G 1000 245744-18-7
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine 51322-75-9
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
WB 4101 hydrochloride 2170-58-3
Xamoterol hemifumarate 73210-73-8
Xylazine α2-adrenoceptor agonist 7361-61-7
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
ZD 2079 178600-17-4
ZD 7114 hydrochloride 129689-28-7
Zinterol hydrochloride 37000-20-7
genes like me logo Genes that share compounds with ADRA2A: view

Drug Products

Transcripts for ADRA2A Gene

mRNA/cDNA for ADRA2A Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA2A Gene

No ASD Table

Relevant External Links for ADRA2A Gene

GeneLoc Exon Structure for
ADRA2A

Expression for ADRA2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA2A Gene

This gene is overexpressed in Cervix - Endocervix (x6.3), Adipose - Subcutaneous (x5.9), and Cervix - Ectocervix (x5.6).

Protein differential expression in normal tissues from HIPED for ADRA2A Gene

This gene is overexpressed in Fetal Brain (39.4), Peripheral blood mononuclear cells (16.4), and Adipocyte (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADRA2A Gene



Protein tissue co-expression partners for ADRA2A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRA2A

SOURCE GeneReport for Unigene cluster for ADRA2A Gene:

Hs.249159

Evidence on tissue expression from TISSUES for ADRA2A Gene

  • Nervous system(4.5)
  • Blood(4.4)
genes like me logo Genes that share expression patterns with ADRA2A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA2A Gene

Orthologs for ADRA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA2A 31 30
  • 99.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADRA2A 31
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADRA2A 30
  • 89.9 (n)
rat
(Rattus norvegicus)
Mammalia Adra2a 30
  • 89.03 (n)
mouse
(Mus musculus)
Mammalia Adra2a 17 31 30
  • 88.03 (n)
oppossum
(Monodelphis domestica)
Mammalia ADRA2A 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRA2A 31 30
  • 75.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRA2A 31
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adra2a 31 30
  • 65.28 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18208 31 32 30
  • 57.2 (n)
ManyToMany
DopR2 32
  • 44 (a)
Oct-TyrR 31
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea octr-1 31 30
  • 47.13 (n)
ManyToMany
F14D12.6 32
  • 42 (a)
ser-2 31
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToMany
Species where no ortholog for ADRA2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADRA2A Gene

ENSEMBL:
Gene Tree for ADRA2A (if available)
TreeFam:
Gene Tree for ADRA2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRA2A: view image

Paralogs for ADRA2A Gene

(3) SIMAP similar genes for ADRA2A Gene using alignment to 1 proteins:

  • ADA2A_HUMAN
genes like me logo Genes that share paralogs with ADRA2A: view

Variants for ADRA2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRA2A Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs1800544 Likely Benign: not specified 111,076,745(+) G/C
rs1800035 - p.Asn266Lys
rs35658213 - p.Cys416Ser

Additional dbSNP identifiers (rs#s) for ADRA2A Gene

Structural Variations from Database of Genomic Variants (DGV) for ADRA2A Gene

Variant ID Type Subtype PubMed ID
nsv527400 CNV loss 19592680
nsv7211 OTHER inversion 18451855
nsv7549 CNV insertion 18451855
nsv825566 CNV gain 20364138

Variation tolerance for ADRA2A Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA2A Gene

Human Gene Mutation Database (HGMD)
ADRA2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA2A Gene

Disorders for ADRA2A Gene

MalaCards: The human disease database

(21) MalaCards diseases for ADRA2A Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADRA2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADRA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA2A Gene

Publications for ADRA2A Gene

  1. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PMID: 20081858) Dupuis J … Barroso I (Nature genetics 2010) 3 23 41 54
  2. A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. (PMID: 19876010) Papathanasopoulos A … Zinsmeister AR (Obesity (Silver Spring, Md.) 2010) 3 23 41 54
  3. Effect of alpha2A-adrenoceptor C-1291G genotype and maltreatment on hyperactivity and inattention in adolescents. (PMID: 19922756) Kiive E … Harro J (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 23 41 54
  4. Association analysis between the C-1291G polymorphism in the promoter region of the adrenergic alpha2A receptor gene and polydipsia in schizophrenia. (PMID: 19439247) Yamaguchi W … Nakamura J (Progress in neuro-psychopharmacology & biological psychiatry 2009) 3 23 41 54
  5. Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. (PMID: 19150055) Cheon KA … Namkoong K (Biological psychiatry 2009) 3 23 41 54

Products for ADRA2A Gene

Sources for ADRA2A Gene