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Aliases for ADRA1D Gene

Aliases for ADRA1D Gene

  • Adrenoceptor Alpha 1D 2 3 5
  • Alpha-1A Adrenergic Receptor 3 4
  • Alpha-Adrenergic Receptor 1a 3 4
  • Alpha-1D Adrenoreceptor 3 4
  • Alpha-1D Adrenoceptor 3 4
  • ADRA1A 3 4
  • Adrenergic, Alpha -1D-, Receptor 3
  • Adrenergic, Alpha-1A-, Receptor 3
  • Adrenergic, Alpha-1D-, Receptor 2
  • Alpha-1D Adrenergic Receptor 3
  • DJ779E11.2 3
  • ADRA1R 3
  • ALPHA1 3
  • ADRA1 3
  • DAR 3

External Ids for ADRA1D Gene

Previous GeneCards Identifiers for ADRA1D Gene

  • GC20M004189
  • GC20M004196
  • GC20M004149

Summaries for ADRA1D Gene

Entrez Gene Summary for ADRA1D Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1D Gene

ADRA1D (Adrenoceptor Alpha 1D) is a Protein Coding gene. Diseases associated with ADRA1D include Prostatic Hyperplasia, Benign and Hyperekplexia. Among its related pathways are GPCRs, Other and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1B.

UniProtKB/Swiss-Prot for ADRA1D Gene

  • This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Tocris Summary for ADRA1D Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1D Gene

Additional gene information for ADRA1D Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1D Gene

Genomics for ADRA1D Gene

GeneHancer (GH) Regulatory Elements for ADRA1D Gene

Promoters and enhancers for ADRA1D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J004248 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 -0.4 -448 1.4 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 GLIS2 ZNF143 NFKBIZ SP3 ADRA1D PIR56216 GC20P004271
GH20J004220 Enhancer 1.2 Ensembl ENCODE 20.5 +27.1 27135 2.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 FOS SP5 MXD4 ADRA1D PRNP LINC01433
GH20J004225 Enhancer 1.1 FANTOM5 Ensembl ENCODE 17.2 +22.5 22546 2.3 CTCF JUN THRB RAD21 TEAD3 ZNF366 POLR2A ZNF143 FOSL2 FOS ADRA1D MAVS SLC4A11 LINC01433
GH20J004230 Enhancer 0.5 FANTOM5 28 +18.2 18207 0.2 ZFHX2 ZNF512 ZKSCAN8 PRDM1 EGR2 ADRA1D LINC01433
GH20J004592 Enhancer 1.1 Ensembl ENCODE 11.8 -343.6 -343591 1.1 FOXA2 SIN3A ZNF48 ZNF143 SP5 MXD4 REST SSRP1 GLIS1 KDM1A RPL7AP12 GC20M004590 ADRA1D PRND PRNP RPS4XP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADRA1D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADRA1D gene promoter:
  • SRF (504 AA)
  • SRF
  • PPAR-gamma2
  • PPAR-gamma1
  • Nkx2-5

Genomic Locations for ADRA1D Gene

Genomic Locations for ADRA1D Gene
28,444 bases
Minus strand
28,444 bases
Minus strand

Genomic View for ADRA1D Gene

Genes around ADRA1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1D Gene

Proteins for ADRA1D Gene

  • Protein details for ADRA1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-1D adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • Q9NPY0

    Protein attributes for ADRA1D Gene

    572 amino acids
    Molecular mass:
    60463 Da
    Quaternary structure:
    • Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.

neXtProt entry for ADRA1D Gene

Post-translational modifications for ADRA1D Gene

  • Glycosylation at Asn82 and Asn65
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA1D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA1D Gene

Domains & Families for ADRA1D Gene

Gene Families for ADRA1D Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADRA1D Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
genes like me logo Genes that share domains with ADRA1D: view

Function for ADRA1D Gene

Molecular function for ADRA1D Gene

UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
GENATLAS Biochemistry:
adrenergic,alpha-1D-,receptor,G protein coupled receptor superfamily,stimulating,acting through the phosphadidylinositol/Ca2+ second messenger system

Phenotypes From GWAS Catalog for ADRA1D Gene

Gene Ontology (GO) - Molecular Function for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IBA --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IBA,IEA --
GO:0004937 alpha1-adrenergic receptor activity IBA,TAS --
genes like me logo Genes that share ontologies with ADRA1D: view
genes like me logo Genes that share phenotypes with ADRA1D: view

Animal Models for ADRA1D Gene

MGI Knock Outs for ADRA1D:

Animal Model Products

CRISPR Products

miRNA for ADRA1D Gene

miRTarBase miRNAs that target ADRA1D

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA1D

Clone Products

  • R&D Systems cDNA Clones for ADRA1D (alpha-1D Adrenergic R/ADRA1D)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1D Gene

Localization for ADRA1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA1D gene
Compartment Confidence
plasma membrane 5
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7746284
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA1D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRA1D Gene

Pathways & Interactions for ADRA1D Gene

genes like me logo Genes that share pathways with ADRA1D: view

Gene Ontology (GO) - Biological Process for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic IBA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA --
GO:0006259 DNA metabolic process TAS 10969806
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADRA1D: view

No data available for SIGNOR curated interactions for ADRA1D Gene

Drugs & Compounds for ADRA1D Gene

(160) Drugs for ADRA1D Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamsulosin Approved, Investigational Pharma Inverse agonist, Antagonist, antagonist, Target 168
Silodosin Approved Pharma Antagonist, Target, antagonist α1-adrenoceptor antagonist 23
Prazosin Approved Pharma Inverse agonist, Antagonist, antagonist, Target 69
Norepinephrine Approved Pharma stimulator, Target, agonist 737
Droxidopa Approved, Investigational Pharma Target, agonist 33

(6) Additional Compounds for ADRA1D Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
Promazine 5-sulfoxide
BMY 7378 dihydrochloride
Urapidil hydrochloride

(5) Tocris Compounds for ADRA1D Gene

Compound Action Cas Number
3-MPPI alpha1 ligand 133399-65-2
A 61603 hydrobromide alpha1A agonist 107756-30-9
BMY 7378 dihydrochloride Selective alpha1D antagonist 21102-95-4
Cirazoline hydrochloride Selective alpha1 agonist 40600-13-3
Urapidil hydrochloride alpha1 antagonist. Also 5-HT1A receptor agonist 64887-14-5

(57) ApexBio Compounds for ADRA1D Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
genes like me logo Genes that share compounds with ADRA1D: view

Drug Products

Transcripts for ADRA1D Gene

mRNA/cDNA for ADRA1D Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA1D Gene

Adrenoceptor alpha 1D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA1D

Clone Products

  • R&D Systems cDNA Clones for ADRA1D (alpha-1D Adrenergic R/ADRA1D)

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1D Gene

No ASD Table

Relevant External Links for ADRA1D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADRA1D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADRA1D Gene

mRNA differential expression in normal tissues according to GTEx for ADRA1D Gene

This gene is overexpressed in Artery - Aorta (x5.5), Brain - Hippocampus (x4.4), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for ADRA1D Gene

This gene is overexpressed in Cervix (55.6) and Kidney (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA1D Gene

Protein tissue co-expression partners for ADRA1D Gene

NURSA nuclear receptor signaling pathways regulating expression of ADRA1D Gene:


SOURCE GeneReport for Unigene cluster for ADRA1D Gene:


Evidence on tissue expression from TISSUES for ADRA1D Gene

  • Nervous system(4.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ADRA1D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA1D Gene

Orthologs for ADRA1D Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADRA1D 33
  • 97.85 (n)
(Canis familiaris)
Mammalia ADRA1D 34
  • 94 (a)
(Bos Taurus)
Mammalia ADRA1D 34 33
  • 82.33 (n)
(Mus musculus)
Mammalia Adra1d 16 34 33
  • 82.27 (n)
(Rattus norvegicus)
Mammalia Adra1d 33
  • 81.94 (n)
(Monodelphis domestica)
Mammalia ADRA1D 34
  • 80 (a)
(Gallus gallus)
Aves ADRA1D 34 33
  • 68.35 (n)
(Anolis carolinensis)
Reptilia ADRA1D 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495969 33
  • 66.05 (n)
(Danio rerio)
Actinopterygii LOC568614 33
  • 61.77 (n)
adra1d 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta DopR2 35
  • 45 (a)
CG7431 35
  • 44 (a)
5-HT1B 35
  • 38 (a)
DopR 35
  • 36 (a)
5-HT1A 35
  • 34 (a)
CG6919 35
  • 34 (a)
CG6989 35
  • 33 (a)
Oamb 34 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea dop-4 34
  • 25 (a)
Species where no ortholog for ADRA1D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1D Gene

Gene Tree for ADRA1D (if available)
Gene Tree for ADRA1D (if available)
Evolutionary constrained regions (ECRs) for ADRA1D: view image

Paralogs for ADRA1D Gene

(16) SIMAP similar genes for ADRA1D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADRA1D: view

Variants for ADRA1D Gene

Sequence variations from dbSNP and Humsavar for ADRA1D Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000010625 -- 4,237,369(-) G/A intron_variant
rs1000050181 -- 4,237,801(-) C/T intron_variant
rs1000107007 -- 4,248,985(-) C/A/G 5_prime_UTR_variant
rs1000141228 -- 4,249,188(-) G/A upstream_transcript_variant
rs1000374645 -- 4,225,515(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA1D Gene

Variant ID Type Subtype PubMed ID
nsv833901 CNV gain 17160897
nsv180352 CNV deletion 16902084
nsv178938 CNV deletion 16902084
nsv1123449 CNV deletion 24896259
nsv1072099 CNV deletion 25765185
esv3645076 CNV loss 21293372
esv3645074 CNV gain 21293372
esv2722130 CNV deletion 23290073
esv2722129 CNV deletion 23290073
esv2722127 CNV deletion 23290073
esv2661469 CNV deletion 23128226

Variation tolerance for ADRA1D Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 52.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA1D Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1D Gene

Disorders for ADRA1D Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADRA1D Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
prostatic hyperplasia, benign
  • bph
  • startle disease, familial
hypertension, essential
  • eht
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADRA1D

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADRA1D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA1D Gene

Publications for ADRA1D Gene

  1. Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy. (PMID: 17404580) Nonen S … Azuma J (The pharmacogenomics journal 2008) 3 22 44 58
  2. Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding. (PMID: 18187928) Nagaoka Y … Nagatomo T (Journal of pharmacological sciences 2008) 3 22 25 58
  3. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. (PMID: 12442007) Sugaya K … Ogawa Y (The Journal of urology 2002) 3 22 44 58
  4. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. (PMID: 7746284) Esbenshade TA … Murphy TJ (Molecular pharmacology 1995) 3 4 22 58
  5. G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation. (PMID: 26460884) Tirupula KC … Karnik SS (Biochemistry 2015) 3 4 58

Products for ADRA1D Gene

Sources for ADRA1D Gene

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