Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene enco... See more...

Aliases for ADRA1D Gene

Aliases for ADRA1D Gene

  • Adrenoceptor Alpha 1D 2 3 5
  • ADRA1A 2 3 4
  • Alpha-1D Adrenergic Receptor 3 4
  • Alpha-1A Adrenergic Receptor 3 4
  • Alpha-Adrenergic Receptor 1a 3 4
  • Alpha-1D Adrenoreceptor 3 4
  • Alpha-1D Adrenoceptor 3 4
  • ADRA1R 2 3
  • ADRA1 2 3
  • Adrenergic, Alpha -1D-, Receptor 3
  • Adrenergic, Alpha-1D-, Receptor 2
  • Adrenergic, Alpha-1A-, Receptor 3
  • DJ779E11.2 3
  • ALPHA1 3
  • ADRA1D 5
  • DAR 3

External Ids for ADRA1D Gene

Previous GeneCards Identifiers for ADRA1D Gene

  • GC20M004189
  • GC20M004196
  • GC20M004149

Summaries for ADRA1D Gene

Entrez Gene Summary for ADRA1D Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1D Gene

ADRA1D (Adrenoceptor Alpha 1D) is a Protein Coding gene. Diseases associated with ADRA1D include Ureterolithiasis and Hypertension, Essential. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1B.

UniProtKB/Swiss-Prot Summary for ADRA1D Gene

  • This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Tocris Summary for ADRA1D Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1D Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADRA1D Gene

Genomics for ADRA1D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADRA1D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J004248 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.7 +0.5 465 2.8 HNRNPL GATAD2A CTCF PRDM10 TFE3 NFKBIZ KDM1A ZNF692 RCOR2 ZNF7 ADRA1D piR-50444-273 SMOX MN298678-039
GH20J004220 Promoter/Enhancer 1.3 Ensembl ENCODE 20.6 +26.9 26900 3.2 GATAD2A CTCF TFE3 LEF1 SOX13 IKZF1 NFKBIZ KDM1A ZNF692 JUND ADRA1D PRNP piR-50444-273 LINC01433 SMOX MN298678-039
GH20J004225 Enhancer 1.1 FANTOM5 Ensembl ENCODE 18.1 +22.2 22226 3.3 CTCF ZNF512 IKZF1 JUND ZNF24 RXRB NR2C1 ZNF37A CEBPB FOS ADRA1D SLC4A11 piR-50444-273 SMOX MN298678-039
GH20J004230 Enhancer 0.7 FANTOM5 Ensembl 28.1 +18.5 18486 0.4 ZNF512 PRDM1 ZKSCAN8 ZFHX2 ZNF3 EGR2 ADRA1D piR-50444-273 SMOX MN298678-039
GH20J004584 Enhancer 0.7 Ensembl ENCODE 17.3 -335.8 -335785 1.3 ZNF512 JUND EP300 TRIM24 FOSL1 CEBPG ZNF584 ATF4 ZNF366 ZNF589 ADRA1D PRND PRNP piR-43105-368 lnc-RASSF2-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRA1D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADRA1D

Top Transcription factor binding sites by QIAGEN in the ADRA1D gene promoter:
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for ADRA1D Gene

Genomic Locations for ADRA1D Gene
chr20:4,220,630-4,249,287
(GRCh38/hg38)
Size:
28,658 bases
Orientation:
Minus strand
chr20:4,201,278-4,229,721
(GRCh37/hg19)
Size:
28,444 bases
Orientation:
Minus strand

Genomic View for ADRA1D Gene

Genes around ADRA1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1D Gene

Proteins for ADRA1D Gene

  • Protein details for ADRA1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25100-ADA1D_HUMAN
    Recommended name:
    Alpha-1D adrenergic receptor
    Protein Accession:
    P25100
    Secondary Accessions:
    • Q9NPY0

    Protein attributes for ADRA1D Gene

    Size:
    572 amino acids
    Molecular mass:
    60463 Da
    Quaternary structure:
    • Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.

neXtProt entry for ADRA1D Gene

Post-translational modifications for ADRA1D Gene

  • Glycosylation at Asn65 and Asn82
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA1D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA1D Gene

Domains & Families for ADRA1D Gene

Gene Families for ADRA1D Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ADRA1D Gene

InterPro:
Blocks:
  • Adrenergic receptor signature
  • Alpha-1A adrenergic receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for ADRA1D Gene

GenScript: Design optimal peptide antigens:
  • Alpha-adrenergic receptor 1a (ADA1D_HUMAN)
  • Adrenergic, alpha-1D-, receptor (B0ZBE0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25100

UniProtKB/Swiss-Prot:

ADA1D_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
genes like me logo Genes that share domains with ADRA1D: view

Function for ADRA1D Gene

Molecular function for ADRA1D Gene

UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
GENATLAS Biochemistry:
adrenergic,alpha-1D-,receptor,G protein coupled receptor superfamily,stimulating,acting through the phosphadidylinositol/Ca2+ second messenger system

Phenotypes From GWAS Catalog for ADRA1D Gene

Gene Ontology (GO) - Molecular Function for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0004935 adrenergic receptor activity IBA --
GO:0004937 alpha1-adrenergic receptor activity IBA 21873635
GO:0005515 protein binding IPI 16533813
GO:0042802 identical protein binding IPI 14645668
genes like me logo Genes that share ontologies with ADRA1D: view
genes like me logo Genes that share phenotypes with ADRA1D: view

Animal Models for ADRA1D Gene

MGI Knock Outs for ADRA1D:

Animal Model Products

CRISPR Products

miRNA for ADRA1D Gene

miRTarBase miRNAs that target ADRA1D

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA1D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1D Gene

Localization for ADRA1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1D Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA1D gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA1D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRA1D Gene

Pathways & Interactions for ADRA1D Gene

genes like me logo Genes that share pathways with ADRA1D: view

Pathways by source for ADRA1D Gene

2 GeneGo (Thomson Reuters) pathways for ADRA1D Gene
  • Development Activation of ERK by Alpha-1 adrenergic receptors
  • Translation Translation regulation by Alpha-1 adrenergic receptors
4 Qiagen pathways for ADRA1D Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • AMPK Enzyme Complex Pathway
  • cAMP Pathway

SIGNOR curated interactions for ADRA1D Gene

Activates:

Gene Ontology (GO) - Biological Process for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADRA1D: view

Drugs & Compounds for ADRA1D Gene

(167) Drugs for ADRA1D Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamsulosin Approved, Investigational Pharma Antagonist, Inverse agonist, Target, antagonist 195
Silodosin Approved Pharma Antagonist, Target, antagonist α1-adrenoceptor antagonist 24
Prazosin Approved Pharma Antagonist, Inverse agonist, Target, Target, antagonist 70
Norepinephrine Approved Pharma Target, agonist, stimulator 952
Alfuzosin Approved, Investigational Pharma Target, antagonist 52

(6) Additional Compounds for ADRA1D Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-niguldipine
Antagonist
Promazine 5-sulfoxide
3-MPPI
133399-65-2
BMY 7378 dihydrochloride
21102-95-4
Urapidil hydrochloride
64887-14-5

(5) Tocris Compounds for ADRA1D Gene

Compound Action Cas Number
3-MPPI alpha1 ligand 133399-65-2
A 61603 hydrobromide alpha1A agonist 107756-30-9
BMY 7378 dihydrochloride Selective alpha1D antagonist 21102-95-4
Cirazoline hydrochloride Selective alpha1 agonist 40600-13-3
Urapidil hydrochloride alpha1 antagonist. Also 5-HT1A receptor agonist 64887-14-5

(57) ApexBio Compounds for ADRA1D Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
genes like me logo Genes that share compounds with ADRA1D: view

Drug Products

Transcripts for ADRA1D Gene

mRNA/cDNA for ADRA1D Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADRA1D

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1D Gene

No ASD Table

Relevant External Links for ADRA1D Gene

GeneLoc Exon Structure for
ADRA1D

Expression for ADRA1D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADRA1D Gene

mRNA differential expression in normal tissues according to GTEx for ADRA1D Gene

This gene is overexpressed in Artery - Aorta (x5.5), Brain - Hippocampus (x4.4), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for ADRA1D Gene

This gene is overexpressed in Cervix (55.6) and Kidney (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA1D Gene



Protein tissue co-expression partners for ADRA1D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADRA1D

SOURCE GeneReport for Unigene cluster for ADRA1D Gene:

Hs.557

Evidence on tissue expression from TISSUES for ADRA1D Gene

  • Nervous system(4.7)
  • Muscle(3.3)
  • Heart(3.2)
  • Blood(2.9)
  • Kidney(2.9)
  • Adrenal gland(2.6)
  • Intestine(2.6)
  • Liver(2.4)
  • Skin(2.2)
  • Lung(2.2)
  • Urine(2.2)
genes like me logo Genes that share expression patterns with ADRA1D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA1D Gene

Orthologs for ADRA1D Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADRA1D 30
  • 97.85 (n)
Dog
(Canis familiaris)
Mammalia ADRA1D 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ADRA1D 30 31
  • 82.33 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Adra1d 30 17 31
  • 82.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adra1d 30
  • 81.94 (n)
Oppossum
(Monodelphis domestica)
Mammalia ADRA1D 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADRA1D 30 31
  • 68.35 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADRA1D 31
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100495969 30
  • 66.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC568614 30
  • 61.77 (n)
adra1d 31
  • 59 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta DopR2 32
  • 45 (a)
CG7431 32
  • 44 (a)
5-HT1B 32
  • 38 (a)
DopR 32
  • 36 (a)
5-HT1A 32
  • 34 (a)
CG6919 32
  • 34 (a)
CG6989 32
  • 33 (a)
Oamb 31 32
  • 24 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dop-4 31
  • 25 (a)
OneToMany
Species where no ortholog for ADRA1D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADRA1D Gene

ENSEMBL:
Gene Tree for ADRA1D (if available)
TreeFam:
Gene Tree for ADRA1D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADRA1D: view image

Paralogs for ADRA1D Gene

(16) SIMAP similar genes for ADRA1D Gene using alignment to 2 proteins:

  • ADA1D_HUMAN
  • B0ZBE0_HUMAN
genes like me logo Genes that share paralogs with ADRA1D: view

Variants for ADRA1D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADRA1D Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
762311 Benign: not provided 4,248,274(-) G/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ADRA1D Gene

Structural Variations from Database of Genomic Variants (DGV) for ADRA1D Gene

Variant ID Type Subtype PubMed ID
esv2661469 CNV deletion 23128226
esv2722127 CNV deletion 23290073
esv2722129 CNV deletion 23290073
esv2722130 CNV deletion 23290073
esv3645074 CNV gain 21293372
esv3645076 CNV loss 21293372
nsv1072099 CNV deletion 25765185
nsv1123449 CNV deletion 24896259
nsv178938 CNV deletion 16902084
nsv180352 CNV deletion 16902084
nsv833901 CNV gain 17160897

Variation tolerance for ADRA1D Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 52.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA1D Gene

Human Gene Mutation Database (HGMD)
ADRA1D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRA1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1D Gene

Disorders for ADRA1D Gene

MalaCards: The human disease database

(17) MalaCards diseases for ADRA1D Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADRA1D

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADRA1D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA1D Gene

Publications for ADRA1D Gene

  1. Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding. (PMID: 18187928) Nagaoka Y … Nagatomo T (Journal of pharmacological sciences 2008) 3 23 26
  2. Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy. (PMID: 17404580) Nonen S … Azuma J (The pharmacogenomics journal 2008) 3 23 41
  3. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. (PMID: 12442007) Sugaya K … Ogawa Y (The Journal of urology 2002) 3 23 41
  4. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. (PMID: 7746284) Esbenshade TA … Murphy TJ (Molecular pharmacology 1995) 3 4 23
  5. G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation. (PMID: 26460884) Tirupula KC … Karnik SS (Biochemistry 2015) 3 4

Products for ADRA1D Gene

Sources for ADRA1D Gene